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71. 发明授权

US4966721A N-N'-dihydrocarbyl substituted phenylene diamine-derived condensation products as antioxidants and lubricant compositions 失效
标题翻译： N-N'-二烃基取代的苯二胺衍生的缩合产物作为抗氧化剂和润滑剂组合物
公开(公告)号：US4966721A
公开(公告)日：1990-10-30
申请号：US381890
申请日：1989-07-19
申请人： Liehpao O. Farng , Andrew G. Horodysky
发明人： Liehpao O. Farng , Andrew G. Horodysky
IPC分类号： C07C211/51 , C07C215/08 , C07C217/08 , C08G12/06 , C10M133/12 , C10M149/16 , C10M159/16
CPC分类号： C10M159/16 , C07C211/51 , C07C215/08 , C07C217/08 , C08G12/06 , C10M133/12 , C10M149/16 , C10M2207/08 , C10M2207/289 , C10M2215/02 , C10M2215/042 , C10M2215/06 , C10M2215/064 , C10M2215/065 , C10M2215/066 , C10M2215/067 , C10M2215/068 , C10M2215/08 , C10M2215/082 , C10M2215/086 , C10M2215/102 , C10M2215/28 , C10M2217/04 , C10M2217/043 , C10M2219/022
摘要： N-N'-dihydrocarbyl substituted phenylenediamine-derived Mannich-type condensation products are effective antioxidants for lubricants.
摘要翻译： N-N'-二烃基取代的苯二胺衍生的曼尼希型缩合产物是润滑剂的有效抗氧化剂。

72. 发明授权

US4922023A Preparation of aliphatic N,N-dialkyl-substituted amino alcohols 失效
标题翻译：脂肪族N，N-二烷基取代氨基醇的制备
公开(公告)号：US4922023A
公开(公告)日：1990-05-01
申请号：US215736
申请日：1988-07-06
申请人： Roman Fischer , Hans J. Mercker , Herbert Mueller
发明人： Roman Fischer , Hans J. Mercker , Herbert Mueller
IPC分类号： C07D295/02 , B01J23/62 , C07C215/08 , C07D267/10 , C07D267/22 , C07D273/01
CPC分类号： C07C215/08
摘要： Preparation of aliphatic N,N-dialkyl-substituted amino alcohols of the general formula I ##STR1## from diols of the general formula IIHO--A--OH (II)and secondary amines of the general formula III ##STR2## where A is an aliphatic chain of at least 2 carbon atoms and R.sup.1 and R.sup.2 are alkyl radicals of from 1 to 6 carbon atoms, which may be joined to form a five-membered or six-membered ring--in the liquid phase at elevated temperature and pressure and in the presence of a hydrogenation/dehydrogenation catalyst, hydrogen, and a basic alkali-metal or alkaline-earth-metal compound, where (a) the temperature is from 150.degree. C. to 250.degree. C.; (b) the total pressure is from 40 bar to 250 bar; (c) the hydrogen partial pressure is from 2 bar to 60 bar; (d) the hydrogenation/dehydrogenation catalyst is based on copper; (e) water is present, the mass being from 1% to 20% of the mass of the reaction mixture.
摘要翻译：由通式II HO-A-OH（II）的二醇和通式III的二胺制备通式I的脂肪族N，N-二烷基取代的氨基醇（I） III）其中A是至少2个碳原子的脂族链，并且R 1和R 2是具有1至6个碳原子的烷基，其可以在液相中连接以形成五元或六元环升高的温度和压力，以及在氢化/脱氢催化剂，氢气和碱性碱金属或碱土金属化合物存在下，其中（a）温度为150℃至250℃。（b）总压力为40巴至250巴; （c）氢分压为2巴至60巴; （d）氢化/脱氢催化剂基于铜; （e）存在水，其质量为反应混合物质量的1％至20％。

73. 发明授权

US4845292A Hydroxy containing amines as phospholipase A2 inhibitors 失效
标题翻译：含羟基胺作为磷脂酶A2抑制剂
公开(公告)号：US4845292A
公开(公告)日：1989-07-04
申请号：US143776
申请日：1988-01-13
申请人： William H. McGregor , Lisa A. Marshall , John H. Musser
发明人： William H. McGregor , Lisa A. Marshall , John H. Musser
IPC分类号： C07C215/08 , C07C215/60 , C07C217/16 , C07D207/08
CPC分类号： C07D207/08 , C07C215/08 , C07C215/60 , C07C217/16
摘要： There are disclosed compounds of the formula ##STR1## R is --CH.sub.2 OH or --CO.sub.2 R.sup.3 ; R.sup.1 is hydrogen, lower alkyl, lower alkoxy or hydroxybenzyl;R.sup.2 is hydroxyloweralkyl or diloweralkoxyalkyl;R.sup.3 is hydrogen or lower alkyl;R.sup.4 is alkyl of 10-20 carbons atoms, phenylalkyl of 11-18 carbon atoms or phenoxyalkyl of 11-18 carbon atoms; orn is 1-3;or a pharmaceutically acceptable salt thereof, and their use in the prevention and/or treatment of conditions such as allergic rhinitis, allergic bronchial asthma and other naso-bronchial obstructive air-passageway conditions, other immediate hypersensitivity reactions such as allergic conjunctivitis and various inflammatory conditions.
摘要翻译：公开了式“IMAGE”的化合物，其中R是-CH 2 OH或-CO 2 R 3; R1是氢，低级烷基，低级烷氧基或羟基苄基; R2是羟基低级烷基或二低级烷氧基烷基; R3是氢或低级烷基; R4是10-20个碳原子的烷基，11-18个碳原子的苯基烷基或11-18个碳原子的苯氧基烷基; 或n为1-3; 或其药学上可接受的盐，以及它们在预防和/或治疗诸如过敏性鼻炎，过敏性支气管哮喘和其他鼻支气管阻塞性空气通道病症之类的病症中的用途，其它立即超敏反应如过敏性结膜炎和各种炎性病症。

74. 发明授权

US4814108A Cationic surfactants based on quaternary ammonium compounds and use thereof in cleaning agents 失效
标题翻译：基于季铵化合物的阳离子表面活性剂及其在清洁剂中的用途
公开(公告)号：US4814108A
公开(公告)日：1989-03-21
申请号：US62536
申请日：1987-06-12
申请人： Juergen Geke , Horst Rutzen
发明人： Juergen Geke , Horst Rutzen
IPC分类号： B01F17/18 , B01F17/38 , C07C67/00 , C07C213/00 , C07C215/08 , C07C215/40 , C07C301/00 , C07C309/57 , C11D1/62
CPC分类号： C11D11/0023 , C11D1/62 , C23G1/02 , C23G1/14 , C23G1/24
摘要： The invention relates to new cationic surfactants based on quaternary ammonium compounds which are characterized by the general formula ##STR1## wherein R.sup.1 may be a linear or branched alkyl residue having from 1 to 22 carbon atoms;R.sup.2 may be hydrogen or a linear or branched alkyl residue having from 1 to 21 carbon atoms, the total number of carbon atoms of the substituents R.sup.1 and R.sup.2 being in the range of from 8 to 22;R.sup.3 and R.sup.4 represent methyl, ethyl, 2-hydroxyethyl or 2-hydroxypropyl;R.sup.5 represents an alkyl residue having from 4 to 6 carbon atoms or a phenalkyl residue having from 1 to 3 carbon atoms in the alkyl residue; andX.sup.- represents the anion of benzoic acid, of benzoic acid monosubstituted with CH.sub.3, NH.sub.3, NO.sub.2, COOH, OH or SO.sub.3 H, of an aliphatic dicarboxylic acid having the general formula HOOC--(CH.sub.2).sub.n --COOH wherein n is a number from 2 to 8, of fumaric acid, of maleic acid or of sulfosuccinic acid;and the use of such cationic surfactants in industrial cleaning agents.
摘要翻译：本发明涉及基于季铵化合物的新型阳离子表面活性剂，其特征在于通式（I）其中R 1可以是具有1至22个碳原子的直链或支链烷基; R 2可以是氢或具有1至21个碳原子的直链或支链烷基，取代基R 1和R 2的碳原子总数在8至22的范围内; R3和R4代表甲基，乙基，2-羟乙基或2-羟丙基; R5代表具有4至6个碳原子的烷基残基或在烷基残基中具有1至3个碳原子的苯烷基残基; X表示具有通式HOOC-（CH 2）n -COOH的脂族二羧酸与CH 3，NH 3，NO 2，COOH，OH或SO 3 H单取代的苯甲酸的阴离子，其中n为 2至8，富马酸，马来酸或磺基琥珀酸; 以及这些阳离子表面活性剂在工业清洁剂中的应用。

75. 发明授权

US4719236A Perylene derivatives 失效
标题翻译：苝衍生物
公开(公告)号：US4719236A
公开(公告)日：1988-01-12
申请号：US661803
申请日：1984-10-17
申请人： Kenneth W. Bair
发明人： Kenneth W. Bair
IPC分类号： C07D295/08 , A61K31/045 , A61K31/135 , A61K31/255 , A61K31/275 , A61K31/415 , A61K31/42 , A61K31/535 , A61K31/5375 , A61P31/00 , A61P35/00 , B01J27/135 , C07B61/00 , C07C29/147 , C07C33/46 , C07C63/44 , C07C63/70 , C07C66/02 , C07C67/00 , C07C69/76 , C07C205/15 , C07C213/00 , C07C213/02 , C07C215/06 , C07C215/08 , C07C215/10 , C07C215/20 , C07C215/28 , C07C215/38 , C07C215/42 , C07C215/44 , C07C217/48 , C07C217/58 , C07C253/00 , C07C255/56 , C07C255/58 , C07C313/00 , C07C315/04 , C07C317/32 , C07C317/36 , C07C319/20 , C07C323/32 , C07C323/36 , C07C323/38 , C07D213/02 , C07D233/61 , C07D263/52 , C07D263/62 , C07D263/64 , C07D295/10 , C07D295/12 , C07D295/135 , C07D309/12 , C07D317/32 , C07D319/06 , C07D498/04 , C07D521/00 , C07J63/00 , C07C67/02 , C07C87/455
CPC分类号： A61K31/045 , C07C205/15 , C07C215/10 , C07C215/28 , C07C215/42 , C07C217/48 , C07C217/58 , C07C255/58 , C07C317/32 , C07C323/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/52 , C07D263/64 , C07D295/135 , C07D309/12 , C07D319/06 , C07J63/008 , C07C2101/14 , C07C2103/24 , C07C2103/26 , C07C2103/40 , C07C2103/42 , C07C2103/48 , C07C2103/50 , Y10S514/908
摘要： The present invention relates to compounds of formula (I)ArCH.sub.2 R.sup.1 (I)or a monomethyl or a monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters thereof; acid additon salts thereof; wherein Ar is a perylene or substituted perylene ring system; R.sup.1 contains not more than eight carbon carbon atoms and is a group ##STR1## wherein m is 0 or 1;R.sup.5 is hydrogen;R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-3 alkyl optionally substituted by hydroxy;R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five- or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl;R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.

76. 发明授权

US4379024A Process for the manufacture of alkylaminoalkanol 失效
标题翻译：制备烷基氨基链烷醇的方法
公开(公告)号：US4379024A
公开(公告)日：1983-04-05
申请号：US286211
申请日：1981-07-23
申请人： David M. Gardner
发明人： David M. Gardner
IPC分类号： C07C67/00 , C07C213/00 , C07C213/04 , C07C215/08 , B01D3/34
CPC分类号： C07C213/04 , C07C215/08
摘要： Color-stable alkylaminoalkanol is prepared by adding, prior to stripping-off excess reactant, an alkali metal borohydride to the reaction product of alkylene oxide and an excess of primary or secondary amine and thereafter distilling the reaction mass to recover residual and reacted (borates) alkali metal borohydride and reduced color-forming bodies as bottoms and alkylaminoalkanol as distillate. If water is present in the reaction between the alkylene oxide and primary or secondary amine, the reaction mass is distilled after recovery of excess amine to recover an azeotrope of the product which is recycled to the reactor.
摘要翻译：通过在将去除过量反应物之前将碱金属硼氢化物加入到氧化烯和过量伯或仲胺的反应产物中，然后蒸馏反应物质以回收残留的和反应的（硼酸盐），从而制备色稳定的烷基氨基烷醇，碱金属硼氢化物和作为底部的还原成色体和作为馏出物的烷基氨基链烷醇。如果在环氧烷和伯胺或仲胺之间的反应中存在水，则在回收过量的胺之后蒸馏反应物质以回收再循环到反应器中的产物的共沸物。

77. 发明授权

US4332969A Substituted 11-aminoundecanols 失效
标题翻译：取代的11-氨基十一烷醇
公开(公告)号：US4332969A
公开(公告)日：1982-06-01
申请号：US124690
申请日：1980-02-26
申请人： Dieter Reinehr , Adolf Hubele
发明人： Dieter Reinehr , Adolf Hubele
IPC分类号： A01N33/08 , A01N49/00 , B01J23/00 , C07C67/00 , C07C213/00 , C07C215/08 , C07C215/20 , C07C215/42 , C07D225/02 , C07D225/06 , C07C85/20 , C07C87/40 , C07C87/453 , C07C91/04
CPC分类号： C07D225/02 , A01N33/08 , A01N49/00 , C07D225/06
摘要： Novel substituted 11-aminoundecanols of the formula ##STR1## and a process for their preparation are described; in the formula, R.sub.1 and R.sub.3 independently of one another are hydrogen or alkyl having 1-8 C atoms and R.sub.2 and R.sub.4 independently of one another are alkyl having 1-8 C atoms, or R.sub.1 and R.sub.2 and/or R.sub.3 and R.sub.4 together with the bonding C atom form a cycloaliphatic ring having 4-8 C atoms, and R.sub.5 and R.sub.6 independently of one another are hydrogen or alkyl having 1-4 C atoms. The compounds of the formula I are valuable active compounds for combating plant pests.
摘要翻译：描述了式（Ⅰ）＆lt; IMAGE＆gt;的新型取代的11-氨基十一烷及其制备方法; 在式中，R 1和R 3彼此独立地是氢或具有1-8个C原子的烷基，R 2和R 4彼此独立地是具有1-8个C原子的烷基，或者R 1和R 2和/或R 3和R 4与键合C原子形成具有4-8个C原子的脂环族环，R 5和R 6彼此独立地是氢或具有1-4个C原子的烷基。式I的化合物是用于防治植物害虫的有价值的活性化合物。

78. 发明授权

US4328370A Ammonation of trialkanolamines 失效
标题翻译：三烷醇胺的氨化
公开(公告)号：US4328370A
公开(公告)日：1982-05-04
申请号：US20891
申请日：1979-03-15
申请人： Michael J. Fazio
发明人： Michael J. Fazio
IPC分类号： C07C215/08 , C07C215/12 , C07C89/00
CPC分类号： C07C215/08 , C07C215/12
摘要： Lower trialkanolamines such as triethanolamine and triisopropanolamine are converted to the corresponding mono- and dialkanolamine by reacting with ammonia at about 150.degree. C.-275.degree. C. under superatmospheric pressure in the presence of a hydrogenation catalyst. The process is particularly useful for the recovery of alkanolamine values from still bottoms of alkanolamine production processes.
摘要翻译：低级三烷醇胺如三乙醇胺和三异丙醇胺通过在氢气催化剂存在下，在大气压下，在约150-275℃与氨反应，转化为相应的单 - 和二烷醇胺。该方法对于从链烷醇胺生产方法的仍然底部回收链烷醇胺特别有用。

79. 发明授权

US4221909A P-Acetamidobenzoic acid salts of 9-(hydroxyalkyl) purines 失效
标题翻译： 9-（羟基烷基）嘌呤的对 - 乙酰氨基苯甲酸盐
公开(公告)号：US4221909A
公开(公告)日：1980-09-09
申请号：US942802
申请日：1978-09-15
申请人： Lionel N. Simon , John W. Hadden
发明人： Lionel N. Simon , John W. Hadden
IPC分类号： A61K31/13 , A61K31/195 , A61K31/52 , A61K31/522 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , C07C215/08 , C07C233/54 , C07D239/48 , C07D473/00 , C07D473/30 , C07D473/34 , C07D473/38 , C07D473/40 , C07D473/28
CPC分类号： C07D239/48 , C07D473/00 , C07D473/30 , C07D473/34 , C07D473/38 , C07D473/40
摘要： Compounds of the formula ##STR1## where X is OH, NH.sub.2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R.sup.1 is H or alkyl of 1 to 8 carbon atoms, R.sup.2 is H or methyl, Y is the salt of an amine of the formula ##STR2## where R.sup.3 and R.sup.4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R.sup.2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH.sub.2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.
摘要翻译：其中X是OH，NH2，SH，OR或SR（其中R是1至4个碳原子的烷基或苄基），R1是H或1至8个碳原子的烷基，R2是H或甲基，Y是下式的胺的盐，其中R 3和R 4是低级烷基，例如1至4个碳原子，n是与对乙酰氨基苯甲酸的2至4的整数，并且其中z是数 0至10作为抗病毒剂可用作免疫调节剂，在特定情况下可具有抗白血病活性。其中z为1至10的化合物和组合物本身是新颖的。当R2为H时，Y的存在增强了免疫调节活性和抗病毒活性。如果X是NH2，则具有免疫抑制活性，但没有免疫刺激（免疫激活）活性。

80. 发明授权

US4181624A Aminoalkanols 失效
标题翻译：氨基链烷醇
公开(公告)号：US4181624A
公开(公告)日：1980-01-01
申请号：US889989
申请日：1978-03-24
申请人： Karl H. Koch
发明人： Karl H. Koch
IPC分类号： C07C215/08 , C07C215/12 , C10M133/08 , C07C91/02
CPC分类号： C10M3/00 , C10M133/08 , C10M2201/02 , C10M2215/042 , C10N2240/402 , C10N2240/403 , C10N2240/404 , C10N2240/405 , C10N2240/406 , C10N2240/407 , C10N2240/408 , C10N2240/409 , C10N2250/02
摘要： The invention provides novel mixtures of at least two aminoalkanols of the formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a C.sub.1-21 alkyl and the sum of the carbon atoms in R.sub.1 and R.sub.2 is 6 to 22; and the R.sub.1 --CH--CH--R.sub.2 units are mixtures containing 8 to 24 carbon atoms of at least two compounds. The vicinal OH and NH.sub.2 substituents are uniformly distributed statistically along the chain. The mixtures are readily prepared from mixtures of C.sub.8 -C.sub.24 olefins by epoxidation followed by reaction with ammonia.The mixtures are useful as intermediates in the production of hydroxyalkyl-aminobutyric acid mixtures for lubricating the cold working of aluminum and as corrosion inhibitors for corrodible iron-containing metals.
摘要翻译：本发明提供了至少两种下式的氨基链烷醇的新混合物：其中R 1和R 2各自表示C 1-12烷基，R 1和R 2中的碳原子之和为6至22; 并且R1-CH-CH-R2单元是含有至少两种化合物的8至24个碳原子的混合物。邻位OH和NH2取代基沿着链均匀分布统计分布。通过环氧化随后与氨反应，容易地由C8-C24烯烃的混合物制备混合物。该混合物可用作生产羟基烷基 - 氨基丁酸混合物的中间体，用于润滑铝的冷加工和用作可腐蚀的含铁金属的腐蚀抑制剂。

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