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81. 发明授权

US10270070B2 Intuitive and space saving battery retention concept providing a double retention of the batteries 有权
公开(公告)号：US10270070B2
公开(公告)日：2019-04-23
申请号：US15164769
申请日：2016-05-25
申请人： Roche Diabetes Care, Inc.
发明人： Michel Alain Jean Marie Cadio
IPC分类号： B23P19/00 , H01M2/10
摘要： A battery retention system is configured to facilitate insertion and removal of batteries from an electronic device. The electronic device includes a housing that defines a battery cavity for receiving a battery. The battery cavity has a floor. A floor contact extends from the floor. The floor contact is configured to provide a biasing force to push the battery away from the floor of the battery cavity. The housing has tabs extending into the battery cavity to hold the battery in the battery cavity against the biasing force of the floor contact. The battery cavity has a recess that allows the battery to move in a lateral direction along the floor to a position where the battery disengages from at least one of the tabs to allow at least a portion of the battery to be pushed out of the battery cavity by the biasing force of the floor contact.

82. 发明授权

US10258737B2 Analyte monitoring and fluid dispensing system 有权
公开(公告)号：US10258737B2
公开(公告)日：2019-04-16
申请号：US14847101
申请日：2015-09-08
申请人： Roche Diabetes Care, Inc.
发明人： Ofer Yodfat , Ruthy Kaidar
IPC分类号： A61M5/142 , A61M5/172
摘要： Disclosed is a skin adherable device for delivering therapeutic fluid into a body of a patient. The device includes a monitoring apparatus, a dispensing apparatus, and a tip for delivering the therapeutic fluid into the body of the patient and for monitoring bodily analyte in the body of the patient. The dispensing apparatus may continuously deliver the therapeutic fluid to the body of the patient and the monitoring apparatus may continuously monitor bodily analytes of the patient.

83. 发明授权

US10251589B2 Method and system for withdrawing blood 有权
公开(公告)号：US10251589B2
公开(公告)日：2019-04-09
申请号：US15217404
申请日：2016-07-22
申请人： Roche Diabetes Care, Inc.
发明人： Stephan Korner , Rainer Jaeggi , Patrick Griss , Emad Sarofim , Irio Giuseppe Calasso
IPC分类号： A61B5/15 , A61B5/151 , A61B5/157
摘要： A system for withdrawing blood from a body part that avoids formation of a drop of blood on the skin surface of the body part after blood removal. The system includes a collecting unit to withdraw blood, a lancing member configured for insertion into the body part and having a capillary to collect blood, and a pressure piece configured to apply pressure to the body part and having an actuator operably connected thereto. The pressure piece is movable relative to a support configured to exert pressure on the body part, and the actuator is configured to reduce the compressive force of the pressure piece after removing an amount of blood, whereby forming a drop of blood on the skin surface of the body part can be avoided.

84. 发明授权

US10238795B2 Device for drug delivery 有权
公开(公告)号：US10238795B2
公开(公告)日：2019-03-26
申请号：US15198169
申请日：2016-06-30
申请人： Roche Diabetes Care, Inc.
发明人： Ofer Yodfat , Gavriel J. Iddan , Illai Gescheit
IPC分类号： A61M5/178 , A61M5/142 , A61M5/14 , A61M5/145
摘要： Disclosed is an ambulatory therapeutic fluid delivery device. The device includes at least one housing connectable to a cannula, the at least one housing retaining a reservoir to hold the therapeutic fluid. The device also includes a mechanically powered pumping mechanism to cause delivery of at least some of the fluid from the reservoir, and a power-transfer mechanism to transfer manually-delivered power provided by a user to mechanically actuate the pumping mechanism.

85. 发明授权

US10194839B2 Method and device for assessment of a series of glucose concentration values of a body fluid of a diabetic for adjustment of insulin dosing 有权
公开(公告)号：US10194839B2
公开(公告)日：2019-02-05
申请号：US11422126
申请日：2006-06-05
申请人： Arnulf Staib , Hans-Martin Klötzer
发明人： Arnulf Staib , Hans-Martin Klötzer
IPC分类号： G01N33/50 , A61B5/145 , G01N33/66 , A61M5/172 , A61M5/142
摘要： The invention relates to a method for assessment of a series of glucose concentration values of a body fluid of a diabetic for adjustment of the dosing of insulin administrations as well as a suitable device for carrying out the method.

86. 发明授权

US10168321B2 Composition comprising up-converting phosphors for detecting an analyte 有权
公开(公告)号：US10168321B2
公开(公告)日：2019-01-01
申请号：US15163153
申请日：2016-05-24
申请人： Roche Diabetes Care, Inc.
发明人： Carina Horn , Timo-Jaakko Valta
IPC分类号： G01N33/52 , G01N21/77 , C12Q1/32 , C12Q1/26 , C12Q1/54
摘要： The present invention relates to a detector matrix for detecting at least one analyte in a sample, preferably a sample of a body fluid, comprising at least one enzyme active in the presence of said at least one analyte and at least one indicator reagent changing at least one optical property dependent on the activity of said enzyme, wherein said detector matrix further comprises up-converting phosphor particles, preferably UV-emitting up-converting phosphor particles. The invention further relates to a test element and a test device for detecting at least one analyte in a sample comprising the detector matrix of the invention, as well as to a method for the manufacture of a detector matrix, a method for the manufacture of a test element, and to a method for detecting an analyte in a sample, comprising contacting a detector matrix according to the invention with a sample suspected to comprise said analyte.

87. 发明授权

US10167497B2 Stable NAD/NADH derivatives 有权
公开(公告)号：US10167497B2
公开(公告)日：2019-01-01
申请号：US15214494
申请日：2016-07-20
申请人： Roche Diabetes Care, Inc.
发明人： Dieter Heindl , Joachim Hoenes , Carina Horn , Claudia Gaessler-Dietsche
IPC分类号： C12Q1/32
摘要： The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.

88. 发明授权

US10166333B2 Method for generating a monitoring signal using a supervising entity or safety module 有权
公开(公告)号：US10166333B2
公开(公告)日：2019-01-01
申请号：US15508302
申请日：2015-09-11
申请人： Roche Diabetes Care, Inc.
发明人： Kurt Friedli , Carsten Mueglitz , Ralf Schmitz , Kai-Oliver Schwenker , Thomas Eissenloeffel
IPC分类号： A61M5/172 , G16H40/40 , G06F19/00 , A61B5/00 , G16H50/20
摘要： The present invention relates to method for generating a monitoring signal by monitoring laboratory values of a patient using a medical app (122). The medical app (122) is executed on a mobile device (102) of the patient, wherein the execution of the medical app (122) on the mobile device (102) of the patient is supervised by a supervising entity or safety module (106, 128), the supervising entity or safety module (106, 128) comprising at least executable program instructions (130). The medical app (122) comprises executable instructions for executing at least one sequence of processes for generating the monitoring signal. The processes comprise safety critical processes. The sequence of processes is triggered by the measurement of the blood glucose level of the patient. The method comprises executing a first process of the sequence of processes, wherein the execution results in the generation of an information, forwarding the information of the executed process to the supervising entity or safety module (106, 128), evaluating the received information by the supervising entity or safety module (106, 128) and executing a second process of the sequence of processes depending on the result of the evaluation.

89. 发明授权

US10159784B2 Initialization of a dosing unit for drug infusion 有权
公开(公告)号：US10159784B2
公开(公告)日：2018-12-25
申请号：US15126628
申请日：2015-02-18
申请人： Roche Diabetes Care, Inc.
发明人： David Teutsch , Peter Kettenmann
IPC分类号： A61M5/14 , A61M5/142 , A61M5/36
摘要： Disclosed is a method for initializing a dosing unit (20) of an ambulatory infusion system, the method including carrying out a first priming routine. The first priming routine includes: providing the dosing unit (20) with a dosing chamber (202) having a minimal dosing chamber volume, a draining valve (205) being closed and a filling valve (204) being open. The first priming routine further includes measuring an initial reservoir fluid pressure p2 and computing, a first priming volume v1. The method further includes increasing the dosing chamber volume by the first priming volume v1, with the first priming volume v1 being computed such that a reservoir coupling conduit is filled with liquid drug substantially completely at the end of the dosing chamber volume increasing. The first priming routine further includes closing the filling valve (204) and opening the draining valve (205) and emptying the dosing unit (20) by decreasing the dosing chamber volume to the minimal dosing chamber volume. Disclosed are further a control unit for controlling operation of a dosing unit as well as an ambulatory infusion device.

90. 发明授权

US10102344B2 System and methods for analyzing blood glucose data and quantifying the success or failure of insulin therapy 有权
公开(公告)号：US10102344B2
公开(公告)日：2018-10-16
申请号：US13803770
申请日：2013-03-14
申请人： Roche Diabetes Care, Inc.
发明人： Christen A Rees , Robin Wagner , Nathan Wegmann
IPC分类号： G16H50/30 , G06F19/00 , A61B5/145 , G01N33/66 , A61B5/00
摘要： A system and technique are enclosed for determining the effectiveness of a blood glucose therapy treatment. Examples of this technique include analyzing sufficiency of blood glucose data collected from a patient with a computing device, analyzing hypoglycemic risk based on the blood glucose data with the computing device, analyzing glycemic control for the blood glucose data with the computing device, analyzing glycemic variability of the blood glucose data with the computing device, and outputting results from said analyzing the sufficiency, said analyzing the hypoglycemic risk, said analyzing the glycemic control, and said analyzing the glycemic variability with the computing device.

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