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71. 发明授权

US5117006A DC-88A derivatives useful as antitumor agents 失效
标题翻译： DC-88A衍生物作为抗菌剂有用
公开(公告)号：US5117006A
公开(公告)日：1992-05-26
申请号：US700507
申请日：1991-05-15
申请人： Hiromitsu Saito , Masaji Kasai , Makoto Morimoto , Eiji Kobayashi , Yoichi Uosaki , Yutaka Kanda , Hiroshi Sano
发明人： Hiromitsu Saito , Masaji Kasai , Makoto Morimoto , Eiji Kobayashi , Yoichi Uosaki , Yutaka Kanda , Hiroshi Sano
IPC分类号： C07D487/04 , C07D487/10
CPC分类号： C07D487/04 , C07D487/10
摘要： A DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an anti-tumor agent.

72. 发明授权

US09115759B2 Roller bearing 有权
标题翻译：滚子轴承
公开(公告)号：US09115759B2
公开(公告)日：2015-08-25
申请号：US14002217
申请日：2012-07-13
申请人： Yutaka Kanda
发明人： Yutaka Kanda
IPC分类号： F16C33/36 , F16C33/58 , F16C19/36 , B60B35/02 , F16C19/38 , F16C25/08
CPC分类号： F16C33/36 , B60B35/02 , F16C19/26 , F16C19/364 , F16C19/38 , F16C19/386 , F16C19/548 , F16C23/086 , F16C25/08 , F16C33/366 , F16C2240/70 , F16C2240/80
摘要： A tapered roller bearing (1a, 1b) satisfies the following three conditions: (a1) 0.8≦Hi/Dw≦1.2, (b1) 1.01≦dm/dh≦1.05, and (c1) 2.1≦L/Dw≦3.0, where a pitch circle diameter at a center of a roller length along an axis line (X) of each tapered roller (4) is (dm), the radial dimension of the inner ring (2) at an intersection of the inner ring raceway (2a) and a perpendicular line (v) extending from a position of the pitch circle diameter in a direction perpendicular to the axis line is the thickness (Hi) of the inner ring, a cross-sectional center diameter of the roller bearing is (dh), the length of the tapered roller (4) is the length (L) of the tapered roller, and a half of the sum of the large diameter dimension and the small diameter dimension of the tapered roller (4) is the diameter (Dw) of the tapered roller.
摘要翻译：圆锥滚子轴承（1a，1b）满足以下三个条件：（a1）0.8＆nlE; Hi / Dw＆nlE; 1.2，（b1）1.01＆nlE; dm / dh＆nlE; 1.05和（c1）2.1＆nlE; L / Dw＆ 3.0，其中沿着每个圆锥滚子（4）的轴线（X）的辊长度的中心处的节圆直径为（dm），内圈（2）在内圈的相交处的径向尺寸滚道（2a）和从节圆直径位于与轴线垂直的方向延伸的垂直线（v）是内圈的厚度（Hi），滚子轴承的横截面中心直径（dh）中，圆锥滚子（4）的长度为圆锥滚子的长度（L），圆锥滚子（4）的大直径尺寸和小直径尺寸之和的一半为直径（Dw）。

73. 发明授权

US08679491B2 Method of modulating the activity of functional immune molecules 有权
标题翻译：调节功能性免疫分子活性的方法
公开(公告)号：US08679491B2
公开(公告)日：2014-03-25
申请号：US12645613
申请日：2009-12-23
申请人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
发明人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
IPC分类号： A61K39/00 , C12Q1/00
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12P21/005 , G01N33/53
摘要： The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
摘要翻译：本发明涉及一种控制免疫功能性分子如抗体，蛋白质，肽等的活性的方法，促进免疫功能性分子活性的试剂和具有促进作用的免疫功能分子活动。

74. 发明申请

US20130336610A1 ROLLER BEARING 有权
标题翻译：滚子轴承
公开(公告)号：US20130336610A1
公开(公告)日：2013-12-19
申请号：US14002217
申请日：2012-07-13
申请人： Yutaka Kanda
发明人： Yutaka Kanda
IPC分类号： F16C33/36
CPC分类号： F16C33/36 , B60B35/02 , F16C19/26 , F16C19/364 , F16C19/38 , F16C19/386 , F16C19/548 , F16C23/086 , F16C25/08 , F16C33/366 , F16C2240/70 , F16C2240/80
摘要： A tapered roller bearing (1a, 1b) satisfies the following three conditions: (a1) 0.8≦Hi/Dw≦1.2, (b1) 1.01≦dm/dh≦1.05, and (c1) 2.1≦L/Dw≦3.0, where a pitch circle diameter at a center of a roller length along an axis line (X) of each tapered roller (4) is (dm), the radial dimension of the inner ring (2) at an intersection of the inner ring raceway (2a) and a perpendicular line (v) extending from a position of the pitch circle diameter in a direction perpendicular to the axis line is the thickness (Hi) of the inner ring, a cross-sectional center diameter of the roller bearing is (dh), the length of the tapered roller (4) is the length (L) of the tapered roller, and a half of the sum of the large diameter dimension and the small diameter dimension of the tapered roller (4) is the diameter (Dw) of the tapered roller.
摘要翻译：圆锥滚子轴承（1a，1b）满足以下三个条件：（a1）0.8 @ Hi / Dw @ 1.2，（b1）1.01 @ dm / dh @ 1.05和（c1）2.1 @ L / Dw @ 3.0，其中沿着每个圆锥滚子（4）的轴线（X）的辊长度的中心处的节圆直径为（dm），内圈（2）在内圈滚道（2a）的交叉处的径向尺寸），并且从节圆直径的与轴线垂直的方向的位置延伸的垂直线（v）是内圈的厚度（Hi），滚子轴承的截面中心直径为（dh）圆锥滚子（4）的长度是圆锥滚子的长度（L），圆锥滚子（4）的大直径尺寸和小直径尺寸之和的一半是直径（Dw）的圆锥滚子。

75. 发明授权

US08501914B2 Recombinant protein S composition 失效
标题翻译：重组蛋白S组成
公开(公告)号：US08501914B2
公开(公告)日：2013-08-06
申请号：US12540501
申请日：2009-08-13
申请人： Yutaka Kanda , Hiroshi Sato , Tsuyoshi Yamada , Akifumi Kato , Mitsuo Satoh
发明人： Yutaka Kanda , Hiroshi Sato , Tsuyoshi Yamada , Akifumi Kato , Mitsuo Satoh
IPC分类号： A61K38/16 , C12P21/02
CPC分类号： C07K14/745 , A61K38/00 , C12P21/005
摘要： A pharmaceutical agent for treating a disease such as inflammatory diseases, blood coagulation diseases associated with deficiency of Protein S has been required. The present invention provides a Protein S composition comprising recombinant Protein S molecules having complex type N-glycoside-linked sugar chains, wherein the Protein S has a higher binding activity to a receptor for advanced glycation end products (hereinafter referred to as “RAGE”) than native Protein S present in healthy human blood, and also has a higher ratio of sugar chains in which fucose is not bound to the complex type N-glycoside-linked sugar chains bound to Protein S than native Protein S present in healthy human blood.
摘要翻译：需要用于治疗诸如炎性疾病，与蛋白S缺乏相关的血液凝固疾病等疾病的药剂。本发明提供了包含具有复合型N-糖苷连接的糖链的重组蛋白S分子的蛋白S组合物，其中蛋白S与晚期糖基化终产物的受体（以下称为“RAGE”）具有较高的结合活性，比存在于健康人血液中的天然蛋白S高，并且与健康人血液中存在的天然蛋白S相比，岩藻糖与其与蛋白S结合的复合型N-糖苷连接的糖链不结合的糖链的比例更高。

76. 发明授权

US08367407B2 Cells with altered fucosylation and producing antibodies therefrom 有权
标题翻译：具有改变的岩藻糖基化并由此产生抗体的细胞
公开(公告)号：US08367407B2
公开(公告)日：2013-02-05
申请号：US12409587
申请日：2009-03-24
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
IPC分类号： C12N5/07 , C12N5/16 , C12N5/00 , C12N5/02 , C12N5/10
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell and mammal in which GDP-mannose 4,6-dehydratase is knocked-out. The cell and mammal are useful for the production of an antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, such as an antibody useful for treating various diseases. The cell and mammal are also useful for the production of a fragment of the antibody, and a fusion protein having the Fc region of the antibody.
摘要翻译：本发明涉及其中GDP-甘露糖4,6-脱水酶被淘汰的细胞和哺乳动物。细胞和哺乳动物可用于生产具有高抗体依赖性细胞介导的细胞毒活性的抗体分子，例如可用于治疗各种疾病的抗体。细胞和哺乳动物也可用于产生抗体的片段，以及具有抗体Fc区的融合蛋白。

77. 发明授权

US07763246B2 Method of modulating the activity of functional immune molecules to platelet-derived growth factor receptor 有权
标题翻译：调节功能性免疫分子对血小板衍生生长因子受体的活性的方法
公开(公告)号：US07763246B2
公开(公告)日：2010-07-27
申请号：US11686404
申请日：2007-03-15
申请人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
发明人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12P21/005 , G01N33/53
摘要： The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
摘要翻译：本发明涉及一种控制免疫功能性分子如抗体，蛋白质，肽等的活性的方法，促进免疫功能性分子活性的试剂和具有促进作用的免疫功能分子活动。

78. 发明授权

US07718175B2 Method of modulating the activity of functional immune molecules to interleukin-5 receptor protein 有权
标题翻译：调节功能性免疫分子对白细胞介素-5受体蛋白的活性的方法
公开(公告)号：US07718175B2
公开(公告)日：2010-05-18
申请号：US11686379
申请日：2007-03-15
申请人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
发明人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12P21/005 , G01N33/53
摘要： The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
摘要翻译：本发明涉及一种控制免疫功能性分子如抗体，蛋白质，肽等的活性的方法，促进免疫功能性分子活性的试剂和具有促进作用的免疫功能分子活动。

79. 发明授权

US07682611B2 Method of modulating the activity of functional immune molecules to CXCR4 protein 有权
标题翻译：调节CXCR4蛋白功能性免疫分子活性的方法
公开(公告)号：US07682611B2
公开(公告)日：2010-03-23
申请号：US11686906
申请日：2007-03-15
申请人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
发明人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12P21/005 , G01N33/53
摘要： The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
摘要翻译：本发明涉及一种控制免疫功能性分子如抗体，蛋白质，肽等的活性的方法，促进免疫功能性分子活性的试剂和具有促进作用的免疫功能分子活动。

80. 发明申请

US20080261301A1 Antibody Composition-Producing Cell 有权
公开(公告)号：US20080261301A1
公开(公告)日：2008-10-23
申请号：US12060617
申请日：2008-04-01
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
IPC分类号： C12N5/06
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

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