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71. 发明授权

US09581801B2 Microscope system 有权
标题翻译：显微镜系统
公开(公告)号：US09581801B2
公开(公告)日：2017-02-28
申请号：US14273235
申请日：2014-05-08
申请人： OLYMPUS CORPORATION
发明人： Nobuhiro Takamizawa
IPC分类号： H04N7/18 , G02B21/36 , G02B21/24 , G02B21/00 , G02B21/32 , G02B21/06 , G02B21/26 , H04N5/225 , H04N5/232 , H01J37/28
CPC分类号： G02B21/365 , G02B21/0076 , G02B21/06 , G02B21/24 , G02B21/26 , G02B21/32 , H01J37/28 , H04N5/2256 , H04N5/23229
摘要： A microscope system including: an observation optical system acquiring an image of an observation position of a sample; a stimulation optical system irradiating the sample with stimulation light; an observation position setting section setting the observation positions; a stimulation position setting section setting a common stimulation position; a stage switching the observation positions; a synchronization condition setting section setting a common synchronization condition in which the timing of the image acquisition is associated with the timing of the irradiation with stimulation light; an observation condition registration section registering the common stimulation position and the common synchronization condition as observation conditions associated with each of the observation positions; and a control section, according to the registered conditions, switching the observation positions, making the observation optical system acquire an image of each of the observation positions, and making the stimulation optical system irradiate each of the stimulation positions with stimulation light.
摘要翻译：一种显微镜系统，包括：观察光学系统，获取样本的观察位置的图像; 刺激光学系统用刺激光照射样品; 观察位置设定部，设定观察位置; 刺激位置设定部，设定共同的刺激位置; 切换观察位置的阶段; 同步条件设定部，其将图像获取的定时与激励光的照射的定时相关联的公共同步状态; 将共同刺激位置和公共同步条件作为与每个观察位置相关联的观察条件登记的观察条件登记部; 以及根据注册条件的控制部分切换观察位置，使得观察光学系统获取每个观察位置的图像，并且使刺激光学系统用刺激光照射每个刺激位置。

72. 发明申请

US20170052384A1 IMAGING APPRATUS AND METHODS USING DIFFRACTION-BASED ILLUMINATION 审中-公开
标题翻译：成像设备和使用基于衍射的照明的方法
公开(公告)号：US20170052384A1
公开(公告)日：2017-02-23
申请号：US15307759
申请日：2014-04-30
申请人： Hewlett-Packard Development Company, L.P.
发明人： Charles M Santori , Alexander Govyadinov
IPC分类号： G02B27/42 , G02B21/36 , F21V8/00 , G01N21/05 , H04N5/225 , G02B21/06
CPC分类号： G02B27/425 , G01N21/05 , G02B6/003 , G02B6/0035 , G02B21/00 , G02B21/0004 , G02B21/06 , G02B21/362 , G03H1/0244 , G03H1/041 , G03H1/0443 , G03H1/0465 , G03H1/0866 , G03H1/265 , G03H2001/0033 , G03H2001/0447 , G03H2001/0452 , G03H2001/0469 , G03H2001/0471 , G03H2001/0473 , G03H2001/2226 , G03H2222/34 , G03H2223/16 , G03H2223/19 , G03H2223/23 , G03H2227/02 , G03H2227/03 , G03H2240/56 , H04N5/2256
摘要： Imaging apparatus and methods using diffraction-based illumination are disclosed. An example apparatus includes a diffraction grating to redirect light from a light source toward a sample to thereby illuminate the sample. The example apparatus also includes an image sensor to detect a diffraction pattern created by the illuminated sample.
摘要翻译：公开了使用衍射照明的成像设备和方法。示例性装置包括衍射光栅，用于将来自光源的光朝向样品重新定向，从而照射样品。示例性装置还包括用于检测由照射样品产生的衍射图案的图像传感器。

73. 发明授权

US09575303B2 Microscope apparatus 有权
标题翻译：显微镜装置
公开(公告)号：US09575303B2
公开(公告)日：2017-02-21
申请号：US13901411
申请日：2013-05-23
申请人： OLYMPUS CORPORATION
发明人： Nobuhiro Takamizawa
IPC分类号： G02B21/36 , G02B21/06 , G01N21/64 , G02B21/16 , G02B21/18
CPC分类号： G02B21/06 , G01N21/6458 , G01N21/648 , G02B21/16 , G02B21/18 , G02B21/36 , G02B21/365
摘要： A microscope apparatus includes: an objective lens; a CCD that constructs an image of a sample S; an illumination intensity change unit for adjusting an intensity of excitation light; a sensitivity adjustment unit for adjusting a detection sensitivity by the CCD; a galvanometer mirror for changing a light focusing position of excitation light at a pupil position of the objective lens; a storage unit that stores, for each observation method, a predetermined intensity, a predetermined detection sensitivity, and the light focusing position; and a control unit that switches the observation method, reads out the intensity, the detection sensitivity, and the light focusing position according to the observation method based on a synchronization signal synchronized with a frame signal for constructing an image, and controls the illumination intensity change unit, the sensitivity adjustment unit, and the galvanometer mirror.
摘要翻译：显微镜装置包括：物镜; 构建样品S的图像的CCD; 用于调节激发光强度的照明强度变化单元; 用于通过CCD调整检测灵敏度的灵敏度调节单元; 用于改变物镜的光瞳位置处的激发光的聚焦位置的电流计镜; 存储单元，其针对每个观察方法存储预定强度，预定检测灵敏度和所述聚光位置; 以及控制单元，其切换观察方法，根据与用于构建图像的帧信号同步的同步信号的观察方法读出强度，检测灵敏度和聚焦位置，并且控制照明强度变化单元，灵敏度调节单元和电流计镜。

74. 发明授权

US09535242B1 Parallel programmable array microscope 有权
标题翻译：并行可编程阵列显微镜
公开(公告)号：US09535242B1
公开(公告)日：2017-01-03
申请号：US14316620
申请日：2014-06-26
申请人： VERILY LIFE SCIENCES LLC
发明人： Victor M. Acosta , Vidya Ganapati
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/18 , G02B21/26 , G02B21/34 , G02B21/367 , G02B26/02 , G02B26/0833
摘要： A microscope system includes a sample tray to hold a plurality of samples to be imaged in parallel. An illumination source generates illumination light and a plurality of spatial light modulators are each positioned to spatially modulate the illumination light onto a corresponding one of the samples. Relay optics are positioned in an optical path between the sample tray and the plurality of spatial light modulators to image the samples onto the plurality of spatial light modulators. A plurality of first cameras is positioned to capture images in parallel of the samples in the sample tray by imaging the plurality of spatial light modulators.
摘要翻译：显微镜系统包括用于平行地保持待成像的多个样品的样品盘。照明源产生照明光，并且多个空间光调制器各自被定位成将照明光空间调制到相应的一个样本上。继电器光学器件位于样品托盘和多个空间光调制器之间的光路中，以将样品成像到多个空间光调制器上。定位多个第一相机以通过对多个空间光调制器进行成像来捕获平行于样品托盘中的样本的图像。

75. 发明申请

US20160377852A1 IMAGING DEVICE FOR MICROSCOPE 审中-公开
标题翻译：微型成像装置
公开(公告)号：US20160377852A1
公开(公告)日：2016-12-29
申请号：US15256981
申请日：2016-09-06
申请人： European Molecular Biology Laboratory , Karlsruher Institut fuer Technologie , ACQUIFER AG
发明人： Lars Hufnagel , Uros Krzic , Urban Liebel
IPC分类号： G02B21/36 , G02B21/26 , G02B21/28 , G02B21/06
CPC分类号： G02B21/362 , G02B21/06 , G02B21/16 , G02B21/26 , G02B21/28
摘要： An imaging device for a microscope (20) is disclosed that comprises a plurality of individual light sources (40) and a detector (15). The plurality of the individual light sources (40) is mounted on a translation stage (110). The imaging device further includes moveable optics arranged to direct a light path (45) onto a stationary sample (60) and collect reflected or fluoresced radiation from the sample (60).
摘要翻译：公开了一种用于显微镜（20）的成像装置，其包括多个单独光源（40）和检测器（15）。多个个体光源（40）安装在平移台（110）上。成像装置还包括可移动光学器件，其布置成将光路（45）引导到固定样品（60）上并收集来自样品（60）的反射或发射的辐射。

76. 发明授权

US09523845B2 High numerical aperture telemicroscopy apparatus 有权
公开(公告)号：US09523845B2
公开(公告)日：2016-12-20
申请号：US14839023
申请日：2015-08-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Daniel Fletcher , Wendy Hansen , Neil Switz , David N. Breslauer , Erik Douglas , Robi Maamari , Wilbur Lam , Jesse Dill
IPC分类号： H04N7/18 , G02B21/36 , G02B21/00 , G02B21/16 , H04M1/02 , G01N21/84 , G02B21/02 , H04N5/44
CPC分类号： G02B21/361 , G01N21/8483 , G02B21/0008 , G02B21/0092 , G02B21/02 , G02B21/025 , G02B21/06 , G02B21/16 , G02B21/26 , G02B21/36 , G02B21/365 , H04M1/0264 , H04N5/44
摘要： An imaging system consisting of a cell-phone with camera as the detection part of an optical train which includes other components. Optionally, an illumination system to create controlled contrast in the sample. Uses include but are not limited to disease diagnosis, symptom analysis, and post-procedure monitoring, and other applications to humans, animals, and plants.

77. 发明申请

US20160363753A1 Integrated Illuminator and Condenser for Microscopes 审中-公开
标题翻译：集成照明器和显微镜冷凝器
公开(公告)号：US20160363753A1
公开(公告)日：2016-12-15
申请号：US15178672
申请日：2016-06-10
申请人： Techshot, Inc.
发明人： Paul W. Todd , N. Samuel Logan , Michael A. Kurk , Nathan A. Thomas , Paul Faget
IPC分类号： G02B21/12 , G02B21/14 , G02B21/02 , G02B21/16 , G02B27/30 , G02B21/08 , F21V23/00 , G02B21/06
CPC分类号： G02B21/125 , F21V23/003 , G02B21/02 , G02B21/06 , G02B21/08 , G02B21/086 , G02B21/14 , G02B21/16 , G02B27/30
摘要： A Light-Emitting Diode (LED) illuminator-condenser capable of supplying bright-field, dark-field, fluorescence, oblique, and phase-contrast illumination under Köhler-like conditions. A single lens may be permanently focused on the specimen plane. Illumination conditions may be made by a combination of uniform LEDs, collimating masks and diffusers. LEDs may be arranged in one or more ring-shaped patterns.
摘要翻译：发光二极管（LED）照明器 - 冷凝器，能够在类似Köhler的条件下提供亮场，暗场，荧光，倾斜和相位对比度照明。单个透镜可以永久地聚焦在样品平面上。照明条件可以通过统一的LED，准直掩模和扩散器的组合来进行。 LED可以以一个或多个环形图案布置。

78. 发明申请

US20160360125A1 IMAGING APPARATUS, ENDOSCOPE APPARATUS, AND MICROSCOPE APPARATUS 有权
标题翻译：成像装置，内窥镜装置和显微镜装置
公开(公告)号：US20160360125A1
公开(公告)日：2016-12-08
申请号：US15238341
申请日：2016-08-16
申请人： OLYMPUS CORPORATION
发明人： Eiji YAMAMOTO , Hiroyuki KAMEE , Hiromasa FUJITA
IPC分类号： H04N5/343 , G02B21/06 , G02B23/24 , G02B21/36 , H04N5/225 , H04N9/07
CPC分类号： H04N5/343 , A61B1/00009 , A61B1/045 , A61B1/05 , A61B1/06 , A61B1/0638 , G02B21/06 , G02B21/365 , G02B23/2461 , G02B23/2484 , G02B23/26 , G03B15/02 , G03B33/00 , H04N5/2256 , H04N5/238 , H04N9/07 , H04N2005/2255
摘要： An imaging apparatus includes an illumination section, an imaging section, and an image processor. The illumination section includes an illumination unit configured to selectively emit illumination light rays of light wavelength bands different from each other, and an illumination switch controller which generates an illumination unit control signal corresponding to each of sets of emission patterns so that combinations of the light wavelength bands of the illumination light rays emitted from the illumination unit are different from each other and the illumination switch controller controlling the illumination unit so that the illumination light rays are sequentially emitted from the illumination unit in the sets of emission patterns different from each other.
摘要翻译：一种成像设备包括照明部分，成像部分和图像处理器。照明部包括：被配置为选择性地发射彼此不同的光波长带的照明光的照明单元;以及照明开关控制器，其产生对应于每组发光图案的照明单元控制信号，使得光波长从照明单元发射的照明光线的条带彼此不同，并且照明开关控制器控制照明单元，使得照明光线以彼此不同的发射图案组从照明单元顺序地发射。

79. 发明申请

US20160357001A1 MICROSCOPE 审中-公开
标题翻译：显微镜
公开(公告)号：US20160357001A1
公开(公告)日：2016-12-08
申请号：US15166278
申请日：2016-05-27
申请人： GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人： Hwanchol JANG , Heung-No LEE
IPC分类号： G02B21/06 , G02B5/02 , G06K9/62 , G02B21/36
CPC分类号： G02B21/06 , G02B5/0242 , G02B21/361 , G06K9/00134 , G06K9/20
摘要： Disclosed herein is a microscope. The microscope includes: a lens system receiving light emitted from a light source and containing image information of an observation object; turbid media interposed between the observation object and the lens system; and an image acquisition device acquiring the image information, wherein the image acquisition device comprises: an image sensor acquiring information of light passing through the lens system; a transmission matrix storage unit previously storing a transmission matrix indicating a transmission state of various light components entering the light entrance portion; and an image recovery unit recovering the image information from the information of light acquired by the image sensor through compressed sensing using a sparse representation based on the transmission matrix. The microscope can provide improved image quality and can acquire an image through simple operation.
摘要翻译：本文公开的是显微镜。显微镜包括：透镜系统，其接收从光源发射的光并包含观察对象的图像信息; 介于观察对象与透镜系统之间的混浊介质; 以及获取图像信息的图像获取装置，其中所述图像获取装置包括：图像传感器，获取通过所述透镜系统的光的信息; 传输矩阵存储单元，其预先存储指示进入所述光入口部分的各种光分量的传输状态的传输矩阵; 以及图像恢复单元，通过使用基于传输矩阵的稀疏表示的压缩感测，从图像传感器获取的光的信息中恢复图像信息。显微镜可以提供改善的图像质量，并且可以通过简单的操作获取图像。

80. 发明申请

US20160341947A1 IMAGE ACQUISITION DEVICE, IMAGE FORMING SYSTEM, AND IMAGE FORMING METHOD 审中-公开
标题翻译：图像获取装置，图像形成系统和图像形成方法
公开(公告)号：US20160341947A1
公开(公告)日：2016-11-24
申请号：US15224712
申请日：2016-08-01
申请人： Panasonic Intellectual Property Management Co.,Ltd
发明人： TAICHI SATO , YOSHIHIDE SAWADA , YASUHIKO ADACHI , HIDETO MOTOMURA
IPC分类号： G02B21/36 , G02B21/06 , H04N5/225 , H04N5/232 , H04N5/235
CPC分类号： G02B21/365 , G01N21/49 , G01N21/59 , G01N2201/0662 , G02B21/0008 , G02B21/06 , G02B21/086 , G02B21/26 , H04N5/2256 , H04N5/23232 , H04N5/2354 , H04N5/2356
摘要： An image acquisition device according to the present disclosure includes a lighting system and an irradiation direction decision section. In a module, a subject and an imaging element are integrally formed. The lighting system sequentially irradiates the subject with illumination light in a plurality of different irradiation directions based on the subject such that the illumination light transmitted through the subject is incident on the imaging element. The module acquires a plurality of images according to the plurality of different irradiation directions. Before the plurality of images are acquired according to the plurality of different irradiation directions, the irradiation direction decision section decides the plurality of different irradiation directions based on a difference between a first preliminary image and a second preliminary image. The first preliminary image is acquired when the subject is irradiated with first illumination light in a first irradiation direction, and the second preliminary image is acquired when the subject is irradiated with second illumination light in a second irradiation direction.
摘要翻译：根据本公开的图像获取装置包括照明系统和照射方向判定部。在模块中，主体和成像元件整体形成。照明系统基于被摄体以多个不同的照射方向的照明光顺序照射被摄体，使得透过被摄体的照明光入射到摄像元件上。模块根据多个不同的照射方向获取多个图像。在根据多个不同的照射方向获取多个图像之前，照射方向判定部基于第一预备图像和第二预备图像之间的差异来决定多个不同的照射方向。当在第一照射方向上照射第一照明光时拍摄第一预备图像，并且当在第二照射方向上照射第二照明光时获取第二预备图像。

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