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71. 发明申请

US20130184497A1 METHOD FOR PRODUCING DITRIMETHYLOLPROPANE 有权
标题翻译：生产二甲基丙烯酸的方法
公开(公告)号：US20130184497A1
公开(公告)日：2013-07-18
申请号：US13820586
申请日：2011-09-05
申请人： Masami Matsumoto , Hiroaki Shigeta , Nozomi Nakagawa , Ikutaro Kuzuhara
发明人： Masami Matsumoto , Hiroaki Shigeta , Nozomi Nakagawa , Ikutaro Kuzuhara
IPC分类号： C07C41/42 , C07C41/01
CPC分类号： C07C41/42 , C07C29/38 , C07C41/01 , C07C41/40 , C07C43/132 , C07C31/22
摘要： The present invention provides a method for producing ditrimethylolpropane which is characterized by the following (1) and (2): (1) a distillation still residue separated from purified trimethylolpropane is subjected to re-distillation under specific conditions to obtain a ditrimethylolpropane-containing solution having given contents of bis-TMP and tri-TMP; and (2) when subjecting the ditrimethylolpropane-containing solution to crystallization with an organic solvent, the crystallization is initiated under pressure at a temperature exceeding a boiling point of the organic solvent as measured under normal pressures, and the resulting crystallization product solution is cooled at a temperature drop rate of 2° C./min or less. According to the above method, it is possible to produce a high-purity ditrimethylolpropane from a distillation still residue obtained upon production of trimethylolpropane in a simple, industrially useful manner.
摘要翻译：本发明提供一种二羟甲基丙烷的制造方法，其特征在于以下（1）和（2）：（1）在纯化的三羟甲基丙烷中分离出的蒸馏残余物在特定条件下进行再蒸馏，得到含二羟甲基丙烷的溶液给出了双TMP和三TMP的内容; 和（2）当使含二羟丙基丙烷的溶液用有机溶剂结晶时，在常压下测量的超过有机溶剂沸点的温度下，在压力下开始结晶，并将所得结晶产物溶液冷却至降温速度为2℃/分钟以下。根据上述方法，可以以简单的工业上有用的方式从由三羟甲基丙烷制备得到的蒸馏釜残渣中制备高纯度的二羟甲基丙烷。

72. 发明申请

US20130178655A1 METHOD FOR SYNTHESIZING 3,5-DICHLOROANISOLE FROM 1,3,5-TRICHLOROBENZENE 有权
标题翻译：从1,3,5-三氯苯腈合成3,5-二氯苯并噻唑的方法
公开(公告)号：US20130178655A1
公开(公告)日：2013-07-11
申请号：US13522291
申请日：2011-01-12
申请人： Eric Pasquinet , Anne Wuillaume , Didier Poullain , François Kosciusko-Morizet , Bénédicte Geneviève Jeanne Marie Treuille , Caroline Marie Catherine Kosciusko-Morizet , Nathalie Geneviève Marie Kosciusko-Morizet , Pierre Thaddée Jacques Hubert Kosciusko-Morizet
发明人： Eric Pasquinet , Anne Wuillaume , Didier Poullain , Etienne Kosciusko-Morizet
IPC分类号： C07C41/01 , C07C209/18
CPC分类号： C07C41/01 , C07C41/16 , C07C201/10 , C07C209/10 , C07C209/18 , C07C43/225 , C07C205/06 , C07C211/52
摘要： The invention relates to a method for synthesizing 3,5-dichloroanisole from 1,3,5-trichlorobenzene, which comprises:a) the reaction between 1,3,5-trichlorobenzene and a methanolate of an alkaline or alkaline-earth metal in a first solvent chosen from among dimethylsulfoxide and 1,1,3,3-tetramethylurea;b) the precipitation of the product resulting from step a) in a second solvent which is not included among substances considered carcinogenic, mutagenic and/or toxic for reproduction by Regulation (EC) n° 1272/2008 of the European Parliament and of the Council of 16 Dec. 2008; thenc) the recovery of the precipitate thus obtained.Application: synthesis of 1,3,5-triamino-2,4,6-trinitrobenzene of which 3,5-dichloroanisole is an intermediate product.
摘要翻译：本发明涉及一种由1,3,5-三氯苯合成3,5-二氯苯甲醚的方法，该方法包括：a）1,3,5-三氯苯与碱金属或碱土金属的甲醇盐在选自二甲基亚砜和1,1,3,3-四甲基脲的第一溶剂; b）由欧洲议会和理事会第1272/2008号（EC）第1272/2008号法规（EC）第（ii）项所述的产品沉淀在第二种溶剂中，该溶剂不包括在被认定为致癌，诱变和/或有毒生殖的物质中 2008年12月16日然后c）如此获得的沉淀物的回收。应用：合成其中3,5-二氯苯甲醚为中间产物的1,3,5-三氨基-2,4,6-三硝基苯。

73. 发明申请

US20130158290A1 PRODUCTION OF OXYGENATED COMPOUNDS IN THE PRESENCE OF A CATALYST SUSPENDED IN AN INERT LIQUID 审中-公开
标题翻译：在惰性液体中悬浮的催化剂存在下生产氧化化合物
公开(公告)号：US20130158290A1
公开(公告)日：2013-06-20
申请号：US13675094
申请日：2012-11-13
申请人： Stephane MARIE-ROSE , Esteban CHORNET
发明人： Stephane MARIE-ROSE , Esteban CHORNET
IPC分类号： B01J29/04 , C07C41/01 , C07C45/61 , C07C67/36
CPC分类号： B01J29/04 , C07C41/01 , C07C45/61 , C07C67/36 , C07C69/14
摘要： A method of producing at least one oxygenated compound such as methyl acetate, dimethyl ether, and formaldehyde, by reacting dimethyl carbonate with carbon monoxide in the presence of at least one solid catalyst, such as a zeolite catalyst, suspended in an inert liquid, such as an inert oil.
摘要翻译：在至少一种悬浮在惰性液体中的固体催化剂如沸石催化剂的存在下，通过使碳酸二甲酯与一氧化碳反应来生产至少一种含氧化合物如乙酸甲酯，二甲醚和甲醛的方法，作为惰性油。

74. 发明申请

US20130115653A1 METHOD FOR PRODUCING BIOBASED CHEMICALS FROM WOODY BIOMASS 审中-公开
标题翻译：从木材生物质生产生物化学品的方法
公开(公告)号：US20130115653A1
公开(公告)日：2013-05-09
申请号：US13292437
申请日：2011-11-09
申请人： John R. Peterson , Christopher M. Yost , Jian Wu
发明人： John R. Peterson , Christopher M. Yost , Jian Wu
IPC分类号： C12P1/00 , C07C63/06 , C07C65/03 , C07C45/00 , C07C39/10 , C07C41/01 , C07C39/04 , C07C43/23 , C07C43/205 , C07C1/00 , C07C31/08 , C08B3/06 , C08B3/00 , C07C55/14 , C07C69/52 , C07C69/66 , C07D307/02 , C07C31/20 , C07D307/33 , C07C31/22 , C07D307/06 , C07C31/26 , C07D307/50 , C07C39/20 , C07C63/04
CPC分类号： C07D307/06 , C07C27/00 , C07D307/33 , C07D307/50 , C07D307/54 , C08B37/0057 , C08H8/00
摘要： A method for utilizing woody biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from woody biomass for producing derivative products while minimizing waste products.
摘要翻译：本文描述了利用木质生物质成分（即纤维素，半纤维素和木质素）并将其转化为增值生物基化学产品的方法。本发明方法提供了从木质生物质获得多个组分流的方法，用于生产衍生产物，同时最小化废物。

75. 发明申请

US20130066097A1 PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF 有权
标题翻译：制备取代的5-羟基苯酚的方法及其合成中间体
公开(公告)号：US20130066097A1
公开(公告)日：2013-03-14
申请号：US13698985
申请日：2010-05-19
申请人： Claude Mercier , Floryan De Campo , Sébastien Righini
发明人： Claude Mercier , Floryan De Campo , Sébastien Righini
IPC分类号： C07C41/01 , C07C309/75
CPC分类号： C07C303/28 , C07C41/26 , C07C303/30 , C07C309/66 , C07C43/23
摘要： A process for preparing a 5-halophenol, ortho-substituted by an electron-donating group, is described. Also described, is a process for preparing a sulphonic ester of an ortho-substituted phenol, which is the synthesis intermediate for the ortho-substituted 5-halophenol. The process for preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester can include reacting a phenol ortho-substituted by an electron-donating group with a sulphonylating agent in the presence of a Lewis acid. The process for preparing a 5-halophenol ortho-substituted by an electron-donating group can include a first step of preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester, as described above; a second step of halogenating the protected phenol intermediate obtained in the preceding step, in the position para to the electron-donating group; and a third step of deprotecting the sulphonic ester function to hydroxyl.
摘要翻译：描述了由给电子基团取代的5-卤代苯酚的制备方法。还描述的是制备邻位取代的苯酚的磺酸酯的方法，其为邻位取代的5-卤代苯酚的合成中间体。制备由供电子基团取代并以磺酸酯形式保护的苯酚的方法可以包括在路易斯酸存在下将由供电子基团邻位取代的苯酚与磺酰化剂反应。制备由给电子基团取代的5-卤代苯酚的方法可以包括如上所述制备被供电子基团邻位取代并以磺酸酯形式保护的苯酚的第一步骤; 将前述步骤中获得的被保护的苯酚中间体卤化到给电子基团的对位的第二步骤; 以及将磺酸酯功能脱保护成羟基的第三步骤。

76. 发明申请

US20120329848A1 PROCESSES FOR THE PREPARATION OF S1P1 RECEPTOR MODULATORS AND CRYSTALLINE FORMS THEREOF 有权
标题翻译：制备S1P1受体调节剂的方法及其结晶形式
公开(公告)号：US20120329848A1
公开(公告)日：2012-12-27
申请号：US13581846
申请日：2011-03-02
申请人： Robert M. Jones , Daniel J. Buzard , Tawfik Gharbaoui , Benjamin R. Johnson , Michelle Kasem , Thomas O. Schrader , Scott Stirn
发明人： Robert M. Jones , Daniel J. Buzard , Tawfik Gharbaoui , Benjamin R. Johnson , Michelle Kasem , Thomas O. Schrader , Scott Stirn
IPC分类号： C07D487/04 , C07C41/01 , A61P37/00 , A61P9/10 , A61P3/10 , A61P17/10 , A61P1/16 , A61P17/06 , A61K31/407 , A61P1/04
CPC分类号： C07D487/04
摘要： The present invention relates to salts, processes, and process intermediates useful in the preparation of (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid of Formula (Ia), salts, and crystalline forms thereof. The compound (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid has been identified as an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions eases characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development, and atherosclerosis).
摘要翻译：本发明涉及可用于制备（R）-2-（9-氯-7-（4-异丙氧基-3-（三氟甲基）苄氧基）-2,3-二氢-1H- - 吡咯并[1,2-a]吲哚-1-基）乙酸，其盐和结晶形式。化合物（R）-2-（9-氯-7-（4-异丙氧基-3-（三氟甲基）苄氧基）-2,3-二氢-1H-吡咯并[1,2-a]吲哚-1-基）乙酸被鉴定为可用于治疗S1P1受体相关疾病的S1P1受体调节剂，例如由淋巴细胞介导的疾病和病症，移植排斥反应，自身免疫性疾病和病症，炎性疾病和病症（例如急性和慢性炎性病症），癌症和病症特征在于血管完整性的潜在缺陷或与血管发生相关的疾病，例如可能是病理性的（例如，可能发生在炎症，肿瘤发展和动脉粥样硬化中）。

77. 发明授权

US08304550B2 Process for the catalytic synthesis of diaryl ethers 有权
标题翻译：催化合成二芳基醚的方法
公开(公告)号：US08304550B2
公开(公告)日：2012-11-06
申请号：US12275316
申请日：2008-11-21
申请人： Alain Cotte , Nikolaus Muller , Matthias Gotta , Matthias Beller , Thomas Schareina , Alexander Zapf
发明人： Alain Cotte , Nikolaus Muller , Matthias Gotta , Matthias Beller , Thomas Schareina , Alexander Zapf
IPC分类号： C07D213/63 , C07C209/00 , C07C41/01 , B01J31/18
CPC分类号： C07C41/16 , C07C201/12 , C07C213/00 , C07C231/12 , C07D213/643 , C07C217/90 , C07C233/25 , C07C205/38 , C07C43/275 , C07C43/263 , C07C43/257
摘要： Described is a process for preparing diaryl ethers of the formula (I) Ar—O—Ar′ (I) In which Ar is an aryl or substituted aryl group and Ar′ is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group,by reacting an aryl of formula (II) or a aryloxy salt of formula (III) Ar—OH (II) Ar—OR (III) In which Ar has the same meaning as in formula (I) and R is an alkali metal,with an aryl or heteroaryl bromide of formula (IV) Ar′—Br (IV) In which Ar′ has the same meaning as in formula (I),characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.
摘要翻译：描述了制备式（I）Ar-O-Ar'（I）的二芳基醚的方法，其中Ar是芳基或取代的芳基，Ar'是芳基，取代的芳基，杂芳基或取代的杂芳基，由使式（II）的芳基或式（III）的芳氧基盐Ar-OH（II）Ar-OR（III）反应其中Ar具有与式（I）中相同的含义，R是碱金属，与式（Ⅳ）的芳基或杂芳基溴Ar'-Br（Ⅳ）其中Ar'具有与式（I）中相同的含义，其特征在于该反应在铜（I）盐和1-取代的咪唑作为催化剂体系。

78. 发明申请

US20120277460A1 Fluorous Dendrimers and Methods for Production Thereof 有权
标题翻译：氟树枝状聚合物及其生产方法
公开(公告)号：US20120277460A1
公开(公告)日：2012-11-01
申请号：US13456607
申请日：2012-04-26
申请人： Virgil Percec , Christopher J. Wilson , Daniela A. Wilson , Andrew E. Feiring
发明人： Virgil Percec , Christopher J. Wilson , Daniela A. Wilson , Andrew E. Feiring
IPC分类号： C07C69/78 , C07C41/01 , C07C67/31
CPC分类号： C07C41/26 , C07C41/22 , C07C67/31 , C07C69/92 , C07C43/23 , C07C43/225
摘要： The present invention concerns the design of an environmentally friendly and efficient fluorous phase based on dendritic architectures containing short semifluorinated groups on their periphery.
摘要翻译：本发明涉及基于在其周边含有短半氟化基团的树枝状结构的环境友好且有效的氟相的设计。

79. 发明申请

US20120232174A1 Method for Increasing the Yield of a Slurry Bed Reactor 有权
标题翻译：提高浆料床反应器产量的方法
公开(公告)号：US20120232174A1
公开(公告)日：2012-09-13
申请号：US13044739
申请日：2011-03-10
申请人： Kuo-Chao Liang , How-Ming Lee , Chin-Ching Tzeng
发明人： Kuo-Chao Liang , How-Ming Lee , Chin-Ching Tzeng
IPC分类号： C07C31/04 , C07C41/01
CPC分类号： C07C41/01 , B01J8/226 , B01J8/228 , C07C29/152 , Y02P20/582 , C07C43/043 , C07C31/04
摘要： Disclosed is a method for increasing the yield of a slurry bed reactor. The method provides a slurry bed reactor with a recycling unit or a replacing unit. An absorbing agent is fed into the slurry bed reactor. The absorbing agent is a substance that can react with at least one product of a primary reaction or at least one reactant of a side reaction. Then, the absorbing agent is transmitted into the recycling unit or the replacing unit. The recycling unit renews the absorbing agent and sends the renewed absorbing agent back into the slurry bed reactor for reuse. The replacing unit replaces the absorbing agent with new absorbing agent and sends the new absorbing agent into the slurry bed reactor for use.
摘要翻译：公开了一种提高浆料床反应器产率的方法。该方法提供具有回收单元或更换单元的淤浆床反应器。将吸收剂送入浆床反应器。吸收剂是能够与副反应的至少一种产物或副反应的至少一种反应物反应的物质。然后，吸收剂被传送到再循环单元或更换单元。回收单元更新吸收剂并将更新的吸收剂送回浆料床反应器中以便再利用。替换单元用新的吸收剂代替吸收剂，并将新的吸收剂送入浆床反应器中使用。

80. 发明申请

US20120095119A1 PROCESS FOR PRODUCING PURIFIED SYNTHESIS GAS 审中-公开
标题翻译：生产纯化合成气的方法
公开(公告)号：US20120095119A1
公开(公告)日：2012-04-19
申请号：US13260749
申请日：2010-03-30
申请人： Isaac Cormelis Van Den Born , Gijsbert Jan Van Heeringen , Cornelis Jacobus Smit , Alex Frederik Woldhuis
发明人： Isaac Cormelis Van Den Born , Gijsbert Jan Van Heeringen , Cornelis Jacobus Smit , Alex Frederik Woldhuis
IPC分类号： C07C1/04 , C07C29/00 , H02K7/18 , C07C51/00 , C01C1/04 , C10L3/08 , C01B3/50 , C07C41/01
CPC分类号： C01B3/16 , B01D53/1425 , B01D53/1462 , B01D2251/206 , B01D2256/16 , B01D2256/20 , B01D2257/304 , B01D2257/308 , B01D2257/406 , B01D2257/408 , B01D2257/504 , C01B3/52 , C01B17/0408 , C01B17/05 , C01B2203/0415 , C01B2203/0475 , C01B2203/0485 , Y02C10/06 , Y02P20/152
摘要： Disclosed is a process for producing a purified synthesis gas stream from a feed synthesis gas stream. The process includes contacting the feed synthesis gas stream with a water gas shift catalyst in a shift reactor and in the presence of water to obtain a shifted synthesis gas stream enriched in H2S and in CO2. H2S and CO2 are removed from the shifted synthesis gas stream by contacting the shifted synthesis gas stream with an absorbing liquid to obtain semi-purified synthesis gas and an absorbing liquid rich in H2S and CO2. At least part of the absorbing liquid rich in H2S and CO2 is heated to obtain heated absorbing liquid rich in H2S and CO2 that is then flashed to obtain a flash gas rich in CO2 and absorbing liquid rich in H2S. That absorbing liquid rich in H2S is contacted at elevated temperature with a stripping gas thereby transferring H2S to the stripping gas to obtain regenerated absorbing liquid and stripping gas rich in H2S. H2S in the stripping gas rich in H2S is converted to elemental sulphur, and H2S is removed from the semi-purified synthesis gas by converting H2S in the semi-purified synthesis gas to elemental sulphur to obtain the purified synthesis gas.
摘要翻译：公开了一种从原料合成气流中生产纯化合成气流的方法。该方法包括在进料反应器和水的存在下使进料合成气流与水煤气变换催化剂接触，以获得富含H 2 S和CO 2的换向合成气流。通过使经移动的合成气流与吸收液接触，从经移动的合成气流中除去H 2 S和CO 2，得到半纯化合成气和富含H 2 S和CO 2的吸收液。将富含H 2 S和CO 2的至少部分吸收液体加热以获得富含H 2 S和CO 2的加热吸收液体，然后闪蒸，以获得富含CO 2的闪蒸气体并吸收富含H 2 S的液体。富含H 2 S的吸收液体在高温下与汽提气体接触，从而将H 2 S转移到汽提气体中，得到再生的吸收液体和富含H 2 S的汽提气体。富H2S的汽提气中的H 2 S转化为元素硫，通过将半纯化合成气中的H 2 S转化为元素硫，从半纯化合成气中除去H 2 S，得到纯化合成气。

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