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71. 发明申请

US20100152852A1 PREPARATION OF TISSUE FOR MENISCAL IMPLANTATION 有权
标题翻译：男性植入组织的制备
公开(公告)号：US20100152852A1
公开(公告)日：2010-06-17
申请号：US12514703
申请日：2007-11-13
申请人： Eileen Ingham , John Fisher , Thomas Stapleton , Joanne Ingram
发明人： Eileen Ingham , John Fisher , Thomas Stapleton , Joanne Ingram
IPC分类号： A61F2/38 , A01N1/00 , C12N5/071
CPC分类号： A61L27/3612 , A61F2/3872 , A61L27/3683 , A61L2430/40
摘要： The present invention relates to a method of preparing a tissue matrix and its subsequent use in the replacement and/or repair of a damaged or defective meniscus. The invention also provides meniscal tissue that is substantially decellularised.
摘要翻译：本发明涉及一种制备组织基质的方法及其随后用于更换和/或修复损伤或有缺陷的半月板。本发明还提供了基本上脱细胞的半月板组织。

72. 发明授权

US07737250B2 Peptides for treating axonal damage, inhibition of neurotransmitter release and pain transmission, and blocking calcium influx in neurons 失效
标题翻译：用于治疗轴突损伤，抑制神经递质释放和疼痛传播以及阻断神经元钙流入的肽
公开(公告)号：US07737250B2
公开(公告)日：2010-06-15
申请号：US10561015
申请日：2004-06-21
申请人： Dan P. Felsenfeld , Maria A. Diverse-Pierluissi
发明人： Dan P. Felsenfeld , Maria A. Diverse-Pierluissi
IPC分类号： C07K7/00 , C07K14/00 , G01N33/53 , G01N33/567 , A61K49/00 , C12N5/06 , C12N5/08 , C12N5/00 , A01N1/00
CPC分类号： A61K38/17 , C07K14/47 , C07K2319/03
摘要： The present invention pertains to methods to promote outgrowth of, or extension across a substrate of, neuronal cells by inhibiting the interaction between the cytoplasmic tail of the L1-CAM cell surface adhesion molecule and the cytoskeletal protein ankyrin. The invention also pertains to a method to treat diseases characterized by axonal damage such as spinal cord injury, traumatic brain injury, stroke, and neurodegenerative disease by administration of novel peptides that inhibit the binding of the L1-CAM cytoplasmic tail to ankyrin, and to pharmaceutical compositions comprising such peptides. The invention further pertains to a method of blocking calcium flux to protect against neural cell death following stroke or traumatic head injury.
摘要翻译：本发明涉及通过抑制L1-CAM细胞表面粘附分子的细胞质尾与细胞骨架蛋白锚蛋白之间的相互作用来促进神经元细胞的底物的延伸或延伸的方法。本发明还涉及通过施用抑制L1-CAM细胞质尾部与锚蛋白结合的新肽来治疗特征在于轴索损伤（例如脊髓损伤，创伤性脑损伤，中风和神经变性疾病）的疾病的方法，以及包含这些肽的药物组合物。本发明还涉及阻断钙通量以防止中风或创伤性头部损伤后的神经细胞死亡的方法。

73. 发明申请

US20100132173A1 SYSTEM AND METHOD FOR REDUCING ENVIRONMENTAL CREMATORIAL RELEASE OF MERCURY FROM MERCURY-CONTAINING DENTAL AMALGAM 有权
标题翻译：用于减少含有含汞牙垢的汞的环境化学释放的系统和方法
公开(公告)号：US20100132173A1
公开(公告)日：2010-06-03
申请号：US12625176
申请日：2009-11-24
申请人： Benjamin Arcand , Bryan N. Rolfes , Nikhil M. Murdeshwar , Joseph E. Hale , Steven M. Johnson , Luke A. Mitlyng , Joseph Mullenbach , Kristopher I. Kapphahn
发明人： Benjamin Arcand , Bryan N. Rolfes , Nikhil M. Murdeshwar , Joseph E. Hale , Steven M. Johnson , Luke A. Mitlyng , Joseph Mullenbach , Kristopher I. Kapphahn
IPC分类号： A01N1/00
CPC分类号： F23G1/00 , F23G5/02
摘要： The invention described herein provides for a simple, economical system and method for reducing environmental release of dental amalgamous mercury from teeth caused by cremation of corpses. The invention controls and reduces the amount of mercury released using a pre-crematorial and non-disfiguring system and method. The system of the invention can include a dental containment and applicator delivery system to apply a curable thermal protectant composition onto the teeth. The composition coating significantly inhibits the extent of thermal destruction of the tooth per se including its amalgam filling content.
摘要翻译：本文描述的发明提供了一种简单的，经济的系统和方法，用于减少牙齿汞合金从牙齿火化引起的环境释放。本发明使用火化前和非破坏性系统和方法来控制和减少释放的汞的量。本发明的系统可以包括将可固化的热保护剂组合物施加到牙齿上的牙齿包封和施用器输送系统。组合物涂层显着抑制了牙齿本身的热破坏程度，包括其汞齐填充量。

74. 发明申请

US20100112067A1 Compositions and methods for biological remodeling with frozen particle compositions 有权
公开(公告)号：US20100112067A1
公开(公告)日：2010-05-06
申请号：US12384202
申请日：2009-03-31
申请人： Edward S. Boyden , Daniel B. Cook , Roderick A. Hyde , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Edward S. Boyden , Daniel B. Cook , Roderick A. Hyde , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, JR.
IPC分类号： A61K9/14 , A61K35/12 , A01N1/00 , C12N5/02 , A61K38/00
CPC分类号： G06F19/00 , A61K9/0014 , A61K9/0019 , A61K9/0021 , A61K9/007 , A61K9/08 , A61K9/14 , A61K9/143 , A61K9/1611 , A61K9/1641 , A61K9/1664 , A61K9/1688 , A61K9/19 , A61K9/7015 , A61K31/00 , A61K31/337 , A61K31/70 , A61K31/7088 , A61K33/00 , A61K35/16 , A61K35/28 , A61K35/32 , A61K35/33 , A61K35/34 , A61K38/00 , A61K38/38 , A61K38/4833 , A61K39/00 , A61K41/0004 , A61K45/06 , A61K51/1244 , A61K2039/505 , A61M5/3015 , A61M2005/005 , A61M2205/3306 , B33Y80/00 , C07K16/2809 , C07K16/283 , C07K16/2848 , C07K16/2863 , C07K16/2878 , C07K16/30 , C07K2317/31 , G06F19/3456 , G06F19/3468 , G06F19/36 , G16H50/20 , G16H50/50 , Y02A90/26 , A61K2300/00
摘要： Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

75. 发明申请

US20100095388A1 Erythropoietin-Producing Organoid Precursor, Production Method Thereof, and Method For Treating Erythropoietin-Related Disorder 审中-公开
标题翻译：红细胞生成素生产有机体前体及其制备方法及其与红细胞生成素相关性疾病的治疗方法
公开(公告)号：US20100095388A1
公开(公告)日：2010-04-15
申请号：US12307133
申请日：2007-07-04
申请人： Takashi Yokoo , Masataka Okabe , Tatsuo Hosoya
发明人： Takashi Yokoo , Masataka Okabe , Tatsuo Hosoya
IPC分类号： A01K67/00 , A01N1/00
CPC分类号： A01K67/0271 , A01K2227/10 , A01K2267/025 , A61K35/12
摘要： The subject of the present invention is to provide a means to producing an erythropoietin-producing organoid using mesenchymal stem cell derived from a mammal. It is a method for producing erythropoietin-producing organoid (organ-like structure) precursor, comprising the step of transplanting mesenchymal stem cell derived from a mammal into an embryo within a pregnant mammalian host or an embryo separated from a pregnant mammalian host to thereby induce the differentiation of the mesenchymal stem cell, in particular, a site to which the mesenchymal stem cell is to be transplanted is a nephrogenic site of the embryo, and a timing of transplantation corresponds to the stage in which a immune system of the host is still immunologically tolerant.
摘要翻译：本发明的主题是提供使用衍生自哺乳动物的间充质干细胞来产生产生促红细胞生成素的组织细胞的方法。制备促红细胞生成素有机体（器官状结构）前体的方法，其包括将哺乳动物的间充质干细胞移植到怀孕哺乳动物宿主或从怀孕哺乳动物宿主分离的胚胎中的胚胎的步骤，从而诱导间充质干细胞的分化，特别是间质干细胞移植的位点是胚胎的肾源性位点，移植时间对应于宿主的免疫系统仍然存在的阶段免疫耐受。

76. 发明申请

US20100075293A1 BIOREACTORS, SYSTEMS, AND METHODS FOR VASCULARIZING TISSUE CONSTRUCTS 有权
标题翻译：用于血管化组织结构的生物反应器，系统和方法
公开(公告)号：US20100075293A1
公开(公告)日：2010-03-25
申请号：US12562832
申请日：2009-09-18
申请人： Carlos C. Chang , James B. Hoying , Stuart K. Williams
发明人： Carlos C. Chang , James B. Hoying , Stuart K. Williams
IPC分类号： A01N1/02 , C12M1/00 , A01N1/00
CPC分类号： A01N1/0247 , C12M21/08 , C12M23/38 , C12M23/44 , C12M25/14 , C12M29/10
摘要： A modular bioreactor is provided that includes an upper biochamber; a lower biochamber; and an intermediate biochamber that is positioned between the upper biochamber and the lower biochamber. Each biochamber of the bioreactor is in fluid communication with each other biochamber of the bioreactor and includes an interior wall, which defines a centrally-disposed cavity for each biochamber, and an inflow port and an outflow port that are in fluid communication with each centrally disposed cavity. Systems and methods for vascularizing a tissue construct are also provided.
摘要翻译：提供了一种模块化生物反应器，其包括上部生物室; 一个较低的生物室; 以及位于上部生物室和下部生物室之间的中间生物室。生物反应器的每个生物室与生物反应器的每个生物室流体连通，并且包括内壁，其限定每个生物室的居中设置的腔，以及与每个中心设置的流体连通的流入端口和流出端口腔。还提供了用于血管化组织构建体的系统和方法。

77. 发明授权

US07645458B2 Method for sterilizing and/or deactivating adventitious agents associated with biological materials 有权
标题翻译：灭菌和/或去活与生物材料相关的外来物质的方法
公开(公告)号：US07645458B2
公开(公告)日：2010-01-12
申请号：US10614448
申请日：2003-07-07
申请人： Lawrence A. Shimp
发明人： Lawrence A. Shimp
IPC分类号： A61F2/28 , A01N1/00 , A01N1/02 , C12N13/00 , B65B55/00
CPC分类号： A61L2/0041 , A23L3/263 , A61L2/0011 , A61L2/0035 , A61L2/007 , A61L2/10 , A61L2/20
摘要： A method is provided for sterilizing and/or deactivating adventitious agent(s) on and/or within a biological material which comprises packaging the biological material, altering the original atmosphere associated with the biological material in order to reduce the level of oxygen to which the biological material is exposed and subjecting the packaged biological material with its altered atmosphere to irradiation.
摘要翻译：提供了用于在生物材料上和/或内部消毒和/或去活外来物质的方法，其包括包装生物材料，改变与生物材料相关联的原始气氛，以便降低生物材料的氧气水平将生物材料暴露并将其包装的生物材料与其改变的气氛一起照射。

78. 发明授权

US07644477B2 Corpse treatment device 失效
标题翻译：尸体治疗装置
公开(公告)号：US07644477B2
公开(公告)日：2010-01-12
申请号：US11794990
申请日：2005-01-18
申请人： Toshiki Okamoto
发明人： Toshiki Okamoto
IPC分类号： A01N1/00 , A61F13/15 , A61F13/20 , B64D10/00
CPC分类号： A01N1/00 , A61M31/007
摘要： A closing member (16) is disengageably fitted to one end of a cylindrical-shaped guide member (4) to close an opening (4a) of the guide member (4). A water-absorbing agent (3) made of water-absorbing resin powder is accommodated in the guide member (4) toward the one end. A column-shaped plug member (2) made of water-swellable fibers is accommodated in the guide member (4) at a location closer to the other end than the water-absorbing agent (3). A push rod (5) is inserted into the guide member (4) through an opening (4b) thereof located at the other end. With the opening (4a) at the one end of the guide member (4) inserted in an anus, the push rod (5) is operated to push the water-absorbing agent (3) and the plug member (2) through the opening (4a) at the one end of the guide member (4) into a rectum. The plug member (2) absorbs water in internal contents and expands to plug the rectum, while the water-absorbing agent (3) also absorbs water in the internal contents. Thus, the internal contents can be prevented from leaking out through the anus.
摘要翻译：闭合构件（16）可分离地装配到圆柱形导向构件（4）的一端以封闭导向构件（4）的开口（4a）。由吸水性树脂粉末制成的吸水剂（3）朝向一端容纳在引导构件（4）中。由水溶胀性纤维制成的柱状塞构件（2）在比吸水剂（3）更靠近另一端的位置容纳在引导构件（4）中。推杆（5）通过位于另一端的开口（4b）插入引导构件（4）中。在引导件（4）的一端插入肛门的开口（4a）上，推杆（5）被操作以将吸水剂（3）和塞件（2）推过开口（4a）在引导构件（4）的一端处成直肠。插塞构件（2）吸收内部内容物中的水并膨胀以堵塞直肠，同时吸水剂（3）也吸收内部物质中的水。因此，可以防止内部物质通过肛门渗出。

79. 发明申请

US20090288181A1 Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation 有权
标题翻译：用于分析CYP3A4细胞色素P450基因调控的转基因动物
公开(公告)号：US20090288181A1
公开(公告)日：2009-11-19
申请号：US12463246
申请日：2009-05-08
申请人： Christopher LIDDLE , Bryan James Goodwin , Graham Robertson
发明人： Christopher LIDDLE , Bryan James Goodwin , Graham Robertson
IPC分类号： A01K67/033 , A01N1/00 , C12Q1/68
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K49/0008 , C12N9/0077
摘要： The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.
摘要翻译：本发明涉及产生非人转基因动物，其包含用于产生可检测量的报告分子的报道构建体，所述报道分子可操作地连接于来自位于基因转录位点的起始点之间的人CYP3A4基因的转录调节核酸分子，和位于位于该位点上游13,000个核苷酸的位置。本发明还涉及这些动物用于测定化合物，特别是但不排除地，异生物或类固醇对人类CYP3A4基因表达调节的影响的用途。

80. 发明授权

US07611830B2 Device to lavage a blood vessel 有权
标题翻译：设备灌洗血管
公开(公告)号：US07611830B2
公开(公告)日：2009-11-03
申请号：US10257176
申请日：2001-04-10
申请人： Hemant Thatte , Kunda Biswas , Shukri Khuri , Thomas Michel
发明人： Hemant Thatte , Kunda Biswas , Shukri Khuri , Thomas Michel
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/0226 , A01N1/0247 , A61K9/0009 , A61K31/198 , A61K31/375 , A61K31/70 , A61K31/727 , A61K35/44 , A61K38/063 , A61K38/58 , Y10S623/916 , A61K2300/00
摘要： The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in the preparation of the solutions of the present invention. The present invention also provides a device for perfusing tissues and organs with the solutions of the present invention.
摘要翻译：本发明提供了离体和原位保存组织和器官的组合物和方法。此外，本发明提供了可用于制备本发明的溶液的试剂盒。本发明还提供了用本发明的溶液灌注组织和器官的装置。

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