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71. 发明授权

US08445272B2 Method of stimulating NKT with 6″-amino-6″-deoxygalactosylceramides 有权
标题翻译：用6“ - 氨基-6'-脱氧半乳糖神经酰胺刺激NKT细胞的方法
公开(公告)号：US08445272B2
公开(公告)日：2013-05-21
申请号：US13196631
申请日：2011-08-02
申请人： Paul B. Savage , Albert Bendelac , Luc Teyton
发明人： Paul B. Savage , Albert Bendelac , Luc Teyton
IPC分类号： C12N5/06 , C12N5/00 , A01N25/00 , A61K31/739
CPC分类号： C07H5/04 , C07H7/06 , C07H13/04 , C07H15/06
摘要： This invention relates to galactosylceramide compounds.
摘要翻译：本发明涉及半乳糖神经酰胺化合物。

72. 发明申请

US20110201795A1 Methods of Producing C-Aryl Glucoside SGLT2 Inhibitors 审中-公开
标题翻译：生产C-Aryl Glucoside SGLT2抑制剂的方法
公开(公告)号：US20110201795A1
公开(公告)日：2011-08-18
申请号：US13093430
申请日：2011-04-25
申请人： Prashant P. Deshpande , Bruce A. Ellsworth , Janak Singh , Theodor W. Denzel , Chiajen Lai , Gerard Crispino , Michael E. Randazzo , Jack Z. Gougoutas
发明人： Prashant P. Deshpande , Bruce A. Ellsworth , Janak Singh , Theodor W. Denzel , Chiajen Lai , Gerard Crispino , Michael E. Randazzo , Jack Z. Gougoutas
IPC分类号： C07H1/00 , C07H23/00 , C07H15/02
CPC分类号： C07H23/00 , C07H5/04 , C07H5/06 , C07H7/00 , C07H15/207
摘要： Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
摘要翻译：生产用于治疗糖尿病和相关疾病的C-芳基葡萄糖苷SGLT2抑制剂的方法。及其中间体。 C-芳基葡糖苷可以与形成氨基酸复合物的试剂络合。

73. 发明申请

US20110124558A1 NOVEL USES OF D-MANNOPYRANOSE DERIVATIVES ACTIVATING ANGIOGENESIS 有权
标题翻译：促进血管生成的D-甘露聚糖衍生物的新用途
公开(公告)号：US20110124558A1
公开(公告)日：2011-05-26
申请号：US12991512
申请日：2009-05-05
申请人： Jean-Louis Montero , Veronique Montero , Jean-Pierre Moles , Pascal De Santa Barbara , Bernard Jover
发明人： Jean-Louis Montero , Veronique Montero , Jean-Pierre Moles , Pascal De Santa Barbara , Bernard Jover
IPC分类号： A61K38/18 , A61K31/7028 , A61K38/27 , A61K38/30 , C07H15/04 , A61P9/00 , A61P7/02 , A61P21/00 , A61P35/00 , A61P17/14
CPC分类号： C07H5/04 , C07H11/00
摘要： The invention relates to the use of certain derivatives of D-mannopyranoside for controlling angiogenesis. These compounds have a pro-angiogenic activity, and can particularly be used for preparing a pharmaceutical composition for treating cardiovascular diseases or for treating muscular atrophy. The invention also relates to certain D-mannopyranoside derivatives, to a pharmaceutical or cosmetic composition containing said derivatives, and to the use of such a cosmetic composition for preventing and/or treating hair loss.
摘要翻译：本发明涉及D-甘露吡喃糖苷的某些衍生物用于控制血管发生的用途。这些化合物具有促血管生成活性，特别可用于制备治疗心血管疾病或治疗肌肉萎缩的药物组合物。本发明还涉及某些D-甘吡喃糖苷衍生物，含有所述衍生物的药物或化妆品组合物，以及这种化妆品组合物用于预防和/或治疗脱发的用途。

74. 发明授权

US07807771B2 Binder and fiber glass product from maillard reactants 有权
公开(公告)号：US07807771B2
公开(公告)日：2010-10-05
申请号：US11657911
申请日：2007-01-25
申请人： Brian Lee Swift , Ruijian Xu , Ronald E. Kissell
发明人： Brian Lee Swift , Ruijian Xu , Ronald E. Kissell
IPC分类号： C08F251/00 , C08G73/10 , C08K3/00
CPC分类号： C09D167/04 , B29C70/68 , C03C17/28 , C03C25/14 , C07H5/04 , C08F251/02 , C08L51/02 , C09D5/08 , C09D105/00 , E04B1/78 , E04B1/84 , E04B1/88 , F16L59/026 , F16L59/14 , Y10T428/31971 , Y10T442/60 , Y10T442/691 , C08L2666/02
摘要： The present disclosure is directed to cured and uncured binders useful in the fabrication of products from loosely assembled fibers. For example, the disclosure describes cured and uncured binders useful in the fabrication of products from loosely assembled glass fibers. The disclosure also describes methods of fabricating products from loosely assembled fibers utilizing the aforementioned binders.

75. 发明授权

US07776842B2 Amino sugar chelates 有权
标题翻译：氨基糖螯合物
公开(公告)号：US07776842B2
公开(公告)日：2010-08-17
申请号：US11466701
申请日：2006-08-23
申请人： Clayton Ericson , DeWayne Ashmead , Stephen D. Ashmead , Amanda Rees
发明人： Clayton Ericson , DeWayne Ashmead , Stephen D. Ashmead , Amanda Rees
IPC分类号： A61K31/7008 , A61K31/7012 , A61K31/70 , A61K31/715
CPC分类号： C07H5/04
摘要： The present invention includes amino sugar chelates and methods for preparing amino sugar chelates of the formula given below, where M is a metal; R2 and R3 are independently selected from H, OH and hydroxyl substituted C1-C8 alkyl; R4 is selected from H, CO2H, OH, and hydroxyl substituted C1-C8 alkyl; each R5 is independently selected from H, OH, and hydroxyl substituted C1-C8 alkyl; A is selected from CH and O; a is from 0-6; b is from 0-6; n is from 1 to 8. The amino sugar chelates may include matrix stabilizing salts. The compounds and compositions disclosed can be used as nutritional supplements to impart health benefits.
摘要翻译：本发明包括氨基糖螯合物和下式给出的氨基糖螯合物的方法，其中M是金属; R2和R3独立地选自H，OH和羟基取代的C1-C8烷基; R 4选自H，CO 2 H，OH和羟基取代的C 1 -C 8烷基; 每个R 5独立地选自H，OH和羟基取代的C 1 -C 8烷基; A选自CH和O; a是0-6; b为0-6; n为1至8.氨基糖螯合物可包括基质稳定盐。所公开的化合物和组合物可用作营养补充剂以赋予健康益处。

76. 发明申请

US20100035961A1 Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof 有权
标题翻译：由苄基取代的新的1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途
公开(公告)号：US20100035961A1
公开(公告)日：2010-02-11
申请号：US12465911
申请日：2009-05-14
申请人： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： A61K31/38 , C07D409/12 , A61P3/10 , A61P25/28 , A61P25/18
CPC分类号： C07H5/06 , A61K31/38 , A61K31/7028 , A61K45/06 , C07D409/12 , C07H5/04 , C07H7/02 , C07H7/027 , C07H13/12 , C07H15/26 , A61K2300/00
摘要： This invention relates to Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof.
摘要翻译：本发明涉及由苄基取代的新型1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途。

77. 发明授权

US07655429B2 Immunoassays for topiramate 有权
标题翻译：托吡酯的免疫测定
公开(公告)号：US07655429B2
公开(公告)日：2010-02-02
申请号：US11858426
申请日：2007-09-20
申请人： Anlong Ouyang , Lili Arabshahi
发明人： Anlong Ouyang , Lili Arabshahi
IPC分类号： G01N33/53 , G01N33/573 , G01N33/532 , C07K16/00 , C07K1/04 , G01N33/533 , C07D321/10
CPC分类号： C07H5/04 , C07H9/04 , G01N33/9473 , Y10S436/815
摘要： Topiramate analogs have substituents at the sulfamate group, 9-position, or 10-position. Topiramate analogs may include immunogenic moieties to prepare anti-topiramate antibodies, or antigenic moieties for immunodiagnostic assays. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the topiramate analogs can be used in immunodiagnostic assays to compete with topiramate for binding with anti-topiramate antibodies. Such an immunodiagnostic assay can be used for detecting the presence of topiramate in a sample obtained from a subject previously administered topiramate by the following: combining an anti-topiramate antibody and a topiramate analog with a sample to form a first composition; allowing any free topiramate from the sample and the topiramate analog to compete for binding with the antibody; detecting binding between the topiramate analog and the antibody.
摘要翻译：托吡酯类似物在氨基磺酸盐基团，9-位或10-位具有取代基。托吡酯类似物可以包括免疫原性部分以制备抗托吡酯抗体或用于免疫诊断测定的抗原部分。此外，托吡酯类似物可以包括用于在免疫诊断测定期间检测模拟物的存在或量的示踪剂部分。此外，托吡酯类似物可用于免疫诊断测定以与托吡酯竞争与抗托吡酯抗体结合。通过以下方法，这种免疫诊断测定可用于检测从先前施用托吡酯的受试者获得的样品中托吡酯的存在：将抗托吡酯与托吡酯类似物与样品结合以形成第一组合物; 允许来自样品和托吡酯类似物的任何游离托吡酯与抗体竞争结合; 检测托吡酯类似物和抗体之间的结合。

78. 发明申请

US20090187013A1 SYNTHETIC HEPARIN PENTASACCHARIDES 有权
标题翻译：合成HEPARIN PENTASACCHARIDES
公开(公告)号：US20090187013A1
公开(公告)日：2009-07-23
申请号：US12354643
申请日：2009-01-15
申请人： Joachim SEIFERT , Latika Singh , Tracie Elizabeth Ramsdale , Michael Leo West , Nicholas Barry Drinnan
发明人： Joachim SEIFERT , Latika Singh , Tracie Elizabeth Ramsdale , Michael Leo West , Nicholas Barry Drinnan
IPC分类号： C07G3/00 , C08B37/10 , C07H5/06
CPC分类号： C07H9/00 , C07H3/06 , C07H5/04 , C07H7/033 , C07H11/00 , C07H13/04 , C07H13/08 , C07H15/10 , C07H15/18
摘要： Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.
摘要翻译：制备用于制备合成类肝素的合成单糖，二糖，三糖，四糖和五糖。

79. 发明授权

US07560231B2 Mannitol and glucitol derivatives 有权
标题翻译：甘露醇和葡萄糖醇衍生物
公开(公告)号：US07560231B2
公开(公告)日：2009-07-14
申请号：US10729570
申请日：2003-12-05
申请人： Frank Bergmann , Herbert Von Der Eltz , Christoph Seidel , Kurt Weindel
发明人： Frank Bergmann , Herbert Von Der Eltz , Christoph Seidel , Kurt Weindel
IPC分类号： C12Q1/68 , C07H21/00 , C07F9/06 , C07D327/00
CPC分类号： C07H21/00 , C07F9/6561 , C07H5/04 , C07H5/06
摘要： The present invention is related to compounds comprising mannitol or glucitol derivatives which may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are disclosed wherein the oligomeric compounds are used.
摘要翻译：本发明涉及可用于构建低聚化合物的包含甘露糖醇或葡萄糖醇衍生物的化合物。本发明还涉及这些寡聚化合物用于杂交和作为探针的用途。此外，公开了用于检测核酸的方法，其中使用寡聚化合物。

80. 发明申请

US20090060930A1 Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes 有权
标题翻译：通过添加αGal表位增强肿瘤相关抗原的免疫原性
公开(公告)号：US20090060930A1
公开(公告)日：2009-03-05
申请号：US11977203
申请日：2007-10-24
申请人： Mario R. Mautino , Nicholas N. Vahanian , Won-Bin Young , Gabriela Rossi , Charles J. Link , Firoz Jaipuri
发明人： Mario R. Mautino , Nicholas N. Vahanian , Won-Bin Young , Gabriela Rossi , Charles J. Link , Firoz Jaipuri
IPC分类号： A61K39/385 , C12P21/06 , C07K4/00 , C07K14/00 , C07C229/00 , C07H3/02 , C07H3/04 , C07H3/06
CPC分类号： C07H5/04 , A61K31/70 , A61K39/0011 , A61K39/39 , A61K2039/55511 , C07H15/00 , C07H15/04
摘要： The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epitopes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
摘要翻译：本发明涉及用于引起肿瘤细胞选择性靶向和杀伤的方法和组合物。本发明描述了基于纯化的TAA蛋白或TAA衍生的合成肽的预防或治疗性癌症疫苗，其通过化学，酶学或化学 - 酶学方法改变以引入αGal表位或αGalglycomimetic表位，以便通过以下方式增强抗原的调理作用天然抗αGal抗体刺激TAA捕获和表达，从而诱导由肿瘤表达的TAA的体液和细胞免疫应答。因此，动物的免疫系统被刺激以产生将攻击和杀死存在于动物中的肿瘤细胞的肿瘤特异性细胞毒性细胞和抗体。

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