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81. 发明申请

US20170115258A1 SPECIFIC ANALYSIS OF KETONE AND ALDEHYDE ANALYTES USING REAGENT COMPOUNDS, LABELING STRATEGIES, AND MASS SPECTROMETRY WORKFLOW 审中-公开
公开(公告)号：US20170115258A1
公开(公告)日：2017-04-27
申请号：US15339119
申请日：2016-10-31
申请人： DH Technologies Development Pte. Ltd.
发明人： Subhakar Dey , Sasi Pillai , Brian L. Williamson , Subhasish Purkayastha , Michal Weinstock
IPC分类号： G01N30/72 , G01N33/74
CPC分类号： G01N30/72 , G01N27/62 , G01N33/64 , G01N33/743 , G01N2030/045 , G01N2030/884 , H01J49/00 , H01J49/0045 , H01J49/164 , Y10T436/147777 , Y10T436/200833
摘要： Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids and includes testosterone. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.

82. 发明授权

US09500622B2 Specific analysis of ketone and aldehyde analytes using reagent compounds, labeling strategies, and mass spectrometry workflow 有权
标题翻译：使用试剂化合物，标记策略和质谱工作流程对酮和醛分析物进行具体分析
公开(公告)号：US09500622B2
公开(公告)日：2016-11-22
申请号：US13897628
申请日：2013-05-20
申请人： DH Technologies Development Pte. Ltd.
发明人： Subhakar Dey , Sasi Pillal , Brian L. Williamson , Subhasish Purkayastha , Michal Weinstock
IPC分类号： G01N24/00 , G01N27/62 , G01N30/72 , G01N33/64 , G01N33/74 , G01N30/04 , G01N30/88 , H01J49/00
CPC分类号： G01N30/72 , G01N27/62 , G01N33/64 , G01N33/743 , G01N2030/045 , G01N2030/884 , H01J49/00 , H01J49/0045 , H01J49/164 , Y10T436/147777 , Y10T436/200833
摘要： Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
摘要翻译：提供了标记试剂，一组标记试剂和标记技术用于酮或醛化合物的相对定量，绝对定量或两者，包括但不限于包含类固醇或酮类固醇的分析物。分析物可以是生物样品中的医药或药物化合物。还公开了用于标记，分析和定量酮或醛化合物的方法，也是也使用质谱法的方法。

83. 发明申请

US20160336161A1 Time-of-Flight Analysis of a Continuous Beam of Ions by a Detector Array 有权
标题翻译：探测器阵列的连续离子束的飞行时间分析
公开(公告)号：US20160336161A1
公开(公告)日：2016-11-17
申请号：US15105089
申请日：2014-12-06
申请人： DH Technologies Development Pte. Ltd.
发明人： Robert Alois Grothe, JR.
IPC分类号： H01J49/40 , H01J49/22 , H01J49/00 , H01J49/20
CPC分类号： H01J49/40 , H01J49/0031 , H01J49/025 , H01J49/20 , H01J49/22
摘要： Systems and methods are provided for time-of-flight analysis of a continuous beam of ions by a detector array. A sample is ionized using an ion source to produce a continuous beam of ions. An electric field is applied to the continuous beam of ions using an accelerator to produce an accelerated beam of ions. A rotating magnetic and/or electric field is applied to the accelerated beam to separate ions with different mass-to-charge ratios over an area of a two-dimensional detector using a deflector located between the accelerator and the two-dimensional detector. An arrival time and a two-dimensional arrival position of each ion of the accelerated beam are recorded using the two-dimensional detector. Alternatively, an electric field that is periodic with time is applied in order to sweep the accelerated beam over a periodically repeating path on the two-dimensional rectangular detector.
摘要翻译：通过检测器阵列为连续的离子束进行飞行时间分析的系统和方法。使用离子源离子化样品以产生连续的离子束。使用加速器将电场施加到连续的离子束，以产生加速的离子束。旋转的磁场和/或电场被施加到加速光束，以使用位于加速器和二维检测器之间的偏转器在二维检测器的区域上分离具有不同质量与电荷比的离子。使用二维检测器记录加速光束的每个离子的到达时间和二维到达位置。或者，施加周期性的电场，以便在二维矩形检测器上的周期性重复路径上扫描加速光束。

84. 发明申请

US20160225594A1 Data Independent Acquisition of Product Ion Spectra and Reference Spectra Library Matching 审中-公开
标题翻译：数据独立采集产品离子谱和参考光谱库匹配
公开(公告)号：US20160225594A1
公开(公告)日：2016-08-04
申请号：US15098196
申请日：2016-04-13
申请人： DH Technologies Development Pte. Ltd. , ETH Zürich
发明人： Ronald F. Bonner , Stephen A. Tate , Rudolf Aebersold , Pedro Jose Navarro Alvarez , Oliver Rinner , Lukas Reiter , Ludovic Gillet
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , G01N30/7233 , G16C20/20 , G16C20/90 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/42
摘要： Systems and methods are disclosed for detecting compounds in a sample using a tandem mass spectrometer. A sample comprising a plurality of detectable compounds that have been separated in time over a time interval is introduced into a tandem mass spectrometer. A sample product ion spectra is obtained. The presence of one or more known compounds of interest in the sample product ion spectra is determined. A compound is identified as present in the sample if the score associated with said compound meets a threshold value set as indicative of the likely presence of the compound in the sample.
摘要翻译：公开了使用串联质谱仪检测样品中的化合物的系统和方法。将包含多个可在时间上分离的可检测化合物的样品引入串联质谱仪。得到样品产物离子光谱。确定样品产物离子光谱中一种或多种已知化合物的存在。如果与所述化合物相关的分数满足设定为指示样品中化合物可能存在的阈值，则鉴定化合物存在于样品中。

85. 发明申请

US20160217991A1 Multiplexed Precursor Isolation for Mass Spectrometry 审中-公开
标题翻译：用于质谱的多重前体隔离
公开(公告)号：US20160217991A1
公开(公告)日：2016-07-28
申请号：US15026235
申请日：2014-10-07
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Takashi Baba
IPC分类号： H01J49/04
CPC分类号： H01J49/0036 , H01J49/0031 , H01J49/004 , H01J49/04 , H01J49/067 , H01J49/4285
摘要： Systems and methods for multiplexed precursor ion selection are provided. A mass isolator includes a selection region of rods, a transmission region of rods, and a barrier electrode lens separating the selection and transmission regions. Two or more different precursor ions are selected by applying two or more different AC voltage frequencies to rods of a selection region in order to resonate the two or more different precursor ions from a continuous beam of ions. The two or more different precursor ions are transmitted by applying a DC voltage to the barrier electrode lens, creating an electric field potential barrier over which only the resonating ions are transmitted. Precursor ions of product ions from combined product ion spectra produced by multiplexed precursor ion selection are identified by grouping the target precursor ions.
摘要翻译：提供了多路前体离子选择的系统和方法。质量隔离器包括杆的选择区域，杆的透射区域和分离选择和透射区域的阻挡电极透镜。通过对选择区域的棒施加两个或更多个不同的AC电压频率来选择两个或更多个不同的前体离子，以便使两个或更多个不同的前体离子与连续离子束共振。通过向阻挡电极透镜施加DC电压来传输两种或更多种不同的前体离子，产生仅在其上传播谐振离子的电场势垒。通过将目标前体离子分组来鉴定由多重前体离子选择产生的组合产物离子光谱的产物离子的前体离子。

86. 发明授权

US09360455B2 Methods for analysis of isomeric lipids 有权
标题翻译：异构脂质分析方法
公开(公告)号：US09360455B2
公开(公告)日：2016-06-07
申请号：US14655263
申请日：2013-12-13
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： John L. Campbell , Yves Leblanc
IPC分类号： G01N33/92 , G01N27/62 , H01J49/00 , H01J49/04
CPC分类号： G01N27/624 , G01N27/622 , G01N33/92 , G01N2458/15 , H01J49/0031 , H01J49/0422 , Y10T436/24
摘要： A method for analyzing a sample that contains a plurality of lipid isomers is described that involves forming one or more lipid metal ion adducts and transporting the one or more lipid metal ion adducts through a differential mobility spectrometer to cause separation of the one or more lipid metal ion adducts from each other. The lipid isomers can be chosen, for example, from fatty acids, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, polyketides, sterol lipids, and prenol lipids. Particular examples include phosphatidylcholine regioisomers such as 1-palmatoyl-2-oleoyl-sn-phosphatidylcholine (POPC) and 1-oleoyl-2-palmatoyl-sn-phosphatidylcholine and triacylglycerols containing palmetic and oleic acid groups. The metal chosen can include a cationization reagent that contains sodium, potassium, silver or lithium.
摘要翻译：描述了分析含有多种脂质异构体的样品的方法，其涉及形成一种或多种脂质金属离子加合物并将一种或多种脂质金属离子加合物输送通过差速迁移谱仪，以引起一种或多种脂质金属离子加合物彼此。脂质异构体可以选自例如脂肪酸，甘油脂，甘油磷脂，鞘脂，蔗糖脂，聚酮化合物，甾醇脂质和牛油醇脂质。特别的实例包括磷脂酰胆碱区域异构体如1-棕榈酰-2-油酰-sn-磷脂酰胆碱（POPC）和1-油酰-2-棕榈酰-sn-磷脂酰胆碱和含有油酸和油酸基团的三酰基甘油。所选择的金属可以包括含有钠，钾，银或锂的阳离子化试剂。

87. 发明申请

US20160148791A1 Intensity Correction for TOF Data Acquisition 审中-公开
标题翻译： TOF数据采集强度校正
公开(公告)号：US20160148791A1
公开(公告)日：2016-05-26
申请号：US15008385
申请日：2016-01-27
申请人： DH Technologies Development Pte. Ltd.
发明人： Nic G. Bloomfield , Alexandre V. Loboda
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0009 , H01J49/0036 , H01J49/025 , H01J49/40
摘要： Systems and methods are provided for correcting uniform detector saturation of a mass analyzer using a calibration curve. In one method, a measured spectrum is received from a mass analyzer that includes a detector and an analog-to-digital converter (ADC) detector subsystem and that analyzes a beam of ions produced by an ion source that ionizes molecules of a sample using a processor. A total ion value of the measured spectrum is calculated by summing intensities of ions in the measured spectrum using the processor. A correction factor is determined by comparing the total ion value to a stored calibration curve that provides correction factors as a function of total ion values using the processor. Intensities of the measured spectrum are multiplied by the determined correction factor producing a corrected measured spectrum using the processor.
摘要翻译：提供了使用校准曲线校正质量分析器的均匀检测器饱和度的系统和方法。在一种方法中，从包括检测器和模拟 - 数字转换器（ADC）检测器子系统的质量分析器接收测量的光谱，并且分析由离子源产生的离子束，其使用离子源离子化样品的分子处理器。通过使用处理器对所测量的光谱中的离子的强度求和来计算测量光谱的总离子值。通过将总离子值与存储的校准曲线进行比较来确定校正因子，该校准曲线使用处理器提供作为总离子值的函数的校正因子。测量光谱的强度乘以确定的校正因子，使用处理器产生校正的测量光谱。

88. 发明授权

US09343282B2 Systems and methods for using interleaving window widths in tandem mass spectrometry 有权
公开(公告)号：US09343282B2
公开(公告)日：2016-05-17
申请号：US14922823
申请日：2015-10-26
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Stephen A. Tate , Ronald F. Bonner
IPC分类号： H01J49/40 , B01D59/44 , G01N30/72 , H01J49/00
CPC分类号： H01J49/0045 , G01N30/7233 , G01N30/8631 , G06F19/703 , H01J49/0009 , H01J49/0031 , H01J49/0036 , H01J49/004
摘要： Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor. The two or more target widths can have the same width or variable widths. A tandem mass spectrometer is instructed to perform two or more fragmentation scans across the mass range using the processor. Each fragmentation scan of the two or more fragmentation scans includes a measured mass selection window width. The two or more measured widths of the two or more fragmentation scans can have the same width or variable widths. At least two of the two or more measured mass selection window widths overlap. The overlap in measured mass selection window widths corresponds to at least one target mass selection window width.

89. 发明授权

US09305762B2 Mass analysis system with low pressure differential mobility spectrometer 有权
标题翻译：质谱分析系统与低压差动迁移谱仪
公开(公告)号：US09305762B2
公开(公告)日：2016-04-05
申请号：US13693837
申请日：2012-12-04
申请人： DH Technologies Development Pte. Ltd.
发明人： Thomas R. Covey , Bradley B. Schneider
IPC分类号： G01N24/00 , H01J49/26 , G01N27/62 , H01J49/00
CPC分类号： H01J49/26 , G01N27/624 , H01J49/004 , Y10T436/24
摘要： A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.
摘要翻译：质量分析系统，包括低压解离区域和差动迁移谱仪。差速迁移谱仪包括至少一对限定离子流路的过滤电极对，其中过滤电极基于样品离子的迁移率特性产生用于通过选定部分样品离子的电场。差分迁移率光谱仪还包括电压源，其向至少一个滤光器电极提供DC和RF电压以产生电场;接收经过低压解离区域的样品离子的离子入口和离子出口其输出所选择的样本离子部分。质谱仪接收样品离子的部分或全部选定部分。

90. 发明授权

US09305757B2 Ion extraction method for ion trap mass spectrometry 有权
标题翻译：离子阱质谱法离子萃取法
公开(公告)号：US09305757B2
公开(公告)日：2016-04-05
申请号：US14369344
申请日：2012-12-06
申请人： DH Technologies Development Pte. Ltd.
发明人： Takashi Baba
IPC分类号： H01J49/42 , H01J49/26 , H01J49/06
CPC分类号： H01J49/06 , H01J49/26 , H01J49/4225 , H01J49/4255
摘要： A method is provided for processing ions in a multipole ion trap, comprising generating RF radial confinement fields within a first and second multipole rod set positioned in tandem, a ratio of q value exhibited by the second rod set relative to the first rod set being greater than one for any m/z, said RF axial confinement fields within the first and second rod sets interacting in an interaction region between the first and second rod sets so as to produce a fringing field; transmitting ions through said first rod set towards said second rod set; and increasing the radial oscillation amplitude of at least a portion of the ions within said first rod set such that at least a portion of said ions having an increased radial oscillation amplitude are repulsed by said fringing field.
摘要翻译：提供了一种用于处理多极离子阱中的离子的方法，包括在串联定位的第一和第二多极棒组内产生RF径向限制场，第二棒组相对于第一棒组显示的q值的比值更大所述第一和第二杆组内的所述RF轴向限制场在所述第一和第二杆组之间的相互作用区域中相互作用以产生边缘场; 将离子通过所述第一杆组传递到所述第二杆组; 并且增加所述第一棒组中的离子的至少一部分的径向振荡振幅，使得具有增加的径向振荡幅度的所述离子的至少一部分被所述边缘场排斥。

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