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81. 发明授权

US08934988B2 Ablation stent with meander structure 有权
标题翻译：消融支架具有曲折结构
公开(公告)号：US08934988B2
公开(公告)日：2015-01-13
申请号：US13422971
申请日：2012-03-16
申请人： Torbjorn Persson , Cecilia Emanuelsson , Hans Abrahamson
发明人： Torbjorn Persson , Cecilia Emanuelsson , Hans Abrahamson
IPC分类号： A61B18/04 , A61B18/14 , A61F2/88 , A61F2/915 , A61B18/00
CPC分类号： A61B18/1492 , A61B18/14 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/1405 , A61F2/88 , A61F2/915
摘要： Hypertension is treated in a patient by implanting an ablation stent in a renal artery of the patient. Energy is transmitted to the ablation stent to induce heating of the ablation stent, which causes ablation of a renal sympathetic nerve present on the outside of the portion of the renal artery comprising the ablation stent. A preferred ablation stent is in the form of an N-turn coil of an electrically conductive wire forming a meander structure. The respective ends of the wire are electrically connected to each other.
摘要翻译：通过在患者的肾动脉中植入消融支架来治疗患者的高血压。能量被传递到消融支架以引起消融支架的加热，这导致存在于包括消融支架的肾动脉部分的外侧上的肾交感神经的消融。优选的消融支架是形成弯曲结构的导电线的N匝线圈的形式。线的相应端部彼此电连接。

82. 发明授权

US08918165B2 Medical device for positioning of a lead 有权
标题翻译：用于定位铅的医疗设备
公开(公告)号：US08918165B2
公开(公告)日：2014-12-23
申请号：US13631570
申请日：2012-09-28
申请人： St. Jude Medical AB
发明人： Sven-Erik Hedberg , Nils Holmstrom , Johan Eckerdal , Torbjorn Persson , Rolf Hill , Fredrik Westman
IPC分类号： A61B5/042
CPC分类号： A61B5/063 , A61B5/042 , A61B5/0538
摘要： The present invention relates generally to medical devices for electrode positioning during implantation procedures. A cardiac signal measuring device measures cardiac signals sensitive to inherent differences between cardiac tissue and blood using at least one electrode of a medical lead arranged at a distal tip of the medical lead and at least a second electrode arranged at a distance from the distal electrode and being connectable to the measuring unit. An analyzing module acquires cardiac signals measured during predetermined measurement sessions. The analyzing module determines at least one cardiac signal value based on the cardiac signals for each measurement session and analyzes changes of the cardiac signal values between different measurement sessions to determine a position of the electrode relative a tissue border. A maximum of the change of the cardiac signal values between two successive measurement sessions indicates that the electrode has reached the tissue border.
摘要翻译：本发明一般涉及在植入过程中用于电极定位的医疗装置。心脏信号测量装置使用布置在医疗引线的远端顶端的医疗引线的至少一个电极和布置在距离远端电极一定距离处的至少第二电极来测量对心脏组织和血液之间固有差异敏感的心脏信号，以及可连接到测量单元。分析模块获取在预定测量会话期间测量的心脏信号。分析模块基于每个测量会话的心脏信号来确定至少一个心脏信号值，并且分析不同测量会话之间的心脏信号值的变化，以确定电极相对于组织边界的位置。在两个连续的测量会话之间的心脏信号值的变化的最大值表明电极已经到达组织边界。

83. 发明授权

US08914132B2 Method for manufacturing a medical implantable lead 有权
标题翻译：医用可植入引线的制造方法
公开(公告)号：US08914132B2
公开(公告)日：2014-12-16
申请号：US14053508
申请日：2013-10-14
申请人： St. Jude Medical AB
发明人： Per Jarl , Rolf Hill
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , Y10T29/49208
摘要： A medical implantable lead has a header in a distal end, a fixation arrangement and an electrode arranged in the header. The lead also has a connector in a proximal end that includes a connector pin and is adapted to be connected to a monitoring and/or controlling device, and an inner coil, which extends inside an outer casing of the lead and is adapted to transmit electrical signals between the monitoring and/or controlling device and the electrode. The inner coil is attached to the connector pin. The inner coil extends through a bore inside the connector pin and is attached to the connector pin in its proximal end. A method for manufacturing such a lead is also provided.
摘要翻译：医疗可植入引线具有远端的头部，固定装置和设置在头部中的电极。引线还具有近端中的连接器，其包括连接器引脚，并且适于连接到监控和/或控制装置，以及内部线圈，其在引线的外部壳体内延伸并适于传输电气监控和/或控制设备与电极之间的信号。内部线圈连接到连接器引脚。内线圈延伸穿过连接器销内的孔，并在其近端附接到连接器销。还提供了制造这种引线的方法。

84. 发明授权

US08896462B2 Methods for low power communication in an implantable medical device 有权
标题翻译：用于可植入医疗设备中的低功率通信的方法
公开(公告)号：US08896462B2
公开(公告)日：2014-11-25
申请号：US13509864
申请日：2009-11-27
申请人： Niklas Skoldengen , Hans Abrahamson , Therese Danielsson
发明人： Niklas Skoldengen , Hans Abrahamson , Therese Danielsson
IPC分类号： G08C15/06 , A61N1/372 , A61N1/37
CPC分类号： A61N1/37276 , A61N1/3718
摘要： The present invention is directed to an implantable medical device and a method for power management for power efficient use of RF telemetry during, for example, conditions where long periods of continuous monitoring of the device and the patient is desired such as during MRI procedures. A protocol module adapted to, at receipt of a low power protocol indication, activate and use a low power protocol for communication between the device and external units. The protocol module is capable of switching between different communication protocols including a low power communication protocol and a default RF communication protocol depending on, for example, whether continuous long-term monitoring of the patient is performed. During the low power communication protocol, the protocol module is adapted to select parts of stored electrophysical and/or hemodynamical signal waveforms for telemetric transmission and to create communication packages having a predetermined length using the selected parts of the electrophysiological and/or hemodynamical signal waveform. Further, a transmitter is instructed to transmit the communication packages at predetermined transmission intervals and the telemetry module is instructed to power down the transmitter or set the transmitter in a lowest possible activation state during intermediate periods between the transmission intervals.
摘要翻译：本发明涉及一种植入式医疗装置和用于在例如在MRI程序期间需要长时间连续监视装置和患者的情况下进行RF遥测的功率有效利用的功率管理的方法。一种协议模块，适于在接收到低功率协议指示时激活并使用低功率协议来进行设备与外部单元之间的通信。该协议模块能够在不同的通信协议之间切换，包括低功率通信协议和默认RF通信协议，这取决于例如是否执行对患者的连续长期监测。在低功率通信协议期间，协议模块适于选择用于遥测传输的存储的电物理和/或血液动力学信号波形的部分，并且使用所选择的电生理和/或血液动力学信号波形的部分来创建具有预定长度的通信包。此外，指示发射机以预定的传输间隔发送通信包，并且指示遥测模块在发射间隔之间的中间周期期间将发射机断电或将发射机设置在最低可能的激活状态。

85. 发明申请

US20140228925A1 IMPLANTABLE MEDICAL LEAD WITH BLOOD SEAL 审中-公开
标题翻译：可植入医疗领域与血液密封
公开(公告)号：US20140228925A1
公开(公告)日：2014-08-14
申请号：US13641654
申请日：2011-10-27
申请人： Johan Eckerdal
发明人： Johan Eckerdal
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： An implantable medical lead comprises an insulating tubing with a channel housing a conductor electrically connected to a shaft present in a lumen of a bearing. The shaft is also connected to a fixation helix present in a lumen of a lead header. A clot-inducing structure of a thrombogenic material is present in a distal portion of the channel and/or in the lumen of the bearing to trigger formation of a clot when blood enters the implantable medical lead and thereby inhibit blood from entering further into the channel.
摘要翻译：可植入医疗引线包括绝缘管，其具有通道，该通道容纳与轴承内腔中存在的轴电连接的导体。轴也连接到存在于引线头的内腔中的固定螺旋。血栓形成材料的凝块诱导结构存在于通道的远端部分和/或在轴承的内腔中，以在血液进入可植入医疗引线时引起凝块的形成，从而抑制血液进一步进入通道。

86. 发明授权

US08750996B2 Medical implantable lead 有权
标题翻译：医用植入式铅
公开(公告)号：US08750996B2
公开(公告)日：2014-06-10
申请号：US14021865
申请日：2013-09-09
申请人： St. Jude Medical AB
发明人： Anders Bjorling , Caroline Sparf
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/056 , A61N2001/0585
摘要： The invention relates to a medical implantable lead for monitoring and/or controlling an organ inside a human or animal body. The lead comprises a first electrode (6I) at a distal end of the lead adapted to be in contact with tissue of the organ, a connector at a proximal end of the lead adapted to be connected to a monitoring and/or controlling device, a conducting arrangement comprising a first conducting coil (9I) of at least one electrically conducting wire (10I) for connecting the first electrode electrically to the connector to receive and/or transmit electric signals from and to the tissue, respectively, and a flexible tubing (7) surrounding the lead from the proximal to the distal end, wherein the lead is tapered in a distal portion and has a smaller cross sectional dimension at the distal portion than at the rest of the lead. The first conducting coil (9I) is terminated at a termination point (14) on a distance from the distal end, and the conducting arrangement comprises also a first end conductor, in form of a non-coiled electric conductor (11I) or an eccentrically positioned small diameter coil (13), which connects the first electrode (6I) electrically with the coil.
摘要翻译：本发明涉及用于监测和/或控制人或动物体内的器官的医用可植入引线。引线包括位于引线的远端处的第一电极（6I），其适于与器官的组织接触，引线的近端处的连接器适于连接到监测和/或控制装置，导电装置，其包括至少一个导电线（10I）的第一导电线圈（9I），用于将第一电极电连接到连接器，以分别从组织接收和/或传输电信号;以及柔性管（ 7）围绕从近端到远端的引线，其中引线在远端部分是锥形的，并且在远端部分具有比在引线的其余部分处更小的横截面尺寸。第一导电线圈（9I）在距离远端一定距离处在终端点（14）处终止，并且导电装置还包括形式为非卷绕电导体（11I）的第一端导体或偏心定位的小直径线圈（13），其将第一电极（6I）与线圈电连接。

87. 发明授权

US08750979B2 Method and implantable medical device (IMD) for monitoring permeability status of cell membranes 有权
标题翻译：用于监测细胞膜渗透性状态的方法和植入式医疗装置（IMD）
公开(公告)号：US08750979B2
公开(公告)日：2014-06-10
申请号：US12865169
申请日：2008-01-29
申请人： Andreas Blomqvist , Anna-Karin Alm , Jörgen Edvinsson , Kjell Norèn , Christopher Graae
发明人： Andreas Blomqvist , Anna-Karin Alm , Jörgen Edvinsson , Kjell Norèn , Christopher Graae
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0031 , A61B5/0538 , A61B5/4878 , A61N1/36521 , A61N1/36557 , A61N1/3702 , A61N1/37258
摘要： An implantable medical device comprises a signal generator for generating a current signal having a frequency in a frequency window slightly less than the β-dispersion frequency of a tissue and applying the signal over the tissue. A signal measurer measures the resulting voltage signal and an impedance parameter is calculated from the applied and measured signal by a parameter determiner. A status monitor monitors the permeability status of cell membranes in the tissue based on this impedance parameter.
摘要翻译：可植入医疗装置包括信号发生器，用于产生具有稍微小于组织的分散频率的频率窗口中的频率并将信号施加在组织上的电流信号。信号测量器测量所得到的电压信号，并且通过参数确定器从施加和测量的信号计算阻抗参数。状态监测器基于该阻抗参数监测组织中细胞膜的渗透性状态。

88. 发明授权

US08718767B2 Cardiac stimulating device 有权
标题翻译：心脏刺激装置
公开(公告)号：US08718767B2
公开(公告)日：2014-05-06
申请号：US13509548
申请日：2009-12-18
申请人： Anders Lindgren
发明人： Anders Lindgren
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61B5/0468 , A61N1/3702
摘要： An implantable medical device, IMD, comprises atrial and ventricular sensing units for sensing atrial or ventricular electric events. The IMD also comprises atrial and ventricular pulse generators for generating atrial or ventricular pacing pulses. The ventricular sensing unit is connectable to a multi-electrode lead to individually sense electric events in a ventricle using multiple electrode pairs implanted at different ventricular sites. A controller blanks the ventricular sensing unit during a blanking period following delivery of an atrial stimulating pulse by the atrial pulse generator and activates the ventricular sensing unit at the expiry of the blanking period. Due to the lower propagation speed of PVC depolarization waves and the multi-site sensing, a PVC depolarization wave initiated at a ventricular site during the blanking period can be detected by the IMD.
摘要翻译：可植入医疗装置IMD包括用于感测心室或心室电事件的心房和心室感测单元。 IMD还包括用于产生心房或心室起搏脉冲的心房和心室脉冲发生器。心室感测单元可连接到多电极引线，以单独使用在不同心室部位植入的多个电极对在心室感测电气事件。控制器在由心房脉冲发生器递送心房刺激脉冲之后的消隐期间空白心室感测单元，并且在消隐期结束时激活心室感测单元。由于PVC去极化波和多位点感测的传播速度较低，在消隐期间在心室部位发起的PVC去极化波可以被IMD检测到。

89. 发明授权

US08630700B2 Implantable heart monitoring device, system and method 有权
标题翻译：可植入心脏监测装置，系统及方法
公开(公告)号：US08630700B2
公开(公告)日：2014-01-14
申请号：US12808041
申请日：2007-12-19
申请人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/053
CPC分类号： A61N1/36521 , A61B5/0456 , A61B5/053 , A61B5/0538 , A61N1/3622 , A61N1/3684
摘要： In an implantable heart monitoring device and a monitoring method, an impedance is measured across at least part of an atrium, such that variation of the impedance is related to the volume change of the atrium. Values are stored at different occasions that indicate the rate of change of the measured impedance. The stored values are determined such that, when the device is used in a living being, the variation of the stored values will be related to the variation of the speed with which the atrium is filled with blood during the atrial diastole.
摘要翻译：在可植入心脏监测装置和监测方法中，跨越心房的至少一部分测量阻抗，使得阻抗的变化与心房的体积变化相关。值存储在指示测量阻抗的变化率的不同场合。确定所存储的值，使得当在生物体中使用该装置时，存储值的变化将与在心房舒张期期间心房充满血液的速度的变化相关。

90. 发明申请

US20130345582A1 IMPLANTABLE HEART MONITORING DEVICE AND METHOD 有权
标题翻译：可注入的心脏监测装置和方法
公开(公告)号：US20130345582A1
公开(公告)日：2013-12-26
申请号：US13971722
申请日：2013-08-20
申请人： ST. JUDE MEDICAL AB
发明人： Andreas Blomqvist , Michael Broome
IPC分类号： A61B5/042 , A61B5/0245 , A61B5/029
CPC分类号： A61B5/026 , A61B5/0245 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/053 , A61B5/6846 , A61N1/3627 , A61N1/36585
摘要： In an implantable heart monitoring device and method, particularly for monitoring diastolic dysfunction, a control circuit (a) detects the heart rate, (b) derives information correlated to the stroke volume of the heart at the detected heart rate, and (c) stores the detected heart rate and the derived information correlated to the stroke volume in a memory. The control circuit automatically implements (a), (b) and (c) at a number of different occasions for a number of different, naturally varying heart rates, so that the memory contains information indicating the stroke volume as a function of the heart rate.
摘要翻译：在可植入心脏监测装置和方法中，特别是用于监测舒张功能障碍，控制电路（a）检测心率，（b）以检测到的心率导出与心脏的搏动体积相关的信息，以及（c）检测到的心率和导出的信息与存储器中的笔画体积相关。控制电路在许多不同的，自然变化的心率的多个不同场合自动实现（a），（b）和（c），使得存储器包含指示作为心率的函数的行程体积的信息。

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