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71. 发明申请

US20150067898A1 EFFICIENT NON-MEIOTIC ALLELE INTROGRESSION 有权
标题翻译：有效的非计量性能
公开(公告)号：US20150067898A1
公开(公告)日：2015-03-05
申请号：US14263446
申请日：2014-04-28
申请人： Recombinetics, Inc.
发明人： Scott C. Fahrenkrug , Daniel F. Carlson
IPC分类号： C12N15/90 , C12N15/85
CPC分类号： C12N15/85 , A01K67/0275 , C07K14/47 , C07K14/715 , C12N15/8509 , C12N15/8771 , C12N15/8778 , C12N15/907 , C12N2750/14143 , C12N2800/30 , C12N2800/90
摘要： Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.
摘要翻译：方法，用途和动物对动物之间的等位基因进行渗入，包括SNP。一个实施方案涉及将靶向靶向内切核酸酶系统和HDR模板引入具有靶向内切核酸酶与靶位点的结合不匹配的细胞中。

72. 发明申请

US20140221734A1 CLONED NON-HUMAN ANIMALS FREE OF SELECTIVE MARKERS 审中-公开
标题翻译：克隆的非人类动物没有选择性标记
公开(公告)号：US20140221734A1
公开(公告)日：2014-08-07
申请号：US14091207
申请日：2013-11-26
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Guochun Gong , Ka-Man Venus Lai , David M. Valenzuela
IPC分类号： A01K67/027 , A61D19/04 , C12N15/877
CPC分类号： A61D19/04 , A01K67/0273 , A01K67/0275 , A01K2217/00 , A01K2217/203 , A01K2227/10 , A01K2267/01 , C12N15/8771 , C12N15/8778 , C12N2800/30 , C12N2830/008 , C12N2840/007 , C12N2999/007
摘要： Genetically modified somatic cells of a non-human animal are provided that are engineered to contain a self-excisable, recombinase expression cassette comprising a site-specific recombinase gene operably linked to an ES cell-specific promoter. Compositions and methods for producing a genetically modified, cloned non-human animal that is free of a selective marker gene and a recombinase gene are provided, wherein a targeting construct comprising a self-excisable recombinase gene operably linked to an ES cell-specific promoter is introduced into differentiated somatic cells. The genetically modified genome of the somatic cells is transferred into an enucleated host oocyte. The artificially created zygote is then cultured in vitro until the blastocyst embryonic stage and subsequently implanted into a uterus of a surrogate mother to form a genetically modified, cloned non-human animal free of selective marker and recombinase genes.
摘要翻译：提供了非人类动物的遗传修饰的体细胞，其被工程改造成含有可自动切除的重组酶表达盒，其包含与ES细胞特异性启动子可操作地连接的位点特异性重组酶基因。提供了一种用于产生无选择性标记基因和重组酶基因的经遗传修饰的克隆非人动物的组合物和方法，其中包含与ES细胞特异性启动子可操作地连接的可自我切除的重组酶基因的靶向构建体是引入分化的体细胞。将体细胞的遗传修饰的基因组转移到去核的宿主卵母细胞中。然后将人造创造的受精卵体外培养直到胚泡胚胎阶段，随后植入代孕母亲的子宫中以形成无选择性标记和重组酶基因的遗传修饰的克隆非人动物。

73. 发明授权

US08581021B2 Pig whose genome comprises a heterologous site-specific recombination site and a transpohon tag 有权
标题翻译：一种猪，其基因组包含异源位点特异性重组位点和转座子标签
公开(公告)号：US08581021B2
公开(公告)日：2013-11-12
申请号：US12529958
申请日：2008-03-07
申请人： Jacob Giehm Mikkelsen , Brian Moldt , Anders Lade Nielsen , Lars Axel Bolund , Peter Michael Kragh , Jannik Ejnar Jakobsen , Arne Lund Jørgensen
发明人： Jacob Giehm Mikkelsen , Brian Moldt , Anders Lade Nielsen , Lars Axel Bolund , Peter Michael Kragh , Jannik Ejnar Jakobsen , Arne Lund Jørgensen
IPC分类号： A01K67/00 , C12N15/00
CPC分类号： A01K67/0275 , A01K67/0273 , A01K2217/05 , A01K2227/108 , A01K2267/035 , C12N15/8509 , C12N15/8778 , C12N2800/30 , C12N2800/90 , C12N2840/203
摘要： The present invention relates to a genetically modified pig comprising at least one site for integration of at least one transgene. The invention also pertains to a porcine embryo, blastocyst, fetus, donor cell and/or cell nucleus, derived from said genetically modified pig. In another aspect, the invention relates to any genetically modified porcine blastocyst, wherein the genetically modified genome comprises at least one site for integration of at least one transgene.
摘要翻译：本发明涉及包含至少一个用于整合至少一个转基因的位点的转基因猪。本发明还涉及源自所述转基因猪的猪胚，胚泡，胎儿，供体细胞和/或细胞核。另一方面，本发明涉及任何遗传修饰的猪胚泡，其中所述经遗传修饰的基因组包含至少一个用于整合至少一个转基因的位点。

74. 发明授权

US08173861B2 Transgenic pig model for a hereditary neurodegenerative autosomal dominant disease 失效
标题翻译：用于遗传性神经退行性常染色体显性疾病的转基因猪模型
公开(公告)号：US08173861B2
公开(公告)日：2012-05-08
申请号：US12298974
申请日：2007-04-30
申请人： Lone Bruhn Madsen , Christian Bendixen , Knud Larsen , Connie Jakobsen Juhl , Bo Thomsen
发明人： Lone Bruhn Madsen , Christian Bendixen , Knud Larsen , Connie Jakobsen Juhl , Bo Thomsen
IPC分类号： C12N15/00 , A01K67/027 , G01N33/00
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/00 , A01K2217/056 , A01K2227/108 , A01K2267/03 , A01K2267/0306 , A01K2267/0312 , A01K2267/0318 , A01K2267/035 , A61K49/0008 , C07K14/4711 , C12N15/8509 , C12N15/8778
摘要： The present invention discloses a non-human animal model for a hereditary autosomal dominant disease. The non-human animal model expresses at least one phenotype associated with the disease and is obtained by a genetic determinant. The invention also relates to sperm cells and embryos comprising the genetic determinant for an autosomal dominant disease. Furthermore, methods for producing the non-human animal model, sperm cell, and embryos are disclosed.
摘要翻译：本发明公开了一种遗传性常染色体显性疾病的非人动物模型。非人动物模型表达与该疾病相关的至少一种表型，并由遗传决定簇获得。本发明还涉及包含常染色体显性疾病的遗传决定簇的精子细胞和胚胎。此外，公开了用于生产非人动物模型，精子细胞和胚胎的方法。

75. 发明申请

US20100154069A1 PIG MODEL 有权
标题翻译： PIG型号
公开(公告)号：US20100154069A1
公开(公告)日：2010-06-17
申请号：US12529958
申请日：2008-03-07
申请人： Jacob Giehm Mikkelsen , Brian Moldt , Anders Lade Nielsen , Lars Axel Bolund , Peter Michael Kragh , Jannik Ejnar Jakobsen , Arne Lund Jørgensen
发明人： Jacob Giehm Mikkelsen , Brian Moldt , Anders Lade Nielsen , Lars Axel Bolund , Peter Michael Kragh , Jannik Ejnar Jakobsen , Arne Lund Jørgensen
IPC分类号： A01K67/027 , C12N5/10 , C12N15/85 , C12N15/09 , A01K67/02
CPC分类号： A01K67/0275 , A01K67/0273 , A01K2217/05 , A01K2227/108 , A01K2267/035 , C12N15/8509 , C12N15/8778 , C12N2800/30 , C12N2800/90 , C12N2840/203
摘要： The present invention relates to a genetically modified pig comprising at least one site for integration of at least one transgene. The invention also pertains to a porcine embryo, blastocyst, foetus, donor cell and/or cell nucleus, derived from said genetically modified pig. In another aspect, the invention relates to any genetically modified porcine blastocyst, wherein the genetically modified genome comprises at least one site for integration of at least one transgene.
摘要翻译：本发明涉及包含至少一个用于整合至少一个转基因的位点的转基因猪。本发明还涉及源自所述转基因猪的猪胚，胚泡，胎儿，供体细胞和/或细胞核。另一方面，本发明涉及任何遗传修饰的猪胚泡，其中所述经遗传修饰的基因组包含至少一个用于整合至少一个转基因的位点。

76. 发明授权

US07547522B2 Method to enrich for α(1,3)-galactosyltransferase null pig cells 有权
标题翻译：富含α（1,3） - 半乳糖转移酶无效猪细胞的方法
公开(公告)号：US07547522B2
公开(公告)日：2009-06-16
申请号：US10524381
申请日：2003-08-13
申请人： Robert J. Hawley
发明人： Robert J. Hawley
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/108 , A01K2267/025 , C12N5/0611 , C12N9/1051 , C12N15/8509 , C12N15/8778 , C12N2517/02 , C12N2517/04
摘要： The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The invention provides a method of selecting GGTA 1 null cells, a viable GGTA 1 null swine, methods for making such swine, and methods of using cells, tissues and organs of such swine for xenotransplantation.
摘要翻译：本发明涉及非人类动物的遗传操作。更具体地说，本发明涉及用于异种移植的非人动物的遗传操作。本发明提供了选择GGTA1无效细胞的方法，可行的GGTA 1无效猪，制备这种猪的方法，以及使用这种猪的细胞，组织和器官进行异种移植的方法。

77. 发明授权

US07531715B1 Double nuclear transfer method and results thereof 有权
标题翻译：双核转移法及其结果
公开(公告)号：US07531715B1
公开(公告)日：2009-05-12
申请号：US09600130
申请日：2000-01-13
申请人： Keith H. S. Campbell
发明人： Keith H. S. Campbell
IPC分类号： C12N15/00 , C12N5/00 , C12N5/02 , G01N33/00 , A01K67/027
CPC分类号： C12N15/8778 , A01K67/0273 , A01K2227/101 , A01K2227/108 , C12N15/8773
摘要： A method is described for the production of an animal (offspring) by the process of nuclear transfer. The animal may be produced using donor genetic material in cells taken directly from any stage of an animal, such as an embryo, foetus or adult or from cell cultures established from material from any stage of an animal, such as embryonic, foetal or adult material. The process may be used to introduce genetic modifications into the resultant offspring by genetic manipulation and selection of the cells to act as nuclear donors prior to embryo reconstruction.The present invention provides a method of reconstituting an animal embryo, the process comprising transferring a nucleus into a first oocyte followed by removing and transferring the nucleus from the oocyte to a further oocyte or to an enucleated fertilized zygote.
摘要翻译：描述了通过核转移过程生产动物（后代）的方法。可以使用来自动物（例如胚胎，胎儿或成年人）的任何阶段的细胞中的供体遗传物质产生动物，或者可以从动物任何阶段的材料建立的细胞培养物，例如胚胎，胎儿或成人材料。该过程可以用于通过遗传操作和细胞的选择将遗传修饰引入所产生的后代中，以在胚胎重建之前充当核供体。本发明提供了一种重建动物胚胎的方法，该方法包括将细胞核转移到第一卵母细胞中，然后将细胞核从卵母细胞去除并转移到另外的卵母细胞或去核受精受精受精卵。

78. 发明申请

US20090092588A1 Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease 审中-公开
标题翻译：克隆有蹄类动物的胚胎和动物，使用细胞，组织和器官进行移植治疗，包括帕金森病
公开(公告)号：US20090092588A1
公开(公告)日：2009-04-09
申请号：US11529720
申请日：2006-09-26
申请人： Steven Stice , Jose Cibelli , James Robl , Paul Golueke , F. Abel Ponce De Leon , D. Joseph Jerry
发明人： Steven Stice , Jose Cibelli , James Robl , Paul Golueke , F. Abel Ponce De Leon , D. Joseph Jerry
IPC分类号： A61K35/12 , C12N15/87 , C12N5/08
CPC分类号： A01K67/02 , A01K67/027 , A01K67/0271 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/101 , A61K35/12 , A61K35/30 , A61K38/00 , C12N5/0603 , C12N15/8771 , C12N15/8778 , C12N2510/00 , C12N2517/02 , C12N2517/04
摘要： Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease.
摘要翻译：提供用于克隆有蹄类胚胎和后代的方法和细胞系，特别是牛和猪。所产生的胎儿，胚胎或后代对于所需的异源DNA的表达特别有用，并且可以用作用于治疗诸如帕金森病之类疾病的移植治疗的细胞或组织来源。

79. 发明授权

US07087371B2 Material and methods for the production of sperm and analysis thereof 有权
标题翻译：用于生产精子的材料和方法及其分析
公开(公告)号：US07087371B2
公开(公告)日：2006-08-08
申请号：US10610302
申请日：2003-06-30
申请人： Ina Dobrinski , Stefan Schlatt , Ali Honaramooz , Hans Scholer
发明人： Ina Dobrinski , Stefan Schlatt , Ali Honaramooz , Hans Scholer
IPC分类号： A01N1/02
CPC分类号： A01K67/0271 , A01K2217/075 , A01K2227/102 , A01K2227/105 , A01K2227/106 , A01K2227/108 , C12N5/061 , C12N15/873 , C12N15/8772 , C12N15/8775 , C12N15/8778
摘要： Provided herein are methods of producing viable sperm from neonatal mammalian testes which have been engrafted in mice.
摘要翻译：本文提供了在新生儿哺乳动物睾丸中生产已经在小鼠中移植的活精子的方法。

80. 发明申请

US20050120400A1 Knockout swine and methods for making the same 有权
标题翻译：淘汰猪和做同样的方法
公开(公告)号：US20050120400A1
公开(公告)日：2005-06-02
申请号：US10499407
申请日：2002-12-23
申请人： Billy Day , Robert Hawley , Randall Prather
发明人： Billy Day , Robert Hawley , Randall Prather
IPC分类号： A01K67/027 , A61K48/00 , A61L27/00 , C12N5/10 , C12N9/10 , C12N15/06 , C12N15/09 , C12N15/85 , C12N15/877 , C12N5/06
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , A01K2267/03 , C12N9/1051 , C12N15/8778 , C12N2517/02 , C12N2800/60 , C12N2840/203 , C12N2840/85
摘要： The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The invention provides viable gene knockout swine including swine in which the α(1,3)-galactosyltransferase gene has been disrupted, methods for making such swine, and methods of using the tissues and organs of such swine for xenotransplantation.
摘要翻译：本发明涉及非人类动物的遗传操作。更具体地说，本发明涉及用于异种移植的非人动物的遗传操作。本发明提供了可行的基因敲除猪，包括其中α（1,3） - 半乳糖转移酶基因被破坏的猪，以及制备这种猪的方法，以及使用这种猪的组织和器官进行异种移植的方法。

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