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71. 发明授权

US5593994A Prostaglandin synthase inhibitors 失效
标题翻译：前列腺素合酶抑制剂
公开(公告)号：US5593994A
公开(公告)日：1997-01-14
申请号：US314991
申请日：1994-09-29
申请人： Douglas G. Batt , Donald J. P. Pinto , Michael J. Orwat , Joseph J. Petraitis , William J. Pitts
发明人： Douglas G. Batt , Donald J. P. Pinto , Michael J. Orwat , Joseph J. Petraitis , William J. Pitts
IPC分类号： C07D295/08 , A61K31/10 , A61K31/11 , A61K31/12 , A61K31/135 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/235 , A61K31/27 , A61K31/275 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/445 , A61K31/4453 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P25/04 , A61P29/00 , A61P43/00 , C07C311/15 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/36 , C07D207/32 , C07D207/325 , C07D207/33 , C07D207/333 , C07D211/14 , C07D213/34 , C07D213/52 , C07D213/65 , C07D213/70 , C07D213/71 , C07D215/12 , C07D217/16 , C07D261/08 , C07D261/20 , C07D263/32 , C07D263/34 , C07D263/56 , C07D275/02 , C07D275/04 , C07D277/26 , C07D277/66 , C07D295/096 , C07D307/38 , C07D307/79 , C07D333/18 , C07D333/22 , C07D333/54 , A01N43/58
CPC分类号： C07D207/33 , C07C311/15 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/36 , C07D213/52 , C07D213/70 , C07D215/12 , C07D261/08 , C07D263/34 , C07D275/02 , C07D295/096 , C07D307/38 , C07D307/79 , C07D333/22 , C07D333/54 , C07C2101/14
摘要： This invention relates to ortho substituted phenyl compounds as inhibitors of prostaglandin synthase, to pharmaceutical compositions comprising such compounds and to methods of using such compounds as antiinflammatory and antipyretic agents. The class of compounds useful in this method of treatment is represented by Formula I below: ##STR1##
摘要翻译：本发明涉及作为前列腺素合成酶抑制剂的邻位取代的苯基化合物，包含这些化合物的药物组合物以及使用这些化合物作为抗炎和解热剂的方法。在这种治疗方法中有用的一类化合物由下式I表示：（I）

72. 发明授权

US5589493A Anilide derivatives and their use for combating botrytis 失效
标题翻译：苯胺衍生物及其应用于酿酒酵母的用途
公开(公告)号：US5589493A
公开(公告)日：1996-12-31
申请号：US478681
申请日：1995-06-07
申请人： Karl Eicken , Norbert Goetz , Albrecht Harreus , Eberhard Ammermann , Gisela Lorenz , Harald Rang
发明人： Karl Eicken , Norbert Goetz , Albrecht Harreus , Eberhard Ammermann , Gisela Lorenz , Harald Rang
IPC分类号： C07D231/16 , A01N37/22 , A01N43/00 , A01N43/08 , A01N43/16 , A01N43/32 , A01N43/40 , A01N43/56 , A01N43/74 , A01N43/76 , A01N43/78 , C07C233/11 , C07C233/64 , C07C233/65 , C07C233/66 , C07C233/75 , C07D213/82 , C07D231/14 , C07D263/34 , C07D277/20 , C07D277/56 , C07D307/68 , C07D309/28 , C07D323/04 , C07D327/06 , C07D213/56
CPC分类号： C07D213/82 , A01N37/22 , A01N43/08 , A01N43/16 , A01N43/32 , A01N43/40 , A01N43/56 , A01N43/74 , C07C233/65 , C07C233/66 , C07C233/75 , C07D231/14 , C07D263/34 , C07D277/56 , C07D307/68 , C07D309/28 , C07D327/06 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/10 , C07C2101/14 , C07C2101/16
摘要： The use of nicotinic anilide derivatives of the general formula ##STR1## where the substituents have the following meanings: R.sup.1 halogen, methyl, trifluoromethyl, methoxy, methylthio, methylsulfinyl, methylsulfonylR.sup.2 unsubstituted or halogen-substituted alkyl, unsubstituted or halogen-substituted alkenyl, alkynyl, unsubstituted or halogen-substituted alkoxy, unsubstituted or halogen-substituted alkenyloxy, alkynyloxy, cycloalkyl, cycloalkenyl, cycloalkyloxy, cycloalkenyloxyfor combating Botrytis, and nicotinic anilides of the formula I.
摘要翻译：使用通式为“IMAGE”I的烟酰苯胺衍生物，其中取代基具有以下含义：R 1卤素，甲基，三氟甲基，甲氧基，甲硫基，甲基亚磺酰基，甲基磺酰基R2未取代或卤素取代的烷基，未取代或卤素取代的烯基，炔基，未取代或卤素取代的烷氧基，未取代的或卤素取代的烯氧基，炔氧基，环烷基，环烯基，环烷氧基，用于防治葡萄孢菌的环烯烃氧基和式I的烟碱酰苯胺。

73. 发明授权

US5463070A Hypoglycemic hydroxyurea derivatives 失效
标题翻译：低血糖羟基脲衍生物
公开(公告)号：US5463070A
公开(公告)日：1995-10-31
申请号：US391308
申请日：1995-02-17
申请人： Steven W. Goldstein , Ruth E. McDermott
发明人： Steven W. Goldstein , Ruth E. McDermott
IPC分类号： A61K31/42 , A61K31/421 , A61P3/06 , A61P3/08 , C07D20060101 , C07D213/12 , C07D213/14 , C07D263/32 , C07D263/34 , C07D263/38 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14
CPC分类号： C07D413/04 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14
摘要： Certain 1-(benzyl or 5-benzofuranylmethyl)-1-hydroxyurea derivatives are useful as hypoglycemic and hypocholesterolemic agents.
摘要翻译：某些1-（苄基或5-苯并呋喃基甲基）-1-羟基脲衍生物可用作低血糖和低胆固醇血症药。

74. 发明授权

US5457205A Substituted thiazoles useful for treatment of diabetes 失效
标题翻译：用于治疗糖尿病的取代的噻唑
公开(公告)号：US5457205A
公开(公告)日：1995-10-10
申请号：US30744
申请日：1993-03-12
申请人： Manfred Reiffen , Rudolph Hurnaus , Robert Sauter , Wolfgang Grell , Eckhard Rupprecht
发明人： Manfred Reiffen , Rudolph Hurnaus , Robert Sauter , Wolfgang Grell , Eckhard Rupprecht
IPC分类号： A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , C07D263/32 , C07D263/34 , C07D263/48 , C07D265/30 , C07D265/32 , C07D277/20 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/32 , C07D277/38 , C07D277/40 , C07D277/42 , C07D277/44 , C07D277/46 , C07D413/04 , C07D417/04 , C07D417/14
CPC分类号： C07D277/22 , C07D263/32 , C07D265/32 , C07D277/24 , C07D277/32 , C07D277/40 , C07D277/42 , C07D277/46 , C07D413/04 , C07D417/04 , C07D417/14
摘要： Compounds of formula ##STR1## where the substituents are as defined herein, are disclosed, which compounds are useful in the treatment of diabetes and obesity, among other uses.
摘要翻译：公开了其中取代基如本文所定义的式（I）的化合物，其中所述化合物可用于治疗糖尿病和肥胖以及其它用途。

75. 发明授权

US5391753A Heteroaryl substituted phenylethenyl compounds having retinoid-like biological activity 失效
标题翻译：具有类视黄醇样生物活性的杂芳基取代的苯乙烯基化合物
公开(公告)号：US5391753A
公开(公告)日：1995-02-21
申请号：US126627
申请日：1993-09-27
申请人： Roshantha A. S. Chandraratna
发明人： Roshantha A. S. Chandraratna
IPC分类号： C07D239/26 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61P3/02 , A61P9/10 , A61P13/08 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/10 , A61P27/02 , A61P35/00 , C07D213/78 , C07D213/80 , C07D239/28 , C07D263/32 , C07D263/34 , C07D277/22 , C07D307/68 , C07D333/16 , C07D333/18 , C07D333/24 , C07D333/38 , C07D333/40 , C07D213/63 , C07D213/69 , C07D213/79
CPC分类号： C07D213/80 , C07D307/68 , C07D333/38
摘要： Compounds of the formula ##STR1## where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently are hydrogen, lower alkyl of 1-6 carbons, halogen or lower alkoxy of 1-6 carbons; R.sub.5 and R.sub.5 ' independently are hydrogen or lower alkyl of 1-6 carbons; Y is oxygen or sulfur; Z is n-alkyl having 1-10 carbons, cyclo or branch-chained alkyl of 3-10 carbons, and straight chain alkenyl having 2-10 carbons, or cyclo or branched chained alkenyl of 3-10 carbons; X is thienyl, pyridyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl and oxazolyl; A is (CH.sub.2).sub.n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR.sub.7, CR.sub.7 (OR.sub.12).sub.2, or CR.sub. 7 OR.sub.13 O, where R.sub.7 is an alkyl, cycloalkyl or alkenyl group containing 1-5 carbons, R.sub.8 is an alkyl group of 1-10 carbons, or a cycloalkyl group of 5-10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.10 independently are hydrogen, an alkyl group of 1-10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R.sub.11 is alkyl of 1-10 carbons, phenyl or lower alkylphenyl, R.sub.12 is lower alkyl, and R.sub.13 is divalent alkyl radical of 2-5 carbons, have retinoic acid like biological activity.
摘要翻译：其中R 1，R 2，R 3和R 4独立地为氢，1-6个碳的低级烷基，卤素或1-6个碳的低级烷氧基的式 R5和R5'独立地是氢或1-6个碳的低级烷基; Y是氧或硫; Z是具有1-10个碳的正烷基，3-10个碳的环或支链烷基，和具有2-10个碳的直链烯基，或3-10个碳的环或支链链烯基; X是噻吩基，吡啶基，呋喃基，哒嗪基，嘧啶基，吡嗪基，噻唑基和恶唑基; A是（CH 2）n，其中n是0-5，具有3-6个碳的低级支链烷基，具有3-6个碳的环烷基，具有2-6个碳的烯基和1或2个双键，具有2-6个碳原子的炔基和 1或2个三键; B是氢，COOH或其药学上可接受的盐，COOR8，CONR9R10，-CH2OH，CH2OR11，CH2OCOR11，CHO，CH（OR12）2，CHOR13O，-COR7，CR7（OR12）2或CR7OR13O，其中R7是含有1-5个碳的烷基，环烷基或烯基，R8是1-10个碳的烷基或5-10个碳的环烷基，或R8是苯基或低级烷基苯基，R9和R10独立地是氢，烷基 1-10个碳的环烷基或5-10个碳的环烷基，或苯基或低级烷基苯基，R11是1-10个碳的烷基，苯基或低级烷基苯基，R12是低级烷基，R13是2的二价烷基 -5碳，具有类似生物活性的视黄酸。

76. 发明授权

US5256632A Herbicidal sulphonylated carboxamides 失效
标题翻译：除草磺酰化甲酰胺
公开(公告)号：US5256632A
公开(公告)日：1993-10-26
申请号：US900867
申请日：1992-06-18
申请人： Hilmar Wolf , Rolf Kirsten , Hans-Joachim Santel , Klaus Lurssen , Robert R. Schmidt
发明人： Hilmar Wolf , Rolf Kirsten , Hans-Joachim Santel , Klaus Lurssen , Robert R. Schmidt
IPC分类号： A01N43/74 , A01N43/80 , A01N43/82 , C07D261/18 , C07D263/34 , C07D271/06 , C07D271/10 , C07D275/02 , C07D275/03 , C07D277/56 , C07D285/12 , A01N43/48 , C07D271/04 , C07D413/02
CPC分类号： C07D263/34 , A01N43/74 , A01N43/80 , A01N43/82 , C07D261/18 , C07D271/06 , C07D271/10 , C07D275/03 , C07D277/56 , C07D285/12
摘要： Herbicidal sulphonylated carboxamides of the formulaR.sup.1 --CO--NH--SO.sub.2 --(A).sub.n --R.sup.2 (I)in whichn represents the numbers 0 or 1,A represents oxygen, iminio (NH) or methylene (CH.sub.2),R.sup.1 represents a five-membered heteroaryl radical which contains 1 or 2 nitrogen atoms and additionally one oxygen or sulphur atom in the ring and which is optionally substituted by halogen or by alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylamino, dialkylamino or phenyl which are in each case optionally substituted, andR.sup.2 represents aryl or heteroaryl which are in each case optionally substituted,or salts thereof, with the exclusion of the compound 2-dimethylamino-N-(4-methyl-phenylsulphonyl)-5-thiazole carboxamide.
摘要翻译：式R 1 -CO-NH-SO 2 - （A）n -R 2（I）的除草磺酰化羧酰胺，其中n表示数字0或1，A表示氧，亚氨基（NH）或亚甲基（CH 2），R 1表示在环中含有1或2个氮原子和另外一个氧或硫原子的五元杂芳基，其任选被卤素或烷基，烷氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，烷基氨基，二烷基氨基或苯基取代。并且R 2代表任意取代的芳基或杂芳基，或其盐，除去化合物2-二甲基氨基-N-（4-甲基 - 苯基磺酰基）-5-噻唑甲酰胺。

77. 发明授权

US5254576A Diphenyl-heterocyclic-oxazole as platelet aggregation inhibitors 失效
标题翻译：二苯基杂环恶唑作为血小板聚集抑制剂
公开(公告)号：US5254576A
公开(公告)日：1993-10-19
申请号：US862680
申请日：1992-04-03
申请人： Jeffrey L. Romine , Nicholas A. Meanwell , Scott W. Martin
发明人： Jeffrey L. Romine , Nicholas A. Meanwell , Scott W. Martin
IPC分类号： C07D263/32 , C07D263/34 , C07D413/04 , C07D413/14 , C07D417/04 , A61K31/54 , A61K31/535
CPC分类号： C07D263/34 , C07D263/32 , C07D413/04 , C07D413/14 , C07D417/04
摘要： A novel series of oxazole derivatives having enhanced water solubility bioavailability and metabolic stability is disclosed in the Formula I ##STR1## X is ##STR2## R is CH.sub.2 R.sup.2, H; R.sup.1 is Ph or Th;R.sup.2 is ##STR3## H, CN, CO.sub.2 R.sup.3, or OR.sup.3 ; and R.sup.3 is H, or C.sub.1 -C.sub.4 lower alkyl;or pharmaceutically acceptable salt thereof.
摘要翻译：在式I中公开了一系列具有增强的水溶性生物利用度和代谢稳定性的恶唑衍生物，其中R是CH 2 R 2，H; R1为Ph或Th; R2是H，CN，CO2R3或OR3; 且R 3为H或C 1 -C 4低级烷基; 或其药学上可接受的盐。

78. 发明授权

US5214162A Process for manufacturing 5-cyano-4-lower alkyloxazoles 失效
标题翻译：制备5-氰基-4-低级烷氧基硅烷的方法
公开(公告)号：US5214162A
公开(公告)日：1993-05-25
申请号：US803004
申请日：1991-12-05
申请人： Paul Nosberger
发明人： Paul Nosberger
IPC分类号： B01J21/08 , B01J23/06 , B01J23/22 , B01J23/28 , B01J23/74 , C07B61/00 , C07D263/34
CPC分类号： C07D263/34
摘要： The invention is concerned with a process for the manufacture of 5-cyano-4-lower alkyl-oxazoles by dehydrating a 5-carbamoyl-4-lower alkyl-oxazole in the gas phase in the presence of a heterogeneous catalyst based on silicon dioxide and in the presence of an inert solvent. The heterogeneous catalyst used is formed SiO.sub.2 or SiO.sub.2 doped with an oxide of V, Mo, Fe, Co and/or Zn. An N-lower alkyl-pyrrolidone is preferably used as the inert solvent.
摘要翻译：本发明涉及通过在基于二氧化硅的多相催化剂存在下，在气相中脱水5-氨基甲酰基-4-低级烷基 - 恶唑来制备5-氰基-4-低级烷基 - 恶唑的方法，以及在惰性溶剂的存在下。使用的非均相催化剂形成掺杂有V，Mo，Fe，Co和/或Zn的氧化物的SiO 2或SiO 2。优选使用N-低级烷基吡咯烷酮作为惰性溶剂。

79. 发明授权

US5066808A Pyridyl insecticidally active cyano compounds 失效
标题翻译：吡啶类杀虫活性氰化合物
公开(公告)号：US5066808A
公开(公告)日：1991-11-19
申请号：US584398
申请日：1990-09-14
申请人： Kozo Shiokawa , Shinichi Tsuboi , Koichi Moriya , Ikuro Honda , Yumi Hattori , Katsuhiko Shibuya
发明人： Kozo Shiokawa , Shinichi Tsuboi , Koichi Moriya , Ikuro Honda , Yumi Hattori , Katsuhiko Shibuya
IPC分类号： C07D237/08 , A01N47/40 , C07D213/38 , C07D213/40 , C07D213/61 , C07D213/74 , C07D231/12 , C07D239/26 , C07D239/30 , C07D241/12 , C07D261/08 , C07D263/34 , C07D271/10 , C07D277/20 , C07D277/28 , C07D277/32 , C07D333/28 , C07D521/00
CPC分类号： C07D213/40 , C07D213/61 , C07D239/26 , C07D241/12 , C07D277/32
摘要： A cyano compound useful as an insecticide, of the formula (I) ##STR1## wherein R.sup.1 is hydrogen, cyano or C.sub.1-4 alkyl, m is 0 or 1,R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.3-4 alkenyl optionally substituted by halogen,C.sub.3-4 alkynyl, C.sub.3-8 cycloalkyl optionally substituted by methyl, optionally substituted phenyl, optionally substituted benzyl, hydroxy, C.sub.1-4 alkoxy or --CH.sub.2 --Z, in which Z has the same meanings as stated below,R.sup.3 is ##STR2## in which R.sup.4 is C.sub.1-6 alkyl, C.sub.3-4 alkenyl, C.sub.3-4 alkynyl, C.sub.3-8 cycloalkyl, optionally substituted phenyl, optionally substituted benzyl or --(CH.sub.2)n-Z, in which n is 1 or 2 andZ has the same meanings as stated below, andR.sup.5 and R.sup.6 are hydrogen, C.sub.1-9 alkyl optionally substituted by at least one selected from a group consisting of halogen, hydroxy, mercapto, C.sub.1-2 alkoxy, C.sub.1-2 alkylthio, C.sub.3-6 cycloalkyl, amino, C.sub.1-2 monoalkylamino, C.sub.2-4 (in total)di-alkylamino, carboxy, C.sub.1-2 alkoxy-carbonyl and cyano, C.sub.3-4 alkenyl optionally substituted by halogen, C.sub.3-4 alkynyl, optionally substituted phenyl, optionally substituted benzyl, C.sub.1-4 alkoxy, hydroxy, formyl, C.sub.1-4 alkoxy-carbonyl, C.sub.1-4 alkylamino, C.sub.2-4 (in total)di-alkylamino, amino, acyl or ##STR3## in which R.sup.1 and m have the same meanings as stated above, and Z has the same meanings as stated below, and in addition,R.sup.5 and R.sup.6 may form, together with the N-atom to which they are bonded, a 3 to 7 membered ring which may be substituted by C.sub.1-2 alkyl and may contain N, O or S as the member of said ring, besides the N-atom to which they are bonded, andZ is a substituted 5 or 6 membered heterocyclic group which contains at least one heteroatom selected from N, O and S as a ring member, provided that where Z is pyridyl substituted by halogen, m is 1, R.sup.2 is C.sub.1-6 alkyl and R.sup.3 is --S--alkyl(C.sub.1-6) or --S--benzyl, then R.sup.1 is cyano or C.sub.1-4 alkyl.

80. 发明授权

US5039694A Substituted-amido compounds and phytopathogenic fungicides containing the same 失效
标题翻译：含有相同的取代的酰氨基化合物和植物病原性杀真菌剂
公开(公告)号：US5039694A
公开(公告)日：1991-08-13
申请号：US344895
申请日：1989-04-28
申请人： Hideo Suzuki , Takeshi Mita , Toshiaki Takeyama , Yoshinori Ochiai , Masami Hanaue , Masao Nishikubo , Kazuhiro Yamagishi
发明人： Hideo Suzuki , Takeshi Mita , Toshiaki Takeyama , Yoshinori Ochiai , Masami Hanaue , Masao Nishikubo , Kazuhiro Yamagishi
IPC分类号： A01N43/50 , A01N43/56 , A01N43/653 , A01N43/74 , A01N43/80 , C07D231/14 , C07D233/90 , C07D261/18 , C07D263/34 , C07D275/02 , C07D275/03 , C07D277/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00
CPC分类号： C07D263/34 , A01N43/50 , A01N43/56 , A01N43/653 , A01N43/74 , A01N43/80 , C07D231/12 , C07D231/14 , C07D233/56 , C07D233/90 , C07D249/08 , C07D261/18 , C07D275/03 , C07D277/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are substituted-amido derivatives of a general formula (I): ##STR1## in which R.sub.1 represents a group as specifically defined herein; R.sub.2 represents a hydrogen atom, a methyl group, a methoxy group or a halogne atom; B represents a 5-membered hetero-aromatic group as specifically defined herein, as well as a method for preparation of the said derivatives and a fungicide containing the said derivative as an active ingredient.
摘要翻译：公开了通式（I）的取代的酰氨基衍生物：其中R 1表示本文具体定义的基团; R2表示氢原子，甲基，甲氧基或卤代原子; B表示本文具体定义的5元杂芳族基团，以及制备所述衍生物的方法和含有所述衍生物作为活性成分的杀真菌剂。

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