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81. 发明申请

US20150065728A1 NOVEL BENZYLIDENE AZOLIDINE DERIVATIVE OR SALT THEREOF 有权
标题翻译：新的苄基胆碱衍生物或其盐
公开(公告)号：US20150065728A1
公开(公告)日：2015-03-05
申请号：US14389139
申请日：2013-03-27
申请人： ROHTO Pharmaceutical Co., Ltd.
发明人： Takashi Shimizu
IPC分类号： C07D233/96 , A61Q17/04 , A61K8/49
CPC分类号： C07D233/96 , A61K8/49 , A61K8/494 , A61K8/4946 , A61Q17/04 , A61Q19/00
摘要： A novel compound which has excellent ultraviolet-absorbing function (especially UVA absorbing function) and excellent hydrophilicity. A benzylidene azolidine derivative represented by structural formula (I) or a salt thereof. In structural formula (I), n represents an integer of 1-5; A1 represents O, S or N-A4; and each of A2, A3 and A4 independently represents a hydrogen atom, an alkyl group which may be substituted by a hydroxyl group and has 1-8 carbon atoms, or the like (provided that at least one of A2, A3 and A4 contains one or more hydroxyl groups). In this connection, when n is an integer of 2-5, the plurality of A3O— moieties may be the same as or different.
摘要翻译：具有优异的紫外线吸收功能（特别是UVA吸收功能）和优异亲水性的新型化合物。由结构式（I）表示的亚苄基偶氮化合物衍生物或其盐。在结构式（I）中，n表示1-5的整数; A1代表O，S或N-A4; A2，A3和A4各自独立地表示氢原子，可以被羟基取代并具有1-8个碳原子的烷基等（条件是A2，A3和A4中的至少一个包含一个或更多的羟基）。在这一点上，当n为2-5的整数时，多个A3O-部分可以相同或不同。

82. 发明申请

US20140371123A1 AQUEOUS OPHTHALMIC COMPOSITION 审中-公开
标题翻译：水性眼科组合物（AQUEOUS OPHTHALMIC COMPOSITION）
公开(公告)号：US20140371123A1
公开(公告)日：2014-12-18
申请号：US14477502
申请日：2014-09-04
申请人： ROHTO PHARMACEUTICAL CO., LTD.
发明人： Atsuko NAKATA
IPC分类号： A61L12/14
CPC分类号： A61L12/14 , A61K9/0048 , A61K31/07 , A61K31/69 , A61K47/14 , A61K2300/00
摘要： This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the number of moles of added ethylene oxide is 2 to 30, and (B) at least one member selected from the group consisting of castor oil and vitamin A. According to the aqueous ophthalmic composition of the present invention, the defoaming time can be reduced even when foam is generated by vibration or impact.
摘要翻译：本发明涉及一种水性眼用组合物，其包含（A）加成环氧乙烷的摩尔数为2〜30的聚氧乙烯蓖麻油，（B）选自蓖麻油和维生素A的至少一种。根据本发明的水性眼用组合物，即使通过振动或冲击产生泡沫，也可以降低消泡时间。

83. 发明申请

US20140243419A1 MUCOSALLY-APPLIED AGENT FOR PREVENTION, AMELIORATION OR TREATMENT OF RETINAL DISEASE 审中-公开
标题翻译：用于预防，治疗或治疗退行性疾病的粘膜剂
公开(公告)号：US20140243419A1
公开(公告)日：2014-08-28
申请号：US14267221
申请日：2014-05-01
申请人： ROHTO PHARMACEUTICAL CO., LTD.
发明人： Takahiro KUROSE , Yoshihiro TAKAI , Takayuki MIYANO , Yusuke TAKEUCHI
IPC分类号： A61K31/121
CPC分类号： A61K31/121 , A61K9/0043 , A61K9/0048 , A61K9/08 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/44
摘要： Application of a pharmaceutical preparation comprising geranylgeranylacetone to the mucosa of, for example, the eye, nose, oral cavity or pharynx can efficiently prevent, ameliorate or treat retinal diseases such as glaucoma, retinitis pigmentosa, age-related macular degeneration, and diabetic retinopathy.
摘要翻译：包含香叶基香叶基丙酮的药物制剂在例如眼睛，鼻子，口腔或咽部的粘膜中的应用可以有效地预防，改善或治疗视网膜疾病如青光眼，色素性视网膜炎，年龄相关性黄斑变性和糖尿病性视网膜病变。

84. 发明申请

US20130303625A1 AGENT FOR THE PREVENTION, IMPROVEMENT OR TREATMENT OF RETINAL DISEASE 审中-公开
标题翻译：预防，改善或治疗退行性疾病的代理人
公开(公告)号：US20130303625A1
公开(公告)日：2013-11-14
申请号：US13775605
申请日：2013-02-25
申请人： ROHTO PHARMACEUTICAL CO., LTD.
发明人： Takahiro KUROSE , Takayuki MIYANO , Mariyo KATO , Yoshihiro TAKAI
IPC分类号： A61K31/121
CPC分类号： A61K31/121 , A61K9/0048 , A61K9/0053 , A61K45/06 , A61K47/02 , A61K47/26 , A61K47/44
摘要： A prophylactic, ameliorating or therapeutic agent for a retinal disease, the agent comprising geranylgeranylacetone which (a) is a mixture of (5E,9E,13E)-geranylgeranylacetone and (5Z,9E,13E)-geranylgeranylacetone, the (5E,9E,13E)-geranylgeranylacetone content of the mixture being 80% by weight or more, (b) consists of (5E,9E,13E)-geranylgeranylacetone, or (c) consists of (5Z,9E,13E)-geranylgeranylacetone directly suppresses the death of a retinal cell, thereby fundamentally preventing, ameliorating or treating the retinal disease.
摘要翻译：（5E，9E，13E）ger anyl ger anyl anyl anyl one one and，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，， 13E）ger anyl ger anyl anyl anyl one one death death death death death death，，，，，death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death death 的视网膜细胞，从而从根本上防止，改善或治疗视网膜疾病。

85. 发明申请

US20040079766A1 Nozzle for a liquid container and a liquid container 有权
标题翻译：用于液体容器和液体容器的喷嘴
公开(公告)号：US20040079766A1
公开(公告)日：2004-04-29
申请号：US10686409
申请日：2003-10-14
申请人： Rohto Pharmaceutical Co., Ltd.
发明人： Shigehiko Kokubo
IPC分类号： B65D037/00
CPC分类号： B65D47/18 , B65D47/0838 , B65D47/123
摘要： A lower portion of a nozzle is held hermetically in contact with an inner circumferential surface of the tubular neck of a container, and an inner surface of a cap is mounted to an outer surface of the tubular neck. A discharging hole of the nozzle is hermetically sealed by an inner top surface of the cap. A ring-shaped projection is formed on an upper portion of the nozzle for hermetically contacting an inner surface of the cap. Thereby, double sealing is provided in cooperation with hermetic sealing of the discharging hole of the nozzle by the inner top surface of the cap. The nozzle prevents a liquid leak and liquid dripping from the nozzle and form liquid drops independently of a dripping angle.
摘要翻译：喷嘴的下部与容器的管状颈部的内周面气密地保持接触，盖的内表面安装在管状颈部的外表面。喷嘴的排出孔被盖的内顶表面气密地密封。在喷嘴的上部形成有环形突起，用于使盖的内表面气密接触。因此，通过盖的内顶表面与喷嘴的排出孔的气密密封配合来提供双重密封。喷嘴防止液体泄漏和液体从喷嘴滴落并独立于滴水角度形成液滴。

86. 发明授权

US12090133B2 Topical composition 有权
公开(公告)号：US12090133B2
公开(公告)日：2024-09-17
申请号：US17498147
申请日：2021-10-11
申请人： The Mentholatum Company , ROHTO Pharmaceutical Co., Ltd.
发明人： Yoshiaki Kawaguchi , Tammam Alama
IPC分类号： A61K31/325 , A61K9/00 , A61K9/06
CPC分类号： A61K31/325 , A61K9/0014 , A61K9/06
摘要： Problem: To provide a topical composition having excellent permeability in the stratum corneum. Solution: A topical composition is prepared that comprises: (A) one antifungal agent or two or more antifungal agents selected from the group consisting of tolnaftate and pharmaceutically acceptable salts thereof; and (B) at least one compound selected from the group consisting of ester compounds of fatty acids having from 8 to 18 carbon atoms and dihydric alcohols having from 2 to 4 carbon atoms, lysine acyl glutamate, lysine diacyl glutamate, pharmaceutically acceptable salts of lysine acyl glutamate or lysine diacyl glutamate, diethylene glycol-based glycol ethers, cyclohexanedicarboxylic acid polyoxyethylene alkyl ethers, mannosylerythritol lipids, and sucrose fatty acid esters.

87. 发明公开

US20240033311A1 COMPOSITION AND FUNCTIONAL FOOD FOR PREVENTING MYOPIA 审中-公开
公开(公告)号：US20240033311A1
公开(公告)日：2024-02-01
申请号：US18483161
申请日：2023-10-09
申请人： TSUBOTA LABORATORY, INC. , ROHTO PHARMACEUTICAL CO., LTD.
发明人： Kazuo TSUBOTA , Toshihide KURIHARA
IPC分类号： A61K36/16 , A61P27/10 , A61K9/00 , A61K31/05 , A61K31/202
CPC分类号： A61K36/16 , A61P27/10 , A61K9/0056 , A61K31/05 , A61K31/202
摘要： The ophthalmic composition effective for the prevention or treatment of myopia or ocular diseases are provided. In particular, the present invention provides an ophthalmic composition effective in a growing child or a young person in whom myopia develops and progresses, as well as a middle-aged and elderly person in whom age-related ocular diseases such as cataract, glaucoma, retinal detachment, retinopathy, maculopathy, choroidal neovascularization, posterior staphyloma, and optic neuropathy develop, a functional food containing the ophthalmic composition, and a screening method capable of searching for the same. [Solution] The above problem is solved by an ophthalmic composition or functional food product containing at least one component selected from the group consisting of crocetin and its pharmaceutically acceptable salts and ginkgo leaf extract.

88. 发明授权

US11357798B2 Mesenchymal stem cell-derived exosome 有权
公开(公告)号：US11357798B2
公开(公告)日：2022-06-14
申请号：US15749766
申请日：2016-08-03
申请人： OSAKA UNIVERSITY , ROHTO PHARMACEUTICAL CO., LTD.
发明人： Kohji Nishida , Ryuuhei Hayashi , Yoichi Honma , Toru Okubo , Shun Shibata
IPC分类号： A61K35/28 , A61P27/02 , C12N5/0775 , C12N5/00 , C12Q1/02 , A61K35/12
摘要： The present invention relates to mesenchymal stem cell-derived microparticles having activity that promotes the growth of corneal epithelial stem cells and/or corneal epithelial cells, activity that maintains corneal epithelial stem cells in an undifferentiated state or promotes the formation of colonies thereby, and function that protects corneal epithelium.

89. 发明授权

US11331390B2 Ophthalmic composition 有权
公开(公告)号：US11331390B2
公开(公告)日：2022-05-17
申请号：US16094919
申请日：2017-04-21
申请人： Rohto Pharmaceutical Co., Ltd.
发明人： Yasuko Matsumura
IPC分类号： A61K47/26 , A61K9/00 , A61K31/045 , A61K31/14 , A61K31/355 , A61K47/44 , A61K47/10 , C08J5/00 , A61K47/18 , A61K47/12 , A61K47/02 , A61K47/22
摘要： The first aspect of the present invention relates to an ophthalmic composition comprising (A) one or more kinds selected from the group consisting of terpenoid, a tocopherol, and a benzyl ammonium compound and a salt thereof, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.
The second aspect of the present invention relates to an ophthalmic composition comprising (A2) a surface active component and (B2) a buffer, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.

90. 发明授权

US11273437B2 Cell treatment apparatus 有权
公开(公告)号：US11273437B2
公开(公告)日：2022-03-15
申请号：US15764731
申请日：2016-10-19
申请人： Rohto Pharmaceutical Co., Ltd.
发明人： Tetsuo Koike , Masahiro Takimoto , Yoshiki Yagi
IPC分类号： B01L1/02 , B25J21/02 , C12M3/00 , B25J21/00 , C12M1/00 , C12M1/12
摘要： Provided is a cell treatment apparatus that includes: an isolator; a disposal box that includes a storage part; and a decontamination unit, wherein the disposal box includes: a first opening and closing device that is configured to allow the isolator and the storage part to be communicated with each other at the time of disposal of the waste product and allow them to be shut off from each other after the putting-in of the waste product and before the disposal of the same; and a second opening and closing device that is configured to allow the storage part and the outside to be communicated with each other at the time of disposal of the waste product, which has been put into the storage part, and allow them to be shut off from each other after the disposal of the waste product.

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