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71. 发明申请

US20140171380A1 Screening Assays Using Stem Cells and Stem Cell-Derived Neurons from Mouse Models of Alzheimer's Disease 有权
标题翻译：使用干细胞和来自阿尔茨海默氏病的小鼠模型的干细胞衍生的神经元的筛选测定
公开(公告)号：US20140171380A1
公开(公告)日：2014-06-19
申请号：US14020776
申请日：2013-09-06
申请人： The Trustees of Columbia University in the City of New York
发明人： Tae-Wan Kim , Laura Beth Johnson McIntire , Natalie Landman , Gina Finan
IPC分类号： G01N33/569 , A61K31/01 , A61K31/145 , A61K31/5375 , A61K31/15 , A61K31/7048 , A61K31/473 , A61K31/137 , A61K31/41
CPC分类号： G01N33/56966 , A61K31/01 , A61K31/03 , A61K31/085 , A61K31/137 , A61K31/145 , A61K31/15 , A61K31/41 , A61K31/473 , A61K31/5375 , A61K31/7048 , C12N5/0619 , C12N2501/385 , C12N2506/02 , C12N2533/50 , C12N2533/52 , G01N33/5058 , G01N2800/2821
摘要： Successful CNS drug discovery requires a scalable, highly physiological neuronal model. Using directed differentiation of mouse embryonic stem (mES) cells, including mES cells isolated from a mouse model of Alzheimer's disease (AD), a highly homogeneous primary neuronal model amenable to phenotypic assays for production and synaptotoxicity of amyloid β-peptide was developed. This model furnishes a highly physiological and AD-relevant platform suitable for high throughput small molecule and functional genetic screens, providing specific small molecule compounds identified by such screens.
摘要翻译：成功的CNS药物发现需要可扩展的，高度生理的神经元模型。使用小鼠胚胎干（mES）细胞的定向分化，包括从阿尔茨海默氏病（AD）的小鼠模型分离的mES细胞，开发了适合淀粉样蛋白和生物肽的生产表型测定和突触毒性的高度均一的原代神经元模型。该模型提供高生理和AD相关平台，适用于高通量小分子和功能遗传筛选，提供通过这种筛选鉴定的特异性小分子化合物。

72. 发明申请

US20140161753A1 Self-Assembling Peptide and Peptide Gel with High Strength 审中-公开
标题翻译：自组装肽和肽凝胶高强度
公开(公告)号：US20140161753A1
公开(公告)日：2014-06-12
申请号：US13929279
申请日：2013-06-27
申请人： NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MENICON CO., LTD.
发明人： YUSUKE NAGAI , HIDENORI YOKOI , KOJI UESUGI , KEIJI NARUSE , SHUGUANG ZHANG
IPC分类号： C07K7/08 , C10M173/02 , A61K47/42
CPC分类号： C07K7/08 , A61K8/64 , A61K9/0048 , A61K9/06 , A61K38/10 , A61K47/42 , A61L15/60 , A61L27/227 , A61L27/52 , A61L29/145 , A61L31/10 , A61L31/145 , A61Q5/00 , A61Q19/00 , B01J20/28047 , C10M173/02 , C12N5/0068 , C12N5/0656 , C12N5/0658 , C12N2533/50
摘要： Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
摘要翻译：提供具有实际足够的机械强度的肽凝胶和能够形成肽凝胶的自组装肽。自组装肽由以下氨基酸序列形成：a1b1c1b2a2b3db4a3b5c2b6a4其中：a1至a4各自表示碱性氨基酸残基; b1至b6各自表示不带电极性氨基酸残基和/或疏水性氨基酸残基，条件是其至少5个各自表示疏水性氨基酸残基; c1和c2各自表示酸性氨基酸残基; d表示疏水性氨基酸残基。

73. 发明申请

US20140093958A1 HYDROGEL COMPOSITION AND USES THEREOF 审中-公开
标题翻译：水凝胶组合物及其用途
公开(公告)号：US20140093958A1
公开(公告)日：2014-04-03
申请号：US14119587
申请日：2012-05-16
申请人： UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO"
发明人： Filippo Reno , Mario Cannas
IPC分类号： A61K35/36
CPC分类号： A61K35/36 , A61L27/3813 , A61L27/52 , A61L27/60 , C12N5/0068 , C12N5/0629 , C12N2533/50 , C12N2533/54
摘要： Hydrogel composition comprising gelatin, poly-glutamic acid and epiregulin suitable for cultivating keratinocytes, preferably human keratinocytes.
摘要翻译：水凝胶组合物，其包含明胶，聚谷氨酸和适用于培养角质形成细胞，优选人角质形成细胞的表孕调制蛋白。

74. 发明授权

US08518390B2 Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells 有权
标题翻译：通过鼻内给药脐带细胞治疗中风和其他急性神经退行性疾病
公开(公告)号：US08518390B2
公开(公告)日：2013-08-27
申请号：US13184378
申请日：2011-07-15
申请人： Brian C. Kramer , Anthony J. Kihm
发明人： Brian C. Kramer , Anthony J. Kihm
IPC分类号： C12N5/00 , C12N5/071
CPC分类号： A61K35/30 , A61K35/48 , A61K35/51 , A61K38/13 , A61K38/47 , C12N5/0605 , C12N5/0668 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2533/50 , A61K2300/00
摘要： This invention relates to methods of treating stroke by intranasal administration of umbilical cord tissue-derived cells, which are isolated from mammalian umbilical cord tissue substantially free of blood or expanded in culture from a cell isolated from mammalian umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, and do not produce CD117 and/or telomerase. The methods of the invention regenerate, repair and improve neural tissue and improve behavior and neurological function in stroke patients.
摘要翻译：本发明涉及通过鼻内施用脐带组织来源的细胞来治疗中风的方法，所述细胞从基本上不含血液的哺乳动物脐带组织分离，或从基本上不含血液的哺乳动物脐带组织分离的细胞中扩增培养物能够自我更新和扩大文化，不生产CD117和/或端粒酶。本发明的方法再生，修复和改善神经组织，改善中风患者的行为和神经功能。

75. 发明申请

US20130171712A1 CULTURE METHOD AND CULTURE DEVICE 有权
标题翻译：文化方法和文化设备
公开(公告)号：US20130171712A1
公开(公告)日：2013-07-04
申请号：US13820907
申请日：2011-09-08
申请人： Junji Fukuda , Hiroaki Suzuki , Naoto Mochizuki , Takahiro Kakegawa
发明人： Junji Fukuda , Hiroaki Suzuki , Naoto Mochizuki , Takahiro Kakegawa
IPC分类号： C12N11/02
CPC分类号： C12N11/02 , C12M23/12 , C12M25/08 , C12M33/00 , C12N5/0068 , C12N2509/00 , C12N2529/00 , C12N2533/50
摘要： Provided are a culture method and a culture device for efficiently producing cells and/or cell tissue suitable for medication applications. A culture method of culturing cells adhered onto an electrode layer, the method including: a first step of adhering the cells onto the electrode layer and culturing the cells thereon, the electrode layer being coated with an oligopeptide including: a terminal amino acid; a cell adhesive sequence; and an alternating sequence to be bound to the one end side of the cell-adhesive sequence, the alternating sequence including a plurality of acidic amino acids and a plurality of basic amino acids, being alternately bound to each other one by one; and a second step of applying, to the electrode layer having the cells adhered thereonto, an electrical potential inducing reductive desorption of the oligopeptide, to thereby detach the cells from the electrode layer.
摘要翻译：提供了用于有效地产生适合于药物应用的细胞和/或细胞组织的培养方法和培养装置。一种培养附着在电极层上的细胞的培养方法，所述方法包括：将细胞粘附到电极层上并在其上培养细胞的第一步骤，所述电极层涂覆有包含末端氨基酸的寡肽; 细胞粘附序列; 以及与细胞粘合剂序列的一端侧结合的交替序列，包含多个酸性氨基酸和多个碱性氨基酸的交替序列彼此交替结合; 以及第二步骤，将具有附着于其上的细胞的电极层应用于引起寡肽的还原性解吸的电位，从而将电极从电极层分离。

76. 发明申请

US20130078656A1 ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE 有权
标题翻译：人工免疫系统：使用方法
公开(公告)号：US20130078656A1
公开(公告)日：2013-03-28
申请号：US13608579
申请日：2012-09-10
申请人： William L. WARREN , Heather FAHLENKAMP , Russell HIGBEE , Anatoly KACHURIN , Conan LI , Mike NGUYEN , Robert PARKHILL , Guzman SANCHEZ-SCHMITZ , Darrell J. IRVINE , Gwendalyn J. RANDOLPH , Nir HACOHEN , Bruce TORBETT
发明人： William L. WARREN , Heather FAHLENKAMP , Russell HIGBEE , Anatoly KACHURIN , Conan LI , Mike NGUYEN , Robert PARKHILL , Guzman SANCHEZ-SCHMITZ , Darrell J. IRVINE , Gwendalyn J. RANDOLPH , Nir HACOHEN , Bruce TORBETT
IPC分类号： C12N5/071
CPC分类号： G01N33/5008 , C12N5/0697 , C12N5/0698 , C12N2501/21 , C12N2502/094 , C12N2502/11 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/1157 , C12N2502/1192 , C12N2502/1323 , C12N2502/28 , C12N2503/04 , C12N2513/00 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5088 , G01N2500/10
摘要： The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
摘要翻译：本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。人工免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。

77. 发明申请

US20130040357A1 Hydrogel Precursor Formulation and Production Process Thereof 审中-公开
标题翻译：水凝胶前体制剂及其制备方法
公开(公告)号：US20130040357A1
公开(公告)日：2013-02-14
申请号：US13640141
申请日：2011-04-19
申请人： Simone Rizzi , Matthias Lutolf
发明人： Simone Rizzi , Matthias Lutolf
IPC分类号： C08G75/23 , C12N11/04 , C09K3/00
CPC分类号： C12N5/0068 , C08G65/3344 , C12N2533/30 , C12N2533/50
摘要： The present invention relates to a hydrogel precursor formulation, its process of production as well as a kit comprising said formulation and a method of production of a hydrogel using said formulation. The precursor formulation comprises at least one structural compound, preferably vinyl sulfone (acrylated branched) poly(ethylene glycol), and at least one linker compound, preferably a peptide with two cysteines, wherein said structural compound and said linker compound are polymerizable by a selective reaction between a nucleophile and a conjugated unsaturated bond or group. The precursor formulation is in the form of a powder.
摘要翻译：本发明涉及水凝胶前体制剂，其制备方法以及包含所述制剂的试剂盒和使用所述制剂生产水凝胶的方法。前体制剂包含至少一种结构化合物，优选乙烯基砜（丙烯酸酯化支链）聚（乙二醇）和至少一种接头化合物，优选具有两个半胱氨酸的肽，其中所述结构化合物和所述接头化合物可通过选择性亲核试剂与共轭不饱和键或基团之间的反应。前体制剂是粉末形式。

78. 发明授权

US08349588B2 Recombinant XRGD-enriched gelatins having high stability 有权
标题翻译：具有高稳定性的重组XRGD富集明胶
公开(公告)号：US08349588B2
公开(公告)日：2013-01-08
申请号：US12527937
申请日：2008-02-21
申请人： Arjo Lysander De Boer , Hendrik Van Urk , Jan Bastiaan Bouwstra , Peter Franciscus Theresius Maria Van Asten
发明人： Arjo Lysander De Boer , Hendrik Van Urk , Jan Bastiaan Bouwstra , Peter Franciscus Theresius Maria Van Asten
IPC分类号： C12P21/06 , C07K14/00
CPC分类号： C07K14/78 , A61K38/00 , C12N2531/00 , C12N2533/50
摘要： The invention concerns recombinant gelatin monomers and recombinant gelatins comprising or consisting of multimers of the monomers. The recombinant gelatins are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.
摘要翻译：本发明涉及包含单体多聚体或由多单体组成的重组明胶单体和重组明胶。重组明胶在涉及细胞附着的几个应用中特别有用，例如在细胞培养工作和涉及锚定依赖细胞的细胞培养物的应用以及各种医学应用中。

79. 发明授权

US08318483B2 Postpartum cells derived from umbilical cord tissue, and methods of making and using the same 有权
标题翻译：来自脐带组织的产后细胞，以及制造和使用它们的方法
公开(公告)号：US08318483B2
公开(公告)日：2012-11-27
申请号：US11481456
申请日：2006-07-06
申请人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Anna Gosiewska
IPC分类号： C12N5/00
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
摘要翻译：公开了源自人脐带的细胞及其治疗用途的方法。描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。

80. 发明申请

US20120296443A1 SERICIN EXTRACTED FABRICS 有权
公开(公告)号：US20120296443A1
公开(公告)日：2012-11-22
申请号：US13561949
申请日：2012-07-30
申请人： Gregory H. Altman , Jingsong Chen , Rebecca Horan , David J. Horan
发明人： Gregory H. Altman , Jingsong Chen , Rebecca Horan , David J. Horan
IPC分类号： A61F2/02
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.

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