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71. 发明申请

US20150374602A1 MULTI-TONAL ONE STEP DYES III 有权
标题翻译：多功能一步式三重奏
公开(公告)号：US20150374602A1
公开(公告)日：2015-12-31
申请号：US14838293
申请日：2015-08-27
申请人： Henkel AG & Co. KGaA
发明人： Constanze Neuba , Frank Janssen
IPC分类号： A61K8/49 , A61K8/34 , A61Q5/10 , A61K8/41
CPC分类号： A61K8/4926 , A61K8/22 , A61K8/347 , A61K8/411 , A61K8/415 , A61K8/4913 , A61K8/494 , A61K8/4946 , A61K8/4953 , A61K2800/4324 , A61K2800/884 , A61Q5/10
摘要： A cosmetic agent (A) is applied to the fibers and is allowed to act for a period of 30 seconds to 30 minutes, after which a cosmetic agent (B) is applied to the keratinic fibers, which continue to be acted on by agent (A). Both agents (A) and (B) are allowed to act for a period of 5 to 45 minutes, after which the agents (A) and (B) are rinsed out. Agent (A) (a1) contains no oxidation dye precursors of the developer type, (a2) contains one or more oxidation dye precursors of the coupler type, (a3) has a pH of 8.0 to 12.0, and agent (B) (b) contains one or more oxidation dye precursors, (b2) contains one or more oxidizing agents, and (b3) has a pH of 8.0 to 12.0.
摘要翻译：将化妆品（A）施用于纤维，并使其起作用时间为30秒至30分钟，然后将化妆品（B）施加到继续作用于其上的角质纤维一个）。试剂（A）和（B）均允许作用5〜45分钟，之后将试剂（A）和（B）冲洗掉。（a）（a1）不含显影剂类型的氧化染料前体，（a2）含有一种或多种成色剂型氧化染料前体，（a3）的pH为8.0〜12.0，试剂（B）（b ）含有一种或多种氧化染料前体，（b2）含有一种或多种氧化剂，（b3）的pH为8.0〜12.0。

72. 发明授权

US09220926B2 Methods for generating new hair follicles, treating baldness, and hair removal 有权
标题翻译：产生新毛囊，治疗秃发和脱毛的方法
公开(公告)号：US09220926B2
公开(公告)日：2015-12-29
申请号：US13327611
申请日：2011-12-15
申请人： George Cotsarelis , Mayumi Ito
发明人： George Cotsarelis , Mayumi Ito
IPC分类号： A61Q7/00 , A61Q5/10 , A61K8/65 , A61Q5/00 , A61B17/00 , A61B18/00
CPC分类号： A61K8/4953 , A61B2017/00765 , A61B2018/00452 , A61K8/65 , A61K9/0014 , A61K31/506 , A61K31/517 , A61K31/65 , A61K35/36 , A61K38/1825 , A61K2800/74 , A61K2800/805 , A61M37/00 , A61M2037/0007 , A61Q5/00 , A61Q5/10 , A61Q7/00
摘要： The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
摘要翻译：本发明提供了治疗受试者的秃发并产生新的毛囊的方法，包括表皮破坏和施用促进将未表达的表皮细胞分化为毛囊细胞的化合物。本发明还提供了脱毛和诱导毛发色素沉着的方法。

73. 发明申请

US20150342854A1 EXTERNAL DERMAL COMPOSITION FOR ANTI-AGEING AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：用于抗老化的外用组合物及其制造方法
公开(公告)号：US20150342854A1
公开(公告)日：2015-12-03
申请号：US14655068
申请日：2013-12-26
申请人： HAYASHIBARA CO., LTD.
发明人： Takashi SHIBUYA , Akiko MIYAKE , Tatsuya ISHIHARA , Masaki MIYAKE , Hitomi WAKE
IPC分类号： A61K8/67 , A61Q19/02 , A61Q19/00 , A61K8/34 , A61K8/92 , A61K8/98 , A61K8/64 , A61K8/49 , A61Q19/08 , A61K8/97
CPC分类号： A61K8/676 , A61K8/345 , A61K8/4926 , A61K8/4953 , A61K8/498 , A61K8/602 , A61K8/64 , A61K8/922 , A61K8/97 , A61K8/9771 , A61K8/9789 , A61K8/988 , A61K31/7048 , A61K2800/5922 , A61K2800/805 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： The present invention has an object to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as wrinkles, fine wrinkles, blemishes, and saggings caused by increasing age or ageing; and maintains or improves the barrier function and the hyaluronic acid production in the skin. The object is solved by providing an external dermal composition for anti-ageing, which contains an aqueous medium as a base material and one or more ingredients selected from L-ascorbic acid, derivatives thereof, and their salts as an effective ingredient(s).
摘要翻译：本发明的目的是提供一种防老化外皮组合物，其防止或改善由老化或老化引起的皱纹，细皱纹，瑕疵和皱纹等明显的皮肤问题; 并维持或改善皮肤中的屏障功能和透明质酸产生。该目的通过提供一种抗老化的外用皮肤组合物来解决，该组合物含有作为基础材料的水性介质和选自L-抗坏血酸，其衍生物及其盐作为有效成分的一种或多种成分。

74. 发明申请

US20150328101A1 Compositions and Method for Hair Loss Prevention 审中-公开
标题翻译：脱发防治的组成和方法
公开(公告)号：US20150328101A1
公开(公告)日：2015-11-19
申请号：US14798415
申请日：2015-07-13
申请人： Giuseppe Trigiante
发明人： Giuseppe Trigiante
IPC分类号： A61K8/36 , A61K31/555 , A61K31/496 , A61K8/362 , A61Q7/00 , A61K8/49 , A61K8/97 , A61K8/35
CPC分类号： A61K8/361 , A61K8/27 , A61K8/33 , A61K8/35 , A61K8/362 , A61K8/37 , A61K8/4926 , A61K8/4946 , A61K8/4953 , A61K8/58 , A61K8/97 , A61K9/0014 , A61K9/08 , A61K31/435 , A61K31/496 , A61K31/505 , A61K31/555 , A61K33/04 , A61K36/61 , A61K45/06 , A61K2800/49 , A61K2800/592 , A61K2800/5922 , A61Q5/006 , A61Q7/00 , A61Q17/005 , A61K2300/00
摘要： The invention encompasses a formulation for hair loss prevention comprising a mixture of water and at least one nonpolar aprotic organic solvent and at least one hair loss preventive ingredient known to inhibit the hormonal mechanism underlying androgenetic hair loss and methods of using the same.
摘要翻译：本发明包括一种用于脱发预防的制剂，其包括水和至少一种非极性非质子有机溶剂的混合物和至少一种已知可抑制雄激素脱发的激素机制的脱发预防成分及其使用方法。

75. 发明授权

US09162984B2 Small-molecule modulators of melanin expression 有权
标题翻译：黑色素表达的小分子调节剂
公开(公告)号：US09162984B2
公开(公告)日：2015-10-20
申请号：US12593673
申请日：2008-03-28
申请人： Benjamin L. Miller , Brian R. McNaughton , Peter Gareiss , Glynis Scott
发明人： Benjamin L. Miller , Brian R. McNaughton , Peter Gareiss , Glynis Scott
IPC分类号： A61K8/49 , C07D215/54 , A61K31/47 , C07D211/14 , C07D261/18 , C07D307/68 , C07D405/06
CPC分类号： C07D215/54 , A61K8/4926 , A61K8/4953 , A61K8/4973 , A61K8/69 , A61Q17/04 , A61Q19/04 , C07D211/14 , C07D261/18 , C07D307/68 , C07D405/06
摘要： The present invention relates to small molecule modulators of melanin expression and methods of making the small molecules. Also disclosed are methods of increasing pigmentation in a cell which involve providing compounds of the present invention and contacting a cell with the compounds under conditions effective to induce melanin expression in the cell, thereby increasing pigmentation. The present invention also relates to compositions containing compounds of the present invention and a carrier.
摘要翻译：本发明涉及黑色素表达的小分子调节剂和制备小分子的方法。还公开了增加细胞色素沉着的方法，其涉及提供本发明的化合物，并且在有效诱导细胞黑色素表达的条件下使细胞与化合物接触，从而增加色素沉着。本发明还涉及含有本发明化合物和载体的组合物。

76. 发明申请

US20150290181A1 COMBINATION OF EFFECTIVE SUBSTANCES CAUSING SYNERGISTIC EFFECTS OF MULTIPLE TARGETING AND USE THEREOF 有权
标题翻译：有效物质的组合引起多重目标的协同效应及其使用
公开(公告)号：US20150290181A1
公开(公告)日：2015-10-15
申请号：US14128616
申请日：2012-06-28
申请人： Doo Hyun Lee , Sunyoung Cho
发明人： Doo Hyun Lee , Sunyoung Cho
IPC分类号： A61K31/445 , A61K31/505 , A61K36/38 , A61K36/884 , A61K36/744 , A61K36/69 , A61K31/198 , A61K36/40 , A61K31/166 , A61K45/06
CPC分类号： A61K31/445 , A23L33/10 , A61K8/41 , A61K8/4953 , A61K31/166 , A61K31/198 , A61K31/505 , A61K36/38 , A61K36/40 , A61K36/69 , A61K36/744 , A61K36/884 , A61K45/06 , A61K2800/10 , A61Q19/00 , A61K2300/00
摘要： Disclosed are a combination of active components inducing synergistic effects of multi-targeting and a use thereof. More particularly, disclosed are a functional food composition, a cosmetic composition, a pain-suppressive composition, and a composition for treatment or prevention of pruritus or atopic dermatitis, which comprise as active components, two or more components selected from a group consisting of (a) a 5-hydroxytryptamine subtype 2 (5-HT2) receptor antagonist; (b) a P2X receptor antagonist; and (c) any one of a glycine receptor agonist, a glycine transporter (GlyT) antagonist, a gamma-aminobutyric acid (GABA) receptor agonist, and a GABA transporter 1 (GAT1) antagonist. The multi-targeting composite composition (specifically, natural substances composite composition) has synergistic effects, and thus a treatment using a combination of respective components may achieve increased biological effects, in which mechanisms targeted by respective components are involved. Thus, the multi-targeting composite composition may not only remarkably control pain but may also increase effects of: alleviating symptoms of skin diseases such as itching and atopic dermatitis; preventing or improving depression, refreshment, pore minimization, improving wrinkles, skin regeneration, skin health, recovery of skin condition, skin whitening, preventing or improving athlete's foot, recovery of scalp health and regeneration of scalp, promoting hair growth, preventing gray hair, and improving dental and periodontal diseases, etc.
摘要翻译：公开了诱导多靶向的协同效应的活性成分及其用途的组合。更具体地，公开了功能性食品组合物，化妆品组合物，止痛组合物和用于治疗或预防瘙痒或特应性皮炎的组合物，其包含两种或更多种选自（ a）5-羟色胺亚型2（5-HT2）受体拮抗剂; （b）P2X受体拮抗剂; 和（c）甘氨酸受体激动剂，甘氨酸转运蛋白（GlyT）拮抗剂，γ-氨基丁酸（GABA）受体激动剂和GABA转运蛋白1（GAT1）拮抗剂）中的任何一种。多靶向复合组合物（具体地，天然物质复合组合物）具有协同效应，因此使用各组分的组合的治疗可以实现增加的生物效应，其中涉及各组分所靶向的机制。因此，多靶向复合组合物不仅可以显着地控制疼痛，还可以增加以下作用：缓解皮肤疾病如瘙痒和特应性皮炎的症状; 预防或改善抑郁症，清爽，减少孔隙，改善皱纹，皮肤再生，皮肤健康，皮肤状况恢复，皮肤美白，预防或改善运动员脚部，恢复头皮健康和头皮再生，促进头发生长，防止灰发，改善牙科和牙周病等。

77. 发明申请

US20150272896A1 COMPOSTIONS AND METHODS FOR ENHANCING THE TOPICAL APPLICATION OF AN ACIDIC BENEFIT AGENT 有权
标题翻译：用于增强酸性有益剂的局部应用的组合物和方法
公开(公告)号：US20150272896A1
公开(公告)日：2015-10-01
申请号：US14230535
申请日：2014-03-31
申请人： Johnson & Johnson Consumer Companies, Inc.
发明人： Ying Sun , Jeffrey M. Wu , Ali Fassih
IPC分类号： A61K9/50 , A61K31/192 , A61K9/00 , A61K47/12 , A61K47/18 , A61K8/02 , A61Q7/00 , A61K47/02 , A61K47/22 , A61K47/10 , A61K8/49
CPC分类号： A61K9/501 , A61K8/022 , A61K8/11 , A61K8/25 , A61K8/345 , A61K8/36 , A61K8/4953 , A61K9/0014 , A61K31/192 , A61K31/196 , A61K31/40 , A61K31/405 , A61K31/60 , A61K31/616 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/22 , A61K2800/41 , A61K2800/652 , A61Q7/00
摘要： A powder is disclosed including core/shell particles having an average particle size of less than 1000 microns, each particle contains a liquid core that is substantially free of water and includes A) a polar liquid having a percent surface polarity of at least 24%, an active ingredient, and C) from about 0.1% to about 20% by weight of at least one solubility enhancing agent that is not an active ingredient; and a shell comprising hydrophobic particles. The powder can be used to topically administer the active ingredient to a human or animal.
摘要翻译：公开了包含平均粒径小于1000微米的核/壳颗粒的粉末，每个颗粒含有基本上不含水的液芯，并且包括A）具有至少24％的表面极性百分比的极性液体，活性成分，和C）约0.1％至约20％重量的至少一种不是活性成分的溶解度增强剂; 和包含疏水性颗粒的壳。该粉末可用于将活性成分局部施用于人或动物。

78. 发明授权

US09132073B2 Oxidation dye precursors 有权
标题翻译：氧化染料前体
公开(公告)号：US09132073B2
公开(公告)日：2015-09-15
申请号：US14465937
申请日：2014-08-22
申请人： Henkel AG & Co. KGaA
发明人： Antje Gebert , Annika Koenen
IPC分类号： A61Q5/10 , C07D327/10 , A61K8/49 , C07D319/20 , C07D327/06 , C07D241/42 , C07D241/44
CPC分类号： A61K8/49 , A61K8/4913 , A61K8/494 , A61K8/4953 , A61K8/498 , A61K2800/10 , A61Q5/10 , C07D241/42 , C07D241/44 , C07D319/20 , C07D327/06
摘要： An agent for oxidative coloring of keratin-containing fibers, in particular human hair, includes as oxidation dye precursor of the developer type at least one compound of formula (I).
摘要翻译：含角蛋白纤维，特别是人发的氧化着色剂包括作为显影剂型至少一种式（I）化合物的氧化染料前体。

79. 发明申请

US20150231051A1 OPEN CHAINED OR FUSED 1,1 '-ALKYLENE-BIS-URACIL DERIVATIVES, USEFUL IN SKIN UV-PROTECTION 有权
标题翻译：开链或熔融1,1' - 亚乙基双 - 尿嘧啶衍生物，有助于皮肤防紫外线
公开(公告)号：US20150231051A1
公开(公告)日：2015-08-20
申请号：US14434722
申请日：2013-10-11
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： Robert Vince , Abbas Raza , Christine Dreis
IPC分类号： A61K8/49 , C07D487/16 , A61Q17/04 , C07D239/54
CPC分类号： A61K8/4953 , A61Q17/04 , A61Q19/08 , C07D239/54 , C07D487/04 , C07D487/16
摘要： The invention provides compounds of formula I; or a salt thereof as described herein. The invention also provides dermatological compositions comprising a compound of formula I or mixtures of one or more compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for protecting skin or DNA from photodamage or repairing photodamaged skin or DNA.
摘要翻译：本发明提供式I化合物; 或其盐。本发明还提供包含式I化合物或一种或多种式I化合物的混合物的皮肤病学组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于保护皮肤或DNA免受光损伤的治疗方法或修复光损伤的皮肤或DNA。

80. 发明授权

US09107853B2 Compositions containing phenolic compounds and hydrotropes for cosmetic use 有权
标题翻译：含有化合物酚类化合物和水溶助长剂的组合物
公开(公告)号：US09107853B2
公开(公告)日：2015-08-18
申请号：US13651038
申请日：2012-10-12
申请人： L'Oreal S.A.
发明人： Zhi Pan , Jean-Thierry Simonnet
IPC分类号： A61K9/00 , A61K8/67 , A61Q19/00 , A61K8/49 , A61K31/455 , A61K31/519 , A61K31/7048 , A61K8/368
CPC分类号： A61K8/676 , A61K8/368 , A61K8/4913 , A61K8/4953 , A61K8/498 , A61K8/675 , A61K31/455 , A61K31/519 , A61K31/7048 , A61Q19/00 , A61K2300/00
摘要： Aqueous compositions comprising (a) at least one phenolic compound and (b) at least one hydrotrope in an amount effective to solubilize said at least one phenolic compound in water are provided for cosmetic and other uses.
摘要翻译：水性组合物包含（a）至少一种酚类化合物和（b）至少一种有助于将所述至少一种酚类化合物溶解在水中的量的水溶助长剂用于化妆品和其它用途。

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