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71. 发明申请

US20070271632A1 DELTA 5 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS 失效
标题翻译： DELTA 5去饱和及其在制备多糖脂肪酸中的用途
公开(公告)号：US20070271632A1
公开(公告)日：2007-11-22
申请号：US11748637
申请日：2007-05-15
申请人： Howard Glenn Damude , Dana M. Walters Pollak , Zhixiong Xue , Quinn Qun Zhu
发明人： Howard Glenn Damude , Dana M. Walters Pollak , Zhixiong Xue , Quinn Qun Zhu
IPC分类号： A01H5/00 , C07H21/04 , C12P7/64 , C12N9/04 , C12N15/74 , C12N15/82 , C12N1/18
CPC分类号： C12N9/0083
摘要： The present invention relates to a Δ5 desaturase, which has the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this Δ5 desaturase in oleaginous yeast are disclosed.
摘要翻译：本发明涉及一种Delta5去饱和酶，其具有将二焦γ-亚麻酸（DGLA; 20：3ω-6）转化为花生四烯酸（ARA; 20：4ω-6）和/或二十碳四烯酸（ ETA; 20：4ω-3）至二十碳五烯酸（EPA; 20：5ω-3）。公开了分离的核酸片段和包含编码Δ5去饱和酶的片段的重组构建物，以及在含油酵母中使用该Delta5去饱和酶制备长链多不饱和脂肪酸（PUFAs）的方法。

72. 发明申请

US20070259410A1 FERMENTIVE PRODUCTION OF FOUR CARBON ALCOHOLS 有权
标题翻译：四碳醇的生产生产
公开(公告)号：US20070259410A1
公开(公告)日：2007-11-08
申请号：US11741892
申请日：2007-04-30
申请人： Gail Donaldson , Andrew Eliot , Vasantha Nagarajan , Charles Nakamura , Lixuan Huang
发明人： Gail Donaldson , Andrew Eliot , Vasantha Nagarajan , Charles Nakamura , Lixuan Huang
IPC分类号： C12P7/16 , C12N1/21 , C12N1/18 , C12P7/26
CPC分类号： C12N9/88 , C12N9/0006 , C12N9/1205 , C12N9/78 , C12P7/16 , C12P7/26 , Y02E50/10
摘要： Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein.
摘要翻译：提供了发酵生产四种碳醇的方法。具体地，通过表达2-丁醇生物合成途径的重组细菌的发酵生长来制备丁醇，优选2-丁醇。本发明的重组微生物和方法也可适用于生产2-丁酮，本文公开的2-丁醇生物合成途径中的中间体。

73. 发明申请

US20070249026A1 Delta 17 desaturases and their use in making polyunsaturated fatty acids 失效
标题翻译： Delta 17去饱和酶及其在制备多不饱和脂肪酸中的应用
公开(公告)号：US20070249026A1
公开(公告)日：2007-10-25
申请号：US11787772
申请日：2007-04-18
申请人： Zhixiong Xue , Quinn Zhu
发明人： Zhixiong Xue , Quinn Zhu
IPC分类号： C12P7/64 , C07H21/04 , C12N9/04 , C12N1/18
CPC分类号： C12P7/6427 , C12N9/0083 , C12N9/0087 , C12N15/8247 , C12P7/6472
摘要： The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to eicosapentaenoic acid [20:5, EPA]). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ17 desaturases along with a method of making long chain polyunsaturated fatty acids (PUFAs) using these Δ17 desaturases in plants and oleaginous yeast is disclosed.
摘要翻译：本发明涉及具有将ω-6脂肪酸转化成它们的ω-3对应物的能力的Delta17去饱和酶（即将花生四烯酸[20：4，ARA]转化为二十碳五烯酸[20：5，EPA]）。公开了分离的核酸片段和包含编码Δ17去饱和酶的片段的重组构建物，以及使用植物中的这些Delta17去饱和酶和含油酵母制备长链多不饱和脂肪酸（PUFA）的方法。

74. 发明申请

US20070212375A1 Process For Producing In Yeast Empty Viral Capsids Consisting Of Proteins Derived From Pvp2 Of The Infectious Bursal Disease Virus (Ibdv) 审中-公开
标题翻译：用于生产源自传染性法氏囊病病毒（Ibdv）的Pvp2的蛋白质的酵母空病毒衣壳的方法
公开(公告)号：US20070212375A1
公开(公告)日：2007-09-13
申请号：US10576778
申请日：2005-04-27
申请人： Jose Caston , Irene Gomez , Daniel Buzo , Fernando Elustondo , Ana Blanco , Maria Dolores De Llano , Jose Francisco Aguirre , Juan Fernandez-Alba
发明人： Jose Caston , Irene Gomez , Daniel Buzo , Fernando Elustondo , Ana Blanco , Maria Dolores De Llano , Jose Francisco Aguirre , Juan Fernandez-Alba
IPC分类号： A61K39/12 , C12N7/00 , C12N15/74 , C12N1/18
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5258 , C12N2720/10022 , C12N2720/10023
摘要： The empty capsids of the infectious bursal disease virus (IBDV) are formed by the assembly of proteins derived from the pVP2 protein of IBDV, with a different size and with an application in producing vaccines and in preparing gene therapy vectors.
摘要翻译：传染性法氏囊病病毒（IBDV）的空衣壳通过汇集来自IBDV的pVP2蛋白的蛋白质形成，其具有不同的大小，并且在生产疫苗中的应用和制备基因治疗载体。

75. 发明申请

US20070196382A1 Saccharomyces cerevisiae strains for hyper-producing glutathione and gamma-glutamylcysteine and processes of use 有权
标题翻译：用于产生高产谷胱甘肽和γ-谷氨酰半胱氨酸的酿酒酵母菌株及其使用过程
公开(公告)号：US20070196382A1
公开(公告)日：2007-08-23
申请号：US11359722
申请日：2006-02-22
申请人： Jinn-Tsyy Lai , Shin-Ying Lee , Chun-Chieh Hsieh , Chin-Fa Hwang , Chii-Cherng Liao
发明人： Jinn-Tsyy Lai , Shin-Ying Lee , Chun-Chieh Hsieh , Chin-Fa Hwang , Chii-Cherng Liao
IPC分类号： A61K36/06 , C12P21/06 , C12N1/18 , C12N15/74
CPC分类号： A61K36/064 , C12N1/18 , C12P21/02 , C12R1/865
摘要： The present invention provides a biologically pure culture of Saccharomyces cerevisiae strain YA02032 or YA03083, which culture has a characteristic nature capable of producing glutathione and the precursor thereof, γ-glutamylcysteine. A composition comprising the culture and a process for the production of glutathione and/or the precursor thereof, γ-glutamylcysteine, are also provided.
摘要翻译：本发明提供了酿酒酵母菌株YA02032或YA03083的生物学纯培养物，其培养物具有能够产生谷胱甘肽及其前体γ-谷氨酰半胱氨酸的特征性质。还提供了包含培养物和用于产生谷胱甘肽和/或其前体，γ-谷氨酰半胱氨酸的方法的组合物。

76. 发明申请

US20070178551A1 Methods for producing modified glycoproteins 审中-公开
标题翻译：生产改性糖蛋白的方法
公开(公告)号：US20070178551A1
公开(公告)日：2007-08-02
申请号：US11265444
申请日：2005-11-01
申请人： Tillman Gerngross
发明人： Tillman Gerngross
IPC分类号： C12P21/04 , C12P21/06 , C07H21/04 , C12N1/18 , C07K14/52 , C07K16/46
CPC分类号： C12P21/005 , C07K2319/04 , C07K2319/05 , C12N1/14 , C12N9/1048 , C12N9/2488 , C12N15/79 , C12N15/80 , C12N15/81 , C12Y302/01 , C12Y302/01113
摘要： Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower eukaryotes, which ordinarily produce high-mannose containing N-glycans, including unicellular and multicellular fungi are modified to produce N-glycans such as Man5GlcNAc2 or other structures along human glycosylation pathways. This is achieved using a combination of engineering and/or selection of strains which: do not express certain enzymes which create the undesirable complex structures characteristic of the fungal glycoproteins, which express exogenous enzymes selected either to have optimal activity under the conditions present in the fungi where activity is desired, or which are targeted to an organelle where optimal activity is achieved, and combinations thereof wherein the genetically engineered eukaryote expresses multiple exogenous enzymes required to produce “human-like” glycoproteins.
摘要翻译：已经开发了具有遗传修饰的糖基化途径的细胞系，其允许它们进行模拟人类中糖蛋白的加工的酶反应序列。在这些工程化宿主中表达的重组蛋白可以产生与其对应物更相似的糖蛋白（如果基本上不相同）。通常产生含有高甘露糖的N-聚糖（包括单细胞和多细胞真菌）的低等真核生物被修饰以产生N-聚糖，例如Man 3或GlcNAc 2 N或其它结构沿着人类糖基化途径。这是使用以下工程和/或选择的组合实现的：不表达产生真菌糖蛋白特征的不合需要的复合结构的某些酶，其表达选择在真菌中存在的条件下具有最佳活性的外源酶其中需要活性或靶向实现最佳活性的细胞器，以及其组合，其中遗传工程真核生物表达产生“人样”糖蛋白所需的多种外源酶。

77. 发明申请

US20070155001A1 Secondary Liquefaction in Ethanol Production 审中-公开
标题翻译：乙醇生产中的二次液化
公开(公告)号：US20070155001A1
公开(公告)日：2007-07-05
申请号：US11620829
申请日：2007-01-08
申请人： Christopher Veit , Claus Felby
发明人： Christopher Veit , Claus Felby
IPC分类号： C12P7/06 , C12N9/32 , C12N15/74 , C12N1/21 , C12N1/18
CPC分类号： C12P7/06 , C12P19/14 , Y02E50/17
摘要： The invention relates to a method of producing ethanol by fermentation, said method comprising a secondary liquefaction step in the presence of a thermostable acid alpha-amylase or a thermostable maltogenic acid alpha-amylase.
摘要翻译：本发明涉及通过发酵生产乙醇的方法，所述方法包括在耐热酸性α-淀粉酶或耐热麦芽糖酸α-淀粉酶存在下的二次液化步骤。

78. 发明申请

US20070141675A1 Process for producing glycoprotein 审中-公开
标题翻译：产生糖蛋白的方法
公开(公告)号：US20070141675A1
公开(公告)日：2007-06-21
申请号：US11705899
申请日：2007-02-14
申请人： Kenichi Suga , Takeshi Omasa , Michimasa Kishimoto , Yoshio Katakura , Toyoo Ohda , Hideo Miki , Kaoru Kobayashi
发明人： Kenichi Suga , Takeshi Omasa , Michimasa Kishimoto , Yoshio Katakura , Toyoo Ohda , Hideo Miki , Kaoru Kobayashi
IPC分类号： C12P21/06 , C07H21/04 , C07K14/47 , C12N1/18
CPC分类号： C12P21/005
摘要： A means of controlling sugar chain-modification and sugar chain structure in the production of a glycoprotein with the use of gene recombination techniques. A process for producing a glycoprotein by culturing a gene recombinant host in a medium characterized in that the relative sugar consumption speed is employed as an indication and changed to thereby modify the sugar chain structure attached to the protein.
摘要翻译：一种利用基因重组技术在糖蛋白生产中控制糖链修饰和糖链结构的方法。通过在培养基中培养基因重组宿主来生产糖蛋白的方法，其特征在于使用相对糖消耗速度作为指示，并改变从而改变与蛋白质相连的糖链结构。

79. 发明申请

US20070134780A1 Fermentation processes and compositions 有权
标题翻译：发酵过程和组成
公开(公告)号：US20070134780A1
公开(公告)日：2007-06-14
申请号：US11299163
申请日：2005-12-09
申请人： Varvara Grichko
发明人： Varvara Grichko
IPC分类号： C12P7/06 , C12N9/02 , C12N1/18
CPC分类号： C12P7/06 , C12P7/08 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The present invention provides improved fermentation processes, including for use in an ethanol production process. The improved fermentation processes include applying at least one fatty acid oxidizing enzyme (especially a lipoxygenase) in a fermentation process. The improved fermentation process may also involve the addition of various additional enzymes and growth stimulators for the fermenting microorganisms, including vitamins and mineral.
摘要翻译：本发明提供改进的发酵方法，包括用于乙醇生产方法。改进的发酵方法包括在发酵过程中应用至少一种脂肪酸氧化酶（特别是脂氧合酶）。改进的发酵方法还可以包括为发酵微生物（包括维生素和矿物质）添加各种另外的酶和生长刺激剂。

80. 发明申请

US20070128706A1 Mutated xylose reductase in xylose-fermentation by S. cerevisiae 审中-公开
标题翻译：酿酒酵母木糖发酵中木糖还原酶的突变
公开(公告)号：US20070128706A1
公开(公告)日：2007-06-07
申请号：US11518658
申请日：2006-09-11
申请人： Marie-Francoise Gorwa-Grauslund , Marie Jeppson
发明人： Marie-Francoise Gorwa-Grauslund , Marie Jeppson
IPC分类号： C12P7/06 , C12N1/18
CPC分类号： C12P7/06 , C12N9/0004 , Y02E50/17
摘要： New xylose-utilizing Saccharomyces cerevisiae mutant strain which ferments xylose to ethanol, wherein the strain expresses a K270M mutated P. stipitis XYL1 gene (1 or 2 copies of the mutated gene) together with the native P. stipitis XYL2 gene and overexpresses the endogenous XKS1 gene.
摘要翻译：新型木糖利用的酿酒酵母突变菌株将木糖发酵成乙醇，其中菌株表达了K270M突变的树干特有的XYL1基因（突变基因的1或2个拷贝）以及天然的白喉树木XYL2基因，过表达内源性XKS1 基因。

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