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71. 发明申请

US20140031256A1 METHODS OF DETECTING THERAPEUTIC EXOSOMES 审中-公开
标题翻译：检测治疗方法
公开(公告)号：US20140031256A1
公开(公告)日：2014-01-30
申请号：US13984203
申请日：2012-02-10
申请人： Sai Kiang Lim
发明人： Sai Kiang Lim
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N33/5005 , G01N33/6848 , G01N2570/00
摘要： We describe a method of detecting a therapeutic exosome, the method comprising detecting an activity of an exosome. The activity may be selected from the group consisting of: (a) immunodulatory activity; (b) complement inhibition activity; (c) proteasome activity; (d) glycolytic enzyme activity; (e) anti-oxidative activity; (f) extracellular matrix (ECM) modifying activity; (g) NT5E (CD73) ecto-5′-ectonucleotidase activity; (h) ion homeostasis activity; and (i) chaperone activity. If the exosome is detected as having one or more such activities, the exosome is likely to comprise a therapeutic exosome having therapeutic activity.
摘要翻译：我们描述了一种检测治疗性外来体的方法，该方法包括检测外来体的活性。该活性可以选自：（a）免疫调节活性; （b）补体抑制活性; （c）蛋白酶体活性; （d）糖酵解酶活性; （e）抗氧化活性; （f）细胞外基质（ECM）修饰活性; （g）NT5E（CD73）ecto-5'-外切核苷酸酶活性; （h）离子稳态活性; 和（i）伴侣活动。如果外来体被检测为具有一种或多种此类活性，外来体可能包含具有治疗活性的治疗性外来体。

72. 发明申请

US20140030718A1 METHOD OF DETECTING AND IDENTIFYING CIRCULATING ANTIGENS IN HUMAN BIOLOGICAL SAMPLES 有权
标题翻译：检测和鉴定人类生物样品中循环抗原的方法
公开(公告)号：US20140030718A1
公开(公告)日：2014-01-30
申请号：US13804621
申请日：2013-03-14
申请人： The Board of Regents of the Nevada System of Higher Education, on Behalf of the University of Nevada
发明人： David P. AuCoin , Thomas R. Kozel , Claire Smalley
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , C12Q1/04 , G01N33/536 , G01N33/569 , G01N2469/10 , G01N2570/00 , G01N2800/26 , G01N2800/52
摘要： Disclosed herein is a method of detecting and identifying antigens that are shed into human bodily fluids during infection. The disclosed method allows circulating antigens associated with a particular infection to be detected within minutes or hours from testing as compared to days required with the current methods. Methods of identifying diagnostic indicators/targets for a given condition or disease are disclosed which include immunizing a veterinary subject with biological fluids obtained from a human infected with particular antigens to identify diagnostic targets for immunoassay. Also disclosed are methods of diagnosing and monitoring a B. pseudomallei-associated condition, such as melioidosis. Point-of-care immunoassays are also provided that can be used to diagnose or monitor the efficacy of a B. pseudomallei-associated condition treatment. These immunoassays can also be used for rapid diagnosis of infection produced by B. pseudomallei, such as meliodosis.
摘要翻译：本文公开了一种检测和鉴定在感染期间流入人体液中的抗原的方法。所公开的方法允许与特定感染相关的循环抗原在与测试相关的几天或几个小时内进行检测，与当前方法所需的天数相比。公开了用于鉴定给定病症或疾病的诊断指标/靶标的方法，其包括用从特定抗原感染的人获得的生物流体免疫兽医受试者以鉴定免疫测定的诊断靶标。还公开了诊断和监测假单胞菌相关病症如蜜id病的方法。还提供了可用于诊断或监测假单胞菌相关病症治疗的功效的点护理免疫测定。这些免疫测定也可用于快速诊断由假单胞菌产生的感染，如蜜iod病。

73. 发明申请

US20140005074A1 METHOD FOR AUTOMATED, LARGE-SCALE MEASUREMENT OF THE MOLECULAR FLUX RATES OF THE PROTEOME OR THE ORGANEOME USING MASS SPECTROMETRY 有权
标题翻译：自动化方法，大规模测量保护剂或使用大量光谱的有机物的分子量
公开(公告)号：US20140005074A1
公开(公告)日：2014-01-02
申请号：US13922207
申请日：2013-06-19
申请人： The Regents of the University of California
发明人： Marc K. Hellerstein
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , A61K49/0002 , G01N33/6803 , G01N2458/15 , G01N2500/10 , G01N2570/00 , G01N2800/52 , G06Q50/22 , Y10T436/24
摘要： Disclosed here is a method for measuring the kinetics (i.e., the molecular flux rates—synthesis and breakdown or removal rates) of a plurality of proteins or organic metabolites in living systems. The methods may be accomplished in a high-throughput, large-scale automated manner, by using existing mass spectrometric profiling techniques and art well known in the fields of static proteomics and static organeomics, without the need for additional biochemical preparative steps or analytic/instrumental devices.
摘要翻译：这里公开了用于测量生物系统中多种蛋白质或有机代谢物的动力学（即分子通量速率 - 合成和分解或除去速率）的方法。这些方法可以通过使用现有的质谱分析技术和静态蛋白质组学和静态组织学领域众所周知的技术，以高通量，大规模的自动化方式完成，而不需要额外的生物化学制备步骤或分析/仪器设备。

74. 发明授权

US08574434B2 Integrated high throughput system for the analysis of biomolecules 有权
公开(公告)号：US08574434B2
公开(公告)日：2013-11-05
申请号：US13764394
申请日：2013-02-11
申请人： Intrinsic Bioprobes, Inc.
发明人： Kemmons Tubbs , Karl F. Gruber , Randall W. Nelson
IPC分类号： B01D15/08
CPC分类号： G01N33/6845 , B01J20/28097 , B01J20/281 , B01J20/286 , B01J20/32 , B01J20/3204 , B01J20/3208 , B01J20/3242 , B01J20/3259 , B01J20/3265 , B01J20/3272 , B01J20/3274 , B01J20/3282 , B01J2220/54 , B01J2220/64 , B82Y30/00 , G01N30/02 , G01N30/48 , G01N30/6095 , G01N33/54366 , G01N33/545 , G01N33/6803 , G01N2570/00 , H01J49/164 , H01J49/40 , Y10T436/255 , B01D15/3804
摘要： Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules.

75. 发明申请

US20130231387A1 PREVENTION OF PROTEOMIC AND GENOMIC DAMAGE BY DICARBONYL SUBSTRATES OF GLO 1 有权
标题翻译：通过GLO 1的二甲基苯基防止预防和遗传损伤1
公开(公告)号：US20130231387A1
公开(公告)日：2013-09-05
申请号：US13806176
申请日：2011-06-20
申请人： Mingzhan Xue , Paul Thornalley , Naila Rabbani
发明人： Mingzhan Xue , Paul Thornalley , Naila Rabbani
IPC分类号： A61K31/26 , C07C331/22 , A61K45/06 , C07C331/20
CPC分类号： A61K31/26 , A61K45/06 , C07C331/20 , C07C331/22 , C12N9/88 , C12Q1/25 , G01N2500/00 , G01N2570/00 , A61K2300/00
摘要： The invention concerns the role of Glo 1 in the prevention and reversal of proteomic and genomic damage by carbonyl substrates thereof and, in particular, therapeutics that promote Glo 1 production.
摘要翻译：本发明涉及Glo1在其羰基底物，特别是促进Glo1产生的治疗剂中预防和逆转蛋白质组学和基因组损伤的作用。

76. 发明申请

US20130045217A1 LIPIDOMIC BIOMARKERS FOR ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASE 有权
公开(公告)号：US20130045217A1
公开(公告)日：2013-02-21
申请号：US13695766
申请日：2011-05-05
申请人： Reijo Laaksonen , Kim Ekroos , Reini Hurme , Minna Janis , Riika Katainen , Kirill Tarasov
发明人： Reijo Laaksonen , Kim Ekroos , Reini Hurme , Minna Janis , Riika Katainen , Kirill Tarasov
IPC分类号： G01N33/92 , G01N24/08 , G01N33/53 , G01N30/02 , G01N21/45 , A61K31/455 , A61K31/56 , A61P9/10 , A61P9/00 , A61K31/40 , A61K31/4418 , A61K31/405 , A61K31/366 , A61K31/47 , A61K31/22 , A61K31/505 , A61K39/395 , G01N27/62
CPC分类号： G01N33/92 , A61K31/366 , A61K31/397 , G01N2405/04 , G01N2570/00 , G01N2800/32 , G01N2800/323 , G01N2800/324 , G01N2800/325 , G01N2800/50 , G01N2800/52
摘要： The present invention inter alia provides a method, and use thereof, of diagnosing and/or predicting atherosclerosis or CVD by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in detecting and predicting atherosclerosis and CVD than currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating atherosclerosis or CVD. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of atherosclerosis or CVD.

77. 发明申请

US20120283954A1 Method for quantitative analysis of complex proteomic data 审中-公开
标题翻译：复杂蛋白质组学数据定量分析方法
公开(公告)号：US20120283954A1
公开(公告)日：2012-11-08
申请号：US13068026
申请日：2011-05-02
申请人： Tyler Stuart Bray , Juliesta Elaine Sylvester , Stephen Joseph Kron
发明人： Tyler Stuart Bray , Juliesta Elaine Sylvester , Stephen Joseph Kron
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G06F19/24 , G01N33/6848 , G01N2570/00
摘要： This invention is a novel method for analysis of data that is produced by test equipment. The preferred embodiment is data produced by liquid chromatography tandem mass spectrometry (LC-MS/MS) equipment, using industry standard methods to generate the initial data from the test equipment. The invention is a method for processing of the data to promptly produce accurate, reliable, and meaningful data that can be used for critical decisions. The unique benefit of the method is to correct the multiple measurement and calculation errors that are inherent in the operation of laboratory equipment. Prior methods result in errors based on circumstances that are difficult to control, accuracy-related errors in machine measurements, and fundamental mathematical errors in the data processing software that used with the laboratory equipment. As an added benefit, this novel method allows comprehensive simultaneous measurement and calculation of correlation of any and all peptide pairs in a single measurement, with the capability to support repeated measurements with changed conditions over time. This novel method allows robust, detailed, and comprehensive measurements of peptide activity and function, which results in substantial improvements over prior methods in accuracy, reliability, and efficiency.
摘要翻译：本发明是用于分析由测试设备产生的数据的新颖方法。优选的实施方案是通过液相色谱串联质谱（LC-MS / MS）设备产生的数据，使用工业标准方法从测试设备产生初始数据。本发明是一种处理数据以便及时产生可用于关键决策的准确，可靠和有意义的数据的方法。该方法的独特优点是校正实验室设备运行中固有的多重测量和计算误差。先前的方法根据难以控制的情况，机器测量中的准确度相关错误以及与实验室设备一起使用的数据处理软件中的基本数学错误导致错误。作为附加的益处，该新方法允许在单个测量中全面同时测量和计算任何和所有肽对的相关性，并具有支持随时间变化的条件重复测量的能力。这种新颖的方法可以对肽活性和功能进行稳健，详细和全面的测量，与现有方法相比，精确度，可靠性和效率都有显着改善。

78. 发明申请

US20120258123A1 BIOMARKERS FOR SENSITIVE DETECTION OF STATIN-INDUCED MUSCLE TOXICITY 有权
标题翻译：敏感性检测不育诱导的肌肉毒性的生物标志物
公开(公告)号：US20120258123A1
公开(公告)日：2012-10-11
申请号：US13332773
申请日：2011-12-21
申请人： Reijo Laaksonen , Kim Ekroos , Reini Hurme , Minna Jänis , Riikka Katainen , Kirill Tarasov
发明人： Reijo Laaksonen , Kim Ekroos , Reini Hurme , Minna Jänis , Riikka Katainen , Kirill Tarasov
IPC分类号： A61K31/40 , C07C57/03 , A61K39/395 , A61K31/575 , C07C57/26 , G01B9/02 , A61K31/404 , A61K31/351 , A61K31/47 , A61K31/506 , G01N30/00 , H01J49/26 , G01N33/53 , A61K31/4418
CPC分类号： G01N33/92 , G01N2570/00 , G01N2800/10 , G01N2800/2871 , G01N2800/325
摘要： The present invention inter alia provides a method, and uses thereof, of predicting statin-induced muscle toxicity or its complications, such as myalgia, myopathy and rhabdomyolysis, by detecting the lipid concentrations or lipid-lipid concentration ratios of a biological sample and comparing them to a control. This method has identified lipid markers that are more specific and sensitive in detecting these statin-induced muscle toxicity than the currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting, diagnosing, statin-induced muscle toxicity. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of statin-induced muscle toxicity.
摘要翻译：本发明尤其提供了通过检测生物样品的脂质浓度或脂质 - 脂质浓度比例来预测他汀类药物诱发的肌肉毒性或其并发症如肌痛，肌病和横纹肌溶解症的方法及其用途，并比较它们控制。该方法已经鉴定了在检测这些他汀类药物诱导的肌肉毒性中比目前使用的临床标记物更具特异性和更灵敏的脂质标记物。还提供了针对所述脂质的抗体及其用于预测，诊断他汀类药物诱导的肌肉毒性的用途。本发明还涉及包含脂质和/或其抗体的试剂盒，用于预测和/或诊断他汀类药物诱导的肌肉毒性。

79. 发明申请

US20120053073A1 Methods for Detecting Signatures of Disease or Conditions in Bodily Fluids 审中-公开
标题翻译：检测身体疾病或病症签名的方法
公开(公告)号：US20120053073A1
公开(公告)日：2012-03-01
申请号：US13188683
申请日：2011-07-22
申请人： Amin I. Kassis
发明人： Amin I. Kassis
IPC分类号： C40B30/04 , C12Q1/02 , G01N33/577
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , G01N33/5091 , G01N33/57484 , G01N2570/00
摘要： This invention provides methods of using cell free bodily fluid and blood cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also relates to methods of using cell free bodily fluid and blood cells to identify markers of diseases or conditions.
摘要翻译：本发明提供了在诊断，预后或监测疾病或病症中使用无细胞体液和血细胞的方法。本发明还涉及使用无细胞的体液和血细胞鉴定疾病或病症的标志物的方法。

80. 发明申请

US20110192778A1 INTEGRATED HIGH THROUGHPUT SYSTEM FOR THE ANALYSIS OF BIOMOLECULES 有权
标题翻译：用于分析生物分子的综合高通量系统
公开(公告)号：US20110192778A1
公开(公告)日：2011-08-11
申请号：US13035942
申请日：2011-02-26
申请人： Kemmons A. Tubbs , Karl F. Gruber , Randall W. Nelson
发明人： Kemmons A. Tubbs , Karl F. Gruber , Randall W. Nelson
IPC分类号： B01D15/08
CPC分类号： G01N33/6845 , B01J20/28097 , B01J20/281 , B01J20/286 , B01J20/32 , B01J20/3204 , B01J20/3208 , B01J20/3242 , B01J20/3259 , B01J20/3265 , B01J20/3272 , B01J20/3274 , B01J20/3282 , B01J2220/54 , B01J2220/64 , B82Y30/00 , G01N30/02 , G01N30/48 , G01N30/6095 , G01N33/54366 , G01N33/545 , G01N33/6803 , G01N2570/00 , H01J49/164 , H01J49/40 , Y10T436/255 , B01D15/3804
摘要： Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules.
摘要翻译：描述了一种亲和力微柱，其包含高表面积材料，其具有包含在壳体内的高流动性和低死体积，并且具有结合到高表面积材料的表面的亲和试剂，其被激活或可激活。结合亲和微柱表面的亲和试剂还包含用于整合生物分子的高通量分析的亲和受体。

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