专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明申请

US20050165005A1 Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them 失效
标题翻译：吡唑基衍生物，该方法的制备方法和中间体作为药物产品和含有它们的药物组合物
公开(公告)号：US20050165005A1
公开(公告)日：2005-07-28
申请号：US10997736
申请日：2004-11-24
申请人： Arielle Genevois-Borella , Jean-Luc Malleron , Jean Bouquerel , Gilles Doerflinger , Andrees Bohme , Gaetan Touyer , Jean-Francois Sabuco , Corrine Terrier , Serge Mignani , Michel Evers , Youssef El-Ahmad
发明人： Arielle Genevois-Borella , Jean-Luc Malleron , Jean Bouquerel , Gilles Doerflinger , Andrees Bohme , Gaetan Touyer , Jean-Francois Sabuco , Corrine Terrier , Serge Mignani , Michel Evers , Youssef El-Ahmad
IPC分类号： A61K31/41 , A61K31/416 , A61K31/435 , A61K31/454 , A61K31/55 , C07D231/12 , C07D231/14 , C07D231/20 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/04 , C07D453/02 , C07D453/06 , C07D487/08 , C07D43/02
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D401/04 , C07D401/06 , C07D403/06 , C07D409/04 , C07D453/02 , C07D453/06 , C07D487/08
摘要： The present invention relates to the novel derivatives of formula (I) in which A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (C4-C7) azacycloalkyl, (C5-C7) azacycloalkenyl, (C5-C9) azabicycloalkyl or (C5-C9) azabicycloalkenyl group; A-R1 is such that the nitrogen of R1 and the nitrogen in the 1-position of the pyrazole are necessarily separated by at least two carbon atoms, R3 is an H, halogen, OH, SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra or NHSO2Ra, R4 is an aryl or heteroaryl; and R5 is an H, halogen, CF3, CHF2, CH2F, linear or branched (C1-C6) alkyl or (C3-C7) cycloalkyl to their racemates, enantiomers and diastereoisomers and to their mixtures, their tautomers and to their pharmaceutically acceptable salts.
摘要翻译：本发明涉及式（I）的新衍生物，其中A是（C 1 -C 6）烷基，（C 3 -C 6）烯基，（C 3 -C 6）炔基，（C 3 （C 5 -C 7）氮杂双环烷基或（C 5 -C 9）氮杂双环链烯基;（C 5 -C 7）氮杂双环烷基或（C 5 -C 9） A-R1使得R 1的氮和吡唑的1位的氮必须分开至少两个碳原子，R 3是H，卤素，OH，SH，NH 2 >，ORc，SRc，SORa，SO 2 Ra，NHCHO，NRaRb，NHC（O）Ra，NHC（S）Ra或NHSO2Ra，R4是芳基或杂芳基; 并且R 5是H，卤素，CF 3，CHF 2，CH 2 F，直链或支链（C 1 -C 6）烷基或（ C3-C7）环烷基与其外消旋体，对映异构体和非对映异构体及其混合物，它们的互变异构体及其药学上可接受的盐。

72. 发明申请

US20050164983A1 Carboxyl-reduced derivatives of dermatan sulfate, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them 审中-公开
标题翻译：硫酸皮肤素的羧基还原衍生物，其制备方法，作为药物的用途以及含有它们的药物组合物
公开(公告)号：US20050164983A1
公开(公告)日：2005-07-28
申请号：US11016501
申请日：2004-12-17
申请人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
发明人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
IPC分类号： A61K31/737
CPC分类号： C08B37/0069
摘要： The present invention relates to the carboxyl-reduced derivatives of dermatan sulfate of formula (I): in which R1, R2, R3 or R4 represents H or SO3M, n is an integer of between 0 and 150, M is an alkali metal, isolated or as mixtures, to the diastereoisomers thereof, to the process for the preparation thereof, to the uses thereof as a medicinal product and to the pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的硫酸皮肤素的羧基还原衍生物：其中R 1，R 2，R 3，或R 4代表H或SO 3 M，n为0至150的整数，M为与其非对映异构体分离或作为混合物的碱金属，其制备方法，其作为药用产品的用途和含有它们的药物组合物。

73. 发明申请

US20050163754A1 Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same 审中-公开
标题翻译：重组病毒及其用于治疗动脉粥样硬化和其他形式的冠状动脉疾病的方法，试剂和试剂盒，用于评估与之相似的易感性
公开(公告)号：US20050163754A1
公开(公告)日：2005-07-28
申请号：US10831268
申请日：2004-04-26
申请人： Patrick Benoit , Patrice Denefle , Michael Perricaudet , M.E. Lewis , Michael Hayden
发明人： Patrick Benoit , Patrice Denefle , Michael Perricaudet , M.E. Lewis , Michael Hayden
IPC分类号： A61K38/00 , A61K38/46 , A61K48/00 , C12N9/20 , C12N15/861 , C12Q1/68
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C12N9/20 , C12N15/86 , C12N2710/10343 , C12N2740/13043 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/44 , C12Q1/6858 , C12Q2600/156 , C12Y301/01034 , C12Q2535/131 , C12Q2525/131
摘要： Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant viruses, especially for the treatment or prevention of dyslipoproteinemia-related pathologies.
摘要翻译：包含编码参与脂蛋白代谢的脂肪酶的异源DNA序列的重组病毒。本发明还涉及在所述重组病毒的治疗中的制备和用途，特别是用于治疗或预防与脂蛋白血症相关的病症。

74. 发明申请

US20050154048A1 Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use 审中-公开
标题翻译：新型酰基肼基噻吩衍生物，其制备方法，用作药用产品，药物组合物和新用途
公开(公告)号：US20050154048A1
公开(公告)日：2005-07-14
申请号：US11028848
申请日：2005-01-04
申请人： Didier Benard , Jean-Francois Gourvest
发明人： Didier Benard , Jean-Francois Gourvest
IPC分类号： A61K31/381 , A61P19/08 , C07D333/22 , C07D333/38 , C07D409/12
CPC分类号： C07D333/38 , C07D409/12
摘要： The invention concerns novel compounds of formula (I), process for making, pharmaceutical compositions and methods of treating diseases associated with abnormal physiological behavior in the secretion and/or the activity of cysteine proteases especially cathepsins.
摘要翻译：本发明涉及式（I）的新型化合物，制备方法，药物组合物和治疗与半胱氨酸蛋白酶特别是组织蛋白酶的分泌和/或活性相关的异常生理行为相关疾病的方法。

75. 发明授权

US06902927B2 Enzymatic process for the enantiomeric resolution of amino acids 有权
标题翻译：用于氨基酸对映异构体拆分的酶法
公开(公告)号：US06902927B2
公开(公告)日：2005-06-07
申请号：US10232674
申请日：2002-09-03
申请人： Christophe Salagnad , Claude Gobert , Marie-Odile Dury
发明人： Christophe Salagnad , Claude Gobert , Marie-Odile Dury
IPC分类号： C07C7/148 , C12P13/04 , C12P41/00
CPC分类号： C12P41/007
摘要： An enzymatic process permitting the enantiomeric resolution of amino acids is provided. More specifically, this process for separating the enantiomers of an amino acid comprises treating a racemic mixture of the amino acid with glutaric anhydride and then with the enzyme glutaryl-7-ACA acylase so as to recover one of the enantiomers of the amino acid, the other enantiomer remaining in the form of the corresponding glutarylamide derivative.
摘要翻译：提供了允许氨基酸的对映体拆分的酶法。更具体地，用于分离氨基酸的对映异构体的方法包括用戊二酸酐处理氨基酸的外消旋混合物，然后用戊二酰-7-ACA酰基转移酶处理，以回收氨基酸的一个对映异构体，以相应的戊二酰胺衍生物形式保留的其它对映异构体。

76. 发明申请

US20050092820A1 Polygonal box 审中-公开
标题翻译：多边形框
公开(公告)号：US20050092820A1
公开(公告)日：2005-05-05
申请号：US10974657
申请日：2004-10-27
申请人： Hakim Chekroune
发明人： Hakim Chekroune
IPC分类号： B65D5/02 , B65D5/54 , B65D5/43
CPC分类号： B65D5/0254 , B65D5/541 , B65D2101/0023
摘要： A polygonal box comprises faces (1, 2, 3), a lid (7) provided with a tab (8) suitable for arranging in a folded position against a first face (1) of the box, and a flap (9) that can be folded down around an edge (29) shared with a second face (2) of the box, the flap (9) having a zone (10) of mechanical weakening that is inclined relative to said edge (29). The inclined zone (10) of weakening does not tear when the box is packed industrially and shows up first opening of the box by tearing-away of a surface (12) of the flap at the time of said first opening (FIG. 2).
摘要翻译：一个多边形盒子包括面（1,2,3），盖子（7）设有一个适于在折叠位置上抵靠盒子的第一面（1）布置的凸片（8）和一个挡板（9）可以围绕与盒的第二面（2）共享的边缘（29）折叠，所述翼片（9）具有相对于所述边缘（29）倾斜的机械弱化区域（10）。当箱体工业包装时，减弱的倾斜区域（10）不会撕裂，并且在所述第一开口时（图2）撕裂折翼的表面（12）并显示箱子的第一开口，。

77. 发明授权

US06872740B2 Use of 2-amino-4-heteroarylethyl-thiazoline derivatives as inhibitors of inducible no-synthase 失效
标题翻译：使用2-氨基-4-杂芳基乙基 - 噻唑啉衍生物作为诱导型无合成酶的抑制剂
公开(公告)号：US06872740B2
公开(公告)日：2005-03-29
申请号：US10291110
申请日：2002-11-08
申请人： Eric Bacque , Antony Bigot , Jean-Christophe Carry , Serge Mignani
发明人： Eric Bacque , Antony Bigot , Jean-Christophe Carry , Serge Mignani
IPC分类号： A61K31/427 , A61K31/4439 , A61P25/16 , C07D239/26 , C07D277/28 , C07D333/20 , C07D413/06 , C07D417/06 , A61K31/431 , C07D409/06
CPC分类号： C07D239/26 , C07D277/28 , C07D333/20 , C07D413/06 , C07D417/06
摘要： The present invention relates to the use of 2-amino-4-heteroarylethyl-thiazoline derivatives of formula (I) in which Het represents a thienyl, pyrimidyl, pyridyl or thiazolyl radical or pharmaceutically acceptable salts thereof as inhibitors of inducible NO-synthase.
摘要翻译：本发明涉及式（I）的2-氨基-4-杂芳基乙基 - 噻唑啉衍生物，其中Het表示噻吩基，嘧啶基，吡啶基或噻唑基或其药学上可接受的盐作为诱导型NO合成酶的抑制剂。

78. 发明申请

US20050065138A1 Acetone solvate of dimethoxy docetaxel and its process of preparation 有权
标题翻译：二甲氧基多西紫杉醇的丙酮溶剂合物及其制备方法
公开(公告)号：US20050065138A1
公开(公告)日：2005-03-24
申请号：US10944254
申请日：2004-09-17
申请人： Eric Didier , Marc-Antoine Perrin
发明人： Eric Didier , Marc-Antoine Perrin
IPC分类号： A61K31/58 , C07D305/14 , C07J71/00
CPC分类号： C07D305/14 , A61K31/58
摘要： This invention discloses and claims an acetone solvate of dimethoxydocetaxel or 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate and its preparation by crystallization from an aqueous/acetone solution.
摘要翻译：本发明公开并要求二甲氧基多西他赛或4-乙酰氧基-2α-苯甲酰氧基-5β，20-环氧-1-羟基-β-7beta，10β-二甲氧基-9-氧杂十一烷-11-烯-13α-基（2R，3S ）-3-叔丁氧基羰基氨基-2-羟基-3-苯基丙酸酯，其制备方法是从水/丙酮溶液中结晶。

79. 发明授权

US06858603B2 Acetindine derivatives, their preparation and medicaments containing them 失效
标题翻译：丙啶衍生物，其制剂和含有它们的药物
公开(公告)号：US06858603B2
公开(公告)日：2005-02-22
申请号：US10320344
申请日：2002-12-16
申请人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Marc Capet , Serg Grisoni , Jean-Luc Malleron , Serge Mignani , Augustin Hittinger
发明人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Marc Capet , Serg Grisoni , Jean-Luc Malleron , Serge Mignani , Augustin Hittinger
IPC分类号： C07D205/04 , A61K31/397 , A61K31/4025 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4523 , A61K31/496 , A61K31/5355 , A61K31/541 , A61P1/00 , A61P1/08 , A61P3/04 , A61P5/00 , A61P9/00 , A61P9/02 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , C07D205/06 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/10 , C07D403/06
CPC分类号： C07D401/06 , C07D205/06 , C07D409/06 , C07D409/14 , C07D417/06
摘要： Disclosed are azetidine derivatives of formula: their optical isomers, their salts, their preparation and medicaments containing them.
摘要翻译：公开的是下式的氮杂环丁烷衍生物：它们的光学异构体，它们的盐，它们的制备物和含有它们的药物。

80. 发明申请

US20040266667A1 Streptogramin derivatives, preparation method and compositions containing same 有权
标题翻译：链球菌素衍生物，制备方法和含有它们的组合物
公开(公告)号：US20040266667A1
公开(公告)日：2004-12-30
申请号：US10790260
申请日：2004-03-02
申请人： Aventis Pharma S.A.
发明人： Pascal Desmazeau , Gilles Doerflinger , Yves Ribeill , Eric Bacque , Jean-Claude Barriere , Gilles Dutruc-Rosset , Gerard Puchault
IPC分类号： A61K038/12 , C07K005/12
CPC分类号： C07K7/06 , A61K38/00
摘要： Group B streptogramin derivatives of general formula (I) are disclosed: 1 wherein Ra, Rb, Rc, Rd, R1, R2 and Y are as defined in the description, including preparation methods and compositions containing the same. Such derivatives are particularly useful as antimicrobial agents, optionally combined with at least one group A streptogramin derivative.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式