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71. 发明授权

US5580740A Antihuman pulmonary adenocarcinoma monoclonal antibody 失效
标题翻译：抗人肺腺癌单克隆抗体
公开(公告)号：US5580740A
公开(公告)日：1996-12-03
申请号：US422660
申请日：1995-04-14
申请人： Hajime Yoshida , Kenya Shitara
发明人： Hajime Yoshida , Kenya Shitara
IPC分类号： A61K38/00 , C07K16/30 , G01N33/574 , C07K16/00
CPC分类号： C07K16/30 , A61K38/00
摘要： An antihuman pulmonary adenocarcinoma monoclonal antibody ALC-390 and a process for producing thereof are disclosed. This monoclonal antibody, which belongs to IgG class and is reactive with human pulmonary adenocarcinoma cell membranes and recognizes protein as the antigen, is highly useful in the pathological diagnosis of pulmonary adenocarcinoma and in the treatment of the same.
摘要翻译：公开了一种抗人肺腺癌单克隆抗体ALC-390及其生产方法。属于IgG类并且与人肺腺癌细胞膜反应并识别蛋白质作为抗原的单克隆抗体在肺腺癌的病理诊断和治疗中是非常有用的。

72. 发明授权

US5245424A Defect detection method 失效
标题翻译：缺陷检测方法
公开(公告)号：US5245424A
公开(公告)日：1993-09-14
申请号：US823328
申请日：1992-01-21
申请人： Hajime Yoshida
发明人： Hajime Yoshida
IPC分类号： G01N21/88 , G01N21/94 , G06T1/00 , G06T7/00
CPC分类号： G06T7/001 , G01N21/88 , G06T7/0002 , G01N2021/8887 , G06T2207/10016 , G06T2207/20021 , G06T2207/30164
摘要： An image of a light irradiated object is picked up by a video camera. Detection of defects on the object is conducted from the image signal from the video camera. Two inspection zones adjacent each other are established on the picture screen, each having a preset size. The brightness of each of the respective two inspection zones is sensed and accumulated as the inspection zones are indexed across the screen. When the difference between the accumulated values of the respective inspection zones exceeds a preset threshold value a defect is defined.
摘要翻译：光照射物体的图像由摄像机拾取。从摄像机的图像信号中检测物体上的缺陷。在图像屏幕上建立彼此相邻的两个检查区域，每个具有预设的尺寸。当检查区跨越屏幕进行索引时，检测并累积相应的两个检查区域中的每一个的亮度。当各个检查区域的累积值之间的差超过预设的阈值时，定义缺陷。

73. 发明授权

US5214132A Polypeptide derivatives of human granulocyte colony stimulating factor 失效
标题翻译：人粒细胞集落刺激因子的多肽衍生物
公开(公告)号：US5214132A
公开(公告)日：1993-05-25
申请号：US337002
申请日：1989-04-12
申请人： Tetsuro Kuga , Hiromasa Miyaji , Moriyuki Sato , Masami Okabe , Makoto Morimoto , Seiga Itoh , Motoo Yamasaki , Yoshiharu Yokoo , Kazuo Yamaguchi , Hajime Yoshida , Yoshinori Komatsu
发明人： Tetsuro Kuga , Hiromasa Miyaji , Moriyuki Sato , Masami Okabe , Makoto Morimoto , Seiga Itoh , Motoo Yamasaki , Yoshiharu Yokoo , Kazuo Yamaguchi , Hajime Yoshida , Yoshinori Komatsu
IPC分类号： A61K38/00 , C07K1/113 , C07K14/535 , C07K16/24 , C07K17/06 , C12N15/70
CPC分类号： C07K14/535 , C07K1/113 , C07K16/243 , C07K17/06 , C12N15/70 , A61K38/00 , Y10S530/82 , Y10S530/825 , Y10S930/145
摘要： Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
摘要翻译：具有衍生自人粒细胞集落刺激因子多肽的氨基酸序列的氨基酸序列的新型hG-CSF多肽衍生物通过用不同氨基酸取代至少一个氨基酸和/或缺失至少一个氨基酸，重组体含有编码这些hG-CSF多肽衍生物中的任何一种的DNA片段插入片段的质粒，携带这种质粒之一的微生物，使用微生物生产hG-CSF多肽衍生物的方法，与hG-CSF多肽衍生物结合的单克隆抗体，以及公开了化学修饰的hG-CSF或其衍生物。

74. 发明授权

US5187573A Inspection method and apparatus 失效
标题翻译：检验方法和装置
公开(公告)号：US5187573A
公开(公告)日：1993-02-16
申请号：US757543
申请日：1991-09-11
申请人： Hajime Yoshida
发明人： Hajime Yoshida
IPC分类号： G01N21/88 , G01N21/90 , H04N7/18
CPC分类号： G01N21/8851 , G01N21/9045 , G01N2021/8887
摘要： An image of the inspected object, irradiated by a light, is picked by a video camera and a video signal therefrom is processed by an electronic processor. A pattern judging window is setup on the inspected object to thereby judge whether a pattern exists on the object, and when it is judged that there is no pattern a plurality of inspection windows are set up to thereby perform a predetermined defect inspection on portions of the inspected object within the plurality of windows. A pattern discrimination window is setup on the inspected object when it is judged that there exists a pattern so as to discriminate the kind of pattern, and either setting up the inspection window or another inspection window depending on the kind of pattern so discriminated.
摘要翻译：由光照射的被检查物体的图像由摄像机拾取，并且其中的视频信号由电子处理器处理。在被检查对象上设置图案判断窗口，从而判断物体上是否存在图案，并且当判断为没有图案时，设置多个检查窗口，从而对该部件进行预定的缺陷检查在多个窗口内检查对象。当判断存在图案以识别图案的种类，并根据所鉴别的图案的种类设置检查窗口或其他检查窗口时，在被检查物体上设置图案识别窗口。

75. 发明授权

US5168657A Bottle mouth top surface polishing apparatus 失效
标题翻译：瓶子顶部表面抛光装置
公开(公告)号：US5168657A
公开(公告)日：1992-12-08
申请号：US689469
申请日：1991-04-22
申请人： Hajime Yoshida
发明人： Hajime Yoshida
IPC分类号： B24B9/12 , B24B19/00
CPC分类号： B24B9/12 , B24B19/006
摘要： A bottle mouth top surface polishing apparatus including rotating machine having a rotary shaft, a rotary plate means coupled at its center to the rotary shaft, a grinding plate fixed to the rotary plate and having a grinding face which is to be made in contact with a bottle mouth top surface to be polished, and a contact adjusting device for making the contact between the grinding face and the bottle mouth top surface always close over whole contact surfaces thereof upon polishing.
摘要翻译：一种瓶口顶面抛光装置，包括具有旋转轴的旋转机械，在其中心与旋转轴连接的旋转板装置，固定到旋转板的研磨板，并具有与并且用于使研磨面和瓶口顶面之间的接触的接触调节装置在抛光时总是接近其整个接触表面。

76. 发明授权

US5051355A Anti-human gastric cancer monoclonal antibody 失效
标题翻译：抗人胃癌单克隆抗体
公开(公告)号：US5051355A
公开(公告)日：1991-09-24
申请号：US445160
申请日：1989-12-06
申请人： Hajime Yoshida , Nobuo Hanai , Akiko Furuya
发明人： Hajime Yoshida , Nobuo Hanai , Akiko Furuya
IPC分类号： A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577
CPC分类号： C07K16/303 , C07K16/3046 , Y10S436/813 , Y10S530/809
摘要： An anti-human gastric cancer monoclonal antibody, AMC-462, which belongs to the class IgG.sub.1, reacts with human digestive system cancer, and recognizes sialylated glycoproteins or glycolipids as the antigen is disclosed. It is effective for diagnosis of digestive system cancer, especially pancreatic cancer.
摘要翻译：属于IgG1类的抗人胃癌单克隆抗体AMC-462与人类消化系统癌症反应，并公开了唾液酸化糖蛋白或糖脂作为抗原。对于消化系统癌症，特别是胰腺癌的诊断是有效的。

77. 发明授权

US4984886A Surface inspection apparatus for objects 失效
标题翻译：物体表面检查装置
公开(公告)号：US4984886A
公开(公告)日：1991-01-15
申请号：US687478
申请日：1984-12-28
申请人： Hajime Yoshida
发明人： Hajime Yoshida
IPC分类号： G01N21/88 , G02B27/18
CPC分类号： G01N21/88
摘要： A photo-electric conversion device is provided with an independent optical system having a lens making an image of the surface of an object to be inspected which is not flat as a flat spatial image at the front stage of the photo-electric conversion device. The photo-electric conversion device receiving the flat spatial image on its target screen produces a video signal. An inspection device for processing an output video signal is provided to judge whether the inspected surface is good or not.
摘要翻译：光电转换装置设置有独立的光学系统，该光学系统具有在光电转换装置的前级处制作作为平坦的平面空间图像的待检查对象的表面的图像的透镜。在其目标屏幕上接收平面空间图像的光电转换装置产生视频信号。提供用于处理输出视频信号的检查装置，以判断被检查表面是否良好。

78. 发明授权

US4962032A Anti-lafora body monoclonal antibody 失效
标题翻译：抗lafora体单克隆抗体
公开(公告)号：US4962032A
公开(公告)日：1990-10-09
申请号：US72293
申请日：1987-07-13
申请人： Hajime Yoshida , Nobuo Hanai , Akiko Furuya
发明人： Hajime Yoshida , Nobuo Hanai , Akiko Furuya
IPC分类号： C07K16/18 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： G01N33/5308 , C07K16/18 , Y10S435/96
摘要： A monoclonal antibody is disclosed capable of reacting with abnormal glycogen from patients with Lafora disease (Lafora bodies) and with abnormal glycogen from patients with type IV glycogenosis but not with normal glycogen, and therefore useful in the diagnosis of Lafora disease and type IV glycogenosis (Andersen's disease).
摘要翻译：公开了能够与来自Lafora病（Lafora体）的患者的异常糖原和来自IV型糖原异常但不与正常糖原的患者异常糖原反应的单克隆抗体，因此可用于诊断Lafora病和IV型糖原安徒生病）。

79. 发明授权

US4896279A Method and an apparatus for inspecting an external shape of an object having a symmetry 失效
标题翻译：用于检查具有对称性的物体的外形的方法和装置
公开(公告)号：US4896279A
公开(公告)日：1990-01-23
申请号：US923126
申请日：1986-10-24
申请人： Hajime Yoshida
发明人： Hajime Yoshida
IPC分类号： G01B11/24 , G01B11/02
CPC分类号： G01B11/022
摘要： An object is sensed by a photoelectric conversion sensor having a photoelectric conversion screen expressed as an XY coordinate grid such that the symmetrical axis of the object is parallel to one axis of the XY coordinate, coordinates at a plurality of right left points which respect to the other axis of the XY coordinate at which an external contour of the object intersects a plurality of straight lines perpendicular to the symmetrical axis are determined. Coordinates at a plurality of center points between the right and left points with respect to the other axis are determined, and the maximum frequency coordinate among the coordinates of center points in designated as a standard center coordinate, and the standard center coordinate is compared with each of the plurality of center coordinates.
摘要翻译：通过具有表示为XY坐标网格的光电转换屏幕的光电转换传感器来感测物体，使得物体的对称轴线平行于XY坐标的一个轴线，在多个左侧点处相对于确定物体的外部轮廓与垂直于对称轴线的多条直线相交的XY坐标的另一轴。确定相对于另一个轴线在左右点之间的多个中心点处的坐标，并且将指定为标准中心坐标的中心点的坐标和标准中心坐标之间的最大频率坐标与每个的多个中心坐标。

80. 发明授权

US4808223A Silver/metal oxide material for electrical contacts and method of producing the same 失效
标题翻译：用于电接点的银/金属氧化物材料及其制造方法
公开(公告)号：US4808223A
公开(公告)日：1989-02-28
申请号：US70577
申请日：1987-07-07
申请人： Ryoji Ozaki , Hisaji Shinohara , Hironobu Yamamoto , Takashi Nara , Hajime Yoshida
发明人： Ryoji Ozaki , Hisaji Shinohara , Hironobu Yamamoto , Takashi Nara , Hajime Yoshida
IPC分类号： C22C5/06 , B22F9/30 , C22C1/04 , C22C1/10 , C22C32/00 , H01H1/0237 , C22C29/12
CPC分类号： C22C1/1026 , B22F9/30 , C22C32/0021 , H01H1/0237
摘要： This invention relates to a silver/metal oxide material for electrical contacts containing no Cd which essentially consists of Ag and 5 to 30% by weight of at least one of oxides of Sb, Sn, Zn, In, Cu, Mn, Bi and Pb, and further, if necessary, 0.05 to 2% by weight of at least one of oxides of Mg, Al, Fe, Ni, Co, Si, Ga, Ge, Te, Ca and Li, the total amount of said metal oxides being 5 to 32% by weight, wherein fine particles of said metal oxides are substantially uniformly distributed in a matrix whose main component is Ag in a sintered state, and wherein there are no grain boundaries formed by agglomerations or agglomerated layers of said metal oxides. Further, the method of producing the same is provided including steps of: changing in steps the hydrogen ion concentration in an aqueous solution of Ag ions and at least one of metal ions of Sb, Sn, Zn, In, Cu, Mn, Bi and Pb, and further, if necessary, at least one of metal ions of Mg, Al, Fe, Ni, Co, Si, Ga, Ge, Te, Ca and Li so as to form precipitates of Ag-oxygen compound and oxides and/or hydroxides of said metals; drying and thereafter heat-treating said precipitates to form mixed powder of Ag and oxides of said metals and shaping and sintering said mixed powder; and further, if necessary, heat-treating the sintered material to stabilize.
摘要翻译：本发明涉及一种不含Cd的电触点用银/金属氧化物材料，其主要由Ag组成，5〜30重量％的Sb，Sn，Zn，In，Cu，Mn，Bi，Pb的氧化物中的至少一种，另外如果需要，可以含有0.05〜2重量％的Mg，Al，Fe，Ni，Co，Si，Ga，Ge，Te，Ca和Li的氧化物中的至少一种，所述金属氧化物的总量为 5〜32重量％，其中所述金属氧化物的细颗粒基本均匀地分布在主要成分为Ag的基体中，烧结状态下，并且不存在由所述金属氧化物的聚集或凝聚层形成的晶界。此外，其制造方法包括以下步骤：逐步改变Ag离子的水溶液中的氢离子浓度和Sb，Sn，Zn，In，Cu，Mn，Bi的金属离子中的至少一种和 Pb，并且如果需要，还可以含有Mg，Al，Fe，Ni，Co，Si，Ga，Ge，Te，Ca和Li中的至少一种金属离子，以形成Ag-氧化合物和氧化物和/ 或所述金属的氢氧化物; 干燥，然后对所述沉淀物进行热处理，以形成Ag和所述金属的氧化物的混合粉末，并对所述混合粉末进行成形和烧结; 此外，如果需要，对烧结材料进行热处理以稳定化。

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