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71. 发明授权

US10501726B2 Population of isolated chicken cells reprogrammed from somatic cells 有权
公开(公告)号：US10501726B2
公开(公告)日：2019-12-10
申请号：US15164618
申请日：2016-05-25
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
发明人： Steven L Stice , Franklin West , Yangqing Lu
IPC分类号： C12N5/00 , C12N5/074 , A01K67/027
CPC分类号： C12N5/0696 , A01K67/0271 , A01K67/0275 , A01K2207/12 , A01K2227/30 , A01K2267/02 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2501/608 , C12N2502/99 , C12N2506/02 , C12N2506/1307 , C12N2760/16111 , C12N2760/18111 , C12N2999/007
摘要： The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lig28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring.

72. 发明授权

US09974288B2 Method of making polyethylene glycol-modified mammalian erythropoietin in a transgenic chicken 有权
公开(公告)号：US09974288B2
公开(公告)日：2018-05-22
申请号：US15207850
申请日：2016-07-12
申请人： KANEKA CORPORATION
发明人： Tomoyuki Nakaishi , Takuya Shindo , Tomoko Awa
IPC分类号： G01N33/00 , A01K67/027 , C07K14/505 , C12N15/85 , A61K38/18 , C07K14/005 , C12N7/00 , C12N15/86 , A61K47/60 , A61K38/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/052 , A01K2227/30 , A01K2267/01 , A01K2267/02 , A61K38/00 , A61K38/1816 , A61K47/60 , C07K14/005 , C07K14/505 , C12N7/00 , C12N15/8509 , C12N15/86 , C12N2015/8518 , C12N2740/10043 , C12N2740/10052 , C12N2760/20222 , C12N2799/027 , C12N2830/008
摘要： The present invention provides to a polyethylene glycol-modified feline-derived protein which is obtained by chemically modifying a feline-derived protein with polyethylene glycol. The feline-derived protein is produced by a method comprising any or a combination of extracting the protein from somatic cells of a transgenic bird and/or an egg laid thereby, purifying and activating the same. The transgenic bird has a foreign gene containing a sequence encoding a feline-derived protein.

73. 发明申请

US20170314000A1 LYSOSOMAL STORAGE DISEASE ENZYMES 审中-公开
公开(公告)号：US20170314000A1
公开(公告)日：2017-11-02
申请号：US15429247
申请日：2017-02-10
申请人： Alexion Pharmaceuticals, Inc .
发明人： ANTHONY QUINN , Alex J. Harvey
IPC分类号： C12N9/20 , A61K38/46 , A61K38/38 , A61K31/194 , A01K67/027
CPC分类号： C12N9/20 , A01K67/0278 , A01K2217/052 , A01K2227/30 , A01K2267/01 , A61K31/194 , A61K38/385 , A61K38/465 , C12N2740/10041 , C12Y301/01013
摘要： The present invention provides compositions of recombinant human lysosomal acid lipase having particular glycosylation patterns for internalization into target cells, a vector containing the nucleic acid encoding human lysosomal acid lipase, a host cell transformed with the vector, pharmaceutical compositions comprising the recombinant human lysosomal acid lipase and method of treating conditions associated with lysosomal acid lipase deficiency.

74. 发明申请

US20170223938A1 TRANSGENIC CHICKENS WITH AN INACTIVATED ENDOGENOUS GENE LOCUS 审中-公开
公开(公告)号：US20170223938A1
公开(公告)日：2017-08-10
申请号：US15358664
申请日：2016-11-22
申请人： Alexion Pharmaceuticals, Inc.
发明人： Marie-Cecile Van De Lavoir , Philip A. Leighton
IPC分类号： A01K67/027 , C12N15/85
CPC分类号： A01K67/0278 , A01K67/0271 , A01K67/0273 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/052 , A01K2217/072 , A01K2217/075 , A01K2217/206 , A01K2227/30 , A01K2267/01 , C07K14/43581 , C07K14/465 , C07K16/00 , C07K16/28 , C12N15/8509 , C12N2015/8518 , C12N2799/027 , C12N2800/30 , C12N2800/40
摘要： The present invention is transgenic chickens obtained from long-term cultures of avian PGCs and techniques to produce and transgenic birds derived from prolonged PGC cultures. In some embodiments, these PGCs can be transfected with genetic constructs to modify the DNA of the PGC, specifically to introduce a transgene encoding an exogenous protein. When combined with a host avian embryo by known procedures, those modified PGCs are transmitted through the germline to yield transgenic offspring. This invention includes compositions comprising long-term cultures of PGCs and offspring derived from them that are genetically modified. The genetic modifications introduced into PGCs to achieve the gene inactivation may also include, but are not restricted to, random integrations of transgenes into the genome, transgenes inserted into the promoter region of genes, transgenes inserted into repetitive elements in the genome, site specific changes to the genome that are introduced using integrase, site specific changes to the genome introduced by homologous recombination, and conditional mutations introduced into the genome by excising DNA that is flanked by lox sites or other sequences that are substrates for site specific recombination.

75. 发明授权

US09635305B1 Display apparatus including a transparent electronic monitor 有权
公开(公告)号：US09635305B1
公开(公告)日：2017-04-25
申请号：US14068920
申请日：2013-10-31
申请人： Iontank, Ltd.
发明人： Stephen Streibig , Robert de la Cretaz
IPC分类号： H04N5/00 , H04N5/66 , G01S3/04 , G09F19/12 , H04N7/18
CPC分类号： G06F3/011 , A01K1/03 , A01K1/031 , A01K29/005 , A01K31/06 , A01K63/003 , A01K63/006 , A01K67/033 , A01K2227/10 , A01K2227/30 , A01K2227/40 , A01K2227/706 , G01S3/04 , G01S5/14 , G01S13/74 , G02F1/13306 , G02F1/133528 , G02F1/13471 , G02F1/137 , G06F1/1605 , G06F3/005 , G06F3/017 , G09F9/35 , G09F27/00 , G09F27/005 , H04N5/66 , H04N7/002 , H04N21/4223 , H04N21/44218
摘要： A display apparatus includes a transparent electronic display such as a non-backlit LCD screen, a display area disposed behind the transparent electronic display, and a light source for illuminating the display area. When the light source is activated, the pixels of the LCD screen, and objects behind the screen, become visible. Various examples of the display apparatus include additional enhancements to the visual image and/or functionality. These enhancements include additional monitors for coordinated displays, user-controlled turntables with coordinated informational displays, parallax compensation, RFID sensors for identifying objects to be displayed, and switchable liquid crystal films and/or polarized mirror coatings to further control revealing and concealing of objects behind the screen. Some examples of the display apparatus may include an animal habitat. The animal habitat may be selectively revealed or concealed. The display apparatus may incorporate screen displays with animal movements for unique visual effects.

76. 发明申请

US20160353718A1 PRODUCTION OF TRANSGENIC AVIANS USING IMPROVED RETROVIRAL VECTORS 审中-公开
标题翻译：使用改进的逆转录矢量生产转基因生物
公开(公告)号：US20160353718A1
公开(公告)日：2016-12-08
申请号：US15181987
申请日：2016-06-14
申请人： ALEXION PHARMACEUTICALS, INC.
发明人： Alex J. Harvey , Jeffrey C. Rapp
IPC分类号： A01K67/027 , C07K14/705 , C07K14/56 , C12N7/00 , C12N15/86 , C12N15/85
CPC分类号： A01K67/0278 , A01K67/0275 , A01K2207/15 , A01K2217/052 , A01K2227/30 , A01K2267/01 , C07K14/56 , C07K14/70521 , C07K2319/30 , C12N7/00 , C12N15/8509 , C12N15/86 , C12N2015/8518 , C12N2740/11043 , C12N2800/24 , C12N2830/008 , C12N2830/15 , C12N2830/90
摘要： A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian.
摘要翻译：在其基因组中含有外源核苷酸序列的转基因禽类，其包含启动子组分和具有降低的启动子干扰的载体，其中外源核苷酸序列整合到基因组和禽类中。

77. 发明申请

US20160353717A1 TRANSGENIC AVIAN WHICH HAS FOREIGN GENE CONTAINING SEQUENCE ENCODING FELINE-DERIVED PROTEIN AND METHOD FOR PRODUCTION THEREOF 审中-公开
标题翻译：具有包含序列编码来源的蛋白质的外源基因的转基因生物及其生产方法
公开(公告)号：US20160353717A1
公开(公告)日：2016-12-08
申请号：US15207850
申请日：2016-07-12
申请人： KANEKA CORPORATION
发明人： Tomoyuki NAKAISHI , Takuya SHINDO , Tomoko AWA
IPC分类号： A01K67/027 , C12N15/86 , A61K47/48 , C12N7/00 , C07K14/005 , A61K38/18 , C12N15/85 , C07K14/505
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/052 , A01K2227/30 , A01K2267/01 , A01K2267/02 , A61K38/00 , A61K38/1816 , A61K47/60 , C07K14/005 , C07K14/505 , C12N7/00 , C12N15/8509 , C12N15/86 , C12N2015/8518 , C12N2740/10043 , C12N2740/10052 , C12N2760/20222 , C12N2799/027 , C12N2830/008
摘要： The present invention provides to a polyethylene glycol-modified feline-derived protein which is obtained by chemically modifying a feline-derived protein with polyethylene glycol. The feline-derived protein is produced by a method comprising any or a combination of extracting the protein from somatic cells of a transgenic bird and/or an egg laid thereby, purifying and activating the same. The transgenic bird has a foreign gene containing a sequence encoding a feline-derived protein.
摘要翻译：本发明提供了通过用聚乙二醇化学修饰猫科动物蛋白质获得的聚乙二醇修饰的猫科动物蛋白质。猫科动物蛋白质是通过包含从转基因鸟的体细胞和/或由此得到的蛋中提取蛋白质的任一种或组合的方法产生的，其纯化和活化。转基因鸟具有含有编码猫科动物蛋白质的序列的外源基因。

78. 发明申请

US20160309686A1 TRANSGENIC BIRDS THAT PRODUCE CHIMERIC HUMAN IMMUNOGLOBULINS 审中-公开
标题翻译：生产人类免疫球蛋白的转基因生物
公开(公告)号：US20160309686A1
公开(公告)日：2016-10-27
申请号：US15142097
申请日：2016-04-29
申请人： Philip A. Leighton , Emily J. Cadera
发明人： Philip A. Leighton , Emily J. Cadera
IPC分类号： A01K67/027 , C07K16/46 , C12N15/85
CPC分类号： A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/052 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/30 , A01K2267/01 , C07K16/00 , C07K16/02 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/23 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C12N15/8509 , C12N2015/8518 , C12N2830/008
摘要： The invention relates to transgenic birds capable of producing chimeric immunoglobulins, with a combination of human and avian sequence, in their B cells. In some embodiments, the birds are chickens. When challenged with an antigen, the transgenic avians produce antigen-specific functional antibodies. The invention also relates to light chain immunoglobulin transgenes for making such transgenic avians, as well as methods and vectors for disrupting endogenous immunoglobulin loci in birds.
摘要翻译：本发明涉及能够在其B细胞中产生具有人和禽类序列的组合的嵌合免疫球蛋白的转基因鸟。在一些实施例中，鸟是鸡。当用抗原攻击时，转基因鸟类产生抗原特异性功能性抗体。本发明还涉及用于制备这种转基因鸟类的轻链免疫球蛋白转基因，以及用于破坏鸟类内源性免疫球蛋白基因座的方法和载体。

79. 发明申请

US20160270375A1 An Eye-friendly Green-blue Mixed LED Lighting Method and System for Chicken Houses 审中-公开
标题翻译：一种适用于鸡舍的绿色蓝蓝混合LED照明方法和系统
公开(公告)号：US20160270375A1
公开(公告)日：2016-09-22
申请号：US14760317
申请日：2014-01-14
申请人： ZHEJIANG UNIVERSITY
发明人： Jinming Pan , Yefeng YANG , Xuke Li , Jinsong JIANG , Fengjia DAI
IPC分类号： A01K31/19
CPC分类号： A01K31/19 , A01K31/18 , A01K2207/35 , A01K2227/30
摘要： Implementations of the present disclosure relate to eye-friendly green-blue mixed LED lighting methods and systems for chicken houses. In a chicken house, an evenly-distributed cyan light environment may be created for rearing broiler chickens. The chicken house may include mixed LED lamps associated with the cyan light environment, and the mixed LED lamp may be formed by combining green LED beads and blue LED beads on a lighting fixture with a mixing proportion of from about 0.2 to about 5. The mixed LED lamps may be used for about 24-hour lighting in the first three days of the breading period. From the fourth day of the breading period, the daily lighting duration may be progressively decreased by about one hour every day. The mixed LED lamps may be evenly arranged in the chicken house to form a square array.
摘要翻译：本公开的实施涉及用于鸡舍的眼睛友好的绿蓝混合LED照明方法和系统。在鸡舍里，可以产生均匀分布的青色环境，用于饲养鸡肉鸡。鸡舍可以包括与青色环境相关联的混合LED灯，并且混合LED灯可以通过在照明器具上组合绿色LED珠和蓝色LED珠而形成，混合比例为约0.2至约5.混合在面食时间的前三天，LED灯可能会使用约24小时的照明。从营养期的第四天开始，每天的照明时间可能会逐渐减少约1小时。混合的LED灯可以均匀地布置在鸡舍中以形成正方形阵列。

80. 发明授权

US09175295B2 Modified transposon vector and its use 有权
标题翻译：改性转座子载体及其用途
公开(公告)号：US09175295B2
公开(公告)日：2015-11-03
申请号：US11994982
申请日：2006-07-04
申请人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
发明人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
IPC分类号： C12N15/79 , C12N5/10 , C12N15/85
CPC分类号： C12N15/79 , A01K2217/05 , A01K2227/30 , C12N15/102 , C12N15/85 , C12N15/90 , C12N2800/30 , C12N2800/90 , C12N2820/00
摘要： A modified transposon vector and a method for introducing a foreign gene into a cell are provided. A modified transposon vector wherein a nucleic acid fragment having the following features (a)-(b) or (a)-(c) is inserted; a cell expressing a foreign gene obtained by introducing said vector into chromosomal DNA of a cell line or an ontogenetic cell and further introducing an expression cassette of a foreign gene into the chromosomal DNA; a genetically recombined animal generated by using said cell (in case of an ontogenetic cell); and a method for producing a foreign protein from said cell and said genetically recombined animal: (a) It consists of 5′- and 3′-TIR sequences of a transposon gene; (b) A sequence where a recombination reaction occurs is inserted between at least either of DR regions present by twos each in 5′- and 3′-TIR sequences of a transposon gene; (c) A restriction enzyme recognition site or an expression cassette of a foreign gene is inserted between 5′- and 3′-TIR sequences of a transposon gene.
摘要翻译：提供了修饰的转座子载体和将外源基因导入细胞的方法。其中插入具有以下特征（a） - （b）或（a） - （c）的核酸片段的修饰的转座子载体; 通过将所述载体导入细胞系或本体细胞的染色体DNA而获得的表达外源基因的细胞，并进一步将外源基因的表达盒导入染色体DNA; 通过使用所述细胞产生的遗传重组的动物（在个体发生细胞的情况下）; 以及从所述细胞和所述遗传重组动物产生外源蛋白的方法：（a）其由转座子基因的5'和3'-TIR序列组成; （b）将重组反应发生的序列插入转座子基因的5'-和3-TIR序列中的两个存在的至少任一个DR区域; （c）将外来基因的限制性内切酶识别位点或表达盒插入转座子基因的5'和3'-TIR序列之间。

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