专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US09187787B2 Method of diagnosing and treating cancer 有权
标题翻译：诊断和治疗癌症的方法
公开(公告)号：US09187787B2
公开(公告)日：2015-11-17
申请号：US13704701
申请日：2011-06-16
申请人： Karni Rotem
发明人： Karni Rotem
IPC分类号： C12N15/11 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： A method of diagnosing and treating a glioma or a breast cancer is disclosed. The method of diagnosing comprises analyzing an amount or activity of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) in a brain or breast cell sample of the subject, wherein an up-regulation in an amount or activity of hnRNP A2/B1 beyond a predetermined threshold with respect to a control cell sample is indicative of the breast cancer or glioma. The method may also be used for staging the cancer and for predicting patient's prognosis of survival. The method of treating glioblastoma and metastatic breast cancer includes inhibiting the expression and/or activity of hnRNP A2/B1.
摘要翻译：公开了一种诊断和治疗胶质瘤或乳腺癌的方法。诊断方法包括分析受试者脑或乳腺细胞样品中异源核核糖核蛋白A2 / B1（hnRNP A2 / B1）的量或活性，其中超过hnRNP A2 / B1的量或活性的上调相对于对照细胞样品的预定阈值表示乳腺癌或神经胶质瘤。该方法还可用于分期癌症和预测患者的生存预后。治疗胶质母细胞瘤和转移性乳腺癌的方法包括抑制hnRNP A2 / B1的表达和/或活性。

72. 发明申请

US20150273076A1 SP1 POLYPEPTIDES, MODIFIED SP1 POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译： SP1 POLYPEPTIDES，改性SP1多肽及其用途
公开(公告)号：US20150273076A1
公开(公告)日：2015-10-01
申请号：US14732732
申请日：2015-06-07
申请人： Fulcrum SP Ltd. , Yissum Research Development Company of the Hebrew University of Jerusalem
发明人： Amnon WOLF , Yehonathan Pouny , Ira Marton , Or Dgany , Arie Altman , Oded Shoseyov
IPC分类号： A61K47/48 , C07K14/415
摘要： SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.
摘要翻译：提供了能够与物质形成可逆分子缔合的SP1和修饰的SP1变体多肽，包含其的物质组合物及其用途。

73. 发明授权

US09145463B2 Compositions comprising fibrous polypeptides and polysaccharides 有权
标题翻译：包含纤维多肽和多糖的组合物
公开(公告)号：US09145463B2
公开(公告)日：2015-09-29
申请号：US14207864
申请日：2014-03-13
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , CollPlant Ltd.
发明人： Oded Shoseyov , Shaul Lapidot , Sigal Meirovitch , Daniel L. Siegel
IPC分类号： A61K39/00 , C08B15/06 , C07K14/435 , C12N15/82 , C08B15/00 , C08L89/00 , C07K17/10 , C07K14/75 , B01J19/12
CPC分类号： C07K14/43581 , A61K31/717 , A61K38/1767 , B01J19/127 , B01J2219/1203 , C07K14/43518 , C07K14/43563 , C07K14/43586 , C07K14/43595 , C07K14/75 , C07K17/10 , C07K2319/20 , C08B15/005 , C08B15/06 , C08L89/00 , C12N15/8257
摘要： Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.
摘要翻译：公开了分离的多肽，其包含编码与异源多糖结合结构域连接的纤维多肽的单体的氨基酸序列。全部公开了包含其的复合材料，其生产方法及其用途。

74. 发明授权

US09133231B2 Compounds for treating bacterial infections 有权
标题翻译：用于治疗细菌感染的化合物
公开(公告)号：US09133231B2
公开(公告)日：2015-09-15
申请号：US13813726
申请日：2011-08-03
申请人： Ezequiel Wexselblatt , Joshua Katzhendler , Ilana Kaspy , Gad Glaser , Roee Vidavski , Hafiz Mawasi , Sigal Ben Yehuda , Yaara Oppenheimer-Shaanan
发明人： Ezequiel Wexselblatt , Joshua Katzhendler , Ilana Kaspy , Gad Glaser , Roee Vidavski , Hafiz Mawasi , Sigal Ben Yehuda , Yaara Oppenheimer-Shaanan
IPC分类号： C07H19/20 , A61K31/708 , C07H19/173 , C07H19/16
CPC分类号： C07H19/20 , A61K31/708 , C07H19/16 , C07H19/173
摘要： Rel proteins as a novel therapeutic agent for treating bacterial threats. More specifically, a novel class of compounds of Formula (I) as disclosed herein which possess antibacterial activity and which inhibit RelA, RelSeq or RelSpo synthetic activity or bacterial spore formation. Also, pharmaceutical compositions of such compounds and a method of combating bacteria, or treating bacterial infections, by administering to a subject in need thereof such compounds or pharmaceutical compositions.
摘要翻译： Rel蛋白作为治疗细菌威胁的新型治疗剂。更具体地，本文公开的新一类式（I）的化合物，其具有抗菌活性并且抑制RelA，RelSeq或RelSpo合成活性或细菌孢子形成。此外，这种化合物的药物组合物以及通过向有需要的受试者施用此类化合物或药物组合物来对待细菌或治疗细菌感染的方法。

75. 发明申请

US20150232875A1 INTRODUCING DNA INTO PLANT CELLS 审中-公开
标题翻译：将DNA引入植物细胞
公开(公告)号：US20150232875A1
公开(公告)日：2015-08-20
申请号：US14641395
申请日：2015-03-08
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
发明人： Ilan SELA , Haim David Rabinowitch , Ofer Gover
IPC分类号： C12N15/82
CPC分类号： C12N15/8261 , C12N15/8203 , C12N15/8257 , Y02A40/146
摘要： The present invention provides means and methods for simple and efficient introduction of foreign genetic material into the plant cell. Particularly, the present invention combines seed priming and virus-based DNA constructs for efficient introduction of heterologous DNA into plants.
摘要翻译：本发明提供了将外来遗传物质简单有效地引入植物细胞的方法和方法。特别地，本发明结合了种子引发和基于病毒的DNA构建体，以有效地将异源DNA引入植物中。

76. 发明申请

US20150182569A1 Neuroprotective Natural Extract from Passion Fruit 有权
标题翻译：来自西番莲果的神经保护性天然提取物
公开(公告)号：US20150182569A1
公开(公告)日：2015-07-02
申请号：US14597674
申请日：2015-01-15
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat
发明人： Alon Samach , Oren Tirosh , Edna Pesis , Avital Artan , Livnat Goldenberg , Aron Troen
IPC分类号： A61K36/185 , A23L1/30
CPC分类号： A61K36/185 , A23L27/13 , A23L33/105 , A23V2002/00
摘要： Methods for the treatment and prevention of neural cell and neuro-pathological disorders are provided, comprising contacting the neural cells, or administering to a subject in need thereof, botanical raw material (BRM) or an extract obtainable from passion fruits. Compositions, as well as a nutraceutical composition comprising the same are also provided.
摘要翻译：提供了治疗和预防神经细胞和神经 - 病理学障碍的方法，包括使神经细胞接触，或向有需要的受试者施用植物性原料（BRM）或从西番莲果获得的提取物。还提供组合物，以及包含其的营养组合物。

77. 发明申请

US20150159191A1 SYSTEMS AND METHODS FOR ANALYZING AND MANIPULATING BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于分析和处理生物样品的系统和方法
公开(公告)号：US20150159191A1
公开(公告)日：2015-06-11
申请号：US14590070
申请日：2015-01-06
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem
发明人： Dan GAZIT , Boris RUBINSKY , Gadi PELLED , Zulma GAZIT
IPC分类号： C12Q1/04 , G01N27/74
CPC分类号： C12Q1/04 , G01N15/1031 , G01N27/745 , G01N2015/1006 , G01N2015/1081
摘要： A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
摘要翻译：提供了用磁性或可磁化部分标记的细胞样品的细胞鉴定系统。该系统包括用于保持单元的单元的单元样本保持器和包括用于向单元施加磁场的磁场源的第一单元分析器和用于限定和/或量化磁场对磁场的影响的传感器细胞。

78. 发明授权

US09012152B2 Anti-bacterial peptides and methods of treating diseases using same 有权
标题翻译：抗菌肽及使用其治疗疾病的方法
公开(公告)号：US09012152B2
公开(公告)日：2015-04-21
申请号：US12522545
申请日：2008-01-08
申请人： Hanna Engelberg-Kulka , Ilana Kolodkin-Gal
发明人： Hanna Engelberg-Kulka , Ilana Kolodkin-Gal
IPC分类号： G01N33/53 , G01N33/569 , C07K14/245
CPC分类号： C07K14/245
摘要： Isolated peptides comprising no more than ten amino acids and having anti-bacterial properties are disclosed. In one embodiment the peptides have a consensus amino acid sequence X1X2X3X4X5, wherein X1 and X5 comprise polar amino acids. In another embodiment, the peptides have a consensus amino acid sequence X1X2X3X4X5, wherein X2 and X4 are asparagine (N) residues and X3 is tryptophan (W). Compositions comprising same are also disclosed and uses thereof.
摘要翻译：公开了不超过10个氨基酸并具有抗细菌特性的分离肽。在一个实施方案中，肽具有共有氨基酸序列X1X2X3X4X5，其中X1和X5包含极性氨基酸。在另一个实施方案中，肽具有共有氨基酸序列X1X2X3X4X5，其中X2和X4是天冬酰胺（N）残基，X3是色氨酸（W）。还公开了包含其的组合物及其用途。

79. 发明授权

US08975213B2 Pseudozyma aphidis as a biocontrol agent against various plant pathogens 有权
公开(公告)号：US08975213B2
公开(公告)日：2015-03-10
申请号：US13700751
申请日：2011-05-31
申请人： Marganit Levy , Aviva Gafni
发明人： Marganit Levy , Aviva Gafni
IPC分类号： A01N25/26 , A01N63/00 , A01N63/04
CPC分类号： A01N63/04
摘要： Biocontrol agents are provided, which protect plant and plant material from pests and pathogens, and promote the growth of plants. Also provided are compositions comprising the same, methods for protecting plant and plant material and promoting growth in plants, and uses of said biocontrol agent in the preparation of a pesticidal composition and a growth-promoting composition.

80. 发明授权

US08932627B2 Liposomal compositions of glucocorticoid and glucocorticoid derivatives 有权
标题翻译：糖皮质激素和糖皮质激素衍生物的脂质体组成
公开(公告)号：US08932627B2
公开(公告)日：2015-01-13
申请号：US11662172
申请日：2005-09-11
申请人： Yechezkel Barenholz , Alberto A. Gabizon , Yuval Avnir
发明人： Yechezkel Barenholz , Alberto A. Gabizon , Yuval Avnir
IPC分类号： A61K9/127 , A61K31/573
CPC分类号： A61K9/127 , A61K9/1271 , A61K31/573
摘要： The present invention provides pharmaceutical compositions comprising a glucocorticoid or glucocorticoid derivative stably encapsulated in a liposome. The glucocorticoid or glucocorticoid derivative is selected from an amphipathic weak base glucocorticoid or glucocorticoid derivative having a pKa equal or below 11 and a logD at pH 7 in the range between −2.5 and 1.5; or an amphipathic weak acid GC or GC derivative having a pKa above 3.5 and a logD at pH 7 in the range between −2.5 and 1.5. The therapeutic effect of the pharmaceutical composition of the invention was exhibited in vivo with appropriate models of multiple sclerosis and cancer.
摘要翻译：本发明提供包含稳定包封在脂质体中的糖皮质激素或糖皮质激素衍生物的药物组合物。糖皮质激素或糖皮质激素衍生物选自pKa等于或低于11的两亲性弱碱性糖皮质激素或糖皮质激素衍生物，在pH7的logD在-2.5和1.5之间的范围内; 或pKa高于3.5的两亲性弱酸GC或GC衍生物，pH7的logD在-2.5和1.5之间的范围内。用适当的多发性硬化症和癌症模型在体内展示本发明的药物组合物的治疗效果。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式