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71. 发明授权

US5346506A Method for establishing defibrillation threshold for a cardiac defibrillator 失效
标题翻译：建立心脏除颤器除颤阈值的方法
公开(公告)号：US5346506A
公开(公告)日：1994-09-13
申请号：US974049
申请日：1992-11-10
申请人： Morton M. Mower , Peng S. Chen
发明人： Morton M. Mower , Peng S. Chen
IPC分类号： A61N1/38 , A61N1/39
CPC分类号： A61N1/385 , A61N1/3943
摘要： A method of determining a defibrillation threshold for an implantable cardiac defibrillator, based upon determining the 50% probability of reaching the upper limit of vulnerability. The 50% probability of reaching the upper limit of vulnerability at the mid-upslope of the T-wave is found to closely approximate the 50% probability of successful defibrillation used to set the shock energy level of the defibrillator. A delayed up-down algorithm is used to determine the shock strength associated with 50% probability of reaching the upper limit of vulnerability.
摘要翻译：基于确定达到脆弱性上限的50％的概率来确定可植入心脏除颤器的除颤阈值的方法。发现在T波中上游达到脆弱性上限的50％概率接近用于设定除颤器的冲击能量水平的成功除颤的50％概率。使用延迟上调算法来确定与达到脆弱性上限的50％概率相关的冲击强度。

72. 发明授权

US4403614A Implantable cardioverter 失效
标题翻译：可植入心脏转复器
公开(公告)号：US4403614A
公开(公告)日：1983-09-13
申请号：US239007
申请日：1981-02-27
申请人： William R. Engle , E. Neil Moore, Jr. , Joseph F. Spear, Jr. , Ronald H. Rockland
发明人： William R. Engle , E. Neil Moore, Jr. , Joseph F. Spear, Jr. , Ronald H. Rockland
IPC分类号： A61N1/38 , A61N1/39 , A61N1/36
CPC分类号： A61N1/385 , A61N1/3956
摘要： A body implantable ventricular cardioverting system. Circuitry is provided which detects the onset of a malignant ventricular tachyarrhythmia and provides a cardioverting signal in response thereto. The cardioverting signal has an energy level that is high relative to the pacing threshhold but below that necessary for defibrillation. In this manner, a ventricular tachyarrhythmia can be cardioverted before the onset of fibrillation and at a lower energy than required for defibrillation. Dependent on such factors as patient threshholds, the tissue/electrode interface and the electrode system employed, the energy level of the cardioverting signal is from 5 millijoules to 15 joules. The system can be configured such that increasingly malignant tachyarrhythmias result in higher energy cardioverting signals, including signals capable of defibrillation. Successful cardioversion with a signal having an energy level lower than necessary for defibrillation reduces the physical damage to the heart as well as the trauma to and discomfort of the patient.
摘要翻译：身体植入式心室心律转复系统。提供电路，其检测恶性室性快速性心律失常的发作，并提供响应于其的心律转换信号。心跳转换信号的能量水平相对于起搏阈值高，但低于除颤所需的水平。以这种方式，可以在纤维颤动发作之前以比除颤所需的能量更低的能量心律失常。根据患者阈值，组织/电极界面和电极系统等因素，心脏转换信号的能量水平从5毫焦耳到15焦耳。可以配置该系统，使得越来越恶性的快速性心律失常导致更高的能量心律转换信号，包括能够除颤的信号。具有低于除颤所需能量水平的信号的成功的心脏复律减少了对心脏的物理损伤以及患者的创伤和不适。

73. 发明申请

US20150306407A1 THERAPY DELIVERY METHODS AND CIRCUITS FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于可植入医疗器械的治疗方法和电路
公开(公告)号：US20150306407A1
公开(公告)日：2015-10-29
申请号：US14260313
申请日：2014-04-24
申请人： Medtronic, Inc.
发明人： Randolph E. Crutchfield , Lonny V. Cabelka
IPC分类号： A61N1/39 , A61N1/38
CPC分类号： A61N1/3925 , A61N1/36125 , A61N1/362 , A61N1/3706 , A61N1/385 , A61N1/3906 , A61N1/3912 , A61N1/3956 , A61N1/3975
摘要： Techniques are disclosed for modulating the generation of charge current by operational circuitry included in an implantable medical device (IMD) for delivery of an induction stimulation pulse waveform by the IMD. The modulation may include modulating a charging circuit of the operational circuitry to facilitate the regulation of the induction stimulation pulse waveform. The techniques include monitoring an electrical parameter of a charging path during the delivery of the induction stimulation pulse and modulating the charging circuit based on the monitored electrical parameter.
摘要翻译：公开了用于通过包括在用于由IMD传送感应刺激脉冲波形的可植入医疗装置（IMD）中的操作电路来调制充电电流的产生的技术。调制可以包括调制操作电路的充电电路以便于调节感应刺激脉冲波形。这些技术包括在传送感应刺激脉冲期间监测充电路径的电参数并且基于所监视的电参数来调制充电电路。

74. 发明授权

US08036741B2 Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure 有权
标题翻译：在医疗过程之前和期间神经刺激和心脏感知的方法和系统
公开(公告)号：US08036741B2
公开(公告)日：2011-10-11
申请号：US12557950
申请日：2009-09-11
申请人： Scott E. Jahns , Michael R. S. Hill , James R. Keogh
发明人： Scott E. Jahns , Michael R. S. Hill , James R. Keogh
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/36114 , A61N1/362 , A61N1/36514 , A61N1/385 , A61N1/39
摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. A sensor to sense a characteristic of a fluid or tissue, such as an impending contraction, may be also used during the medical procedure. Systems and devices for performing the medical procedure are also provided.
摘要翻译：提供了一种执行诸如手术的医疗程序的方法。刺激神经以将心脏的跳动调节到第一状态，例如停止或减缓的状态。医疗程序在心脏或另一个器官上进行。停止对神经的刺激，以便将心脏的跳动调节到第二状态，例如打浆状态。心脏本身也可能被刺激到跳动状态，例如通过起搏。可以继续刺激神经以允许继续医疗程序。也可以在医疗过程中使用用于感测流体或组织的特征的传感器，例如即将收缩的收缩。还提供用于执行医疗程序的系统和设备。

75. 发明申请

US20100030289A1 PRE-QUALIFICATION OF AN ALTERNATE SENSING CONFIGURATION 有权
标题翻译：预备感应配置的预认证
公开(公告)号：US20100030289A1
公开(公告)日：2010-02-04
申请号：US12183971
申请日：2008-07-31
申请人： David Casavant , Catherine R. Condie , Jon W. Spence , Nathan Munsterman
发明人： David Casavant , Catherine R. Condie , Jon W. Spence , Nathan Munsterman
IPC分类号： A61N1/39 , A61N1/365
CPC分类号： A61N1/385 , A61N1/3622 , A61N1/368 , A61N1/3686 , A61N1/3704 , G06F19/00 , G06F19/3418
摘要： Multiple sensing configurations may be qualified based on one induced tachyarrhythmia, e.g., ventricular fibrillation, or other qualification event during an implantation procedure. Each sensing configuration comprises a different combination of two or more electrodes used for sensing electrical signals of the heart of the patient. In some examples, an implantable medical device or other device generates qualification information for each sensing configuration, which may indicate whether the sensing configuration is qualified for subsequent cardiac event detection based on an accuracy of the cardiac event detection for the sensing configuration during the qualification event. One of the qualified configurations may initially be selected as a primary sensing configuration for subsequent cardiac event detection. Switching to an alternate sensing configuration, e.g., upon identification of any sensing integrity condition of the primary sensing configuration, may be expedited by the previous collection of qualification data for at least one other sensing configuration.
摘要翻译：可以基于一种诱导的快速性心律失常，例如心室颤动或植入手术期间的其他鉴定事件来限定多个感测构造。每个感测配置包括用于感测患者心脏的电信号的两个或更多个电极的不同组合。在一些示例中，可植入医疗装置或其他装置产生用于每个感测配置的鉴定信息，其可以基于在资格事件期间的感测配置的心脏事件检测的精度来指示感测配置是否适合于随后的心脏事件检测。最初可以选择其中一个合格配置作为随后的心脏事件检测的主感测配置。例如在识别主要感测配置的任何感测完整性状况时，切换到备选感测配置可以通过先前收集的至少一个其他感测配置的限定数据来加速。

76. 发明申请

US20070276443A1 METHOD AND SYSTEM FOR VAGAL NERVE STIMULATION WITH MULTI-SITE CARDIAC PACING 有权
标题翻译：用于多位点心脏瓣膜神经刺激的方法和系统
公开(公告)号：US20070276443A1
公开(公告)日：2007-11-29
申请号：US11835808
申请日：2007-08-08
申请人： Lisa SHAFER , Steve LaPORTE , James KEOGH , Michael HILL , Matthew BONNER
发明人： Lisa SHAFER , Steve LaPORTE , James KEOGH , Michael HILL , Matthew BONNER
IPC分类号： A61N1/00
CPC分类号： A61N1/39 , A61N1/36114 , A61N1/362 , A61N1/3627 , A61N1/36514 , A61N1/3684 , A61N1/385 , A61N1/3956
摘要： A method of performing a medical procedure is provided. The medical procedure includes stimulation of a patient's heart while stimulating a nerve of the patient in order to modulate the patient's inflammatory process. More particularly, the medical procedure includes pacing the ventricles of the patient's heart while stimulating the vagal nerve of the patient. Systems and devices for performing the medical procedure are also provided.
摘要翻译：提供了一种执行医疗程序的方法。医疗过程包括刺激患者的心脏同时刺激患者的神经以调节患者的炎症过程。更具体地，医疗过程包括在刺激患者的迷走神经的同时起搏患者心脏的心室。还提供用于执行医疗程序的系统和设备。

77. 发明申请

US20070208388A1 Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure 审中-公开
标题翻译：在医疗过程之前和期间神经刺激和心脏感知的方法和系统
公开(公告)号：US20070208388A1
公开(公告)日：2007-09-06
申请号：US11796663
申请日：2007-04-27
申请人： Scott Jahns , Michael Hill , James Keogh
发明人： Scott Jahns , Michael Hill , James Keogh
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/362 , A61N1/385
摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. A sensor to sense a characteristic of a fluid or tissue, such as an impending contraction, may be also used during the medical procedure. Systems and devices for performing the medical procedure are also provided.
摘要翻译：提供了一种执行诸如手术的医疗程序的方法。刺激神经以将心脏的跳动调节到第一状态，例如停止或减缓的状态。医疗程序在心脏或另一个器官上进行。停止对神经的刺激，以便将心脏的跳动调节到第二状态，例如打浆状态。心脏本身也可能被刺激到跳动状态，例如通过起搏。可以继续刺激神经以允许继续医疗手术。也可以在医疗过程中使用用于感测流体或组织的特征的传感器，例如即将收缩的收缩。还提供用于执行医疗程序的系统和设备。

78. 发明授权

US07225019B2 Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure 有权
公开(公告)号：US07225019B2
公开(公告)日：2007-05-29
申请号：US10724978
申请日：2003-12-01
申请人： Scott E. Jahns , Michael R. S. Hill , James R. Keogh
发明人： Scott E. Jahns , Michael R. S. Hill , James R. Keogh
IPC分类号： A61N1/362
CPC分类号： A61N1/36017 , A61N1/36114 , A61N1/385
摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. A sensor to sense a characteristic of a fluid or tissue, such as an impending contraction, may be also used during the medical procedure. Systems and devices for performing the medical procedure are also provided.

79. 发明授权

US07184829B2 Method and system for nerve stimulation prior to and during a medical procedure 有权
标题翻译：在医疗过程之前和期间神经刺激的方法和系统
公开(公告)号：US07184829B2
公开(公告)日：2007-02-27
申请号：US10768999
申请日：2004-01-30
申请人： Michael R. S. Hill , Scott E. Jahns , James R. Keogh
发明人： Michael R. S. Hill , Scott E. Jahns , James R. Keogh
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/056 , A61N1/362 , A61N1/36514 , A61N1/37288 , A61N1/385 , A61N1/39
摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. Systems and devices for performing the medical procedure are also provided.
摘要翻译：提供了一种执行诸如手术的医疗程序的方法。刺激神经以将心脏的跳动调节到第一状态，例如停止或减缓的状态。医疗程序在心脏或另一个器官上进行。停止对神经的刺激，以便将心脏的跳动调节到第二状态，例如打浆状态。心脏本身也可能被刺激到跳动状态，例如通过起搏。可以继续刺激神经以允许继续医疗程序。还提供用于执行医疗程序的系统和设备。

80. 发明授权

US07184828B2 Method and system for spinal cord stimulation prior to and during a medical procedure 有权
标题翻译：在医疗过程之前和期间脊髓刺激的方法和系统
公开(公告)号：US07184828B2
公开(公告)日：2007-02-27
申请号：US10716810
申请日：2003-11-19
申请人： Michael R. S. Hill , Scott E. Jahns , James R. Keogh
发明人： Michael R. S. Hill , Scott E. Jahns , James R. Keogh
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61N1/36021 , A61N1/3625 , A61N1/385
摘要： A method of performing a medical procedure, such as surgery, is provided. The spinal cord is stimulated in order to control at least one physiological function. The medical procedure is performed and stimulation of the spinal cord is stopped.
摘要翻译：提供了一种执行诸如手术的医疗程序的方法。刺激脊髓以控制至少一种生理功能。执行医疗程序并停止对脊髓的刺激。

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