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81. 发明申请

US20160214918A1 COMPOSITION FOR TREATING METABOLIC SYNDROME AND A PREPARATION METHOD THEREOF 审中-公开
标题翻译：用于治疗代谢综合征的组合物及其制备方法
公开(公告)号：US20160214918A1
公开(公告)日：2016-07-28
申请号：US15003705
申请日：2016-01-21
申请人： Kaohsiung Medical University
发明人： Fang-Rong Chang , Yang-Chang Wu , Tusty-Jiuan Hsieh , Chi-Ting Hsieh , Ferenc Fülöp , Sándor Balázs Ötvös
IPC分类号： C07C49/84 , C07C49/794
CPC分类号： A61K31/12 , A61K31/085
摘要： A compound for treating a metabolic syndrome, comprising a structure of a 6Cs unit-3Cs unit-6Cs unit (C6-C3-C6) as shown in formula I, wherein: when R1 and R2 are both hydrogens, C3 has only single bonds; when R1 is an oxygen and R2 is one selected from a group consisting of an alkoxy, a benzyloxy and a halogen, C3 has only single bonds; when R1 is a deuterium and R2 is one selected from a group consisting of a hydrogen, an alkoxy, a benzyloxy and a halogen, C3 has one of a single bond and a double bond.
摘要翻译：一种用于治疗代谢综合征的化合物，其包含如式I所示的6Cs单元-3Cs单元-6C单元（C6-C3-C6）的结构，其中：当R 1和R 2均为氢时，C 3仅具有单键; 当R 1为氧且R 2为选自烷氧基，苄氧基和卤素的基团时，C 3仅具有单键; 当R 1为氘并且R 2为选自氢，烷氧基，苄氧基和卤素的基团时，C 3具有单键和双键之一。

82. 发明申请

US20160158190A1 Methods and Compositions for Inhibition of ATR and FANCD2 Activation 有权
标题翻译：抑制ATR和FANCD2激活的方法和组合
公开(公告)号：US20160158190A1
公开(公告)日：2016-06-09
申请号：US15016690
申请日：2016-02-05
申请人： Kaohsiung Medical University
发明人： Hui-Chun WANG , Yang-Chang Wu , Fang-Rong Chang , Chin-Chung WU
IPC分类号： A61K31/352 , A61K45/06
CPC分类号： A61K31/352 , A61K45/06 , C07D311/30 , C07D311/78 , A61K2300/00
摘要： This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
摘要翻译：本发明公开了式I或式II化合物中类黄酮骨架的组合物，其中每个取代基都给出如说明书和权利要求书中所阐述的定义。该组合物具有治疗或预防受试者的病毒感染的能力。

83. 发明申请

US20160152656A1 Methods of Using Phosphoramidation Reaction for Conjugation-Labeling Nucleic Acids 审中-公开
标题翻译：磷酰胺化反应用于缀合标记核酸的方法
公开(公告)号：US20160152656A1
公开(公告)日：2016-06-02
申请号：US14555770
申请日：2014-11-28
申请人： Kaohsiung Medical University
发明人： Tzu-Pin Wang , Yu-Chih Su
IPC分类号： C07H21/04
CPC分类号： C07H21/04 , C07H1/00 , C07H21/00
摘要： Methods are provided to label nucleic acids through two-step phosphoramidation reactions with regiospecificity and high sensitivity. The methods can be widely used for synthesizing conjugates of nucleic acids. Through the two-step phosphoramidation reactions, nucleic acids are directly or indirectly labeled for easier and more efficient applications. The present invention also uses fluorescence quenching and DNA melting profile studies to demonstrate that the nucleic acids modified through the two-step phosphoramidation reactions preserve intrinsic base-pairing specificity and bestow regioselectivity in nucleic acids with high yield. Thus, the present invention has significant contribution to basic nucleic acid research; and, in the future, can be applied to effectively and quantitatively detect and measure nucleic acids inside and outside living organisms.
摘要翻译：提供了通过具有区域特异性和高灵敏度的两步氨基磷酰化反应来标记核酸的方法。该方法可广泛用于合成核酸的缀合物。通过两步磷酰胺化反应，核酸被直接或间接标记，以便更容易和更有效的应用。本发明还使用荧光猝灭和DNA熔解曲线研究来证明通过两步磷酰胺化反应修饰的核酸保持内在的碱基配对特异性并且以高产率赋予核酸的区域选择性。因此，本发明对碱性核酸研究有重要贡献; 并且在未来可以应用于有效和定量地检测和测量生物体内外的核酸。

84. 发明授权

US09322017B2 Diagnosis and treatment of endometriosis 有权
标题翻译：子宫内膜异位症的诊断和治疗
公开(公告)号：US09322017B2
公开(公告)日：2016-04-26
申请号：US14483936
申请日：2014-09-11
申请人： KAOHSIUNG MEDICAL UNIVERSITY
发明人： Eing-Mei Tsai , Chia-Yi Hsu
IPC分类号： C12N15/11 , A61K48/00 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/141 , C12N2320/10 , C12Q1/6883 , C12Q2600/106 , C12Q2600/178
摘要： The invention discloses a diagnosis of endometriosis, by determining a level of miR-199a-5p as a biomarker to diagnose endometriosis. The invention also discloses a treatment of endometriosis, by administering pre-miR-199a to a subject in need thereof in a dosage of 4 to 8 mg/per kilogram of body weight per 1 to 3 days for 4 weeks to inhibit the processes of endometriosis development.
摘要翻译：本发明通过确定miR-199a-5p作为诊断子宫内膜异位症的生物标志物的水平来公开子宫内膜异位症的诊断。本发明还公开了子宫内膜异位症的治疗方法，其通过以有效剂量的4至8mg /每千克体重每1至3天施用pre-miR-199a给予有需要的受试者4周以抑制子宫内膜异位症的过程发展。

85. 发明授权

US09241962B2 Water extract of Antrodia camphorata for immunostimulatory effect and preparation method thereof 有权
标题翻译：樟芝提取物的免疫刺激作用及其制备方法
公开(公告)号：US09241962B2
公开(公告)日：2016-01-26
申请号：US14577605
申请日：2014-12-19
申请人： Kaohsiung Medical University
发明人： Yang-Chang Wu , Mei-Chin Lu , Fang-Rong Chang , Ying-Chi Du , Tung-Ying Wu
IPC分类号： A61K36/07 , A61K39/39 , C12N5/0784 , A61K39/00
CPC分类号： A61K36/07 , A61K39/39 , A61K2039/60 , C12N5/0639 , C12N2500/74
摘要： A preparation method for a water extract of the fruiting body of Antrodia camphorata (ACW) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract. This polysaccharide-rich water extract from A. camphorata induces the maturation of dendritic cells, enhances T cell proliferation and INF-γ production, and polarizes them toward the Th1 pathway. ACW can be effectively applied in cancer immunotherapy.
摘要翻译：提供了一种樟树（ACW）子实体的水提取物的制备方法。该方法包括以下步骤：（a）提供子实体; 和（b）在水中煮子实体以获得水提取物。来自樟脑的丰富多糖的水提取物诱导树突状细胞的成熟，增强T细胞增殖和INF-γ产生，并将它们极化为Th1途径。 ACW可有效应用于癌症免疫治疗。

86. 发明申请

US20150329592A1 ALL GOLD FLUORESCENCE RESONANCE ENERGY TRANSFER PROBE AND USE THEREOF 审中-公开
标题翻译：所有金色荧光共振能量转移探测及其使用
公开(公告)号：US20150329592A1
公开(公告)日：2015-11-19
申请号：US14708305
申请日：2015-05-11
申请人： KAOHSIUNG MEDICAL UNIVERSITY
发明人： Chih-Kuang Wang , Mei-Ling Ho , Chung-Hwan Chen , Yin-Chih Fu , Jia-Huie Lin , Chih-Yun Lee , Je-Ken Chang
IPC分类号： C07K7/06
CPC分类号： C07K7/06 , C12Q1/34 , G01N33/542 , G01N33/587 , Y10T428/2982
摘要： The present invention relates to a gold fluorescence resonance energy transfer nanoprobe comprising a gold fluorescence donor, a gold fluorescence acceptor, and a linker fragment that connects the gold fluorescence donor and the gold fluorescence acceptor, wherein the fluorescence resonance energy transfer is carried out between the gold fluorescence donor and the gold fluorescence acceptor. This all gold probe employing fluorescence resonance energy transfer technique can be used for detecting diseases such as arthritis, osteoporosis, and cancer metastasis.
摘要翻译：本发明涉及金荧光共振能量转移纳米探针，其包含金荧光供体，金荧光受体和连接金荧光供体和金荧光受体的连接体片段，其中荧光共振能量转移在金荧光供体和金荧光受体。这种使用荧光共振能量转移技术的所有金探针可用于检测关节炎，骨质疏松症和癌症转移等疾病。

87. 发明申请

US20150291959A1 Diagnosis and Treatment of Endometriosis 有权
标题翻译：子宫内膜异位症的诊断与治疗
公开(公告)号：US20150291959A1
公开(公告)日：2015-10-15
申请号：US14483936
申请日：2014-09-11
申请人： KAOHSIUNG MEDICAL UNIVERSITY
发明人： Eing-Mei TSAI , Chia-Yi HSU
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/141 , C12N2320/10 , C12Q1/6883 , C12Q2600/106 , C12Q2600/178
摘要： The invention discloses a diagnosis of endometriosis, by determining a level of miR-199a-5p as a biomarker to diagnose endometriosis. The invention also discloses a treatment of endometriosis.
摘要翻译：本发明通过测定miR-199a-5p作为诊断子宫内膜异位症的生物标志物的水平来公开子宫内膜异位症的诊断。本发明还公开了子宫内膜异位症的治疗。

88. 发明申请

US20150261925A1 AVATAR-BASED CHARTING METHOD AND SYSTEM FOR ASSISTED DIAGNOSIS 审中-公开
标题翻译：用于辅助诊断的基于AVATAR的查询方法和系统
公开(公告)号：US20150261925A1
公开(公告)日：2015-09-17
申请号：US14478527
申请日：2014-09-05
申请人： KAOHSIUNG MEDICAL UNIVERSITY
发明人： Cheng-Yuan Wang , Ying-Fong Huang , Jer-Chia Tsai , Jer-Min Tsai , Yu-Hsien Chiu , I-Te Chen
IPC分类号： G06F19/00
CPC分类号： G16H50/20 , G06F19/00 , G06F19/321 , G16H10/60 , G16H15/00 , G16H30/20 , G16H50/50
摘要： An avatar-based charting method for assisted diagnosis to improve the efficiency of medical practice. Through an anthropomorphic symptom record interface, the first page is the Genetic-Psycho-Social-Bio (GPSB) which assists in understanding the genetic, psychological, social-environmental, and biological characteristics of patients. A Subjective-Objective-Assessment-Plan (SOAP) diagnosis page aids in doctor diagnosis. A decision support diagnostic summary interface automatically generates the diagnosis summary and notifies of any unusual circumstances. Finally, a medical records module saves all information into a medical database in order to provide health care for subsequent tracking and evaluation.
摘要翻译：一种基于头像的绘图方法，用于辅助诊断，以提高医疗实践的效率。通过拟人症状记录界面，第一页是遗传 - 心理社会生物（GPSB），有助于了解患者的遗传，心理，社会环境和生物学特征。主观客观评估计划（SOAP）诊断页面有助于医生诊断。决策支持诊断摘要界面自动生成诊断摘要并通知任何异常情况。最后，医疗记录模块将所有信息保存到医疗数据库中，以便为后续跟踪和评估提供医疗保健。

89. 发明申请

US20150119443A1 METHOD OF THERAPY AND DIAGNOSIS OF ENDOTHELIAL DYSFUNCTION 审中-公开
标题翻译：治疗方法和诊断内皮功能障碍
公开(公告)号：US20150119443A1
公开(公告)日：2015-04-30
申请号：US14149528
申请日：2014-01-07
申请人： Kaohsiung Medical University
发明人： Suh-Hang Juo
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12Q1/6883 , C12N15/113 , C12N2310/141 , C12Q2600/158 , C12Q2600/178
摘要： The invention discloses a method of therapy of endothelial dysfunction, by administering microRNA let-7g to a subject in need, wherein the microRNA let-7g inhibits SMAD2 transcription factor from activation and translocation into nucleus, thereby decreasing monocyte cell adhesion, inflammation and thrombosis and increasing angiogenesis.
摘要翻译：本发明公开了通过向需要的受试者施用microRNA let-7g来治疗内皮功能障碍的方法，其中所述microRNA let-7g抑制SMAD2转录因子从激活和转位入细胞核，由此降低单核细胞粘附，炎症和血栓形成，以及增加血管生成。

90. 发明申请

US20150104481A1 WATER EXTRACT OF ANTRODIA CAMPHORATA FOR IMMUNOSTIMULATORY EFFECT AND PREPARATION METHOD THEREOF 有权
标题翻译： ANTRODIA CAMPHORATA水提取物免疫效果及其制备方法
公开(公告)号：US20150104481A1
公开(公告)日：2015-04-16
申请号：US14577605
申请日：2014-12-19
申请人： Kaohsiung Medical University
发明人： Yang-Chang Wu , Mei-Chin Lu , Fang-Rong Chang , Ying-Chi Du , Tung-Ying Wu
IPC分类号： A61K36/07
CPC分类号： A61K36/07 , A61K39/39 , A61K2039/60 , C12N5/0639 , C12N2500/74
摘要： A preparation method for a water extract of the fruiting body of Antrodia camphorata (ACW) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract. This polysaccharide-rich water extract from A. camphorata induces the maturation of dendritic cells, enhances T cell proliferation and INF-γ production, and polarizes them toward the Th1 pathway. ACW can be effectively applied in cancer immunotherapy.
摘要翻译：提供了一种樟树（ACW）子实体的水提取物的制备方法。该方法包括以下步骤：（a）提供子实体; 和（b）在水中煮子实体以获得水提取物。来自樟脑的丰富多糖的水提取物诱导树突状细胞的成熟，增强T细胞增殖和INF-γ产生，并将它们极化为Th1途径。 ACW可有效应用于癌症免疫治疗。

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