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81. 发明申请

US20180043034A1 GENE AUGMENTATION THERAPIES FOR INHERITED RETINAL DEGENERATION CAUSED BY MUTATIONS IN THE PRPF31 GENE 审中-公开
公开(公告)号：US20180043034A1
公开(公告)日：2018-02-15
申请号：US15555915
申请日：2016-03-07
申请人： Massachusetts Eye and Ear Infirmary
发明人： Eric A. Pierce , Michael H. Farkas , Maria E. Sousa
IPC分类号： A61K48/00 , A61K9/00 , C12N15/90 , C12N15/63
CPC分类号： A61K48/005 , A61K9/0048 , C12N15/113 , C12N15/63 , C12N15/90 , C12N2310/20 , C12N2750/14143 , C12N2800/22 , C12N2830/008 , C12N2310/14 , C12N2310/531
摘要： The present invention relates to methods and compositions for gene therapy of retinitis pigmentosa related to mutations in pre-mRNA processing factor 31 (PRPF31).

82. 发明申请

US20180042718A1 ARTIFICIAL TYMPANIC MEMBRANE DEVICES AND USES 审中-公开
公开(公告)号：US20180042718A1
公开(公告)日：2018-02-15
申请号：US15559582
申请日：2016-03-21
申请人： Massachusetts Eye and Ear Infirmary , President and Fellows of Harvard College
发明人： Aaron K. Remenschneider , Elliott Kozin , Nicole Black , Michael J. McKenna , Daniel J. Lee , Jennifer Lewis , John Rosowski , David Kolesky , Mark A. Skylar-Scott , Alexander D. Valentine
IPC分类号： A61F2/18 , A61L27/54 , A61L27/38 , A61L27/26
CPC分类号： A61F2/18 , A61F2002/183 , A61F2230/0006 , A61F2230/0067 , A61F2250/0067 , A61L27/26 , A61L27/3839 , A61L27/54 , A61L2430/14
摘要： This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the under-lay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a “lock and key” manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.

83. 发明申请

US20170340754A1 Efficient delivery of therapeutic molecules in vitro and in vivo 审中-公开
公开(公告)号：US20170340754A1
公开(公告)日：2017-11-30
申请号：US15523325
申请日：2015-10-29
申请人： Massachusetts Eye and Ear Infirmary
发明人： Zheng-Yi Chen , David Liu
IPC分类号： A61K48/00 , C07J7/00 , C07K7/06 , C12N9/22 , C07K7/08 , C12N15/11 , C12N9/52 , C07K19/00 , C07K14/47 , C07K14/46 , A61K9/127 , C12N15/113 , C12N2310/20
CPC分类号： A61K48/0008 , A61K9/1272 , A61K38/00 , A61K38/10 , A61K47/64 , A61K47/6911 , A61K48/0075 , A61K48/0083 , C07J7/009 , C07K7/06 , C07K7/08 , C07K14/463 , C07K14/47 , C07K19/00 , C07K2319/06 , C07K2319/21 , C07K2319/33 , C07K2319/60 , C12N5/062 , C12N9/00 , C12N9/22 , C12N9/52 , C12N15/11 , C12N15/113 , C12N15/87 , C12N15/88 , C12N15/907 , C12N2310/20 , C12N2310/3513 , C12N2510/00 , C12Y304/2207
摘要： Compositions are described for direct protein delivery into multiple cell types in the mammalian inner ear. The compositions are used to deliver protein(s) (such as gene editing factors) editing of genetic mutations associated with deafness or associated disorders thereof. The delivery of genome editing proteins for gene editing and correction of genetic mutations protect or restore hearing from genetic deafness. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.

84. 发明申请

US20170216022A1 Drug-Eluting Stapes Prosthesis 审中-公开
公开(公告)号：US20170216022A1
公开(公告)日：2017-08-03
申请号：US15491401
申请日：2017-04-19
申请人： Massachusetts Eye and Ear Infirmary , The Charles Stark Draper Laboratory, Inc.
发明人： Mark E. Keegan , Michael J. McKenna
IPC分类号： A61F2/18 , A61L27/14 , A61L27/54
CPC分类号： A61F2/18 , A61F2002/183 , A61F2230/0004 , A61F2230/0069 , A61F2240/001 , A61F2250/0024 , A61F2250/0067 , A61L27/14 , A61L27/54 , A61L2300/602 , Y10T29/49826 , Y10T29/49828
摘要： A medical implant device includes a prosthesis adapted to replace at least a portion of a bone. The prosthesis includes a drug-eluting polymer adapted to deliver a drug to at least a portion of an area surrounding the prosthesis.

85. 发明授权

US09719070B2 Methods of predicting ancestral virus sequences and uses thereof 有权
公开(公告)号：US09719070B2
公开(公告)日：2017-08-01
申请号：US15291470
申请日：2016-10-12
申请人： Massachusetts Eye and Ear Infirmary , Schepens Eye Research Institute
发明人： Luk H. Vandenberghe , Eric Zinn
IPC分类号： A61K39/23 , A61K39/00 , C12N7/00 , C07K14/00 , C12N15/86 , C07K14/005 , C07K16/22
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , A61K2039/6075 , C07K14/00 , C07K14/005 , C07K16/22 , C07K2317/24 , C07K2317/76 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14123 , C12N2750/14141 , C12N2750/14142 , C12N2750/14143 , C12N2750/14171
摘要： Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.

86. 发明授权

US09670288B2 Osteoprotegerin in neuroprotection 有权
公开(公告)号：US09670288B2
公开(公告)日：2017-06-06
申请号：US14218507
申请日：2014-03-18
申请人： Massachusetts Eye and Ear Infirmary
发明人： Konstantina Stankovic , Michael McKenna , Shyan-Yuan Kao , Albert Edge
IPC分类号： A61P27/16 , C07K16/40 , A61K38/17 , A61K31/675 , A61K39/395 , A61K31/352 , A61K31/7105 , A61K31/713 , C07K16/28
CPC分类号： C07K16/40 , A61K31/352 , A61K31/675 , A61K31/7105 , A61K31/713 , A61K38/1793 , A61K39/3955 , C07K16/2878 , C07K2317/76
摘要： Methods for treating neurodegeneration, e.g., sensorineural hearing loss, or a demyelinating disease, using bisphosphonates, ERK kinase inhibitors, and osteoprotegerin (OPG) proteins or nucleic acids.

87. 发明申请

US20170051257A1 METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF 有权
标题翻译：预防病原菌病毒序列的方法及其用途
公开(公告)号：US20170051257A1
公开(公告)日：2017-02-23
申请号：US15291470
申请日：2016-10-12
申请人： Massachusetts Eye and Ear Infirmary , Schepens Eye Research Institute
发明人： Luk H. Vandenberghe , Eric Zinn
IPC分类号： C12N7/00 , C07K16/22
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , A61K2039/6075 , C07K14/00 , C07K14/005 , C07K16/22 , C07K2317/24 , C07K2317/76 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14123 , C12N2750/14141 , C12N2750/14142 , C12N2750/14143 , C12N2750/14171
摘要： Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
摘要翻译：描述了用于预测病毒的祖先序列或其部分的方法。还描述了腺相关病毒（AAV）衣壳多肽的预测祖先序列。本公开还提供了基因转移的方法和通过施用可操作地连接到AAV衣壳多肽的靶抗原来接种受试者的方法。

88. 发明申请

US20170020909A1 METHODS OF TREATING GLAUCOMA USING AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS 审中-公开
标题翻译：使用AMP激活蛋白激酶（AMPK）激活剂治疗葡萄球菌的方法
公开(公告)号：US20170020909A1
公开(公告)日：2017-01-26
申请号：US15125049
申请日：2015-03-10
申请人： Massachusetts Eye and Ear Infirmary
发明人： Douglas J. Rhee , Guadalupe Villarreal, Jr. , Ayan Chatterjee , Dong-Jin Oh , Min Kang
IPC分类号： A61K31/7056 , A61K9/00
CPC分类号： A61K31/7056 , A61K9/0019 , A61K9/0048 , A61K9/10 , A61K9/148
摘要： Methods of reducing intraocular pressure in a mammal using AMPK activators, e.g., for treating glaucoma.
摘要翻译：使用AMPK激活剂降低哺乳动物眼内压的方法，例如用于治疗青光眼。

89. 发明申请

US20160367619A1 METHODS AND COMPOSITIONS FOR PRESERVING RETINAL GANGLION CELLS 有权
标题翻译：用于保留末梢神经细胞的方法和组合物
公开(公告)号：US20160367619A1
公开(公告)日：2016-12-22
申请号：US15093480
申请日：2016-04-07
申请人： Massachusetts Eye and Ear Infirmary
发明人： Demetrios G. Vavvas , Joan W. Miller , Maki Kayama
IPC分类号： A61K38/06 , A61K31/4178 , A61K9/00
CPC分类号： A61K38/06 , A61K9/0048 , A61K31/195 , A61K31/40 , A61K31/403 , A61K31/4166 , A61K31/4178 , A61K38/005 , A61K2300/00 , A61K31/401
摘要： Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and/or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder.
摘要翻译：提供了用于维持具有眼部疾病（例如青光眼和视神经损伤）的受试者的视网膜神经节细胞的存活力的方法和组合物。视网膜神经节细胞的活力可以通过单独给予坏死抑制剂或与细胞凋亡抑制剂组合施用于具有眼睛状况的眼睛的受试者来保存。组合物在施用时维持细胞的活力和/或促进轴突再生，从而使与眼部疾病相关的视力丧失或视觉功能最小化。

90. 发明申请

US20160235297A1 MOLECULAR IMAGING METHODS FOR DIAGNOSIS AND EVALUATION OF OCULAR AND SYSTEMIC DISEASES 审中-公开
标题翻译：用于诊断和评估眼科和系统疾病的分子成像方法
公开(公告)号：US20160235297A1
公开(公告)日：2016-08-18
申请号：US14880536
申请日：2015-10-12
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： Ali Hafezi-Moghadam
IPC分类号： A61B3/12 , A61B5/145
CPC分类号： A61B3/1233 , A61B3/1025 , A61B3/1241 , A61B5/14546
摘要： This invention relates generally to minimally-invasive, in vivo methods of detecting one or more ligands on an intraluminal surface of a blood vessel using microparticles coated with one or more ligand binding partners. More particularly, in certain embodiments, the invention relates to minimally-invasive, in vivo methods of detecting endothelial and leukocyte antigens that are predictive of diabetic retinopathy (DR) and/or other conditions using protein-conjugated microparticles detectable by a non-invasive detection system, for example, a scanning laser ophthalmoscope. In other embodiments, the invention relates to targeted delivery of drugs or other substances to specific regions of an intraluminal surface of a blood vessel using drug-containing microparticles coated with one or more ligand binding partners.
摘要翻译：本发明一般涉及利用涂覆有一种或多种配体结合配偶体的微粒来检测血管腔内表面上的一种或多种配体的微创体内方法。更具体地，在某些实施方案中，本发明涉及使用通过非侵入性检测可检测的蛋白质共轭微粒来检测预测糖尿病性视网膜病变（DR）和/或其他病症的内皮细胞和白细胞抗原的微创体内方法系统，例如扫描激光检眼镜。在其它实施方案中，本发明涉及使用涂覆有一种或多种配体结合配偶体的含药微粒将药物或其它物质靶向递送至血管腔内表面的特定区域。

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