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71. 发明申请

US20070032739A1 Device for forming an effective sensor-to-tissue contact 有权
标题翻译：用于形成有效传感器与组织接触的装置
公开(公告)号：US20070032739A1
公开(公告)日：2007-02-08
申请号：US11196732
申请日：2005-08-04
申请人： Dan Hashimshony , Gil Cohen , Iddo Geltner
发明人： Dan Hashimshony , Gil Cohen , Iddo Geltner
IPC分类号： A61B5/00
CPC分类号： A61B5/4381 , A61B5/6834
摘要： A device and method for tissue characterization are provided, the device comprising: a structure; a first mechanism, associated with said structure, configured for exerting a first force on a tissue, for fixing the tissue to said structure, so as to substantially immobilize the tissue; and a second mechanism, associated with said structure, configured for pressing a sensor against an external surface of the immobilized tissue, thereby exerting a second force on the immobilized tissue, wherein at least a component of said first force is in opposition to at least a component of said second force, forcing the immobilized tissue against said sensor, and forcing said sensor against the immobilized tissue, bringing about an effective contact between said sensor and the immobilized tissue.
摘要翻译：提供了用于组织表征的装置和方法，所述装置包括：结构; 与所述结构相关联的第一机构被配置为在组织上施加第一力，用于将组织固定到所述结构，以便基本上固定所述组织; 以及与所述结构相关联的第二机构，其配置成将传感器压靠在固定化组织的外表面上，从而对固定化组织施加第二力，其中所述第一力的至少一部分与至少一个所述第二力的分量，强制所述固定化组织抵靠所述传感器，并迫使所述传感器抵靠所述固定的组织，从而在所述传感器和所述固定的组织之间产生有效的接触。

72. 发明申请

US20060051734A1 Apparatus for mapping biological tissue quality 审中-公开
标题翻译：用于绘制生物组织质量的装置
公开(公告)号：US20060051734A1
公开(公告)日：2006-03-09
申请号：US10537412
申请日：2003-12-03
申请人： Stuart McNeill , Robert Reuben
发明人： Stuart McNeill , Robert Reuben
IPC分类号： C12M1/34 , C12Q1/00
CPC分类号： A61B5/0051 , A61B5/411 , A61B5/4381
摘要： The present invention provides an apparatus suitable for use in investigating multi-phase biological tissue histology, which apparatus comprises a trans-ductally deployable probe mounting a periodically displaceable body of at least one tactile sensing device, said periodically displaceable body having an excitation frequency bandwidth in the range of from 1 Hz to 500 KHz, a maximum stroke length of less than 1 mm and a displacement force in the range from 0.01 N to 1 N, said displaceable body being provided with a displacement device having a displacement controller fro controlling at least said excitation frequency, said displaceable body being coupled to a displacement monitoring device and a displacement force monitoring device, for monitoring the viscoelastic response of said biological tissue to periodic compression by said displacement force applied to said tissue by periodic displacement of said periodically displaceable body. The present invention also includes a method for producing a histological profile of a biological tissue adjacent a body duct, and a diagnostic method, using the apparatus of the invention.
摘要翻译：本发明提供一种适用于调查多相生物组织组织学的装置，该装置包括安装至少一个触觉感测装置的周期性可移位的主体的透水性展开探针，所述周期性可移位体具有激发频率带宽 1Hz至500KHz的范围，小于1mm的最大行程长度和在0.01N至1N的范围内的位移力，所述可移位主体设置有具有位移控制器的位移装置，至少控制所述激发频率，所述可移动体联接到位移监测装置和位移力监测装置，用于通过所述周期性可移位体的周期性位移施加到所述组织的所述位移力来监测所述生物组织的周期性压缩的粘弹性响应。本发明还包括使用本发明的装置制造邻近体导管的生物组织的组织学特征的方法和诊断方法。

73. 发明申请

US20050203436A1 Method and system for detecting electrophysiological changes in pre-cancerous and cancerous tissue 有权
公开(公告)号：US20050203436A1
公开(公告)日：2005-09-15
申请号：US11096665
申请日：2005-04-01
申请人： Richard Davies
发明人： Richard Davies
IPC分类号： A61B5/05 , A61B5/053 , A61B6/00
CPC分类号： A61B5/4381 , A61B5/04002 , A61B5/0531 , A61B5/0538 , A61B5/4312 , A61B5/4839 , A61B5/6806 , A61B5/6834
摘要： A method and system are provided for determining a condition of a selected region of epithelial tissue. At least two current-passing electrodes are located in contact with a first surface of the selected region of the tissue. A plurality of measuring electrodes are located in contact with the first surface of the selected region of tissue as well. Electropotential and impedance are measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue.

74. 发明申请

US20030216661A1 Method and system for detecting electrophysiological changes in pre-cancerous and cancerous tissue 失效
标题翻译：检测癌前和癌组织电生理变化的方法和系统
公开(公告)号：US20030216661A1
公开(公告)日：2003-11-20
申请号：US10151233
申请日：2002-05-20
发明人： Richard J. Davies
IPC分类号： A61B005/05
CPC分类号： A61B5/4381 , A61B5/04002 , A61B5/0531 , A61B5/0538 , A61B5/4312 , A61B5/4839 , A61B5/6806 , A61B5/6834
摘要： A method and system are provided for determining a condition of a selected region of epithelial tissue. At least two current-passing electrodes are located in contact with a first surface of the selected region of the tissue. A plurality of measuring electrodes are located in contact with the first surface of the selected region of tissue as well. Electropotential and impedance are measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue.
摘要翻译：提供了一种用于确定所选择的上皮组织区域的状况的方法和系统。至少两个通电电极定位成与组织的选定区域的第一表面接触。多个测量电极也位于与组织的选定区域的第一表面接触的位置。在一个或多个位置测量电位和阻抗。可以将药剂引入组织区域以增强电生理特征。基于上皮，组织或器官的不同深度处的电位和阻抗曲线确定组织的状况，以及由于离子迁移和组织的电生理特性引起的上皮功能变化的估计。

75. 发明申请

US20030055358A1 Apparatus for sensing human prostate tumor 有权
标题翻译：用于感测人类前列腺肿瘤的装置
公开(公告)号：US20030055358A1
公开(公告)日：2003-03-20
申请号：US10204719
申请日：2002-08-22
发明人： Harvey W. Ko , Dexter G Smith
IPC分类号： A61B005/05
CPC分类号： A61B5/0522 , A61B5/05 , A61B5/053 , A61B5/0536 , A61B5/4381
摘要： An electromagnetic bioimpedance measurement apparatus uses an alternating magnetic field to induce electrical eddy currents in biological tissue. The eddy currents produce secondary magnetic fields that have the effect of changing the mutual inductance between the tissue and the coil that applied to the initial magnetic field. The amplitude of the resultant voltage, as measured by the same coil or a different receiver coil, is proportional to the conductivity of the tissue. A simple, marginally stable oscillator circuit is used to generate the current into the coil. Nearfield holographic signal processing is then used for holographic image formation. Bioimpedance is used to distinguish between normal tissue and cancerous tissue, especially cancerous prostate tissue. An invasive embodiment includes driven needle electrodes that are inserted into the body segment to be tested. Noninvasive embodiments include single or multiple coils arranged on a probe shaft.
摘要翻译：电磁生物阻抗测量装置使用交变磁场来诱导生物组织中的电涡流。涡流产生二次磁场，其具有改变应用于初始磁场的组织和线圈之间的互感的作用。由相同线圈或不同的接收器线圈测量的合成电压的幅度与组织的电导率成比例。使用简单的，稍微稳定的振荡器电路来产生线圈中的电流。然后将近场全息信号处理用于全息图像形成。生物阻抗用于区分正常组织和癌组织，特别是癌前列腺组织。侵入性实施例包括被插入被检体内段的驱动针电极。非侵入性实施例包括布置在探针轴上的单个或多个线圈。

76. 发明申请

US20030014098A1 Device for treating tissue and methods thereof 失效
标题翻译：用于治疗组织的装置及其方法
公开(公告)号：US20030014098A1
公开(公告)日：2003-01-16
申请号：US09900586
申请日：2001-07-06
发明人： Rodolfo C. Quijano , Hosheng Tu
IPC分类号： A61N001/00
CPC分类号： A61B5/053 , A61B5/0538 , A61B5/4381
摘要： A method and devices for treating a target tissue comprising providing thermal energy to the target tissue and simultaneously providing cryogenic energy to peripheral tissue adjacent or surrounding said target tissue adapted for shielding the peripheral tissue from any adverse effect of the thermal energy. The cooling may be accomplished with a cryogenic arrangement comprising two elements of different electromotive potential conductively connected at a probe junction, and passing an electrical current through the elements to reduce a temperature of the probe junction in accordance with the Peltier effect.
摘要翻译：一种用于治疗靶组织的方法和装置，包括向靶组织提供热能，并且同时向毗邻或围绕所述靶组织的周围组织提供低温能量，适用于屏蔽周边组织免受热能的任何不利影响。冷却可以通过低温装置来实现，该低温装置包括在探针结处导电连接的不同电动势的两个元件，并且使电流通过元件以根据珀耳帖效应降低探针结的温度。

77. 发明申请

US20020169375A1 RF coil, RF signal transmitter receiver, RF signal receiver, and magnetic resonance imaging system 失效
标题翻译： RF线圈，RF信号发射机接收机，RF信号接收机和磁共振成像系统
公开(公告)号：US20020169375A1
公开(公告)日：2002-11-14
申请号：US10139977
申请日：2002-05-07
发明人： Akira Nabetani
IPC分类号： A61B005/055
CPC分类号： G01R33/3678 , A61B5/055 , A61B5/4381 , G01R33/34084 , G01R33/3415
摘要： For the purpose of providing an RF coil that enables satisfactory imaging of the prostate, the RF coil is composed of a first saddle coil and a second saddle coil. The first saddle coil has two loop portions opposed to each other so that they can sandwich the inferior abdomen of a human body antero-posteriorly. The second saddle coil has two loop portions opposed to each other so that they will permit insertion of the inferior limbs of a human body thereinto and can sandwich the inferior abdomen thereof laterally.
摘要翻译：为了提供使得能够令人满意的前列腺成像的RF线圈，RF线圈由第一鞍形线圈和第二鞍形线圈构成。第一鞍形线圈具有彼此相对的两个环部，使得它们可以前后夹住人体的下腹部。第二鞍形线圈具有彼此相对的两个环部，使得它们能够将人体的下肢插入其中并且可以横向夹住下腹部。

78. 发明授权

US6135968A Differential temperature measuring device and method 失效
标题翻译：差温测量装置及方法
公开(公告)号：US6135968A
公开(公告)日：2000-10-24
申请号：US926790
申请日：1997-09-10
申请人： Donald B. Brounstein
发明人： Donald B. Brounstein
IPC分类号： A61B5/00 , A61B5/01 , A61B5/103
CPC分类号： A61B5/6826 , A61B5/015 , A61B5/4381 , A61B5/6838
摘要： A device and method for sensing temperatures at internal body locations non-surgically accessible only through body orifices is disclosed. The device is particularly useful in medical applications such as screening for cancer and other abnormal biological activity signaled by an increase in temperature at a selected site. As applied to prostate examinations, a device is provided which may be temporarily, adhesively affixed to a user's fingertip or to a mechanical probe. In the preferred embodiment, the device includes two temperature sensing elements which may include a plurality of chemical indicators. Each indicator changes color in response to detection of a predetermined particular temperature. When properly aligned and installed, the first element is located on the palmar surface of the fingertip while the second element is located on the dorsal surface of the fingertip. After an examination glove has been donned over the fingertip carrying the device, a prostate examination is performed during which the first element is brought into constant but brief contact with the prostate region and the second element is similarly, simultaneously brought into contact with a dermal surface opposing the prostate region. Upon withdrawal of the fingertip from the rectum and removal of the glove, the two temperature sensing elements may be visually examined in order to determine the temperatures detected by each one. A significant difference in observed temperatures indicates the possibility of abnormal biological activity and the need for further diagnostic or medical procedures.
摘要翻译：公开了一种用于仅通过身体孔口非手术地访问内部身体位置处的温度的装置和方法。该装置在医疗应用中特别有用，例如筛选癌症和由选定部位的温度升高而发出的其他异常生物活性。如应用于前列腺检查，提供了可临时地，粘附地固定到使用者的指尖或机械探针上的装置。在优选实施例中，该装置包括可包括多个化学指示器的两个温度感测元件。每个指示器响应于预定特定温度的检测而改变颜色。当正确对准和安装时，第一元件位于指尖的手掌表面上，而第二元件位于指尖的背面。在检查手套已经穿过携带该装置的指尖之后，执行前列腺检查，其中第一元件被保持恒定但与前列腺区域短暂接触，并且第二元件同样地与皮肤表面接触反对前列腺区域。当从直肠取出指尖并取出手套时，可以目视检查两个温度感测元件，以确定由每个温度检测到的温度。观察温度的显着差异表明生物活性异常的可能性以及进一步诊断或医疗程序的需要。

79. 发明授权

US5476095A Intracavity probe and interface device for MRI imaging and spectroscopy 失效
标题翻译：用于MRI成像和光谱学的腔内探针和界面装置
公开(公告)号：US5476095A
公开(公告)日：1995-12-19
申请号：US203245
申请日：1994-03-01
申请人： Mitchell D. Schnall , Robert E. Lenkinski , Herbert Y. Kressel , Howard M. Pollack
发明人： Mitchell D. Schnall , Robert E. Lenkinski , Herbert Y. Kressel , Howard M. Pollack
IPC分类号： A61B5/055 , A61F2/958 , A61M25/095 , G01R33/34 , G01R33/36
CPC分类号： G01R33/341 , A61B5/055 , A61B5/4381 , A61M25/1011 , G01R33/34084 , A61M2025/1013 , A61M25/1002 , G01R33/34007 , G01R33/3657
摘要： An insertable pickup probe and interface network for magnetic resonance imaging and spectroscopy. The pickup probe in the preferred embodiment is for use in imaging the male prostate and comprises an elongated shaft supporting a patient interface balloon at its distal end which contains a RF receiving coil. The interface balloon comprises an inflatable inner balloon enclosed by a flexible outer balloon. The receiving coil is positioned between the inner and outer balloons and placed intimately adjacent the region of interest by inflating the inner balloon to expand outwardly against the outer balloon. In addition, a non-stretchable planar material is provided on the surface on the inner balloon adjacent the receiving coil for ensuring that the receiving coil is placed adjacent the region of interest. The inner balloon is inflated by an inflator cuff connected to the shaft and communicated to the inner balloon by a first lumen in the shaft. The receiving coil is electrically connected to an interconnecting cable which is connected to the proximal end of the shaft and communicated to the receiving coil by a second lumen in the shaft. The interface network receives the interconnecting cable of the pickup probe and includes impedance matching means, tuning means, and decoupling means for interfacing the probe with a magnetic resonance imaging scanner. In addition, the interface includes an electronic circuit for automatically adjusting the control voltage of a varactor diode in a Pi network which comprises the tuning means.
摘要翻译：可插入的探头和用于磁共振成像和光谱学的接口网络。优选实施例中的拾取探头用于成像男性前列腺，并且包括在其远端支撑患者接口球囊的细长轴，其包含RF接收线圈。界面气囊包括由柔性外气囊包围的可充气内球囊。接收线圈定位在内气囊和外气囊之间，通过使内气囊膨胀而相对于外球囊向外膨胀而紧密地邻近感兴趣区域。此外，在邻近接收线圈的内球囊的表面上设置非伸缩平面材料，以确保接收线圈位于感兴趣区域附近。内球囊被连接到轴的充气器套筒充气，并且通过轴中的第一内腔与内球囊相通。接收线圈电连接到互连电缆，该互连电缆连接到轴的近端并通过轴中的第二内腔连接到接收线圈。接口网络接收拾取探头的互连电缆，并且包括阻抗匹配装置，调谐装置和用于将探针与磁共振成像扫描器对接的去耦装置。此外，该接口包括用于在包括调谐装置的Pi网络中自动调节变容二极管的控制电压的电子电路。

80. 发明申请

US20190183429A1 DEEP-LEARNING-BASED CANCER CLASSIFICATION USING A HIERARCHICAL CLASSIFICATION FRAMEWORK 审中-公开
公开(公告)号：US20190183429A1
公开(公告)日：2019-06-20
申请号：US16104131
申请日：2018-08-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Kyung Hyun Sung , William Hsu , Shiwen Shen , Xinran Zhong
IPC分类号： A61B5/00 , A61B5/055 , G06K9/42 , G06K9/52 , G06K9/62 , G06K9/66
CPC分类号： A61B5/7267 , A61B5/055 , A61B5/08 , A61B5/201 , A61B5/4244 , A61B5/4381 , G06K9/42 , G06K9/527 , G06K9/6269 , G06K9/66
摘要： An automatic classification method for distinguishing between indolent and clinically significant carcinoma using multiparametric MRI (mp-MRI) imaging is provided. By utilizing a convolutional neural network (CNN), which automatically extracts deep features, the hierarchical classification framework avoids deficiencies in current schemes in the art such as the need to provide handcrafted features predefined by a domain expert and the precise delineation of lesion boundaries by a human or computerized algorithm. This hierarchical classification framework is trained using previously acquired mp-MRI data with known cancer classification characteristics and the framework is applied to mp-MRI images of new patients to provide identification and computerized cancer classification results of a suspicious lesion.

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