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71. 发明授权

US06380211B1 Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity 失效
标题翻译：用于抑制PARP活性的烷氧基取代的化合物，方法和组合物
公开(公告)号：US06380211B1
公开(公告)日：2002-04-30
申请号：US09711953
申请日：2000-11-15
申请人： Paul F. Jackson , Keith M. Maclin , Jie Zhang
发明人： Paul F. Jackson , Keith M. Maclin , Jie Zhang
IPC分类号： A61K3147
CPC分类号： C07D471/06 , C07D217/22 , C07D217/24 , C07D221/12 , C07D221/18 , C07D237/30 , C07D237/32 , C07D237/34 , C07D239/88 , C07D239/93 , C07D239/94 , C07D475/02 , C07D491/04 , C07F9/6561
摘要： A compound, compositions, methods of use, and processes of making formula I: or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein: R1, when present, is hydrogen or lower alkyl; R2 is lower alkyl, aryl, aralkyl, lower alkanoyl, or —(CH2)n—(CHOH)y(CH2)mA, wherein n is 1-4, y is 0 or 1, m is 0-5, and A is cycloalkyl, cycloalkenyl, lower alkanoyl, aryl, aralkyl, —NH2, —NH—(lower alkyl), Y represents the atoms necessary to form a fused 5- to 6-membered ring that is aromatic or nonaromatic and carbocyclic or heterocyclic; Z is (i) —CHR2CHR3— where R2 and R3 are independently hydrogen, alkyl, aryl or aralkyl; (ii) —R6C═CR3— where R6 and R3 are independently hydrogen, lower alkyl, aryl, aralkyl, chlorine, bromine or —NR7R8, where R7 and R8 are independently hydrogen or lower alkyl, or, R6 and R3, taken together, form a fused 5- to 6-membered ring that is aromatic or nonaromatic and carbocyclic or heterocyclic; (iii) —R2C═N—; (iv) —CR2(OH)—NR7—; or (v) —C(O)—NR7—.
摘要翻译：化合物，组合物，使用方法和制备式I的方法：或其药学上可接受的盐，水合物，酯，溶剂化物，前药，代谢物，立体异构体或其混合物，其中：R 1当存在时为氢或低级烷基或 - （CH 2）n - （CHOH）y（CH 2）mA，其中n为1-4，y为0或1，m为0-5，A为是环烷基，环烯基，低级烷酰基，芳基，芳烷基，-NH 2，-NH-（低级烷基），Y表示形成芳族或非芳族和碳环或杂环的稠合5-至6-元环所必需的原子; Z 是（i）-CHR2CHR3-，其中R2和R3独立地是氢，烷基，芳基或芳烷基;（ii）-R6C = CR3-，其中R6和R3独立地是氢，低级烷基，芳基，芳烷基，氯，溴或-NR7R8 其中R 7和R 8独立地为氢或低级烷基，或者R 6和R 3一起形成芳族或非芳族和碳环或杂环的稠合5-至6-元环;（ⅲ）-R2C = N-; （iv ）-CR2（OH）-NR7-; 或（ⅴ）-C（O）-NR7-。

72. 发明授权

US06245347B1 Methods and apparatus for improved administration of pharmaceutically active compounds 有权
公开(公告)号：US06245347B1
公开(公告)日：2001-06-12
申请号：US09162890
申请日：1998-09-29
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61F1302
CPC分类号： A61K9/0009 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30 , Y10S514/817 , Y10S514/937 , Y10S514/944
摘要： Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.

73. 外观设计

USD1041229S1 Heating stove 有权
公开(公告)号：USD1041229S1
公开(公告)日：2024-09-10
申请号：US29832192
申请日：2022-03-25
申请人： Jie Zhang
设计人： Jie Zhang
摘要： FIG. 1 is a perspective view of a heating stove, showing my new design;
FIG. 2 is another perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top plan view thereof;
FIG. 8 is a bottom plan view thereof;
FIG. 9 is an enlarged view of portion of FIG. 1; and,
FIG. 10 is another enlarged view of portion of FIG. 1.
The dash-dash broken lines show portions of the heating stove and form no part of the claimed design. The dot-dash broken lines shown in FIGS. 1, 9 & 10 define the boundary of the enlargement area and form no part of the claimed design.

74. 发明申请

US20160345828A1 SYSTEM AND METHOD FOR MULTI-SCALE CLOSED-LOOP EYE TRACKING WITH REAL-TIME IMAGE MONTAGING 有权
标题翻译：用于实时图像聚合的多尺度闭环眼跟踪的系统和方法
公开(公告)号：US20160345828A1
公开(公告)日：2016-12-01
申请号：US15158803
申请日：2016-05-19
申请人： Qiang Yang , Jie Zhang
发明人： Qiang Yang , Jie Zhang
IPC分类号： A61B3/15 , G02B26/10 , A61B3/12 , A61B3/113 , A61B3/00
CPC分类号： A61B3/152 , A61B3/0025 , A61B3/113 , A61B3/1225 , G02B26/105
摘要： A system for multi-scale closed-loop eye tracking to compensate for translation and rotation motion while imaging in vivo a surface area of an internal structure of an eye of a subject includes a narrow field imaging device optically coupled to an optical path to receive light reflected from the surface area of the structure of the eye. A wide field camera is optically coupled to the optical path by a beam splitter disposed in the optical path. A tracking mirror is disposed in the optical path between the beam splitter and the structure of the eye. A control process algorithm actively compensates substantially in real time for both translational and rotational movements of the eye. A system where a torsional correction device causes a rotating movement of a subject's head and a method for multi-scale closed-loop eye tracking are also described.
摘要翻译：一种用于多尺度闭环眼睛跟踪的系统，用于补偿平移和旋转运动，同时在体内成像对象的眼睛的内部结构的表面区域包括光学耦合到光路以接收光的窄场成像装置从眼睛结构的表面积反射出来。通过设置在光路中的分束器将宽视场摄像机光耦合到光路。跟踪镜设置在分束器和眼睛结构之间的光路中。控制过程算法主动地实时补偿眼睛的平移和旋转运动。还描述了一种系统，其中扭转校正装置引起受试者的头部的旋转运动以及用于多尺度闭环眼睛跟踪的方法。

75. 发明授权

US09346245B2 Laminar composite toilet lid and seat 有权
标题翻译：层压复合马桶盖和座椅
公开(公告)号：US09346245B2
公开(公告)日：2016-05-24
申请号：US13083161
申请日：2011-04-08
申请人： Chengdong Wu , Jie Zhang
发明人： Chengdong Wu , Jie Zhang
IPC分类号： A47K13/14 , B32B21/02 , A47K13/02 , B32B27/30
CPC分类号： B32B21/02 , A47K13/02 , B32B27/308 , B32B2307/412 , B32B2317/12 , B32B2317/16 , B32B2333/12 , B32B2509/00 , Y10T428/24802
摘要： Embodiments of the present disclosure include a laminate composite toilet lid and seat and a method of manufacturing thereof. The toilet lid includes a core structural layer having a shape and size associated with the toilet lid. The toilet lid also includes a first decorative graphic layer disposed on a first surface of the core structural layer. The toilet lid further includes a plurality of exterior layers disposed on exterior surfaces of the core structural layer and the first decorative graphic layer, the exterior layers configured to envelop the toilet lid.
摘要翻译：本公开的实施例包括层压复合马桶盖和座椅及其制造方法。马桶盖包括具有与马桶盖相关联的形状和尺寸的芯结构层。马桶盖还包括设置在芯结构层的第一表面上的第一装饰图形层。马桶盖还包括设置在芯结构层和第一装饰图形层的外表面上的多个外层，外层构造成包封马桶盖。

76. 发明授权

US09205180B2 Method and device for loading medical appliance with medicaments and/or polymers 有权
标题翻译：用药物和/或聚合物装载医疗器具的方法和装置
公开(公告)号：US09205180B2
公开(公告)日：2015-12-08
申请号：US13522819
申请日：2011-01-19
申请人： Jie Zhang , Bo Yi , Changsheng Wu , Zhirong Tang , Qiyi Luo
发明人： Jie Zhang , Bo Yi , Changsheng Wu , Zhirong Tang , Qiyi Luo
IPC分类号： A61L33/00 , A61L31/06 , A61L31/16 , A61F2/91
CPC分类号： A61F2/82 , A61F2/91 , A61F2240/001 , A61F2250/0068 , A61L31/06 , A61L31/16 , A61L2300/416 , B05C21/00 , C08L67/04
摘要： A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.
摘要翻译：一种用于装载具有药物和/或聚合物的医疗器具的方法和装置包括使用图像捕获装置捕获医疗器具的多个凹槽或孔的图像; 对每个凹槽或孔的图像执行数字图像处理以获得每个凹槽或孔的图案; 计算每个凹槽或孔的图案的中心位置，以及基于中心位置确定每个凹槽或孔的装载位置; 以及调整加载装置和医疗器具之间的相对位置，以将装载装置的出口与医疗器具的装载位置对齐，并且用药物和/或聚合物装载每个凹槽或孔。该方法和装置可以快速且有效地加载具有药物和/或聚合物的医疗器具。

77. 发明授权

US08869383B2 Method of making magnetics assembly 有权
标题翻译：制作磁性装配的方法
公开(公告)号：US08869383B2
公开(公告)日：2014-10-28
申请号：US13523076
申请日：2012-06-14
申请人： Yong-Chun Xu , Jie Zhang
发明人： Yong-Chun Xu , Jie Zhang
IPC分类号： H01F7/06 , H01F17/06 , H01F27/28
CPC分类号： H01F17/062 , H01F27/2823 , H01F27/2828 , H01F41/07 , H01F41/08 , Y10T29/4902 , Y10T29/49069 , Y10T29/49071 , Y10T29/49073 , Y10T29/49075
摘要： A magnetics assembly (100) including a transformer (1) made of litz wire. The transformer includes a toroid core (2) and a bundle of wires (3) winding around the toroid core. The bundle of wires includes first to eighth wires, and has a central portion with all eight wires twisted together and winding around the toroid core. First and second ends of the bundle of wires oppositely extend out from the toroidal core. The ends of the first to eighth wires are connected to form a primary and a secondary coils of the transformer, wherein the second ends of the first wire and the second wire, and the first ends of the third wire and the fourth wire are sorted out to form central taps (35, 36) of the primary and secondary coils, respectively.
摘要翻译：磁性组件（100）包括由绞合线制成的变压器（1）。变压器包括环形磁芯（2）和缠绕在环形磁芯周围的电线束（3）。电线束包括第一至第八导线，并且具有中心部分，所有八条线绞合在一起并围绕环形芯线缠绕。线束的第一和第二端从环形芯相对地延伸出来。连接第一至第八导线的端部以形成变压器的初级线圈和次级线圈，其中第一线和第二线的第二端以及第三线和第四线的第一端被整理以分别形成初级和次级线圈的中心抽头（35,36）。

78. 发明授权

US08765925B2 Process for preparation of timosaponin B II 有权
标题翻译： timosaponin B的制备方法II
公开(公告)号：US08765925B2
公开(公告)日：2014-07-01
申请号：US11579101
申请日：2005-04-21
申请人： Baiping Ma , Hao Chen , Chengqi Xiong , Liping Kang , Jie Zhang
发明人： Baiping Ma , Hao Chen , Chengqi Xiong , Liping Kang , Jie Zhang
IPC分类号： C07H1/08 , C07H19/01 , C07J71/00
CPC分类号： C07J71/00
摘要： A method for preparation of Timosaponin BII, which uses Chinese traditional medicine Rhizoma Anemarrhenae or fresh rhizoma or fibrous root of Anemarrhena asphodeloides Bge. as raw material, and comprises isolation of Timosaponin BII by one or more processes selected from solvent extraction, resin adsorption, polyamide chromatography, reversed phase column chromatography, Sephadex LH-20 column chromatography, etc, combining with conventional drying method such as reduced pressure drying, freeze drying, spray drying, and so on. Timosaponin BII obtained by the present method is of over 90% purity, and the method is simple, practicable and suitable for industrial production.
摘要翻译：一种使用中药根茎或新鲜根茎或Anemarrhena asphodeloides Bge的纤维根的Timosaponin BII的制备方法。作为原料，通过选自溶剂萃取，树脂吸附，聚酰胺色谱法，反相柱色谱法，Sephadex LH-20柱色谱法等一种或多种方法分离Timosaponin BII，结合常规干燥方法如减压干燥，冷冻干燥，喷雾干燥等。本方法获得的Timosaponin BII纯度超过90％，方法简单，实用，适合工业生产。

79. 发明授权

US08726315B2 Method and server side and terminal for finding interactive electric service guide 有权
标题翻译：方法和服务器端和终端查找交互式电气服务指南
公开(公告)号：US08726315B2
公开(公告)日：2014-05-13
申请号：US12403843
申请日：2009-03-13
申请人： Chuxiong Zhang , Teng Shi , Jie Zhang , Yuanyuan Zhang
发明人： Chuxiong Zhang , Teng Shi , Jie Zhang , Yuanyuan Zhang
IPC分类号： H04N7/025 , H04N7/10 , H04N7/173 , H04N5/445 , H04W4/00 , H04N21/00 , H04N21/61
CPC分类号： H04N21/00 , H04H20/38 , H04H20/57 , H04H20/93 , H04H60/72 , H04N7/17318 , H04N21/26283 , H04N21/4821 , H04N21/6125
摘要： A method and a service side and a terminal for finding an interactive electronic service guide. Said method comprises: the server side down-issuing the information corresponding to the finding interactive ESG service to the terminal through the broadcast channel, and the terminal acquires the information for finding the interactive ESG service in the broadcast channel. Said server side comprises a sending module of the related information for finding interactive ESG service and a down-issue module for the ESG supplier list. The terminal comprises a receiving module of the related information for finding the interactive ESG service and a receiving module for the ESG supplier list.
摘要翻译：一种用于查找交互式电子服务指南的方法和服务端以及终端。所述方法包括：服务器端通过广播信道向终端发送与发现的交互式ESG业务相对应的信息，并且终端获取用于在广播信道中查找交互式ESG业务的信息。所述服务器侧包括用于发现交互式ESG服务的相关信息的发送模块和用于ESG供应商列表的下发模块。终端包括用于查找交互式ESG服务的相关信息的接收模块和用于ESG供应商列表的接收模块。

80. 发明授权

US08679772B2 Immunoassay 失效
标题翻译：免疫测定
公开(公告)号：US08679772B2
公开(公告)日：2014-03-25
申请号：US12996609
申请日：2008-06-06
申请人： Zhiqiang Gao , Jie Zhang
发明人： Zhiqiang Gao , Jie Zhang
IPC分类号： G01N33/53
CPC分类号： G01N33/5438 , G01N33/54306
摘要： The invention provides a highly sensitive immunoassay for detection of a biological species. The immunoassay comprises exposing an electrode to an analyte liquid putatively containing the biological species so as to couple the biological species, if present in the analyte liquid, to a binding antibody on the electrode. The electrode comprises a binding antibody and an anchor group, each being coupled to an electrically conductive substrate, said binding antibody being capable of binding to the biological species and said anchor group being capable of binding to a redox polymer. The electrode is then exposed to an antibody-enzyme liquid comprising an antibody-enzyme species, said antibody-enzyme species comprising a detection antibody capable of binding to the biological species, said detection antibody being coupled to a redox enzyme, whereby, if the analyte liquid comprises the biological species, the redox enzyme couples to the electrode by means of the coupling of both the detection antibody and the binding antibody to the biological species. The electrode is then exposed to a polymer solution comprising the redox polymer and to an enzyme substrate, whereby if the redox enzyme is coupled to the anchor group on the electrode the redox polymer is reduced and couples to the anchor group on the electrode. A voltage is then applied between the electrode and a reference electrode and the electrode is exposed to an oxidizable species, whereby a magnitude of an electric current between said electrode and a reference electrode is indicative of the presence or absence of the biological species.
摘要翻译：本发明提供用于检测生物物种的高度灵敏的免疫测定。免疫测定包括将电极暴露于假设含有生物物质的分析物液体，以将生物物质（如果存在于分析物液体中）与电极上的结合抗体相连接。电极包含结合抗体和锚定基团，每个锚定基团与导电底物偶联，所述结合抗体能够结合生物物种，所述锚定基团能够结合至氧化还原聚合物。然后将电极暴露于包含抗体 - 酶物质的抗体 - 酶液体，所述抗体 - 酶物质包含能够结合生物物种的检测抗体，所述检测抗体与氧化还原酶偶联，由此，如果分析物液体包括生物物种，氧化还原酶通过检测抗体和结合抗体与生物物种的偶联而与电极偶联。然后将电极暴露于包含氧化还原聚合物和酶底物的聚合物溶液，由此如果氧化还原酶与电极上的锚定基团偶联，则氧化还原聚合物被还原并连接到电极上的锚定基团上。然后将电压施加在电极和参考电极之间，并且电极暴露于可氧化物质，由此所述电极和参比电极之间的电流的大小指示生物物种的存在或不存在。

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