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71. 发明申请

US20120276131A1 ANTI-TRYPANOSOMIASIS VACCINES AND DIAGNOSTICS 审中-公开
标题翻译：抗血栓形成疫苗和诊断
公开(公告)号：US20120276131A1
公开(公告)日：2012-11-01
申请号：US13508851
申请日：2010-11-10
申请人： Virginie Coustou Linares , Theo Baltz , Nicolas Plazolles
发明人： Virginie Coustou Linares , Theo Baltz , Nicolas Plazolles
IPC分类号： C12N9/24 , A61K39/005 , C07K16/20 , C12N15/11 , A61P37/04 , G01N33/573 , C12N15/63 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/52 , A61P33/00
CPC分类号： C12N9/1081 , C12N9/2402 , C12Y204/99 , C12Y302/01018
摘要： The present invention has as an object a novel genetic material coding for trans-sialidase-like proteins of African trypanosomes, and relates to the use of said genes and proteins in vaccines, therapeutics and diagnostics. The present invention also relates to the immunization of human and/or nonhuman animals against trypanosomosis.
摘要翻译：本发明的目的是编码非洲锥虫的跨唾液酸酶样蛋白质的新型遗传物质，并涉及所述基因和蛋白质在疫苗，治疗和诊断中的用途。本发明还涉及人和/或非人动物免受锥虫病的免疫。

72. 发明申请

US20120093871A1 MODIFIED PROTOZOAN EXPRESSING AT LEAST TWO VARIABLE SURFACE PROTEINS (VSP), A VACCINE COMPRISING IT AND PROCEDURES, USES, AND METHODS THEREOF 有权
标题翻译：对两种可变表面蛋白（VSP）进行修饰的原生质体，包含其中的疫苗和程序，用途及其方法
公开(公告)号：US20120093871A1
公开(公告)日：2012-04-19
申请号：US13132468
申请日：2009-12-02
申请人： Hugo Daniel Lujan
发明人： Hugo Daniel Lujan
IPC分类号： A61K39/018 , A61K39/002 , A61K39/005 , A61P33/02 , C07H21/04 , C07H21/02 , C12N15/79 , A61P37/04 , C12N1/11 , C07K1/14
CPC分类号： A61K39/002 , A61K35/68 , A61K38/00 , A61K2039/522 , A61K2039/542 , A61K2039/552 , C07K14/44 , C07K16/20 , C12N1/10 , C12N1/20 , C12N15/86 , Y02A50/491
摘要： Modified protozoa parasites comprising simultaneous expression on its surface of at least two ariable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-plymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism.
摘要翻译：修饰的原生动物寄生虫包括在其表面上同时表达至少两种有利的表面蛋白（VSP）。修饰的原生动物也可以同时表达可变表面蛋白的完整谱。原生动物显示减少Dicer，RNA依赖性RNA聚合酶（RdRP）酶或两者的表达，其中RdRP基因和/或Dicer基因已被沉默。原生动物可以是显示抗原变异机制的任何原生动物。

73. 发明申请

US20110182847A1 USE OF TLR AGONISTS AND/OR TYPE 1 INTERFERONS TO ALLEVIATE TOXICITY OF TNF-R AGONIST THERAPEUTIC REGIMENS 审中-公开
标题翻译： TLR激动剂和/或1型干扰素对TNF-α激动剂治疗方案的致敏性的使用
公开(公告)号：US20110182847A1
公开(公告)日：2011-07-28
申请号：US12664921
申请日：2008-06-16
申请人： Randolph Noelle , Ross Kedl , Cory Ahonen
发明人： Randolph Noelle , Ross Kedl , Cory Ahonen
IPC分类号： A61K38/21 , A61K39/395 , A61K35/74 , A61K35/66 , A61K39/00 , A61K39/12 , A61K39/02 , A61K39/002 , A61K39/112 , A61K39/21 , A61K39/125 , A61K39/193 , A61K39/29 , A61K39/205 , A61K39/275 , A61K39/285 , A61K39/25 , A61K39/245 , A61K39/145 , A61K39/108 , A61K39/08 , A61K39/07 , A61K39/106 , A61K39/05 , A61K39/09 , A61K39/015 , A61K39/005 , A61K39/018 , A61K39/012 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/00 , A61P33/02 , A61P33/06 , A61P33/10 , A61P37/04
CPC分类号： A61K39/3955 , A61K31/135 , A61K35/74 , A61K36/06 , A61K38/191 , A61K38/21 , A61K39/00 , A61K39/0002 , A61K39/0005 , A61K39/0011 , A61K39/002 , A61K39/02 , A61K39/12 , A61K45/06 , A61K47/6881 , C07K14/555 , A61K2300/00
摘要： Improved (safer and more effective) methods of therapy using TNF-R agonists, e.g., CD40 agonists are provided. These methods provide for the addition of an amount of a type 1 interferon and/or a TLR agonist that is effective to prevent or reduce the toxicity (liver toxicity) that may otherwise result in some patients of the TNF-R agonist is used as a monotherapy (without the type 1 interferon and/r TLR agonist).
摘要翻译：提供使用TNF-R激动剂（例如CD40激动剂）的改进（更安全和更有效的）治疗方法。这些方法提供了一定量的1型干扰素和/或TLR激动剂的量，其有效预防或降低可能导致TNF-R激动剂的一些患者的毒性（肝毒性）单一疗法（不含1型干扰素和/ r TLR激动剂）。

74. 发明申请

US20100297173A1 PROPHYLACTIC AND THERAPEUTIC IMMUNIZATION AGAINST PROTOZOAN INFECTION AND DISEASE 有权
标题翻译：抗真菌和抗菌素对原虫感染和疾病的免疫
公开(公告)号：US20100297173A1
公开(公告)日：2010-11-25
申请号：US12830063
申请日：2010-07-02
申请人： Rick L. TARLETON
发明人： Rick L. TARLETON
IPC分类号： A61K39/005 , A61P33/02
CPC分类号： A61K39/005 , A61K2039/53
摘要： Polypeptide and polynucleotide vaccines effective to treat or prevent infection of a mammal, such as a dog, a cat, or a human, by a protozoan. Methods of treatment and prevention are also provided, including therapeutic administration of the vaccine to an infected mammal to prevent progression of infection to a chronic debilitating disease state. Preferred embodiments of the polynucleotide vaccine contain nucleotide coding regions that encode polypeptides that are surface-associated or secreted by T. cruzi. Optionally the efficacy of the polynucleotide vaccine is increased by inclusion of a nucleotide coding region encoding a cytokine. Preferred embodiments of the polypeptide vaccine include immunogenic peptides that contain membrane transducing sequences that allow the polypeptides to translocate across a mammalian cell membrane.
摘要翻译：通过原生动物有效治疗或预防哺乳动物（例如狗，猫或人）感染的多肽和多核苷酸疫苗。还提供了治疗和预防方法，包括将疫苗治疗性给予受感染的哺乳动物以预防感染进展为慢性衰弱疾病状态。多核苷酸疫苗的优选实施方案含有编码由克氏锥虫表面缔合或分泌的多肽的核苷酸编码区。任选地，通过包含编码细胞因子的核苷酸编码区来提高多核苷酸疫苗的功效。多肽疫苗的优选实施方案包括含有允许多肽转移穿过哺乳动物细胞膜的膜转导序列的免疫原性肽。

75. 发明申请

US20090324634A1 Trypanosoma Antigens, Vaccine Compositions, and Related Methods 有权
标题翻译：锥虫抗原，疫苗组合物和相关方法
公开(公告)号：US20090324634A1
公开(公告)日：2009-12-31
申请号：US12110877
申请日：2008-04-28
申请人： Elisabeth Knapp , Vidadi Yusibov
发明人： Elisabeth Knapp , Vidadi Yusibov
IPC分类号： A61K39/005 , C07K14/00 , C12P21/02 , C07H21/00 , C12N5/10
CPC分类号： A61K39/005 , A61K2039/552 , A61K2039/6075 , C07K2319/35 , C07K2319/40 , C12N15/8257 , C12N15/8258
摘要： The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by Trypanosoma protozoa. Provided are recombinant protein antigens, compositions, and methods for the production and use of such antigens and vaccine compositions.
摘要翻译：本发明涉及免疫学和蛋白质工程领域的交叉，特别涉及可用于预防原虫恶臭虫感染的抗原和疫苗。提供了用于生产和使用这些抗原和疫苗组合物的重组蛋白抗原，组合物和方法。

76. 发明申请

US20090191242A1 NOVEL HOMEOPATHIC STRAIN COMPRISING A NOSODE FROM A PROTOZOON OF THE GENUS TRYPANOSOMA 审中-公开
标题翻译：来自天竺葵的原生动物的NOSODE的新生家系
公开(公告)号：US20090191242A1
公开(公告)日：2009-07-30
申请号：US12330049
申请日：2008-12-08
申请人： Isabelle DELBOSC , Bruno ENJALBERT
发明人： Isabelle DELBOSC , Bruno ENJALBERT
IPC分类号： A61K39/005 , A61K35/68 , A61P33/02
CPC分类号： A61K35/68 , A61K39/005
摘要： The present invention relates to a novel homeopathic strain characterized in that it comprises a nosode from a protozoon of the genus Trypanosoma. The invention also relates to the use of this homeopathic strain in the preparation of a medicament intended for the treatment of the clinical pathological signs similar to those observed in the trypanosomiases. It also relates to a process for the preparation of this homeopathic strain as well as a process for the preparation of a homeopathic medicinal speciality comprising said homeopathic strain.
摘要翻译：本发明涉及一种新型顺势疗法菌株，其特征在于其包含来自锥虫属的原生动物的一种诺丝菌素。本发明还涉及这种顺势疗法菌株在制备用于治疗类似于在锥虫病病人中观察到的临床病理学体征的药物中的用途。它还涉及一种用于制备该顺势疗法菌株的方法，以及用于制备包含所述顺势疗法菌株的顺势疗法药用特异性的方法。

77. 发明申请

US20050232937A1 Paramycobacterial diagnostics and vaccines 审中-公开
标题翻译：副分枝杆菌诊断和疫苗
公开(公告)号：US20050232937A1
公开(公告)日：2005-10-20
申请号：US10501127
申请日：2003-01-13
申请人： Petrus Theodorus Willemsen , Sjoukje Westerveen , Douwe Bakker , Fred Zijderveld , Jelle Egbertus Thole
发明人： Petrus Theodorus Willemsen , Sjoukje Westerveen , Douwe Bakker , Fred Zijderveld , Jelle Egbertus Thole
IPC分类号： G01N33/53 , A61K39/00 , A61K39/005 , A61K39/02 , A61K39/04 , A61K39/085 , A61K39/09 , A61K39/108 , A61K39/135 , A61K39/145 , A61K39/155 , A61K39/215 , A61K39/245 , A61P31/04 , A61P31/06 , A61P31/12 , C07K14/35 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12Q1/02 , C12Q1/04 , C12Q1/68 , G01N33/569 , C07H21/04 , C12N15/74
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/505 , A61K2039/51 , A61K2039/53
摘要： The present invention relates to nucleic acid sequences encoding Mycobacterium avium subspecies paratuberculosis proteins, to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to Mycobacterium avium subspecies paratuberculosis proteins and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins or immunogenic parts thereof. Also, the invention relates to the use of said proteins in vaccines and for the manufacture of vaccines. Moreover, the inventions relates to the use of said nucleic acid sequences, proteins, or antibodies for diagnostic or vaccination purposes. Also, the invention relates to methods for the preparation of such vaccines. Finally the invention relates to diagnostic kits comprising such nucleic acids, proteins or antibodies against such proteins.
摘要翻译：本发明涉及将编码鸟分枝杆菌亚种副结核分枝杆菌蛋白的核酸序列与编码这种蛋白质的免疫原性片段的这些核酸序列的部分部分涉及DNA片段，重组DNA分子，活重组载体和包含该核酸序列的宿主细胞或其部分。本发明还涉及由这种序列编码的鸟分枝杆菌亚型副结核杆菌蛋白及其免疫原性部分。此外，本发明涉及包含此类核酸序列及其部分的DNA疫苗，DNA片段，重组DNA分子，活重组载体和包含此类核酸序列或其部分的宿主细胞，蛋白质或其免疫原性部分和针对此类蛋白质的抗体或其免疫原性部分。此外，本发明涉及所述蛋白质在疫苗中的用途以及制造疫苗。此外，本发明涉及用于诊断或疫苗接种目的的所述核酸序列，蛋白质或抗体的用途。此外，本发明涉及制备这种疫苗的方法。最后，本发明涉及包含这种蛋白质的核酸，蛋白质或抗体的诊断试剂盒。

78. 发明授权

US06153191A Giardia treatment and antibody 失效
标题翻译：贾第鞭毛虫治疗和抗体
公开(公告)号：US06153191A
公开(公告)日：2000-11-28
申请号：US322154
申请日：1999-05-28
申请人： Merle E. Olson , Howard Ceri , Douglas W. Morck
发明人： Merle E. Olson , Howard Ceri , Douglas W. Morck
IPC分类号： C12P1/00 , A61K38/00 , A61K39/00 , A61K39/002 , A61K39/395 , A61P33/02 , C07K14/44 , C07K16/20 , C12N1/10 , C12P21/00 , C12P21/08 , C12R1/90 , A61K39/005 , A61K39/008
CPC分类号： C07K16/20 , A61K39/002 , C07K14/44 , A61K38/00 , A61K39/00
摘要： The invention provides vaccines and methods for preventing or treating intestinal protozoal infections in an animal. In particular, vaccines and methods for prevention or treatment of giardiasis are provided. The invention also encompasses methods of preparing and methods of use of novel toxins, antibodies, vaccine strains and compositions that result from or are used in these methods.
摘要翻译：本发明提供用于预防或治疗动物肠道原虫感染的疫苗和方法。特别地，提供了预防或治疗贾第虫病的疫苗和方法。本发明还包括由这些方法产生或被使用的新毒素，抗体，疫苗菌株和组合物的制备方法和使用方法。

79. 发明授权

US5756662A Compounds and methods for the detection of T. cruzi infection 失效
标题翻译：用于检测克氏锥虫感染的化合物和方法
公开(公告)号：US5756662A
公开(公告)日：1998-05-26
申请号：US403379
申请日：1995-03-14
申请人： Steven G. Reed
发明人： Steven G. Reed
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/005 , A61P33/02 , C07K14/44 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , G01N33/569 , G01N33/577 , C07K5/00 , C12P21/00
CPC分类号： C07K14/44 , G01N33/56905 , A61K38/00 , A61K39/00 , G01N2333/44
摘要： Compounds and methods for diagnosing Trypanosoma cruzi infection, or for screening for T. cruzi or Leishmania infection, are disclosed. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more antigenic epitopes of T. cruzi proteins. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for preventing Chagas' disease in individuals exposed to T cruzi.
摘要翻译：公开了用于诊断克氏锥虫感染或用于筛选克氏锥虫或利什曼原虫感染的化合物和方法。所公开的化合物是含有一个或多个克氏锥虫蛋白抗原表位的多肽或其抗体。该化合物可用于各种用于检测克氏锥虫感染的免疫测定。多肽化合物还可用于疫苗和药物组合物，用于预防暴露于克氏锥虫的个体中的恰加斯氏病。

80. 发明授权

US5726292A Immuno-potentiating systems for preparation of immunogenic materials 失效
标题翻译：用于制备免疫原性材料的免疫增强系统
公开(公告)号：US5726292A
公开(公告)日：1998-03-10
申请号：US143365
申请日：1993-10-29
申请人： George H. Lowell
发明人： George H. Lowell
IPC分类号： A61K39/005 , A61K39/008 , A61K39/015 , A61K39/21 , A61K39/385 , C07K1/107 , C12P21/02
CPC分类号： A61K39/008 , A61K39/005 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/385 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018 , A61K2039/6031 , A61K2039/6068 , C12N2740/16134
摘要： The invention is directed to improved immunopotentiating systems for preparation of immunogenic materials. More particularly, the invention is directed to immunogenic compositions containing a protein, polypeptide, or peptide, a hydrophobic anchor, and a proteosome. The immunogenic compositions are suitable for use as therapeutic agents and vaccines.
摘要翻译：本发明涉及用于制备免疫原性材料的改进的免疫增强系统。更具体地，本发明涉及含有蛋白质，多肽或肽，疏水锚和蛋白体的免疫原性组合物。免疫原性组合物适合用作治疗剂和疫苗。

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