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71. 发明授权

US09561095B1 Body augmentation device 有权
标题翻译：身体增强装置
公开(公告)号：US09561095B1
公开(公告)日：2017-02-07
申请号：US14881028
申请日：2015-10-12
申请人： Phi Nguyen , Loc Phan , Bao Tran , Thuan Nguyen , Duy Bui
发明人： Phi Nguyen , Loc Phan , Bao Tran , Thuan Nguyen , Duy Bui
IPC分类号： A61F2/02 , A61F2/12 , A61M5/172 , A61L27/20 , A61L27/16 , A61L27/54 , A61L27/52 , A61K31/496 , A61K9/00 , A61B5/103 , A61M5/20
CPC分类号： A61F2/02 , A61B5/103 , A61B5/1079 , A61B2034/105 , A61F2/12 , A61K9/0024 , A61K31/496 , A61K47/32 , A61K47/36 , A61L27/16 , A61L27/20 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/21 , A61L2300/41 , A61L2300/602 , A61L2400/06 , A61M5/1723 , A61M5/20 , G06F19/00 , G06F19/30 , C08L29/04 , C08L5/08
摘要： Systems and methods are disclosed for filler injection. The apparatus includes a processor; a body sensor to provide body patient data to the processor; and an injector to inject a filler into a patient.
摘要翻译：公开了用于填料注入的系统和方法。该装置包括处理器; 身体传感器，用于向处理器提供身体患者数据; 以及将填料注射到患者体内的注射器。

72. 发明申请

US20170014549A1 TISSUE FILLER COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：组织填充剂组合物和使用方法
公开(公告)号：US20170014549A1
公开(公告)日：2017-01-19
申请号：US15301189
申请日：2015-04-01
申请人： KLOX Technologies Inc.
发明人： Andreas Nikolis , Lise Hébert
IPC分类号： A61L27/50 , A61N5/06 , A61L27/20 , A61K41/00 , A61L27/52 , A61L27/58
CPC分类号： A61L27/50 , A61B2018/0047 , A61K8/498 , A61K8/735 , A61K41/00 , A61K2800/81 , A61K2800/884 , A61K2800/91 , A61L27/20 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/442 , A61L2400/06 , A61L2430/34 , A61N5/0616 , A61N5/062 , A61Q19/08
摘要： The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and a fluorophore; and illuminating the area with light having a wavelength which can be absorbed by the fluorophore.
摘要翻译：本公开涉及刺激胶原合成，软组织的化妆品增强和/或抑制或治疗瘢痕形成的方法，包括将组合物施用于在软组织内待治疗的区域，其中所述组合物包含组织填充培养基和荧光团; 并用具有可被荧光团吸收的波长的光照射该区域。

73. 发明申请

US20160368211A1 3D PRINTER 审中-公开
标题翻译： 3D打印机
公开(公告)号：US20160368211A1
公开(公告)日：2016-12-22
申请号：US14746595
申请日：2015-06-22
申请人： Bao Tran
发明人： Bao Tran
IPC分类号： B29C67/00 , A61L27/36 , A61L27/38
CPC分类号： A61L27/3834 , A61L27/20 , A61L27/3604 , A61L27/3813 , A61L27/48 , C08L5/08 , C08L89/06
摘要： A method for printing an object by providing a 3D printing engine in a pen body with a camera; imaging a target area with the camera; and injecting materials onto the target area based on the imaged target area.
摘要翻译：一种通过在具有相机的笔体中提供3D打印引擎来打印对象的方法; 用相机成像目标区域; 并且基于成像的目标区域将材料注入到目标区域上。

74. 发明申请

US20160367723A1 Bioactive Grafts and Composites 审中-公开
标题翻译：生物活性接枝和复合材料
公开(公告)号：US20160367723A1
公开(公告)日：2016-12-22
申请号：US15252737
申请日：2016-08-31
申请人： Amit Prakash GOVIL , Christian GAMBOA
发明人： Amit Prakash GOVIL , Christian GAMBOA
IPC分类号： A61L27/20 , A61L27/12 , A61L27/36 , A61L27/54
CPC分类号： A61L27/20 , A61F2/4644 , A61F2002/4646 , A61K35/32 , A61L27/12 , A61L27/3608 , A61L27/365 , A61L27/50 , A61L27/54 , A61L2300/232 , A61L2300/404 , A61L2300/412 , A61L2300/45 , A61L2300/60 , A61L2300/62 , A61L2400/16 , A61L2430/02 , C08L5/08
摘要： Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopaedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.
摘要翻译：公开了各种生物活性移植物和/或生物相容性材料及其制备方法。在一个实施方案中，从供体收获骨材料。收获的骨材料暴露于裂解剂，裂解剂配置为从收获的骨材料的细胞材料中释放生长因子和生物活性物质。然后用收集的骨材料用漂洗剂漂洗。收获的骨材料的pH被基本上中和。在另一个实施方案中，矫形植入物包括抗菌多糖。植入物还可以包括骨质疏松剂。

75. 发明申请

US20160354520A1 INTERPENETRATING NETWORKS WITH COVALENT AND IONIC CROSSLINKS 审中-公开
标题翻译：互动网络与共享和离子交互
公开(公告)号：US20160354520A1
公开(公告)日：2016-12-08
申请号：US15172549
申请日：2016-06-03
申请人： President and Fellows of Harvard College , Seoul National University Industry Foundation
发明人： Jeong-Yun Sun , Xuanhe Zhao , Widusha R.K. Illeperuma , Kyu H. Oh , Joost J. Vlassak , Zhigang Suo , Jianyu Li , David J. Mooney
IPC分类号： A61L27/52 , C08L71/02 , C08L33/26 , C08L5/04 , A61L27/26 , A61L27/50
CPC分类号： A61L27/52 , A61L27/16 , A61L27/20 , A61L27/26 , A61L27/48 , A61L27/50 , A61L27/60 , C08J3/075 , C08J3/246 , C08J2333/26 , C08J2405/04 , C08L5/04 , C08L33/26 , C08L71/02 , C08L2201/54 , C08L2203/02 , C08L2205/04
摘要： The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer.
摘要翻译：本发明的特征在于包含包含第一网络和第二网络的自愈互穿网络水凝胶的组合物。第一网络包括共价交联，第二网络包括离子或物理交联。例如，第一网络包括聚丙烯酰胺聚合物，第二网络包括藻酸盐聚合物。

76. 发明申请

US20160354518A1 BONE PASTES COMPRISING BIOFUNCTIONALIZED CALCIUM PHOSPHATE CEMENTS WITH ENHANCED CELL FUNCTIONS FOR BONE REPAIR 审中-公开
标题翻译：包含生物功能化磷酸钙化合物的骨胶囊用于骨修复的增强细胞功能
公开(公告)号：US20160354518A1
公开(公告)日：2016-12-08
申请号：US15241950
申请日：2016-08-19
申请人： Huakun XU
发明人： Huakun XU
IPC分类号： A61L27/36 , A61L24/00 , A61L24/08 , A61L24/10 , A61L27/56 , A61L27/20 , A61L27/22 , A61L27/38 , A61L27/54 , A61L24/02 , A61L27/12
CPC分类号： A61L27/365 , A61L24/0005 , A61L24/0015 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/02 , A61L24/043 , A61L24/08 , A61L24/106 , A61L24/108 , A61L27/12 , A61L27/20 , A61L27/225 , A61L27/227 , A61L27/3616 , A61L27/3633 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2400/06 , A61L2430/02 , C08L5/08
摘要： The invention provides injectable, biofunctional agent-containing calcium phosphate cement bone pastes for bone tissue engineering, and methods of making and using the same.
摘要翻译：本发明提供了用于骨组织工程的可注射的含有生物功能的磷酸钙骨水泥骨膏及其制造和使用方法。

77. 发明申请

US20160346218A1 HYBRID HOLLOW MICROCAPSULE, SCAFFOLD FOR SOFT TISSUE INCLUDING SAME, AND METHODS OF PREPARING SAME 审中-公开
标题翻译：混合中空微胶囊，包括其的软组织的SCAFFOLD及其制备方法
公开(公告)号：US20160346218A1
公开(公告)日：2016-12-01
申请号：US15166189
申请日：2016-05-26
申请人： GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人： Gi-Yoong TAE , Raja RAJAMANICKAM , Jong-Chul KIM
IPC分类号： A61K9/48 , A61L27/22 , B05D3/00 , A61L27/18 , A61L27/20 , A61L27/12 , A61L27/02
CPC分类号： A61K9/4891 , A61K9/4808 , A61K9/485 , A61K9/4866 , A61K9/5115 , A61K9/5161 , A61L27/025 , A61L27/12 , A61L27/18 , A61L27/20 , A61L27/222 , A61L2430/34 , B01J13/14 , B01J13/203 , B01J13/22
摘要： Disclosed is a method of preparing a hollow microcapsule using freezing of macroporous materials including a crosslinked inorganic particle network capable of elastically recovering from a highly compressed deformation state, and use of the same as a scaffold for soft tissue engineering and as a drug delivery system.
摘要翻译：公开了一种使用能够从高度压缩变形状态弹性回复的交联无机粒子网络的大孔材料的冷冻以及作为软组织工程用支架用作药物输送系统的中空微胶囊的制造方法。

78. 发明申请

US20160338831A1 INTRAMYOCARDIAL PATTERNING FOR GLOBAL CARDIAC RESIZING AND RESHAPING 审中-公开
标题翻译：用于全球心脏重塑和重塑的内分泌方案
公开(公告)号：US20160338831A1
公开(公告)日：2016-11-24
申请号：US15161255
申请日：2016-05-22
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N Sabbah , Randall J. Lee , Andrew G. Hinson
IPC分类号： A61F2/24 , A61M5/14 , A61K9/00 , A61L27/52 , A61L27/20 , A61M37/00 , A61M5/178
CPC分类号： A61F2/2451 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61K9/0024 , A61L27/20 , A61L27/3873 , A61L27/52 , A61L2400/06 , A61M5/14 , A61M5/178 , A61M37/00 , A61M37/0069
摘要： Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress and stabilize or even reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Over time the relief of wall stress reduces oxygen consumption and promotes healing. Moreover, various long-term therapeutic effects may be realized depending on the properties of the space-occupying agent, including combinations with other therapeutic materials. Specific cardiac conditions treatable by these systems and methods include, for example, dilated cardiomyopathy (with or without overt aneurismal formations), congestive heart failure, and ventricular arrhythmias. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
摘要翻译：心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内分布空间占位剂来治疗，使得空间改变剂整合到腔室周围的至少部分心脏壁并使其增厚，降低壁面应力，稳定或甚至减小腔室尺寸。一些模式也引起了对室的有益的全局整形。这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。随着时间的推移，墙壁压力的减轻会降低氧气消耗并促进愈合。此外，根据空间占据剂的特性，包括与其它治疗材料的组合，可以实现各种长期治疗效果。可通过这些系统和方法治疗的特异性心脏病症包括例如扩张型心肌病（有或没有明显的动脉瘤形成），充血性心力衰竭和室性心律失常。用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况，例如心肌梗死，通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流到不合规的二尖瓣。这些技术也可用于治疗可能尚未进展为心肌病的局部病症。

79. 发明授权

US09498494B2 Glycosaminoglycans 有权
公开(公告)号：US09498494B2
公开(公告)日：2016-11-22
申请号：US13603569
申请日：2012-09-05
申请人： Simon McKenzie Cool , Victor Nurcombe , Christian Dombrowski
发明人： Simon McKenzie Cool , Victor Nurcombe , Christian Dombrowski
IPC分类号： A61K31/727 , A61K38/18 , A61L27/54 , C08B37/00 , C08B37/10 , A61L27/20 , A61K9/00
CPC分类号： A61K31/727 , A61K9/0024 , A61K35/28 , A61K38/1875 , A61L27/20 , A61L27/54 , C08B37/0075
摘要： Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.

80. 发明申请

US20160333320A1 SKIN EQUIVALENT CULTURE 审中-公开
标题翻译：皮肤等效文化
公开(公告)号：US20160333320A1
公开(公告)日：2016-11-17
申请号：US15153499
申请日：2016-05-12
申请人： SMITH & NEPHEW, INC.
发明人： Paul KEMP , David SHERING , Andrew SHERING , Penny JOHNSON , Damian MARSHALL
IPC分类号： C12N5/071 , A61L27/36 , A61L27/24 , A61L27/60 , A61L27/20 , A61L27/22 , A61L27/38 , A61L27/54
CPC分类号： C12N5/0698 , A61L27/20 , A61L27/225 , A61L27/24 , A61L27/3687 , A61L27/3691 , A61L27/3804 , A61L27/3839 , A61L27/3886 , A61L27/3895 , A61L27/54 , A61L27/60 , C12N2500/25 , C12N2500/30 , C12N2500/32 , C12N2501/11 , C12N2501/15 , C12N2502/094 , C12N2502/1323 , C12N2533/56
摘要： Disclosed is a method of preparing a collagenous construct comprising (i) casting viable collagen-producing human dermal fibroblasts in a support matrix comprising fibrin onto a support material, (ii) incubating in situ said support matrix with said viable collagen-producing human dermal fibroblasts in a collagen-inducing medium thereby (a) inducing or enhancing collagen production by said viable collagen-producing human dermal fibroblasts to form a collagenous construct, and (b) degrading said fibrin, (iii) rendering said collagenous construct free of said viable collagen-producing human dermal fibroblasts, and (iv) cross-linking said collagenous construct with a chemical or exposure to ultraviolet light.
摘要翻译：公开了一种制备胶原构建体的方法，其包括（i）将含有纤维蛋白的载体基质中的活的产生胶原的人真皮成纤维细胞置于载体材料上，（ii）将所述载体基质与所述活性胶原产生的人真皮成纤维细胞在胶原诱导培养基中，由此（a）诱导或增强所述活性胶原产生人真皮成纤维细胞的胶原产生以形成胶原构建体，和（b）降解所述纤维蛋白，（iii）使所述胶原构建体不含所述活性胶原 - 生产人类真皮成纤维细胞，和（iv）用化学物质或暴露于紫外线的方式将所述胶原构建体交联。

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