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71. 发明授权

US5563158A Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists 失效
标题翻译：含有碱性和酸性末端的芳族化合物可用作纤维蛋白原受体拮抗剂
公开(公告)号：US5563158A
公开(公告)日：1996-10-08
申请号：US343159
申请日：1994-11-22
申请人： William F. DeGrado , Chu-Biao Xue
发明人： William F. DeGrado , Chu-Biao Xue
IPC分类号： C07C257/18 , C07C271/22 , C07C311/06 , C07D207/34 , C07D207/38 , C07D211/22 , C07D211/46 , C07D213/56 , C07D213/81 , C07D261/18 , C07D263/34 , C07D275/02 , C07D275/03 , C07D277/56 , C07D307/68 , C07D333/38 , C07D413/02 , A61K31/42 , A61K31/44 , C07D261/02
CPC分类号： C07D213/81 , C07C257/18 , C07C271/22 , C07C311/06 , C07D207/34 , C07D207/38 , C07D211/22 , C07D211/46 , C07D213/56 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D307/68 , C07D333/38 , C07C2101/14
摘要： This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
摘要翻译：本发明涉及含有碱性和酸性末端的新化合物，含有这些化合物的药物组合物，制备这些化合物的方法，以及使用这些化合物单独或与其它治疗剂组合用于抑制血小板聚集作为溶血栓剂的方法，和/或用于治疗血栓栓塞性疾病。

72. 发明授权

US5532259A Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use 失效
标题翻译：异恶唑-4-甲酰胺和羟烷基亚乙烯基乙酰胺，含有这些化合物的药物及其用途
公开(公告)号：US5532259A
公开(公告)日：1996-07-02
申请号：US476278
申请日：1995-06-07
申请人： Robert R. Bartlett , Friedrich-Johannes Kammerer
发明人： Robert R. Bartlett , Friedrich-Johannes Kammerer
IPC分类号： C07C233/58 , A61K31/00 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/275 , A61K31/36 , A61K31/395 , A61K31/415 , A61K31/416 , A61K31/4184 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/505 , A61K31/506 , A61P35/00 , A61P35/02 , C07C237/16 , C07C255/21 , C07C255/23 , C07C255/41 , C07C317/40 , C07D211/16 , C07D211/40 , C07D213/00 , C07D213/75 , C07D231/56 , C07D235/30 , C07D235/32 , C07D239/30 , C07D239/42 , C07D261/08 , C07D261/18 , C07D277/20 , C07D277/30 , C07D277/38 , C07D277/46 , C07D277/68 , C07D277/82 , C07D295/16 , C07D317/66 , C07D413/12 , A61K31/41 , C07D261/02
CPC分类号： C07D277/82 , A61K31/275 , A61K31/42 , C07C255/23 , C07C317/40 , C07D213/75 , C07D231/56 , C07D235/30 , C07D239/42 , C07D277/46 , C07D317/66 , C07D413/12
摘要： Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their useIsoxazole-4-carboxamide derivatives and hydroxyalkylidene-cyanoacetamide derivatives are suitable for the treatment of carcinoses. These compounds can be prepared by known processes. Some of the compounds are novel and are additionally suitable for the treatment of rheumatic disorders.
摘要翻译：异恶唑-4-甲酰胺和羟基亚烷基氰基乙酰胺，含有这些化合物的药物及其用途异恶唑-4-甲酰胺衍生物和羟基亚烷基 - 氰基乙酰胺衍生物适用于治疗癌症。这些化合物可以通过已知方法制备。一些化合物是新颖的，并且另外适用于治疗风湿性疾病。

73. 发明授权

US5120722A Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia 失效
标题翻译：用于治疗白血病的三羟基 - 胆囊塞醇和三羟基 - 麦角钙化醇
公开(公告)号：US5120722A
公开(公告)日：1992-06-09
申请号：US495519
申请日：1990-03-19
申请人： Enrico G. Baggiolini , Andrew D. Batcho , Gary A. Truitt , Milan R. Uskokovic , Peter M. Wovkulich
发明人： Enrico G. Baggiolini , Andrew D. Batcho , Gary A. Truitt , Milan R. Uskokovic , Peter M. Wovkulich
IPC分类号： C07C35/32 , C07C401/00 , C07D261/02 , C07D317/20 , C07D317/26 , C07D317/28 , C07F7/18
CPC分类号： C07D261/02 , C07C35/32 , C07C401/00 , C07D317/20 , C07D317/26 , C07D317/28 , C07F7/1856
摘要： The compounds 1.alpha.,25(S), 26-trihydroxy-.DELTA..sup.22 -cholecalciferol; 1.alpha.,25(R), 26-trihydroxy-.DELTA..sup.22 -cholecalciferol; 1.alpha.,25(S),26-trihydroxyergocalciferol, 1.alpha.,25(R),26-trihydroxyergocalciferol and pharmaceutical compositions comprising the compounds as well as methods of making and using these compounds are disclosed.
摘要翻译：化合物1α，25（S），26-三羟基-DTA22-胆钙化甾醇; 1α，25（R），26-三羟基-DTA 22-胆钙化醇; 公开了1α，25（S），26-三羟基麦角钙化醇，1α，25（R），26-三羟基麦角钙化醇和包含该化合物的药物组合物以及制备和使用这些化合物的方法。

74. 发明授权

US5047406A Substituted cyclohexanols as central nervous system agents 失效
标题翻译：取代的环己醇作为中枢神经系统药剂
公开(公告)号：US5047406A
公开(公告)日：1991-09-10
申请号：US517913
申请日：1990-05-02
申请人： Bradley W. Caprathe , Juan C. Jaen , Sarah J. Smith , Lawrence D. Wise
发明人： Bradley W. Caprathe , Juan C. Jaen , Sarah J. Smith , Lawrence D. Wise
IPC分类号： C07D295/08 , A61K31/00 , A61K31/42 , A61K31/435 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P9/12 , A61P13/02 , A61P15/00 , A61P15/10 , A61P15/14 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/26 , C07D211/00 , C07D211/82 , C07D213/74 , C07D213/75 , C07D213/82 , C07D261/02 , C07D265/02 , C07D401/08 , C07D401/12 , C07D405/12 , C07D409/00 , C07D409/08 , C07D409/12 , C07D417/12 , C07D521/00
CPC分类号： C07D211/82 , C07D213/74 , C07D213/82 , C07D401/08 , C07D401/12 , C07D405/12 , C07D409/08 , C07D409/12 , C07D417/12
摘要： Substituted cyclohexanols and cyclohexylamines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.

75. 发明授权

US4877786A Aminomethylisoxazolidines, fungicidal compositions and use 失效
标题翻译：氨基甲基异恶唑烷，杀真菌剂及用途
公开(公告)号：US4877786A
公开(公告)日：1989-10-31
申请号：US130375
申请日：1987-12-08
申请人： Joachim Weissmuller , Dieter Berg , Gerd Hanssler , Paul Reinecke
发明人： Joachim Weissmuller , Dieter Berg , Gerd Hanssler , Paul Reinecke
IPC分类号： F16K1/22 , A01N43/80 , C07C45/00 , C07C49/175 , C07C67/00 , C07C239/00 , C07C239/20 , C07D261/02 , C07D413/06 , F02D9/10 , F02M3/14
CPC分类号： F02D9/1015 , A01N43/80 , C07D261/02 , F02M3/14 , Y10T137/86984 , Y10T137/87024 , Y10T137/87032
摘要： Fungicidally active aminomethyl-isoxazolidines of the ##STR1## in which R.sup.1 represents optionally substituted alkyl, or represents optionally substituted cycloalkyl, or represents optionally substituted tetrahydronaphthyl, or represents optionally substituted decahydronaphthyl andR.sup.2 and R.sup.3 independently of one another each represent hydrogen, or represent in each case optionally substituted alkyl, alkenyl, cycloalkyl or aryl, or together with the nitrogen atom to which they are bonded represent an optionally substituted saturated heterocyclic radical, which can optionally contain further hetero atoms,and acid addition salts thereof. Some intermediates therefor are also new.
摘要翻译：其中R 1表示任意取代的烷基，或表示任意取代的环烷基，或表示任意取代的四氢萘基，或表示任选取代的十氢萘基，R 2和R 3彼此独立地表示氢，或表示氢原子，每种情况下任选取代的烷基，烯基，环烷基或芳基，或与它们所键合的氮原子一起代表任选取代的饱和杂环基团，其可任选地含有其它杂原子，及其酸加成盐。一些中间人也是新的。

76. 发明授权

US4751323A Novel polyaromatic cyanates 失效
标题翻译：新型多芳香族氰酸酯
公开(公告)号：US4751323A
公开(公告)日：1988-06-14
申请号：US552234
申请日：1983-11-16
申请人： Edmund P. Woo , Daniel J. Murray
发明人： Edmund P. Woo , Daniel J. Murray
IPC分类号： C07C67/00 , C07C261/02 , C07C313/00 , C07D261/02 , C07D495/00 , C07D495/08 , C08G18/76 , C08G73/00 , C08G73/06 , C07C69/00 , C07D335/04 , C08G63/38
CPC分类号： C08G73/0655 , C07C261/02 , C07C2103/68
摘要： This invention relates to a polyaromatic cyanate which corresponds to the formula ##STR1## wherein Ar is an aromatic radical;B is a C.sub.7-20 polycyclic aliphatic radical;D is independently in each occurrence any non-active hydrogen-containing substituent;q, r and s are independently in each occurrence the integers b 0, 1, 2, l or b 3l ; with the proviso that the sum of q, 4 and s is greater than or equal to 2;t is independently in each occurrence an integer of between about 0 and 4 inclusive; andx is a number between about 0 and 5 inclusive.Another aspect of this invention is a novel polytriazine which comprises the reaction product of the polyaromatic cyanate esters of this invention. The novel polytriazines may further comprise the reaction product of the novel polyaromatic cyanates of this invention in admixture with other cyanates known in the art as useful for the preparation of polytriazines.
摘要翻译：本发明涉及对应于式“IMAGE”的多芳族氰酸酯，其中Ar是芳族基团; B是C7-20多环脂族基团; D在每次出现时都是独立的任何非活性含氢取代基; q，r和s在每次出现时独立地为整数b 0,1,2,1或b 3l; 条件是q，4和s之和大于或等于2; t在每次出现时独立地为约0和4之间的整数; x是包括0和5之间的数字。本发明的另一方面是一种新的聚三嗪，其包括本发明的多芳族氰酸酯的反应产物。新颖的三叉嗪可以进一步包括本发明的新型多芳族氰酸酯与本领域已知的用于制备聚三嗪的其它氰酸酯的混合物的反应产物。

77. 发明授权

US4678797A Biologically active agents containing substituted isoxazolidines 失效
标题翻译：含有取代异恶唑烷的生物活性剂
公开(公告)号：US4678797A
公开(公告)日：1987-07-07
申请号：US733449
申请日：1985-05-10
申请人： Axel Ingendoh , Friedrich Berschauer , Benedikt Becker , Wilhelm Stendel , Bernhard Homeyer , Martin Scheer , Anno de Jong , Gerd Hanssler , Paul Reinecke
发明人： Axel Ingendoh , Friedrich Berschauer , Benedikt Becker , Wilhelm Stendel , Bernhard Homeyer , Martin Scheer , Anno de Jong , Gerd Hanssler , Paul Reinecke
IPC分类号： A01N43/80 , A23K1/16 , A61K31/42 , A61K31/44 , A61P3/00 , A61P33/00 , C07C67/00 , C07C209/00 , C07C211/52 , C07C239/00 , C07C239/08 , C07D261/02 , C07D317/00 , C07D413/04
CPC分类号： C07D261/02 , A01N43/80 , A23K20/137 , C07D413/04
摘要： Substituted isoxazolidines of the formula ##STR1## in which R.sup.1 represents optionally substituted alkyl, cycloalkyl, aralkyl, aryl or heteroaryl or radicals of the formula --COR.sup.4,R.sup.4 represents optionally substituted alkyl, aryl, alkoxy, alkylthio, aroxy, arylthio, amino, alkylamino, dialkylamino, arylamino, arylalkylamino, diarylamino or cycloalkylamino, or optionally substituted heterocyclic radicals which are bonded via nitrogen,R.sup.2 represents hydrogen or the radicals mentioned for R.sup.1, it being possible for R.sup.1 and R.sup.2 to be identical or different, andR.sup.3 represents optionally substituted alkyl, cycloalkyl, alkenyl, alkinyl or aryl, or saturated heterocyclic radicals, which are optionally substituted,and acid salts thereof, are pesticidally active and increase animals' utilization of feed. Intermediates therefor are also new.
摘要翻译：取代的式“IMAGE”的异恶唑烷，其中R 1表示任选取代的烷基，环烷基，芳烷基，芳基或杂芳基或式-COR 4的基团，R 4表示任选取代的烷基，芳基，烷氧基，烷硫基，芳氧基，芳硫基，氨基，，二烷基氨基，芳基氨基，芳基烷基氨基，二芳基氨基或环烷基氨基，或通过氮键合的任选取代的杂环基，R 2表示氢或R1所述的基团，R 1和R 2可以相同或不同，并且R 3表示任选取代烷基，环烷基，烯基，炔基或芳基，或任选被取代的饱和杂环基，及其酸式盐是杀虫活性的并增加动物饲料的利用。中间体也是新的。

78. 发明授权

US4508651A Synthesis of 1.alpha.,25-dihydroxyergocalciferol 失效
标题翻译： 1α，25-二羟基麦角钙化醇的合成
公开(公告)号：US4508651A
公开(公告)日：1985-04-02
申请号：US477059
申请日：1983-03-21
申请人： Enrico G. Baggiolini , Andrew D. Batcho , Alfred Boris , Milan R. Uskokovic
发明人： Enrico G. Baggiolini , Andrew D. Batcho , Alfred Boris , Milan R. Uskokovic
IPC分类号： A61K31/59 , A61P3/02 , C07C35/32 , C07C45/00 , C07C45/30 , C07C45/44 , C07C47/192 , C07C49/743 , C07C67/00 , C07C253/00 , C07C255/31 , C07C401/00 , C07D261/02 , C07F7/18 , C07J9/00
CPC分类号： C07D261/02 , C07C35/32 , C07C45/305 , C07C45/44 , C07C49/743 , C07F7/1856
摘要： The invention is directed to a process and intermediates for the preparation of 1.alpha.,25-dihydroxyergocalciferol as well as substantially pure and crystalline 1.alpha.,25-dihydroxyergocolciferol. The end-product 1.alpha.,25-dihydroxyergocalciferol is useful in the treatment of disease states which are characterized by insufficient amounts of 1.alpha.,25-dihydroxycholecalciferol.
摘要翻译：本发明涉及制备1α，25-二羟基麦角钙化醇以及基本上纯的和结晶的1α，25-二羟基麦角胆醇的方法和中间体。最终产物1α，25-二羟基麦角钙化醇可用于治疗以不足量的1α，25-二羟基胆钙化甾醇为特征的疾病状态。

79. 发明授权

US4494978A Herbicidal N-(N'-hydrocarbyloxycarbamylalkyl)-2,6-dialkyl-alpha-haloacetanilides 失效
标题翻译：除草剂N-（N'-烃氧基氨基甲酰基烷基）-2,6-二烷基-α-卤代乙酰苯胺
公开(公告)号：US4494978A
公开(公告)日：1985-01-22
申请号：US755883
申请日：1976-12-30
申请人： David C. K. Chan
发明人： David C. K. Chan
IPC分类号： A01N37/46 , A01N43/80 , C07D261/02 , A01N37/22
CPC分类号： C07D261/02 , A01N37/46 , A01N43/80
摘要： N-(N'-hydrocarbyloxycarbamylalkyl)-2,6-dialkyl-alpha-haloacetanilides have herbicidal activity, particularly in preemergent applications.
摘要翻译： N-（N'-烃氧基氨基甲酰基烷基）-2,6-二烷基-α-卤代乙酰苯胺具有除草活性，特别是在预先应用中。

80. 发明授权

US4218450A Method for treatment of gastrointestinal spasmodic disease conditions or symptoms in mammals 失效
公开(公告)号：US4218450A
公开(公告)日：1980-08-19
申请号：US1637
申请日：1979-01-08
申请人： George H. Douglas , William L. Studt , Stuart A. Dodson
发明人： George H. Douglas , William L. Studt , Stuart A. Dodson
IPC分类号： C07D209/48 , C07D261/02 , C07D265/06 , A61K31/535 , A61K31/42
CPC分类号： C07D209/48 , C07D261/02 , C07D265/06 , Y10S514/867 , Y10S514/925
摘要： A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.

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