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71. 发明申请

US20160367500A1 COMPOSITIONS COMPRISING VITAMIN C, VITAMIN E, AND COENZYME Q10 AND USE THEREOF FOR PROMOTING FEMALE FERTILITY AND REPRODUCTIVE HEALTH 审中-公开
标题翻译：包含维生素C，维生素E和聚苯乙烯Q10的组合物及其用于促进女性肥胖和生殖健康的用途
公开(公告)号：US20160367500A1
公开(公告)日：2016-12-22
申请号：US15187318
申请日：2016-06-20
申请人： FERTILIFY INC.
发明人： Cytlalli Dianne RUIZ-CHAPMAN , Antonio Franco MARRATO , Rolando RUIZ-CEPEDA
IPC分类号： A61K31/122 , A61K31/355 , A61K31/4745 , A61K9/00 , A61K31/714 , A61K31/59 , A61K31/519 , A61K31/375 , A61K31/05
CPC分类号： A61K31/122 , A61K9/0053 , A61K31/05 , A61K31/355 , A61K31/375 , A61K31/4745 , A61K31/519 , A61K31/59 , A61K31/592 , A61K31/714 , A61K2300/00
摘要： A new composition including substances that prolong and enhance the quality of the female reproductive system; effectively reducing the physiological effects of aging of the female reproductive system. In some aspects, the composition of the present invention includes coenzyme Q10, vitamin C, and vitamin E. As well, in some aspects, the composition of the present invention includes coenzyme Q10, resveratrol and pyrroloquinoline quinone (PQQ). In another aspect, the composition of the present invention further comprises vitamin D. In another aspect, the composition of the present invention comprises folic acid. In some aspects, the composition of the present invention increases the rate of fertility in women and promotes the development of the fetal nervous system.
摘要翻译：包括延长和提高女性生殖系统质量的物质的新组合物; 有效降低女性生殖系统老化的生理影响。在一些方面，本发明的组合物包括辅酶Q10，维生素C和维生素E.在某些方面，本发明的组合物还包括辅酶Q10，白藜芦醇和吡咯并喹啉醌（PQQ）。另一方面，本发明的组合物还包含维生素D.在另一方面，本发明的组合物包含叶酸。在一些方面，本发明的组合物增加了妇女的生育率并促进了胎儿神经系统的发育。

72. 发明授权

US09439913B1 Fat-soluble vitamin formulations 有权
标题翻译：脂溶性维生素配方
公开(公告)号：US09439913B1
公开(公告)日：2016-09-13
申请号：US14278794
申请日：2014-05-15
申请人： Michael J. Walters
发明人： Michael J. Walters
IPC分类号： A61K31/59 , A61K31/593 , A61K31/122 , A61K47/44 , A61K31/315
CPC分类号： A61K31/593 , A61K9/0056 , A61K31/122 , A61K31/315 , A61K31/355 , A61K31/375 , A61K31/51 , A61K33/30 , A61K47/42 , A61K2300/00
摘要： The present disclosure generally pertains to formulations containing two or more fat-soluble vitamins, lemon oil, and zinc. Also disclosed are kits containing such formulations and methods for administering such formulations to treat malabsorption in subjects diagnosed with CF, Crohn's Disease, Colitis, Irritable Bowel Syndrome, Celiac Disease, and other like conditions.
摘要翻译：本公开一般涉及含有两种或更多种脂溶性维生素，柠檬油和锌的制剂。还公开了含有这样的制剂和方法的试剂盒和方法，用于施用这些制剂以治疗被诊断患有CF，克罗恩病，结肠炎，肠易激综合征，腹腔疾病和其它类似病症的受试者的吸收不良。

73. 发明授权

US09402855B2 Method of treating and preventing secondary hyperparathyroidism 有权
标题翻译：治疗和预防继发性甲状旁腺功能亢进的方法
公开(公告)号：US09402855B2
公开(公告)日：2016-08-02
申请号：US13680997
申请日：2012-11-19
申请人： CYTOCHROMA INC. , PROVENTIV THERAPEUTICS, LLC
发明人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner , P. Martin Petkovich , Christian F. Helvig
IPC分类号： A61K31/59 , A61K31/593 , A61K31/592
CPC分类号： A61K31/593 , A61K9/48 , A61K31/59 , A61K31/592
摘要： The method of treating elevated blood levels of iPTH by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in a patient by administering, as necessary, both Vitamin D repletion and Vitamin D hormone replacement therapies, is disclosed. The blood concentrations of 25-hydroxyvitamin D are increased to and maintained at or above 30 ng/mL, and blood concentrations of 1,25-dihydroxyvitamin D are increased to or maintained within a patient's normal historical physiological range for 1,25-dihydroxyvitamin D without causing substantially increased risk of hypercalcemia, hyperphosphatemia or over suppression of plasma iPTH in the patient. The blood levels of 25-hydroxyvitamin D are maintained at or above 30 ng/mL between doses of Vitamin D repletion therapies, and the blood levels of 1,25-dihydroxyvitamin D are maintained in the patient's normal historical physiological range between doses of Vitamin D hormone replacement therapies. In one aspect, the disclosure includes methods wherein the blood concentration of 25-hydroxyvitamin D during treatment comprises predominantly 25-hydroxyvitamin D3, and/or wherein the method includes administering predominantly or solely 25-hydroxyvitamin D3 for 25-hydroxyvitamin D repletion and/or maintenance.
摘要翻译：公开了通过根据需要施用维生素D补充剂和维生素D激素替代疗法来增加或维持25-羟基维生素D和1,25-二羟基维生素D的血液浓度来治疗iPTH升高的血液水平的方法。 25-羟基维生素D的血液浓度增加并保持在30ng / mL以上，1,25-二羟基维生素D的血液浓度增加至1,25-二羟基维生素D的患者正常的历史生理范围内而不会导致患者高钙血症，高磷血症或过度抑制血浆iPTH的风险显着增加。在维生素D补充疗法的剂量之间，25-羟基维生素D的血液水平维持在或高于30ng / mL，1,25-二羟基维生素D的血液水平维持在维生素D剂量之间的患者正常的历史生理范围内激素替代疗法。一方面，本公开内容包括其中治疗期间25-羟基维生素D的血液浓度主要包含25-羟基维生素D3和/或其中所述方法包括主要或单独使用25-羟基维生素D补充的25-羟基维生素D3用于25-羟基维生素D补充和/或保养。

74. 发明申请

US20160175408A1 DIRECT APPLICATION SYSTEM AND METHOD FOR THE DELIVERY OF BIOACTIVE COMPOSITIONS AND FORMULATIONS 审中-公开
标题翻译：用于生物活性成分和配方的直接应用系统和方法
公开(公告)号：US20160175408A1
公开(公告)日：2016-06-23
申请号：US14909954
申请日：2014-08-04
申请人： Sobin CHANG , David J. GOLDBERG , David SHAFER , Michael A. WEINSTEIN , AQUAVIT PHARMACEUTICALS, INC.
发明人： Sobin Chang , David J. Goldberg , David Shafer , Michael A. Weinstein
IPC分类号： A61K38/48 , A61K31/728 , A61K8/73 , A61K31/714 , A61K8/67 , A61K31/375 , A61K31/455 , A61K31/51 , A61K31/675 , A61K31/525 , A61K33/30 , A61K8/27 , A61K31/355 , A61K31/59 , A61K33/04 , A61K8/23 , A61K8/19 , A61K8/46 , A61K8/49 , A61K8/36 , A61K8/55 , A61K8/35 , A61K8/65 , A61K8/98 , A61K8/42 , A61K8/41 , A61K9/00 , A61M37/00 , A61J3/00 , A61K8/66
CPC分类号： A61K38/4893 , A61K8/19 , A61K8/23 , A61K8/27 , A61K8/355 , A61K8/361 , A61K8/498 , A61K8/553 , A61K8/65 , A61K8/66 , A61K8/675 , A61K8/678 , A61K8/735 , A61K8/98 , A61K9/0014 , A61K31/122 , A61K31/202 , A61K31/352 , A61K31/355 , A61K31/592 , A61K31/685 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/30 , A61K38/063 , A61K2800/91 , A61M5/24 , A61M5/30 , A61M5/3298 , A61M2037/0023 , A61M2037/0061 , A61M2205/505 , A61M2205/6054 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12Y304/24069 , A61K2300/00
摘要： The embodiments relate to improved skin quality, health and appearance using a new delivery method and certain bioactive compositions and formulations. The system incorporates microneedle delivery technology with unique compositions and formulations. Such development allows for the pursuit of personalized medicine, or treatment delivery that can expand to remote controlled environment, immediate compounding and ultimate personalization with a state of the art longitudinal data predictive analytics. Certain formulations described herein are unique, combinatory and synergistic. Secured by high-tech proprietary system, there are unlimited potentials using AQT technology including but not limited to 3-D printing of a biodegradable micro chips that can be delivered via injection, AQT or any other possible route.
摘要翻译：实施方案涉及使用新的递送方法和某些生物活性组合物和制剂来改善皮肤质量，健康和外观。该系统采用具有独特组成和配方的微针输送技术。这种发展允许追求个性化医学，或者通过最先进的纵向数据预测分析来扩展到远程控制环境，立即复合和最终个性化的治疗传递。本文描述的某些制剂是独特的，组合的和协同的。通过高科技专有系统保证，使用AQT技术具有无限的潜力，包括但不限于可通过注射，AQT或任何其他可能途径输送的可生物降解的微芯片的3-D印刷。

75. 发明授权

US09370527B2 Amelioration of intestinal fibrosis and treatment of Crohn's disease 有权
标题翻译：改善肠纤维化和治疗克罗恩病
公开(公告)号：US09370527B2
公开(公告)日：2016-06-21
申请号：US14134587
申请日：2013-12-19
申请人： The Regents of the University of Michigan
发明人： Robert U. Simpson , Peter D. R. Higgins , Laura A. Johnson
IPC分类号： A61K31/59 , C07C401/00
CPC分类号： A61K31/59 , A61K9/0053 , A61K31/592 , A61K45/06
摘要： Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or related compound.
摘要翻译：治疗炎性肠病，肠纤维化或克罗恩病的患者的方法涉及给予治疗量的CARD-024或相关化合物。

76. 发明授权

US09353058B2 Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles 有权
公开(公告)号：US09353058B2
公开(公告)日：2016-05-31
申请号：US14051248
申请日：2013-10-10
申请人： BioResponse, L.L.C.
发明人： Michael A. Zeligs
IPC分类号： A61K31/40 , C07D209/04 , A61K31/405 , A61K45/06 , A61K31/12 , A61K31/155 , A61K31/357 , A61K31/404 , A61K31/407 , A61K31/4164 , A61K31/4706 , A61K31/49 , A61K31/59 , A61K33/24 , A61K36/00 , A61K36/06 , A61K36/258 , A61K36/886 , A61K36/8962 , A61K38/19 , C07D209/52
CPC分类号： C07D209/04 , A61K31/12 , A61K31/155 , A61K31/357 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4164 , A61K31/4706 , A61K31/49 , A61K31/59 , A61K33/24 , A61K36/00 , A61K36/06 , A61K36/258 , A61K36/886 , A61K36/8962 , A61K38/193 , A61K45/06 , C07D209/52 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/492 , A61K2300/00
摘要： The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.

77. 发明申请

US20160120828A1 COLONOSCOPY PREPARATION KIT 审中-公开
标题翻译：结肠准备工具包
公开(公告)号：US20160120828A1
公开(公告)日：2016-05-05
申请号：US14925834
申请日：2015-10-28
申请人： ASCLEMED USA, INC. dba EnovaChem Manufacturing
发明人： Robert P. Nickell
IPC分类号： A61K31/194 , A61K31/166 , A61K31/07 , A61K31/59 , B65D85/00 , A61K31/4402
CPC分类号： A61K31/194 , A61K9/0014 , A61K9/0095 , A61K31/07 , A61K31/166 , A61K31/4402 , A61K31/59 , A61K2300/00
摘要： Provides is a kit comprising: a) a container; and b) following components placed inside of the container: i) magnesium citrate oral Solution; ii) a laxative in form of an oral pharmaceutical dosage form; iii) a topical formulation for application to the skin to relieve irritation; iii) a container of polyethylene glycol powder; iv) an oral pharmaceutical dosage form for treating nausea; and v) an electrolyte drink mix; wherein the kit is used by a patient to clean the patient's colon prior to a colonoscopy.
摘要翻译：提供是一个套件，其包括：a）容器; 和b）放置在容器内的以下组分：i）柠檬酸镁口服溶液; ii）口服药物剂型形式的泻药; iii）用于皮肤以缓解刺激的局部制剂; iii）聚乙二醇粉末容器; iv）用于治疗恶心的口服药物剂型; 和v）电解质饮料混合物; 其中所述试剂盒由患者用于在结肠镜检查之前清洁患者的结肠。

78. 发明授权

US09205095B2 Viral vector encoding a toll-like receptor and encoding a toll-like receptor agonist 有权
标题翻译：编码长尾状受体并编码长耳状受体激动剂的病毒载体
公开(公告)号：US09205095B2
公开(公告)日：2015-12-08
申请号：US13500552
申请日：2010-10-06
申请人： Andrei V. Gudkov
发明人： Andrei V. Gudkov
IPC分类号： C12N15/00 , A61K31/59 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/22 , A61K38/27 , A61K48/00 , C07K14/705 , C12N15/85 , C12N15/63 , C12N15/79 , A61K39/00 , C12N15/86
CPC分类号： A61K31/59 , A61K38/164 , A61K38/177 , A61K38/18 , A61K38/2257 , A61K38/27 , A61K39/0011 , A61K48/005 , C07K14/705 , C12N15/63 , C12N15/79 , C12N15/85 , C12N15/86 , C12N2799/021 , C12N2830/20 , A61K2300/00
摘要： The present invention is directed to methods and agents used for treating cancer or infectious diseases by providing toll-like receptors such as toll-like receptor 5 (TLR-5) in combination with providing a toll-like receptor agonists such as flagellin resulting in a cis and in-trans effect that recruits cells involved in both the innate (cis effect) and adaptive (trans effect) immune response to specifically kill cancer cells and cells infected with a pathogen via the NF-κB apoptosis pathway.
摘要翻译：本发明涉及用于治疗癌症或感染性疾病的方法和试剂，其通过提供toll样受体例如toll样受体5（TLR-5）与提供toll样受体激动剂如鞭毛蛋白相结合，产生顺式和反转效应，招募参与先天（顺式作用）和适应性（反式效应）免疫应答的细胞，以通过NF-和κB凋亡途径特异性杀死癌细胞和感染病原体的细胞。

79. 发明授权

US09173835B2 Compositions and methods for treating hyperproliferative epidermal diseases 有权
公开(公告)号：US09173835B2
公开(公告)日：2015-11-03
申请号：US11914102
申请日：2006-05-10
申请人： Avikam Harel , Zeev Even-Chen , Olga Bloch
发明人： Avikam Harel , Zeev Even-Chen , Olga Bloch
IPC分类号： A61K31/593 , A61K9/00 , A61K31/455 , A61K31/59 , A61K45/06 , A61K47/10
CPC分类号： A61K31/59 , A61K9/0014 , A61K31/355 , A61K31/455 , A61K31/593 , A61K45/06 , A61K47/10 , A61K47/34 , A61K2300/00
摘要： The present invention provides compositions and methods for use in the treatment of hyperproliferative dermal diseases. Specifically, the present invention teaches pharmaceutical compositions for topical administration where the compositions contain nicotinamide and a vitamin D metabolite, calcipotriol, which are particularly effective in treating and in the maintenance treatment of psoriasis and other related dermal disorders and diseases.

80. 发明授权

US09149528B2 Topical vitamin D oral supplement compositions 有权
标题翻译：局部维生素D口服补充剂组合物
公开(公告)号：US09149528B2
公开(公告)日：2015-10-06
申请号：US13650963
申请日：2012-10-12
申请人： Premier Dental Products Company
发明人： William A. McHale , Dale G. Brown
IPC分类号： A61K9/107 , A61P29/00 , A61K31/59 , A61P1/02 , A61K47/10 , A61K9/00 , A61K47/24 , A61K47/26 , A61K9/06 , A61K31/593 , A61C15/04 , A61C19/06 , A61K8/34 , A61K8/67 , A61Q11/00 , A61K8/891 , A61K8/90
CPC分类号： A61K31/09 , A61C15/041 , A61C19/063 , A61K8/345 , A61K8/67 , A61K8/891 , A61K8/90 , A61K9/006 , A61K9/0063 , A61K9/06 , A61K31/122 , A61K31/593 , A61K47/10 , A61K47/24 , A61K47/26 , A61Q11/00 , A61K2300/00
摘要： Topical, vitamin D, oral supplement compositions useful in treating oral inflammation comprising vitamin D in an aqueous-free emulsion containing a trans-oral mucosal absorption facilitator, where said emulsion forms a mucoadhesive coating in the presence of saliva; wherein saliva dissolution of the mucoadhesive gel releases vitamin D and the trans-oral mucosal, absorption facilitator; effecting: vitamin D passive diffusion; regulating in vivo availability and immune response of vitamin D; and maintaining adequate levels of circulating vitamin D while minimizing the risk of hypercalcemia.
摘要翻译：局部维生素D口服补充剂组合物，其可用于治疗包含维生素D的口服炎症，所述维生素D含有含有口腔粘膜吸收促进剂的无水乳液，其中所述乳液在唾液存在下形成粘膜粘附性涂层; 其中粘膜粘附性凝胶的唾液溶解释放维生素D和经口粘膜，吸收促进剂; 影响：维生素D被动扩散; 调节维生素D的体内可利用性和免疫应答; 并维持足够的循环维生素D水平，同时尽量减少高钙血症的风险。

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