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71. 发明授权

US10100029B2 Combretastatin analogs 有权
公开(公告)号：US10100029B2
公开(公告)日：2018-10-16
申请号：US15849150
申请日：2017-12-20
申请人： BioVentures, LLC
发明人： Narsimha Reddy Penthala , Peter Crooks , Vijayakumar Sonar
IPC分类号： C07D333/60 , C07D307/79 , C07D277/64 , C07D209/18 , C07D307/80 , C07D215/14
摘要： The present invention relates novel heterocyclic analogs of combretastatin, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I), Formula (II), and Formula (V) are provided.

72. 发明授权

US10071060B2 Asymmetrically coated table 有权
公开(公告)号：US10071060B2
公开(公告)日：2018-09-11
申请号：US11443666
申请日：2006-05-30
申请人： Cherng-ju Kim
发明人： Cherng-ju Kim
IPC分类号： A61K9/24 , A61K9/28 , A61K9/20
CPC分类号： A61K9/5021 , A61K9/2072 , A61K9/209 , A61K9/28 , A61K9/2886 , A61K9/2893 , A61K9/5089
摘要： A tablet for the controlled release of a drug. The tablet is in the form of an asymmetrically coated tablet so that immediate release or time-delayed release times can be precisely controlled and the extended release slab may provide zero-order or first-order extended release and pulsatile release depending on the excipients used in the tablet formulations. The core of the tablet is coated with an asymmetrical coating, that is, a coating with regions having different properties. The coatings may include drugs in varying concentrations. Further, different regions of the coating may have different rates of dissolution. The core of the tablet may be provided with a constant cross-sectional area along a longitudinal length of the tablet, a coating having a first region with a more rapid rate of dissolution than a second region. The dissolution of the first region exposes only the cross-sectional area to the dissolution medium. The second region of the coating prevents any other portion of the core of the tablet from being exposed to the dissolution medium. Therefore, since the cross-sectional area remains constant as it is dissolved, the rate of release of the drug from the core of the tablet remains constant. The cross-sectional area may be of any geometrical configuration so long as the area remains constant as the core dissolves.

73. 发明授权

US10022358B2 Methods for improving muscle and heart function 有权
公开(公告)号：US10022358B2
公开(公告)日：2018-07-17
申请号：US15424311
申请日：2017-02-03
申请人： BioVentures, LLC
发明人： Robert R. Wolfe , Jeanne Wei
IPC分类号： A61K31/197 , A61K31/198 , A61K31/4188 , A61K31/405 , A61K31/4172 , A61K31/205 , A61K31/202 , A23L33/175
摘要： The present invention encompasses combinations comprising a plurality of amino acids, formulations thereof for use in humans and animals, as well as methods for increasing muscle protein synthesis, muscle strength, and/or muscle function in a subject with chronic heart failure, cardiac cachexia or a combination thereof.

74. 发明申请

US20170342501A1 USE OF GENE EXPRESSION PROFILING TO PREDICT SURVIVAL IN CANCER PATIENT 审中-公开
公开(公告)号：US20170342501A1
公开(公告)日：2017-11-30
申请号：US15593937
申请日：2017-05-12
申请人： BIOVENTURES, LLC
发明人： John D. Shaughnessy , Fenghuang Zhan , Bart Barlogie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： Gene expression profiling in multiple myeloma patients identifies genes that distinguish between patients with subsequent early death or long survival after treatment. Poor survival is linked to over-expression of genes such as ASPM, OPN3 and CKS1B which are located in chromosome 1q. Given the frequent amplification of 1q in many cancers, it is possible that these genes can be used as powerful prognostic markers and therapeutic targets for multiple myeloma and other cancer.

75. 发明授权

US09687268B2 Dermatome with adjustable width and depth guards 有权
公开(公告)号：US09687268B2
公开(公告)日：2017-06-27
申请号：US14183788
申请日：2014-02-19
申请人： Gal Shafirstein , Anjay K. Khandelwal , James C. Walker
发明人： Gal Shafirstein , Anjay K. Khandelwal , James C. Walker
IPC分类号： A61B17/50 , A61B17/322
CPC分类号： A61B17/322
摘要： A dermatome including a battery unit, a handle, and a head portion. The head portion includes guards capable of being adjusted to control the width and the depth of the cut without an interruption in the medical procedure.

76. 发明授权

US09650677B2 Use of gene expression profiling to predict survival in cancer patient 有权
公开(公告)号：US09650677B2
公开(公告)日：2017-05-16
申请号：US13899196
申请日：2013-05-21
申请人： Board of Trustees of the University of Arkansas
发明人： John D. Shaughnessy , Fenghuang Zhan , Bart Barlogie
IPC分类号： G01N33/50 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： Gene expression profiling in multiple myeloma patients identifies genes that distinguish between patients with subsequent early death or long survival after treatment. Poor survival is linked to over-expression of genes such as ASPM, OPN3 and CKS1B which are located in chromosome 1q. Given the frequent amplification of 1q in many cancers, it is possible that these genes can be used as powerful prognostic markers and therapeutic targets for multiple myeloma and other cancer.

77. 发明授权

US09066804B2 Method and apparatus for femoral and tibial resection 有权
标题翻译：股骨和胫骨切除术的方法和装置
公开(公告)号：US09066804B2
公开(公告)日：2015-06-30
申请号：US13169728
申请日：2011-06-27
申请人： Timothy G. Haines , David B. Goldstein
发明人： Timothy G. Haines , David B. Goldstein
IPC分类号： A61B17/15 , A61F2/38 , A61B17/16 , A61B17/17
CPC分类号： A61F2/3859 , A61B17/155 , A61B17/157 , A61B17/1675 , A61B17/1764 , A61B17/1767 , A61B2017/1602
摘要： Methods for a primary total knee arthroplasty procedure on a knee joint of a human patient.
摘要翻译：用于人类患者膝关节的初步全膝关节置换手术的方法。

78. 发明授权

US12128099B2 Myxoma virus compositions and methods of use 有权
公开(公告)号：US12128099B2
公开(公告)日：2024-10-29
申请号：US17058765
申请日：2019-05-24
申请人： BIOVENTURES, LLC
发明人： Jia Liu , Martin Cannon
IPC分类号： A61K35/00 , A61K39/00 , A61K39/275 , A61K45/06 , A61P35/00
CPC分类号： A61K39/275 , A61K39/0011 , A61K45/06 , A61P35/00 , A61K2039/5254 , A61K2039/545 , A61K2039/585 , A61K2039/892
摘要： Mutant Myxoma viruses are provided herein and methods of using these viruses to treat cancer or elicit an interferon response in a subject are also provided. The mutant Myxoma virus is modified to reduce or eliminate the activity or expression of Myxoma virus protein M62 as compared to a control virus. The mutant virus is capable of stimulating an interferon response in subjects after administration and can also lead to inhibition, reduction or elimination of the CD14+ tumor associated macrophage inhibition of CD4+ T cells in a subject having cancer and lead to a change in the tumor microenvironment to treat the cancer or work in combination with other cancer therapeutics to treat the cancer as described herein.

79. 发明授权

US12084423B2 Piperlongumine analogues and uses thereof 有权
公开(公告)号：US12084423B2
公开(公告)日：2024-09-10
申请号：US17056705
申请日：2018-05-18
申请人： BioVentures, LLC
发明人： Guangrong Zheng , Daohong Zhou , Xuan Zhang
IPC分类号： A61K31/44 , A61K45/06 , C07D211/88 , C07D223/10 , C07D265/02
CPC分类号： C07D223/10 , A61K45/06 , C07D211/88 , C07D265/02
摘要： The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine derivative thereof. The selective killing of senescent cells may delay aging and/or treat age-related disorders.

80. 发明公开

US20240109892A1 POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) INHIBITORS AGAINST COVID MACRODOMAIN AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：US20240109892A1
公开(公告)日：2024-04-04
申请号：US18262682
申请日：2022-01-24
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , BIOVENTURES, LLC
发明人： John A. TAINER , Zamal AHMED , Darin E. JONES , Davide MOIANI , Chris Arlen BROSEY
IPC分类号： C07D473/22 , C07D473/08
CPC分类号： C07D473/22 , C07D473/08
摘要： The present disclosure provides compounds of Formula (Ia) and Formula (Ib) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, A2, R1, R2, R3, and R4 are defined as set forth in the specification. The present disclosure also provides the use of compounds of Formula (Ia) or Formula (Ib) to treat a coronavirus infection in a subject.

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