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71. 发明申请

US20070031332A1 Angiogenic agents from plant extracts, gallic acid, and derivatives 有权
标题翻译：来自植物提取物，没食子酸和衍生物的血管生成剂
公开(公告)号：US20070031332A1
公开(公告)日：2007-02-08
申请号：US10559091
申请日：2004-05-27
申请人： Frank Greenway , Zhijun Liu , Eugene Woltering
发明人： Frank Greenway , Zhijun Liu , Eugene Woltering
IPC分类号： A61K51/00 , A61K38/21 , A61K38/18 , A61K31/7024 , A61K31/454 , A61M36/14
CPC分类号： A61K31/192 , A61K31/454 , A61K31/7024 , A61K36/40 , A61K36/44 , A61K36/708 , A61K36/73
摘要： An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.
摘要翻译：已经发现中国黑莓（Rubus suavissimus）的提取物抑制血管生成，并分离出两种活性级分。没食子酸通过体外人血管生成模型显示为活性抗血管生成化合物之一。已知或发现有没食子酸的其他植物的水提取物也被发现具有抗血管生成活性。发现没食子酸的各种衍生物抑制血管生成。中国黑莓的提取物也减缓了大鼠胰腺肿瘤和角膜新血管形成的发生。石榴提取物显示抑制脂肪组织中的血管发生。来自红豆杉和其他具有没食子酸的植物和没食子酸及其衍生物的提取物可用于治疗与新生血管形成相关的各种疾病，包括糖尿病性视网膜病变，牛皮癣，肿瘤，肥胖症，癌症，类风湿性关节炎等。

72. 发明申请

US20070020332A1 Tannate compositions, methods of making and methods of use 有权
标题翻译：丹宁酸组合物，制备方法和使用方法
公开(公告)号：US20070020332A1
公开(公告)日：2007-01-25
申请号：US11501649
申请日：2006-08-09
申请人： Jeffrey Kiel , H. Thomas , Narasimhan Mani
发明人： Jeffrey Kiel , H. Thomas , Narasimhan Mani
IPC分类号： A61K31/7024 , A61K31/5415 , A61K31/495 , A61K31/4184
CPC分类号： A61K9/0056 , A61K9/007 , A61K9/06 , A61K9/10 , A61K9/1611 , A61K9/1623 , A61K9/2004 , A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K9/4866 , A61K31/205 , A61K31/4184 , A61K31/495 , A61K31/5415 , A61K31/7024 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , Y10S514/849 , Y10S514/85 , Y10S514/853 , Y10S514/937 , A61K2300/00
摘要： Tannate compositions containing active pharmaceutical ingredients to be used for treating nausea, vomiting, pain, convulsions, and insomnia and manufacturing processes for preparing the tannate compositions.
摘要翻译：含有用于治疗恶心，呕吐，疼痛，惊厥和失眠的活性药物成分的鞣酸盐组合物和制备鞣酸盐组合物的制备方法。

73. 发明申请

US20060280721A1 Nutritional supplements and therapeutic compositions comprising (r)-3- hydroxybutyrate derivatives 审中-公开
标题翻译：营养补充剂和包含（r）-3-羟基丁酸酯衍生物的治疗组合物
公开(公告)号：US20060280721A1
公开(公告)日：2006-12-14
申请号：US10559258
申请日：2004-06-03
申请人： Richard Veech , Michael King
发明人： Richard Veech , Michael King
IPC分类号： A61K31/765 , A61K31/7024 , C07H13/02 , C08F20/00 , C08G63/91 , C08G63/48
CPC分类号： C12P7/625 , C07C51/09 , C07C69/675 , C07H13/04 , C08G63/06 , C12P7/26 , C12P7/62 , Y02P20/544 , C07C59/01
摘要： Novel compounds and compositions containing (R)-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making R-3-hydroxybutyrate derivatives also are disclosed. Exemplary methods employ a supercritical solvent, such as supercritical carbon dioxide, and employ a lipase catlyzed esterification or transesterification reaction to produce the (R)-3-hydroxybutyrate derivatives.
摘要翻译：公开了含有（R）-3-羟基丁酸酯衍生物的新型化合物和组合物。化合物和组合物可以用作营养补充剂以增加物理性能，并且作为治疗剂来改善医学状况，特别是神经学病症如阿尔茨海默病和类似病症的症状。还公开了制备R-3-羟基丁酸酯衍生物的新方法。示例性方法使用超临界溶剂，例如超临界二氧化碳，并且使用脂肪酶聚合的酯化反应或酯交换反应以产生（R）-3-羟基丁酸酯衍生物。

74. 发明申请

US20060240066A1 Elastin stabilization of connective tissue 有权
公开(公告)号：US20060240066A1
公开(公告)日：2006-10-26
申请号：US11387454
申请日：2006-03-23
申请人： Narendra Vyavahare , Jason Isenburg , Dan Simionescu
发明人： Narendra Vyavahare , Jason Isenburg , Dan Simionescu
IPC分类号： A61K31/7024 , A61F2/00
CPC分类号： A61K31/7024
摘要： A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents employ certain unique properties of phenolic compounds to develop a protocol for reducing elastin degradation, such as that occurring during aneurysm formation in vasculature. According to the invention, elastin can be stabilized in vivo and destruction of connective tissue, such as that leading to life-threatening aneurysms in vasculature, can be tempered or halted all together. The treatment agents can be delivered or administered acutely or chronically according to various delivery methods, including sustained release methods incorporating perivascular or endovascular patches, use of microsphere carriers, hydrogels, or osmotic pumps.

75. 发明申请

US20060234949A1 Adduct of topiramate and tramadol hydrochloride and uses thereof 有权
标题翻译：托吡酯和曲马多盐酸盐的加合物及其用途
公开(公告)号：US20060234949A1
公开(公告)日：2006-10-19
申请号：US10514739
申请日：2003-05-16
申请人： Rainer Naeff , Sonja Spycher-Huber , Thomas Hunziker , Guenter Laufer
发明人： Rainer Naeff , Sonja Spycher-Huber , Thomas Hunziker , Guenter Laufer
IPC分类号： A61K31/7024 , A61K31/138
CPC分类号： C07C217/74 , A61K45/06 , C07C2601/14 , C07H7/00 , C07H9/04
摘要： This invention relates to a new pharmaceutically useful compound which is a stoichiometrically 1:1 adduct of tramadol hydrochloride and topiramate, and to the manufacture and use thereof.
摘要翻译：本发明涉及一种新的药学上可用的化合物，其是盐酸曲马多和托吡酯的化学计量1:1的加合物，以及其制备和用途。

76. 发明申请

US20060223763A1 C-glycoside compounds for stimulating the synthesis of glycosaminoglycans 有权
公开(公告)号：US20060223763A1
公开(公告)日：2006-10-05
申请号：US11373485
申请日：2006-03-13
申请人： Maria Dalko , Lionel Breton
发明人： Maria Dalko , Lionel Breton
IPC分类号： A61K31/7008 , A61K31/7024 , A61K31/70
CPC分类号： A61K8/602 , A61Q19/08 , C07H7/00
摘要： C-glycoside compounds are suited for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes.

77. 发明申请

US20060204578A1 Dual controlled release dosage form 有权
公开(公告)号：US20060204578A1
公开(公告)日：2006-09-14
申请号：US11355315
申请日：2006-02-15
申请人： Juan Vergez , Marcelo Ricci
发明人： Juan Vergez , Marcelo Ricci
IPC分类号： A61K31/7024 , A61K31/551 , A61K31/55 , A61K31/473 , A61K31/426 , A61K9/24 , A61K31/277
CPC分类号： A61K9/0004 , A61K9/2072 , A61K9/2077 , A61K9/2081 , A61K9/209 , A61K9/2866 , A61K9/2886 , A61K9/4808 , A61K9/5042 , A61K9/5078 , A61K31/135 , A61K31/137 , A61K31/216 , A61K31/365 , A61K31/381 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/4025 , A61K31/4422 , A61K31/4439 , A61K31/5415 , A61K31/5517 , A61K45/06 , A61K2300/00
摘要： A dosage form that provides a controlled release of at least two different active agents is provided. Particular embodiments include a dosage form that provides therapeutically effective levels of a first active agent and a second active agent in a mammal for an extended period of time following oral administration. An osmotic device containing a bi-layered core is provided. The osmotic device provides a dual controlled release of both drugs from the core. The layers of the core are in stacked, substantially concentric or substantially eccentric arrangement.

78. 发明申请

US20060147520A1 Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation 审中-公开
标题翻译：用微粒制剂治疗吸入伊洛前列素的肺动脉高压
公开(公告)号：US20060147520A1
公开(公告)日：2006-07-06
申请号：US11189553
申请日：2005-07-26
申请人： Curtis Ruegg
发明人： Curtis Ruegg
IPC分类号： A61K31/7024 , A61K31/557 , A61K9/20 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/0073 , A61K9/145 , A61K9/1617 , A61K9/1641 , A61K9/1647 , A61K31/557 , A61K31/5578 , A61K31/7024
摘要： Microparticles comprising iloprost are disclosed. In some embodiments, the microparticles are used to treat pulmonary hypertension. Devices comprising the microparticles are also disclosed. Combination therapies utilizing the microparticles are also provided.
摘要翻译：公开了包含伊洛前列素的微粒。在一些实施方案中，微粒用于治疗肺动脉高压。还公开了包含微粒的装置。还提供了利用微粒的组合疗法。

79. 发明申请

US20060128659A1 Sulfotransferase inhibitors 审中-公开
标题翻译：磺酰转移酶抑制剂
公开(公告)号：US20060128659A1
公开(公告)日：2006-06-15
申请号：US10520659
申请日：2003-07-10
申请人： Osami Habuchi , Hirofumi Nakano , Toshihiko Sawada , Sonoko Fujii , Shiori Ohtake
发明人： Osami Habuchi , Hirofumi Nakano , Toshihiko Sawada , Sonoko Fujii , Shiori Ohtake
IPC分类号： A61K31/7024 , A61K31/7008
CPC分类号： C07H15/203 , A61K31/7034
摘要： A galactosamine derivative represented by the following formula (1): wherein R1, R2 and R5 each independently represents SO3− or H, and at least one of them represents SO3−; R3 represents H, acetyl or SO3−; R4 represents H, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted acyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group; X represents O, S, NH or CH2; and represents an α bond or a β bond, and a sulfotransferase inhibitor comprising the derivative.
摘要翻译：由下式（1）表示的半乳糖胺衍生物：其中R 1，R 2和R 5各自独立地表示SO 3 或H，并且它们中的至少一个表示SO 3 - 。 R 3表示H，乙酰基或SO 3 - 。 R 4表示H，取代或未取代的烷基，取代或未取代的烯基，取代或未取代的炔基，取代或未取代的酰基，取代或未取代的芳基或取代或未取代的芳烷基; X表示O，S，NH或CH 2; “img id =”custom-character-00001“he =”2.79mm“wi =”6.35mm“file =”US20060128659A1-20060615-P00001.TIF“alt =”custom character“img-content =”character“img- format =“tif”/>表示α键或β键，以及包含该衍生物的磺基转移酶抑制剂。

80. 发明申请

US20060128637A1 Phenolic acid complexes of hyoscyamine and process for preparing the same 审中-公开
标题翻译：莨菪碱的酚酸配合物及其制备方法
公开(公告)号：US20060128637A1
公开(公告)日：2006-06-15
申请号：US11302577
申请日：2005-12-14
申请人： Jeffrey Kiel , H. Thomas , Emily Ware , Brady Ware
发明人： Jeffrey Kiel , H. Thomas , Emily Ware , Brady Ware
IPC分类号： C07D451/02 , A61K31/7024 , A61K31/46
CPC分类号： C07D451/06
摘要： The present invention provides a novel tannate complex of hyoscyamine for human and veterinary pharmaceutical use. Tannate complexes of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. A process for preparing the tannate complex of hyoscyamine is provided.
摘要翻译：本发明提供了一种用于人和兽用药物用途的新鲜鞣酸复合物。活性药物成分的鞣酸复合物用于持续释放应用，并改善某些感官特性如味道。提供了一种制备莨菪碱的鞣酸复合物的方法。

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