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71. 发明申请

US20090270484A1 WWOX Vectors and Uses in Treatment of Cancer 审中-公开
标题翻译： WWOX载体和用于治疗癌症
公开(公告)号：US20090270484A1
公开(公告)日：2009-10-29
申请号：US12083067
申请日：2006-10-04
申请人： Carlo M. Croce , Muller Fabbri , Francesco Trapasso
发明人： Carlo M. Croce , Muller Fabbri , Francesco Trapasso
IPC分类号： A61K48/00 , C12N15/87 , C12N15/11 , C12N15/00 , C12N5/06
CPC分类号： A61K38/443 , A61K48/005 , A61K48/0075 , C12N15/86 , C12N2710/10343 , C12Y101/01
摘要： The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer in a subject, by administering to the subject a polynucleotide encoding a functional WWOX gene product.
摘要翻译：本发明通过向受试者施用编码功能性WWOX基因产物的多核苷酸来提供用于诊断，预后和治疗受试者的新颖方法和组合物。

72. 发明申请

US20090235969A1 TERNARY THERMOELECTRIC MATERIALS AND METHODS OF FABRICATION 审中-公开
标题翻译：三元热电材料和制造方法
公开(公告)号：US20090235969A1
公开(公告)日：2009-09-24
申请号：US12359052
申请日：2009-01-23
申请人： Joseph P. Heremans , Vladimir Jovovic , Donald T. Morelli
发明人： Joseph P. Heremans , Vladimir Jovovic , Donald T. Morelli
IPC分类号： H01L35/12 , C22C5/06 , C22C12/00 , C22C28/00
CPC分类号： C01B19/007 , C01B19/002 , C01P2006/40 , H01L35/16 , H01L35/34 , Y02P20/129
摘要： A thermoelectric material and a method of fabricating a thermoelectric material are provided. The thermoelectric material includes a compound having an elemental formula of A1−xB1+yC2+z and having a coefficient of thermal expansion greater than 20 parts-per-million per degree Celsius in at least one direction at one or more operating temperatures. The A component of the compound includes at least one element selected from the group consisting of: at least one Group Ia element and at least one Group Ib element, the B component of the compound includes at least one element selected from the group consisting of: at least one Group V element and at least one Group VIII element, and the C component of the compound includes at least one Group VI element. In addition, x is between −0.2 and 0.3, y is between −0.2 and 0.4, and z is between −0.2 and 0.8. Furthermore, the A component includes no more than 95 atomic % silver when the B component includes antimony and the C component includes tellurium, the B component includes no more than 95 atomic % antimony when the A component includes silver and the C component includes tellurium, and the C component includes no more than 95 atomic % tellurium when the A component includes silver and the B component includes antimony.
摘要翻译：提供热电材料和制造热电材料的方法。热电材料包括具有A1-xB1 + yC2 + z的元素式的化合物，并且在一个或多个工作温度下，在至少一个方向上的热膨胀系数大于每百万摄氏度20百万分之一。化合物的A组分包括至少一种选自以下的元素：至少一种Ia族元素和至少一种Ib族元素，该化合物的B成分包括至少一种选自以下的元素：至少一个V族元素和至少一个VIII族元素，并且该化合物的C成分包括至少一个VI族元素。此外，x在-0.2和0.3之间，y在-0.2和0.4之间，z在-0.2和0.8之间。此外，当B成分含有锑，C成分含有碲时，A成分含有不超过95原子％的银，当A成分含有银时，B成分含有不超过95原子％的锑，C成分含有碲，当A成分含有银，B成分含有锑时，C成分含有不超过95原子％的碲。

73. 发明授权

US07592506B2 Transgenic plants with altered levels of phenolic compounds 失效
标题翻译：具有改变酚类化合物水平的转基因植物
公开(公告)号：US07592506B2
公开(公告)日：2009-09-22
申请号：US11615494
申请日：2006-12-22
申请人： Erich Grotewold , Anusha P Dia , Edward L. Braun
发明人： Erich Grotewold , Anusha P Dia , Edward L. Braun
IPC分类号： C12N15/29 , C12N15/82 , A01H5/00
CPC分类号： C12N15/8243 , C12N15/8217 , C12N15/825
摘要： Methods for altering levels in plants of one or more phenolic compounds that are intermediates or final products of the plant phenylpropanoid pathway are provided. One method comprises transforming a plant cell with an expression construct comprising a nucleic acid which encodes a transactivator protein comprising the myb domain of the maize “ZmMyb-IF35” protein and an activation domain. Another method comprises transforming a plant cell with an expression construct comprising a transgene which encodes an antisense ZmMyb-IF35 RNA. The present invention also relates to expression constructs and vectors used in the present methods, transformed plant cells and transgenic plants prepared according to the present methods, and the seeds of such transgenic plants.
摘要翻译：提供了一种或多种作为植物苯丙素途径的中间体或最终产物的酚类化合物在植物中改变水平的方法。一种方法包括用包含编码包含玉米“ZmMyb-IF35”蛋白的myb结构域的反式激活蛋白和激活结构域的核酸的表达构建体转化植物细胞。另一种方法包括用包含编码反义ZmMyb-IF35 RNA的转基因的表达构建体转化植物细胞。本发明还涉及本方法中使用的表达构建体和载体，根据本发明方法制备的转化植物细胞和转基因植物以及这些转基因植物的种子。

74. 发明申请

US20090203631A1 PEPTIDE DEFORMYLASE INHIBITORS AS NOVEL ANTIBIOTICS 审中-公开
标题翻译：肽类抗坏血酸酶抑制剂作为新型抗生素
公开(公告)号：US20090203631A1
公开(公告)日：2009-08-13
申请号：US12424282
申请日：2009-04-15
申请人： Dehua Pei
发明人： Dehua Pei
IPC分类号： A61K38/05 , C07C237/12 , A01N37/18 , A01P1/00 , A61P31/04
CPC分类号： C07D245/02 , A61K38/00 , Y02A50/473
摘要： A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P1′, P2′, and P3′, wherein P2′ connects P1′ and P3′, wherein P1′ and P3′ each have a side chain, and wherein the side chains on P1′ and P3′ are crosslinked to form the macrocyclic PDF inhibitor. The side chains of P1′ and P3′ interact with the PDF active site, and preferably, P2′ has a side chain that interacts with a solvent. Also provided are methods of inhibiting the growth of a bacterium, the methods comprising contacting the bacterium with an anti-bacterial effective amount of the inventive macrocyclic PDF inhibitor. Additionally, a method of treating a bacterial infection in a subject comprising administering an effective amount of a macrocyclic PDF inhibitor to a subject in need of treatment. Additionally, methods of preparing macrocyclic PDF inhibitors comprising a) choosing an acyclic base molecule, having at least some PDF inhibitory activity, the acyclic base molecule having a first residue having a first side chain that interacts with the PDF active site and a second residue having a second that interacts with the PDF active site; and b) crosslinking the first side chain and the second side chain to form a macrocyclic PDF inhibitor.
摘要翻译：包含具有3个残基P1'，P2'和P3'的肽或肽模拟物的大环肽变性酶（PDF）抑制剂，其中P2'连接P1'和P3'，其中P1'和P3'各自具有侧链，并且其中P1'和P3'上的侧链交联以形成大环PDF抑制剂。 P1'和P3'的侧链与PDF活性位点相互作用，优选P2'具有与溶剂相互作用的侧链。还提供了抑制细菌生长的方法，所述方法包括使细菌与抗细菌有效量的本发明的大环PDF抑制剂接触。另外，治疗受试者的细菌感染的方法包括向需要治疗的受试者施用有效量的大环的PDF抑制剂。另外，制备大环PDF抑制剂的方法包括：a）选择具有至少一些PDF抑制活性的无环碱基分子，所述无环碱基分子具有具有与所述PDF活性位点相互作用的第一侧链的第一残基和具有与所述PDF活性位点相互作用的第二残基，第二个与PDF活动网站进行交互; 和b）交联第一侧链和第二侧链以形成大环PDF抑制剂。

75. 发明授权

US07572919B2 Heteroaryl-containing isoflavones as aromatase inhibitors 失效
标题翻译：含杂芳基的异黄酮作为芳香酶抑制剂
公开(公告)号：US07572919B2
公开(公告)日：2009-08-11
申请号：US11212229
申请日：2005-08-26
申请人： Robert W. Brueggemeier , Young-Woo Kim , John C. Hackett
发明人： Robert W. Brueggemeier , Young-Woo Kim , John C. Hackett
IPC分类号： C07D311/04 , C07D311/74 , C07D401/02
CPC分类号： C07D311/04 , C07D405/12
摘要： Compounds and methods useful for treating and prevention of cancer, particularly hormone-dependent breast cancer. Provided are compounds of formula I: wherein X is selected from O, N, S, SO, SO2, and S(CH2)n, wherein n=1-10; R1 and R2 may be the same or different and are selected from H, OH, OCH3, OCH2CH3, OCH2C6H5, NH2, NHCH3, N(CH3)2, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, C(CH3)3, NO2, F, Cl, Br, CF3, SH, SCH3, SCH2CH3, OCOCH3, OCOC(CH3)3, OCOCH2COOH, and CN; and R3 is a nitrogen-containing heterocyclic ring. Also provided are method for treating or preventing cancer in a subject by administering a therapeutically effective amount of a heteroaryl-containing isoflavone, or a pharmaceutically acceptable salt or prodrug thereof, to a subject in need of treatment. Also provided is a method for the synthesis of 2-substituted isoflavones by first reacting deoxybenzoins with a phase transfer catalyst to provide a 2-(alkylthio)isoflavone; second deprotecting the 2-(alkylthio)isoflavone; and third applying selective debenzylation to form the final compound.
摘要翻译：用于治疗和预防癌症，特别是激素依赖性乳腺癌的化合物和方法。提供式I化合物：其中X选自O，N，S，SO，SO 2和S（CH 2）n，其中n = 1-10; R1和R2可以相同或不同，选自H，OH，OCH3，OCH2CH3，OCH2C6H5，NH2，NHCH3，N（CH3）2，CH3，CH2CH3，CH2CH2CH3，CH（CH3）2，C（CH3）3 ，NO 2，F，Cl，Br，CF 3，SH，SCH 3，SCH 2 CH 3，OCOCH 3，OCOC（CH 3）3，OCOCH 2 COOH和CN; R3为含氮杂环。还提供了通过向需要治疗的受试者施用治疗有效量的含杂芳基的异黄酮或其药学上可接受的盐或前药来治疗或预防受试者的癌症的方法。还提供了通过首先使脱氧苯偶姻与相转移催化剂反应以提供2-（烷硫基）异黄酮来合成2-取代的异黄酮的方法; 第二次脱保护2-（烷硫基）异黄酮; 并且第三次施加选择性脱苄基以形成最终化合物。

76. 发明申请

US20090151014A1 SOYBEAN CULTIVAR HFPR-5 失效
标题翻译：大豆品种HFPR-5
公开(公告)号：US20090151014A1
公开(公告)日：2009-06-11
申请号：US11952525
申请日：2007-12-07
申请人： Steven K. St. Martin , Anne Dorrance , Ronald J. Fioritto , Sue Ann Berry , Scott McIntyre , Marcia Feller
发明人： Steven K. St. Martin , Anne Dorrance , Ronald J. Fioritto , Sue Ann Berry , Scott McIntyre , Marcia Feller
IPC分类号： A01H5/00
CPC分类号： A01H5/10
摘要： A soybean cultivar designated HFPR-5 is disclosed. The invention relates to the seeds of soybean cultivar HFPR-5, to the plants of soybean HFPR-5, to plant parts of soybean cultivar HFPR-5 and to methods for producing a soybean plant produced by crossing soybean cultivar HFPR-5 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars or breeding cultivars and plant parts derived from soybean variety HFPR-5, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar HFPR-5 and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants and plant parts produced by crossing the cultivar HFPR-5 with another soybean cultivar.
摘要翻译：公开了一种称为HFPR-5的大豆品种。本发明涉及大豆品种HFPR-5的种子，大豆HFPR-5的植物，大豆品种HFPR-5的植物部分，以及通过将大豆品种HFPR-5与其本身交叉而生产的大豆植物的方法，与另一大豆品种。本发明还涉及含有一种或多种转基因的遗传物质的大豆植物的制备方法以及通过这些方法制备的转基因大豆植物和植物部分的方法。本发明还涉及来自大豆品种HFPR-5的大豆品种或繁殖品种和植物部分，其生产其他大豆品种，来自大豆品种HFPR-5的品系或植物部分的方法以及大豆植物，品种及其大豆品种派生自使用这些方法的部分。本发明还涉及通过将品种HFPR-5与另一个大豆品种杂交而制备的杂交大豆种子，植物和植物部分。

77. 发明申请

US20090137679A1 ZN2+Chelating Motif-Tethered Short-Chain Fatty Acids as a Novel Class of Histone Deacetylase Inhibitors 有权
标题翻译： ZN2 +螯合基因敲除短链脂肪酸作为组合脱乙酰酶抑制剂的新型
公开(公告)号：US20090137679A1
公开(公告)日：2009-05-28
申请号：US12361626
申请日：2009-01-29
申请人： Ching-Shih Chen , Qiang Lu
发明人： Ching-Shih Chen , Qiang Lu
IPC分类号： A61K31/16 , A61P35/00
CPC分类号： C07D213/81 , A61K31/167 , A61K31/19 , A61K31/4402 , C07B2200/07 , C07C237/22 , C07C237/42 , C07C259/06 , C07C259/10
摘要： Zn2+-chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests.
摘要翻译： Zn2 +螯合基序 - 拴系脂肪酸作为组蛋白脱乙酰酶（HDAC）抑制剂。化合物在体外和体内测试中表现良好。

78. 发明申请

US20090111799A1 ANTI-INFECTIVE AGENTS AGAINST INTRACELLULAR PATHOGENS 有权
标题翻译：抗细菌病毒的抗感染药物
公开(公告)号：US20090111799A1
公开(公告)日：2009-04-30
申请号：US12179134
申请日：2008-07-24
申请人： Ching-Shih Chen , Hao-Chieh Chiu , Dasheng Wang
发明人： Ching-Shih Chen , Hao-Chieh Chiu , Dasheng Wang
IPC分类号： A61K31/5415 , C07D231/10 , C12N5/00 , A61K31/415 , C07D257/04 , A61P35/00 , A61P31/00 , A61K31/41 , C07D403/02 , A61K31/496 , C07D279/18
CPC分类号： C07D231/12 , C07D403/04 , C07D403/10 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , C12N2501/06
摘要： A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: wherein X wherein X is —CF3, Ar is selected from and R is selected from where R′ is L-Lys, D-Lys, β-Ala, L-Lue, L-Ile, Phe, SO2CH2CH2NH2, SO2NH2, Asn, Glu or Gyl, and R″ is methyl, ethyl, allyl, CH2CH2OH, CH2CN, CH2CH2CN, CH2CONH2,
摘要翻译：式I的新一类磷酸肌醇依赖性激酶-1（PDK-1）抑制剂：其中X为X为-CF 3，Ar为选自其中R为选自其中R'为L-Lys，D-Lys，β -Ala，L-Lue，L-Ile，Phe，SO2CH2CH2NH2，SO2NH2，Asn，Glu或Gyl，R“为甲基，乙基，烯丙基，CH2CH2OH，CH2CN，CH2CH2CN，CH2CONH2，

79. 发明申请

US20090010956A1 EHRLICHIA EWINGII PROTEINS, NUCLEIC ACIDS, AND METHODS OF THEIR USE 有权
标题翻译： EHRLICHIA EWINGII蛋白，核酸及其使用方法
公开(公告)号：US20090010956A1
公开(公告)日：2009-01-08
申请号：US12115490
申请日：2008-05-05
申请人： Yasuko Rikihisa
发明人： Yasuko Rikihisa
IPC分类号： A61K39/00 , C07K14/00 , C07H21/04 , A61P31/00 , G01N33/566 , C07K16/18
CPC分类号： A61K39/0233 , A61K38/00 , A61K38/04 , A61K2039/552 , A61K2039/575 , A61K2039/6031 , C07K7/08 , C07K14/29 , G01N33/53 , G01N33/56911 , G01N33/6854 , G01N2333/29 , G01N2469/20 , Y02A50/402
摘要： The novel omp-1 gene cluster encoding twenty one Ehrlichia ewingii (EE) proteins was isolated and sequenced completely. This invention relates to isolated E. ewingii (EE) polypeptides, isolated polynucleotides encoding EE polypeptides, probes, primers, isolated antibodies and methods of their production, immunogenic compositions and vaccines, as well as methods of using the EE polypeptides, antibodies, probes, and primers for the purpose of diagnosis, therapy and production of vaccines against E. ewingii.
摘要翻译：分离编码二十一种Ehilichia ewingii（EE）蛋白质的新型omp-1基因簇，并完全测序。本发明涉及分离的E.Ewingii（EE）多肽，编码EE多肽的分离的多核苷酸，探针，引物，分离的抗体及其生产方法，免疫原性组合物和疫苗，以及使用EE多肽，抗体，探针，和引物，用于诊断，治疗和生产针对大肠埃希氏芽孢杆菌的疫苗。

80. 发明授权

US07393922B2 Insecticidal Cry4Ba proteins with enhanced toxicity 失效
标题翻译：具有增强毒性的杀虫Cry4Ba蛋白
公开(公告)号：US07393922B2
公开(公告)日：2008-07-01
申请号：US10929754
申请日：2004-08-30
申请人： Donald H. Dean , Mohd Amir Abdullah
发明人： Donald H. Dean , Mohd Amir Abdullah
IPC分类号： C07K5/00 , C07H21/02 , C12H15/63 , C12N1/12
CPC分类号： C07K14/325
摘要： The present invention relates generally to modified Bacillus thuringiensis (Bt) insecticidal crystal proteins, also referred to as mutant toxins, with enhanced toxicity against a variety of insect genera, particularly mosquitos. The invention provides modified Bt Cry4Ba proteins, or mutant toxins, which have toxicity-enhancing sequence modifications at one or more positions within the amino acid sequence of the protein. The invention also provides polynucleotides encoding modified Cry4Ba proteins. The invention also provides insecticidal compositions comprising mutant toxins with a new or broadened insecticidal spectrum, and insecticidal compositions comprising polynucleotides encoding the modified Cry4Ba proteins.
摘要翻译：本发明一般涉及改良的苏云金芽孢杆菌（Bt）杀虫结晶蛋白，也称为突变毒素，对各种昆虫属，特别是蚊子具有增强的毒性。本发明提供了修饰的Bt Cry4Ba蛋白或突变毒素，其在蛋白质的氨基酸序列内的一个或多个位置具有毒性增强的序列修饰。本发明还提供编码修饰的Cry4Ba蛋白的多核苷酸。本发明还提供包含具有新的或扩大的杀虫谱的突变毒素和包含编码修饰的Cry4Ba蛋白的多核苷酸的杀虫组合物的杀虫组合物。

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