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71. 发明申请

US20020068098A1 Combinations of diterpene triepoxide lactones and ditepene lactones or triterpenes for synergistic inhibition of cyclooxygenase-2 失效
标题翻译：二萜三环内酯和二萜烯内酯或三萜烯的组合用于环加氧酶-2的协同抑制
公开(公告)号：US20020068098A1
公开(公告)日：2002-06-06
申请号：US09920339
申请日：2001-08-01
申请人： Ashni Naturaceuticals, Inc.
发明人： John G. Babish , Terrence Howell , Linda Pacioretty
IPC分类号： A61K035/78 , A61K031/335 , A61K038/06 , A61K031/737 , A61K031/7008
CPC分类号： A61K31/365 , A61K47/54 , Y10S514/825 , Y10S514/885 , Y10S514/886 , A61K31/34 , A61K2300/00
摘要： A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a diterpene triepoxide lactone species and an effective amount of a second component selected from the group consisting of a diterpene lactone species and a triterpene species or derivatives thereof, and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.
摘要翻译：提供了一种用于抑制动物炎症反应的新型制剂。该制剂包含作为第一组分的有效量的二萜三环内酯物质和有效量的选自二萜内酯物质和三萜类物质或其衍生物的第二组分，并提供协同的抗炎作用响应于由于生物制剂或未知病因引起的身体或化学损伤或异常免疫刺激。

72. 发明授权

US06395309B1 Use of an extract of Alchemilla vulgaris to inhibit angiogenesis 失效
标题翻译：使用炼金术提取物抑制血管生成
公开(公告)号：US06395309B1
公开(公告)日：2002-05-28
申请号：US09381889
申请日：1999-12-22
申请人： Gerhard Franz , Dietrich H. Paper
发明人： Gerhard Franz , Dietrich H. Paper
IPC分类号： A01N6500
CPC分类号： A61K36/73 , Y10S514/863 , Y10S514/886 , Y10S514/914
摘要： Use of an extract of alchemilla vulgaris, or a fraction or a lyophilizate thereof, or one or more active principles contained in said extract, for inhibiting angiogenesis.
摘要翻译：使用通常的炼金术提取物，或其部分或冻干物质，或所述提取物中所含的一种或多种活性成分，用于抑制血管生成。

73. 发明授权

US06391581B1 DNA encoding interleukin-4 receptors 失效
标题翻译：编码白细胞介素-4受体的DNA
公开(公告)号：US06391581B1
公开(公告)日：2002-05-21
申请号：US09094917
申请日：1998-06-15
申请人： Bruce Mosley , David J. Cosman , Linda Park , M. Patricia Beckmann , Carl J. March , Rejean Idzerda
发明人： Bruce Mosley , David J. Cosman , Linda Park , M. Patricia Beckmann , Carl J. March , Rejean Idzerda
IPC分类号： C12N1512
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , G01N33/6869 , Y10S514/826 , Y10S514/885 , Y10S514/886
摘要： Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.
摘要翻译：公开了哺乳动物白细胞介素-4受体蛋白，编码哺乳动物IL-4受体的DNA和表达载体，以及作为细胞培养产物的哺乳动物IL-4受体的制备方法。通过施用有效量的可溶性IL-4受体（sIL-4R）和合适的稀释剂或载体，抑制哺乳动物（包括人）中IL-4依赖性免疫或炎性反应的方法。

74. 发明授权

US06383495B1 Herbal formulation useful for treatment of skin disorders 有权
标题翻译：草药制剂可用于治疗皮肤疾病
公开(公告)号：US06383495B1
公开(公告)日：2002-05-07
申请号：US09659124
申请日：2000-09-11
申请人： Sistla Ramakrishna , Bhamidipalli Subrahmanya Sitaramam , Prakash Vaman Rao Diwan , Kondapuram Vijaya Raghavan
发明人： Sistla Ramakrishna , Bhamidipalli Subrahmanya Sitaramam , Prakash Vaman Rao Diwan , Kondapuram Vijaya Raghavan
IPC分类号： A61K3578
CPC分类号： A61K36/9066 , A61K8/97 , A61K36/27 , A61K36/28 , A61K36/324 , A61K36/886 , A61K36/8962 , A61Q19/00 , A61Q19/004 , A61Q19/007 , Y10S514/861 , Y10S514/886 , Y10S514/887 , A61K2300/00
摘要： The invention provides a novel herbal formulation useful for the treatment of skin disorders and comprising two or more plant extracts selected from Tagetes erecta, Moringa oleifera, Ocimum sanctum, Tridax procumbens, Aloe vera, and Gum olibanum together with conventional additives.
摘要翻译：本发明提供了一种用于治疗皮肤病症的新型草药制剂，并且包含两种或多种选自Tagetes erecta，Moringa oleifera，Ocimum sanctum，Tridax procumbens，芦荟和Gum olibanum的植物提取物以及常规添加剂。

75. 发明申请

US20020006904A1 Method of treating inflammation in the joints of a body 审中-公开
标题翻译：治疗身体关节炎症的方法
公开(公告)号：US20020006904A1
公开(公告)日：2002-01-17
申请号：US09852593
申请日：2001-05-09
发明人： Allan R. Dunn
IPC分类号： A61M031/00 , A61K038/00
CPC分类号： A61K38/27 , Y10S514/886 , Y10S530/84 , A61K2300/00
摘要： A process for treating inflammation in a joint whether heat, redness, pain, swelling and/or stiffness, and for increasing motion and increasing joint space and correcting mal-alignment, comprising the steps of dissolving a quantity of growth hormone (somatotropin), preferably in purified form, in a buffer solution, and injecting one time or multiple repeat times, a single dosage of the mixture of purified growth hormone and buffer solution into the joint of a body so as to initiate the treatment process. The present invention is also directed to a process of preparing a joint for treatment of inflammation, as described herein, by injecting or otherwise applying one or more of a group of agents, such as an anti-growth factor, an anti-cytokine or an anti-kinase (or a combination thereof) to quiet and reduce deleterious activity in the joint. This preparation step can be carried out either simultaneously or prior to the step of injecting the mixture of purified growth hormone (commonly known as somatotropin) and a buffer solution into the joint, whether of a human or other animal.
摘要翻译：一种治疗关节炎症的过程，无论是热，发红，疼痛，肿胀和/或僵硬，以及用于增加运动和增加关节间隙以及纠正错位，包括以下步骤：将一定数量的生长激素（生长激素）以缓冲溶液的形式，以一次或多次的重复次数将单次剂量的纯化生长激素和缓冲溶液的混合物加入到身体的关节中以引发治疗过程。本发明还涉及如本文所述制备用于治疗炎症的关节的方法，其通过注射或以其它方式施用一组或多种试剂，例如抗生长因子，抗细胞因子或抗激酶（或其组合）以安静并减少关节中的有害活性。该制备步骤可以在将纯化的生长激素（通常称为生长激素）和缓冲溶液的混合物注射到人或其他动物的接头中的同时或之前同时进行。

76. 发明授权

US06335349B1 Substituted 2(2,6-dioxopiperidin-3-yl)isoindolines 有权
标题翻译：取代的2（2,6-二氧代哌啶-3-基）异吲哚啉
公开(公告)号：US06335349B1
公开(公告)日：2002-01-01
申请号：US09716528
申请日：2000-11-20
申请人： George W. Muller , David I. Stirling , Roger Shen-Chu Chen
发明人： George W. Muller , David I. Stirling , Roger Shen-Chu Chen
IPC分类号： A61K31454
CPC分类号： A61K31/445 , C07D401/04 , Y10S514/825 , Y10S514/886 , Y10S514/908
摘要： Substituted 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines and 1-oxo-2-(2,6-dioxo-piperidin-3-yl)isoindolines reduce the levels of TNF&agr; in a mammal and are useful in treating oncogenic conditions, inflammation, and autoimmune diseases. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroiso-indoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.
摘要翻译：取代的1,3-二氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉和1-氧代-2-（2,6-二氧代 - 哌啶-3-基）异吲哚啉降低哺乳动物的TNFα水平并且可用于治疗致癌条件，炎症和自身免疫性疾病。典型的实施方案是1-氧代-2-（2,6-二氧代-3-甲基哌啶-3-基）-4,5,6,7-四氟异二氢吲哚和1,3-二氧代-2-（2,6-二氧代 - 二氧代-3-甲基哌啶-3-基）-4-氨基异吲哚啉。

77. 发明授权

US06270759B1 Method of using IL-11 for treating gingivitis 失效
标题翻译：使用IL-11治疗牙龈炎的方法
公开(公告)号：US06270759B1
公开(公告)日：2001-08-07
申请号：US09337965
申请日：1999-06-22
申请人： James Keith , Paul Schendel
发明人： James Keith , Paul Schendel
IPC分类号： A61K4500
CPC分类号： A61K38/2073 , Y10S514/867 , Y10S514/885 , Y10S514/886
摘要： Provided by the present invention are methods of treating a variety of disorders including AIDS, arthritis (rheumatoid arthritis, osteoarthritis, spondyloarthropathies), antibiotic induced diarrheal diseases (Clostridium difficile), multiple sclerosis, osteoporosis, gingivitis, peptic ulcer disease, esophagitis, diabetes, retinitis, uveitis, reperfusion injury after myocardial infarction (MI) or cerebral vascular accident (CVA), aphthous ulcers (oral), atherosclerosis (plaque rupture), prevention of tumor metastases, asthma, preeclampsia, and allergic disorders such as rhinitis, conjunctivitis, and urticaria.
摘要翻译：本发明提供了治疗各种疾病的方法，包括AIDS，关节炎（类风湿性关节炎，骨关节炎，脊柱关节病），抗生素诱发的腹泻病（艰难梭菌），多发性硬化症，骨质疏松症，牙龈炎，消化性溃疡病，食道炎，糖尿病，视网膜炎，葡萄膜炎，心肌梗死（MI）或脑血管意外（CVA），口腔溃疡（口腔），动脉粥样硬化（斑块破裂），预防肿瘤转移，哮喘，先兆子痫和过敏性疾病如鼻炎，结膜炎，和荨麻疹。

78. 发明授权

US06235294B1 Flavonoide esters and their use notably in cosmetics 失效
标题翻译： Flavonoide酯及其在化妆品中的应用
公开(公告)号：US06235294B1
公开(公告)日：2001-05-22
申请号：US09113158
申请日：1998-07-10
申请人： Eric Perrier , Anne-Marie Mariotte , Ahcéne Boumendjel , Delphine Bresson-Rival
发明人： Eric Perrier , Anne-Marie Mariotte , Ahcéne Boumendjel , Delphine Bresson-Rival
IPC分类号： A61K600
CPC分类号： A61K8/498 , A61Q1/06 , A61Q5/02 , A61Q19/06 , A61Q19/08 , A61Q19/10 , C07D311/30 , C07D311/32 , C07H17/07 , Y10S514/844 , Y10S514/886 , Y10S514/887 , Y10S514/969
摘要： The invention relates to a flavonoid ester. This flavonoid ester results from the reaction product of at least one flavonoid selected from the group consisting of a flavonoid with a ketone group in the 4-position, a salt, ester or ether of such a flavonoid, and a C-heteroside and/or O-heteroside derivative of such a flavonoid, with the proviso that this flavonoid contains at least one free alcohol group, with an organic monoacid having from 3 to 30 carbon atoms. These flavonoid esters constitute useful active principles for the manufacture of cosmetic, dermopharmaceutical, pharmaceutical, dietetic or agri-foodstuff compositions.
摘要翻译：本发明涉及类黄酮酯。该类黄酮酯是由选自4-位的类黄酮与酮基的至少一种类黄酮，这种类黄酮的盐，酯或醚，以及C-杂苷和/或这种类黄酮的O-杂苷衍生物，条件是该类黄酮含有至少一个游离醇基，具有3至30个碳原子的有机一元酸。这些类黄酮酯构成用于制造化妆品，皮肤药物，药物，饮食或农产品组合物的有用的活性成分。

79. 发明授权

US5925376C1 Method for treating psoriasis using selected phosphorylase kinase inhibitor and additional compounds 失效
标题翻译：使用选择的磷酸化酶激酶抑制剂和其他化合物治疗牛皮癣的方法
公开(公告)号：US5925376C1
公开(公告)日：2001-03-20
申请号：US51899195
申请日：1995-08-24
申请人： HENG MADALENE C Y
发明人： HENG MADALENE C Y
IPC分类号： A61K31/12 , A61K31/23 , A61K31/55 , A61K9/20 , A61K9/06
CPC分类号： A61K31/59 , A61K31/12 , A61K31/23 , A61K31/55 , Y10S514/863 , Y10S514/886 , Y10S514/937 , Y10S514/944 , Y10S514/962 , Y10S514/969 , A61K2300/00

80. 发明授权

US06201011B1 Therapeutic agent for allergic dermatitis 失效
标题翻译：过敏性皮炎的治疗剂
公开(公告)号：US06201011B1
公开(公告)日：2001-03-13
申请号：US09242894
申请日：1999-02-26
申请人： Hiroaki Shirahase , Akihisa Yoshimi , Shohei Nakamura , Mamoru Kanda
发明人： Hiroaki Shirahase , Akihisa Yoshimi , Shohei Nakamura , Mamoru Kanda
IPC分类号： A01N4316
CPC分类号： C07D311/24 , A61K31/352 , Y10S514/886
摘要： A therapeutic agent for allergic dermatitis caused by type IV allergic reaction, which contains diethyl L-lysylcromoglycate of the formula: or a nontoxic salt thereof as an active ingredient. This therapeutic agent for allergic dermatitis is effective for the treatment of allergic dermatitis caused by type IV allergic reaction, such as contact dermatitis mainly induced by type IV allergic reaction and atopic dermatitis induced by type I and type IV allergic reactions.
摘要翻译：由IV型过敏反应引起的过敏性皮炎的治疗剂，其包含下式的二乙基L-赖氨酰色甘酸酯或其无毒盐作为活性成分。这种过敏性皮炎治疗剂对于治疗由IV型过敏反应引起的过敏性皮炎，如主要由IV型过敏反应引起的接触性皮炎和I型和IV型过敏反应引起的特应性皮炎是有效的。

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