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71. 发明申请

US20160331298A1 DEVICES AND METHODS TO MEASURE GASTRIC RESIDUAL VOLUME 审中-公开
标题翻译：测量胃肠残留量的装置和方法
公开(公告)号：US20160331298A1
公开(公告)日：2016-11-17
申请号：US15222670
申请日：2016-07-28
申请人： TheraNova, LLC
发明人： Daniel R. BURNETT , Marcie HAMILTON , Evan S. LUXON , Alexander VERGARA , Saheel SUTARIA
IPC分类号： A61B5/00 , A61B5/01 , A61B5/107 , A61B5/145 , A61B1/273 , A61B5/03
CPC分类号： A61B5/4238 , A23L33/30 , A23L35/00 , A61B1/2736 , A61B5/01 , A61B5/036 , A61B5/1073 , A61B5/14507 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/4848 , A61B5/486 , A61B5/6847 , A61B5/6852 , A61B5/6865 , A61B5/6871 , A61B5/742 , A61B2562/0204 , A61J15/008
摘要： Devices and methods to measure gastric residual volume (GRV) are described where at least one additive component (a GRV indicator) may be dispersed in a body lumen such as a stomach. The GRV indicator may changes a physical (chemical, electrical, thermal, mechanical, optical, etc.) characteristic within the stomach by a measureable degree. This degree of change and/or the rate of return to the previous state, may be used to determine the GRV of a patient. The determined GRV can also be used to automatically or semi-automatically control the patient's feeding rate and/or volume and/or frequency to adequately nourish the patient but avoid complications. The physical characteristic(s) may also be used to detect that the feeding catheter or tube is in the correct location (ie stomach vs lung or esophagus.
摘要翻译：描述了测量胃残留体积（GRV）的装置和方法，其中至少一种添加剂组分（GRV指示剂）可以分散在诸如胃的体腔中。 GRV指示器可以改变胃内物理（化学，电，热，机械，光学等）特性的可测量程度。这种变化程度和/或返回到先前状态的速率可用于确定患者的GRV。确定的GRV也可用于自动或半自动地控制患者的进食速率和/或体积和/或频率以适当地滋养患者，但避免并发症。物理特征也可用于检测进食导管或管是否在正确的位置（即胃与肺或食管）。

72. 发明申请

US20160206517A1 INTERACTIVE NGT SYSTEM 有权
标题翻译：互动NGT系统
公开(公告)号：US20160206517A1
公开(公告)日：2016-07-21
申请号：US15081895
申请日：2016-03-27
申请人： ART Healthcare Ltd.
发明人： Liron ELIA
IPC分类号： A61J15/00 , A61B5/053 , A61B5/03 , A61B5/145 , A61B5/01 , A61M1/00 , A61B5/00
CPC分类号： A61J15/00 , A61B5/0084 , A61B5/01 , A61B5/037 , A61B5/0538 , A61B5/145 , A61B5/14539 , A61B5/4233 , A61B5/4238 , A61B5/4836 , A61J15/0003 , A61J15/0073 , A61J15/0076 , A61J15/008 , A61J15/0084 , A61J15/0088 , A61M1/0066 , G06F19/00
摘要： Disclosed is an NGT system, the system comprises a nasogastric tube having a diameter and length configured to pass through an esophagus such that the lumen of the NGT maintains fluid communication with a portion of the digestive tract, and a digestive tract sensor operatively associated with the NGT, the digestive tract sensor configured to sense from inside the body and transmit signals in response to one or both of conditions relating to nourishment states of the digestive tract, and positioning of the NGT.
摘要翻译：公开了一种NGT系统，该系统包括具有配置成穿过食道的直径和长度的鼻胃管，使得NGT的内腔维持与消化道的一部分的流体连通，以及与该消化道可操作地相关联的消化道传感器 NGT，消化道传感器被配置为响应于与消化道的营养状态有关的一个或两个条件以及NGT的定位来感测身体内部并传递信号。

73. 发明申请

US20160121111A1 Conditional Gastrointestinal Stimulation for Improved Motility 有权
标题翻译：有条件的胃肠道刺激改善运动
公开(公告)号：US20160121111A1
公开(公告)日：2016-05-05
申请号：US14933555
申请日：2015-11-05
申请人： Enterastim, Inc.
发明人： Andy H. Levine , Michael Partsch , Jay Pasricha , Jiande Chen
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36007 , A61B5/04884 , A61B5/073 , A61B5/4238 , A61B5/4255 , A61B5/6852 , A61B5/6871 , A61B5/6873 , A61N1/0509 , A61N1/37205 , A61N1/37217
摘要： Systems and methods for gastrointestinal electrical stimulation to treat abnormalities in gastrointestinal motility are provided. In some embodiments, a system for relieving ileus includes an intraluminal catheter comprising: a catheter body having a proximal tip and a distal tip and a duodenal portion proximal to the distal tip of the catheter; and at least one electrode pair disposed along the duodenal portion of the intraluminal catheter, the at least one electrode pair being configured to detect a sensing information indicative of myoelectric activity of a patient and to provide stimulation energy; a sensing system in communication with the at least one electrode pair to receive the sensing information; and an energy delivery system in communication with the at least one electrode pair and the sensing system, the electrical energy delivery system being configured to delivery energy to the patient through the at least one second electrode pair based on the sensing information from the sensing system.
摘要翻译：提供了胃肠电刺激治疗胃肠蠕动异常的系统和方法。在一些实施例中，用于缓解肠梗塞的系统包括管腔内导管，其包括：导管本体，其具有近端和远端，以及靠近导管的远端的十二指肠部分; 以及沿着管腔内导管的十二指肠部分设置的至少一个电极对，所述至少一个电极对被配置为检测指示患者的肌电活动并且提供刺激能量的感测信息; 感测系统，与所述至少一个电极对通信以接收感测信息; 以及与所述至少一个电极对和所述感测系统连通的能量输送系统，所述电能输送系统被配置为基于来自所述感测系统的感测信息，通过所述至少一个第二电极对将能量递送至所述患者。

74. 发明申请

US20160058323A1 MEDICAL DEVICE FOR ANALYTE MONITORING AND DRUG DELIVERY 审中-公开
标题翻译：用于分析监测和药物递送的医疗设备
公开(公告)号：US20160058323A1
公开(公告)日：2016-03-03
申请号：US14816426
申请日：2015-08-03
申请人： Theranos, Inc.
发明人： Elizabeth A. Holmes , Shaunak Roy , John HOWARD , Chengwang WANG
IPC分类号： A61B5/07 , A61B5/00 , A61B5/1473
CPC分类号： A61B5/073 , A61B5/0024 , A61B5/0031 , A61B5/1411 , A61B5/145 , A61B5/14514 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1455 , A61B5/14556 , A61B5/1473 , A61B5/1477 , A61B5/1486 , A61B5/150022 , A61B5/150221 , A61B5/150229 , A61B5/150251 , A61B5/150282 , A61B5/150343 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/150969 , A61B5/150984 , A61B5/15107 , A61B5/15117 , A61B5/15119 , A61B5/15121 , A61B5/15123 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417 , A61B5/4238 , A61B5/4839 , A61B5/4848 , A61B5/6833 , A61B5/685 , A61B5/6865 , A61B5/7282 , A61B2560/0412 , A61M5/14276 , A61M37/0015 , A61M2005/14513 , A61M2005/1726 , A61M2037/0023 , A61M2205/0244 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , B01L3/5027 , B01L3/502707 , B01L3/502761 , B01L3/502776 , B01L2200/10 , B01L2300/023 , B01L2300/024 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0472 , B01L2400/0487 , G01N2035/00158
摘要： The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.
摘要翻译：本发明涉及一种可摄入的，可植入的或可穿戴的医疗装置，其包括微阵列，其包含能够与疾病标记生物分析物相互作用的生物活性剂; 储存器，其包含至少一种治疗剂并能够从所述医疗装置释放所述治疗剂; 以及多个微芯片，其包括微阵列扫描装置，其能够获得疾病标记生物分析物与生物活性剂之间的相互作用的物理参数数据; 能够将物理参数数据与分析物相互作用谱进行比较的生物识别装置; 任选的能够控制治疗剂从储存器释放的治疗剂释放装置; 能够促进微阵列扫描装置，生物识别装置和治疗剂释放装置之间的通信的接口装置; 以及为医疗装置供电的能量源。具体地说，本发明涉及一种能够检测体液中分析物的医疗装置，其包含能够获得体液样品的至少一个微针，所述样品流过的第一微通道至少与所述至少一个微流体连通一个微针，与第一微通道流体连通的第二微通道，缓冲液流过其中，其中第二通道包含具有生物活性剂的微阵列，微阵列扫描装置，用于检测身体中生物活性剂和分析物之间的相互作用流体; 和接口设备。

75. 发明授权

US09241655B2 Measuring device for measuring a physiological parameter of an aspirate 有权
标题翻译：用于测量抽吸物的生理参数的测量装置
公开(公告)号：US09241655B2
公开(公告)日：2016-01-26
申请号：US13363968
申请日：2012-02-01
申请人： Ciara Deighan , Paul J. Daly , Alan Fitzgerald
发明人： Ciara Deighan , Paul J. Daly , Alan Fitzgerald
IPC分类号： A61M16/00 , A61B5/06 , A61B5/145 , A61B5/00 , A61M16/04 , A61M16/08 , A61M1/00 , G01N21/75 , A61J15/00
CPC分类号： A61B5/061 , A61B5/14539 , A61B5/4238 , A61J15/0026 , A61J15/0084 , A61M1/0025 , A61M16/00 , A61M16/04 , A61M16/0411 , A61M16/0816 , A61M16/0841 , A61M2205/3324 , A61M2205/584 , A61M2205/75 , G01N21/75
摘要： A measuring device for measuring a physiological parameter of an aspirate. The device includes a sensor element for measuring the physiological parameter, a connection port for fluid communication with a medical tube, a collection tube for aspirating and/or collecting the aspirate, a housing, wherein the sensor element is mounted within the housing and a communication passage enabling the aspirate to enter the housing from the collection tube such that the sensor element can measure the physiological parameter. Further, a method for measuring the parameter is disclosed.
摘要翻译：一种用于测量抽吸物的生理参数的测量装置。该装置包括用于测量生理参数的传感器元件，用于与医疗管流体连通的连接端口，用于吸入和/或收集吸出物的收集管，其中传感器元件安装在壳体内，并且通信通过使得吸入物从收集管进入壳体，使得传感器元件可以测量生理参数。此外，公开了一种用于测量参数的方法。

76. 发明申请

US20160000375A1 ENDOSCOPY CAPSULE AND METHOD OF PRODUCING AN ENDOSCOPY CAPSULE 审中-公开
标题翻译：内窥镜胶囊和生产内膜囊的方法
公开(公告)号：US20160000375A1
公开(公告)日：2016-01-07
申请号：US14767146
申请日：2013-06-25
申请人： SIEMENS AKTIENGESELLSCHAFT
发明人： Stefan FÖRTSCH , Rainer KUTH
IPC分类号： A61B5/00 , A61B1/04 , A61B1/00 , A61B5/1473
CPC分类号： A61B5/6861 , A61B1/0011 , A61B1/041 , A61B1/273 , A61B5/073 , A61B5/1473 , A61B5/42 , A61B5/4238 , A61B2560/0468 , A61B2562/125 , A61B2562/162
摘要： An endoscopy capsule is provided for detecting a metabolic product of a bacterium located in a gastrointestinal tract, wherein the endoscopy capsule has a sensor unit with two electrodes and has a capsule shell that encloses a usable space, and wherein the electrodes are routed through the capsule shell.
摘要翻译：提供了一种用于检测位于胃肠道中的细菌的代谢产物的内窥镜检查胶囊，其中所述内窥镜检查胶囊具有具有两个电极的传感器单元，并且具有包围可用空间的胶囊壳，并且其中所述电极通过所述胶囊贝壳。

77. 发明授权

US09173734B2 Intragastric implant devices 有权
标题翻译：内植入装置
公开(公告)号：US09173734B2
公开(公告)日：2015-11-03
申请号：US13627627
申请日：2012-09-26
申请人： IBIS Medical, Inc.
发明人： Jaime Vargas
IPC分类号： A61F2/04 , A61M29/00 , A61B5/145 , A61F5/00 , A61B5/00
CPC分类号： A61F2/04 , A61B5/14503 , A61B5/14507 , A61B5/14539 , A61B5/4238 , A61B5/686 , A61B5/6884 , A61B2560/0219 , A61B2560/028 , A61B2560/066 , A61F5/0036 , A61F5/0076 , A61F5/0079 , A61F5/0089 , A61M29/00
摘要： An intragastric anchor implant device with an elongate member having proximal and distal ends with atraumatic features disposed thereon is described herein. The atraumatic features inhibit damage to the tissues of the stomach and the gastrointestinal tract and help anchor the device. The elongate member may be substantially rigid to resist bending and engage a tissue of the stomach or gastrointestinal tract to prevent passage therethrough and may include one or more bends to conform to the shape of the tract. The anchor implant device may be coupled with a therapeutic device, such as an intestinal bypass sleeve with a sliding seal, such as an expandable structure, that secures the sleeve to direct a flow of food particles from the stomach therethrough, for use in treating various disorders, including obesity and diabetes. Methods of deploying the anchor implant devices are also disclosed.
摘要翻译：本文描述了具有细长构件的胃内锚固植入装置，其具有近端和远端，其上设置有无创伤特征。无创伤的特征抑制对胃和胃肠道的组织的损伤并帮助锚定装置。细长构件可以是基本上刚性的，以抵抗弯曲并接合胃或胃肠道的组织以防止通过，并且可以包括一个或多个弯曲部以符合管道的形状。锚固植入装置可以与诸如具有滑动密封件（例如可扩张结构）的肠旁路套管的治疗装置联接，其固定套管以将胃中的食物颗粒流从胃引导，用于治疗各种疾病，包括肥胖和糖尿病。还公开了展开锚固植入装置的方法。

78. 发明申请

US20150238128A1 Sensor Instrument 审中-公开
标题翻译：传感器仪器
公开(公告)号：US20150238128A1
公开(公告)日：2015-08-27
申请号：US14423060
申请日：2013-07-19
申请人： SIEMENS AKTIENGESELLSCHAFT
发明人： Mario Bechtold , Stefan Förtsch , Rainer Kuth
IPC分类号： A61B5/1473 , A61B1/273 , A61B5/00
CPC分类号： A61B5/1473 , A61B1/2736 , A61B5/0538 , A61B5/4233 , A61B5/4238 , A61B5/4255 , A61B5/6852
摘要： The invention relates to a sensor instrument (2) for examining the mucous membrane of the oesophagus, stomach and duodenum of a patient to see whether it is infected with bacteria. Said instrument comprises an evaluation unit (4) and a catheter probe (6) with an ammonia-sensitive sensor (8) and a catheter.
摘要翻译：本发明涉及一种用于检查患者的食道，胃和十二指肠的粘膜以检测其是否被细菌感染的传感器（2）。所述仪器包括具有氨敏感传感器（8）和导管的评估单元（4）和导管探针（6）。

79. 发明申请

US20150087608A1 Methods and Devices for Treating Conditions Associated with Autonomic Dysfunction 有权
标题翻译：用于治疗与自主功能障碍相关的病症的方法和装置
公开(公告)号：US20150087608A1
公开(公告)日：2015-03-26
申请号：US14537672
申请日：2014-11-10
申请人： Palo Alto Investors
发明人： Anthony Joonkyoo Yun
IPC分类号： A61F7/00 , A61N1/362 , A61N1/36 , A61H23/00 , A61K31/21 , A61K31/454 , A61K31/4468 , A61K31/166 , A61K31/137 , A61N1/30 , A61K31/7048
CPC分类号： A61K31/7048 , A61B5/02405 , A61B5/1116 , A61B5/14521 , A61B5/4035 , A61B5/4238 , A61B5/4266 , A61F7/00 , A61H23/00 , A61K31/137 , A61K31/166 , A61K31/21 , A61K31/4468 , A61K31/454 , A61M5/00 , A61N1/30 , A61N1/36 , A61N1/36007 , A61N1/362
摘要： Methods and devices treating an autonomic nervous system associated disease condition in a subject are provided. Aspects of the invention include inducing one or more physiological response selected from the group consisting of sweating, gastric emptying, enhanced heart rate variability and enhanced quantitative sensory test responsiveness in a manner sufficient to modify the autonomic nervous system so as to treat the subject for the disease condition. The methods and devices find use in a variety of applications, e.g. in the treatment of subjects suffering from conditions arising from disorders of the autonomic nervous system.
摘要翻译：提供了治疗受试者中自主神经系统相关疾病状况的方法和装置。本发明的方面包括以足以改变自主神经系统的方式诱导一种或多种选自汗液，胃排空，增强的心率变异性和增强的定量感觉测试反应性的生理反应，以便治疗受试者疾病状况。所述方法和装置可用于各种应用，例如，治疗患有由自主神经系统紊乱引起的病症的受试者。

80. 发明授权

US08976365B2 Interferometric material sensing apparatus including adjustable coupling and associated methods 有权
标题翻译：干涉材料感测装置包括可调耦合和相关方法
公开(公告)号：US08976365B2
公开(公告)日：2015-03-10
申请号：US14108540
申请日：2013-12-17
申请人： Harris Corporation
发明人： Robert M. Montgomery , Randy L. Carmean , Charles Franklin Middleton, IV , James G. Tonti
IPC分类号： G01B11/02 , G01B9/02
CPC分类号： G01B9/0205 , A61B1/0684 , A61B1/24 , A61B1/32 , A61B5/0084 , A61B5/02007 , A61B5/4233 , A61B5/4238 , A61B5/4255 , A61B5/6886 , A61B2562/0233 , G01B9/02068 , G01B11/0666 , G01N9/00 , G01N21/1717 , G01N21/63 , G01N33/48 , G01N2201/06113 , G01N2201/067 , G01N2201/0697 , G01N2201/08 , G02B6/10
摘要： A material sensing apparatus comprises an excitation source configured to induce waves in a workpiece, and an optical waveguide interferometer configured to sense the induced waves in the workpiece. The optical waveguide interferometer comprises a probe segment having a probe segment end, and an adjustable coupler configured to permit setting a gap between the probe segment end and the workpiece. A controller is coupled to the adjustable coupler and configured to set the gap between the probe segment end and the workpiece.
摘要翻译：材料感测装置包括被配置为在工件中感应波的激励源和被配置为感测工件中的感应波的光波导干涉仪。光波导干涉仪包括具有探针段末端的探针段和被配置为允许设置探针段端和工件之间的间隙的可调耦合器。控制器耦合到可调节耦合器并且被配置成设置探针段端部和工件之间的间隙。

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