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71. 发明授权

US07974695B2 Method and apparatus for optimizing stroke volume during DDD resynchronization therapy using adjustable atrio-ventricular delays 有权
标题翻译：使用可调节的心房延迟在DDD再同步治疗期间优化卒中量的方法和装置
公开(公告)号：US07974695B2
公开(公告)日：2011-07-05
申请号：US11567933
申请日：2006-12-07
申请人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟心室起搏脉冲的最佳时机。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

72. 发明授权

US07957802B2 Method, apparatus, and system to optimize cardiac preload based on measured pulmonary artery pressure 有权
标题翻译：基于测量的肺动脉压力来优化心脏预压的方法，装置和系统
公开(公告)号：US07957802B2
公开(公告)日：2011-06-07
申请号：US11894082
申请日：2007-08-20
申请人： Abhilash Patangay , Jiang Ding , Jonathan T. Kwok , Barun Maskara , Yinghong Yu
发明人： Abhilash Patangay , Jiang Ding , Jonathan T. Kwok , Barun Maskara , Yinghong Yu
IPC分类号： A61N1/362
CPC分类号： A61N1/36564 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Optimizing cardiac preload based on measured pulmonary artery pressure involves varying, for each repetition of an acute burst protocol, a parameter of pacing applied to a patient's heart during the acute burst protocol. Pulmonary artery pressure is measured during the repetitions of the acute burst protocol. The length of the repetitions is chosen so that the patient's baroreflex system does not adjust to the varied parameter of pacing during the repetitions of the acute burst protocol. An optimum ventricular preload is determined based on the measured pulmonary artery pressure. Pacing therapy is provided using a value of the parameter that is selected based on the determination of optimum ventricular preload.
摘要翻译：基于测量的肺动脉压优化心脏预压，对于急性突发协议的每个重复，涉及在急性突发协议期间应用于患者心脏的起搏参数的变化。在急性突发方案的重复期间测量肺动脉压。选择重复的长度，使得患者的压力反射系统在急性突发协议的重复期间不适应起搏的不同参数。基于测量的肺动脉压力确定最佳心室预负荷。使用基于最佳心室预压的确定选择的参数的值提供起搏治疗。

73. 发明申请

US20110106202A1 METHOD AND SYSTEM FOR SETTING CARDIAC RESYNCHRONIZATION THERAPY PARAMETERS 有权
标题翻译：用于设置心脏再生治疗参数的方法和系统
公开(公告)号：US20110106202A1
公开(公告)日：2011-05-05
申请号：US12987700
申请日：2011-01-10
申请人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
发明人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.
摘要翻译：提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

74. 发明授权

US07904155B2 Cardiac resynchronization method and apparatus employing mechanical measurement of cardiac walls 有权
标题翻译：心脏再同步化方法和采用机械测量心脏壁的装置
公开(公告)号：US07904155B2
公开(公告)日：2011-03-08
申请号：US11549676
申请日：2006-10-16
申请人： Yinghong Yu , Jiang Ding , Qingsheng Zhu
发明人： Yinghong Yu , Jiang Ding , Qingsheng Zhu
IPC分类号： A61N1/365
CPC分类号： A61N1/36578 , A61N1/3627 , A61N1/36542 , A61N1/3684
摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.
摘要翻译：公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。加速度计响应于心室壁位置的运动产生信号。然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

75. 发明授权

US07613514B2 Selective resynchronization therapy optimization based on user preference 失效
标题翻译：基于用户偏好的选择性再同步治疗优化
公开(公告)号：US07613514B2
公开(公告)日：2009-11-03
申请号：US11109603
申请日：2005-04-19
申请人： Richard Fogoros , Jiang Ding , Yinghong Yu
发明人： Richard Fogoros , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method and system for calculating an atrio-ventricular delay interval based upon an inter-atrial delay exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may optimize the stroke volume exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may be blended with another atrio-ventricular delay interval that may optimize another performance characteristic, such as left ventricular contractility. Such blending may include finding an arithmetic mean, geometric mean, or weighted mean of two or more proposed atrio-ventricular delay intervals.
摘要翻译：一种用于根据患者心脏表现的心房间延迟来计算心房延迟间隔的方法和系统。上述的心室延迟间隔可以优化患者心脏展示的搏动量。上述房室延迟间隔可以与可以优化另一性能特征（例如左心室收缩力）的另一心房延迟间隔混合。这种混合可以包括找到两个或更多个提出的心房延迟间隔的算术平均值，几何平均值或加权平均值。

76. 发明申请

US20090163970A1 AV DELAY FEATURES 有权
标题翻译： AV延迟功能
公开(公告)号：US20090163970A1
公开(公告)日：2009-06-25
申请号：US12336064
申请日：2008-12-16
申请人： Yinghong Yu , Jiang Ding
发明人： Yinghong Yu , Jiang Ding
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61B5/0452 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： At least one of a left intraventricular conduction defect, a right intraventricular conduction defect, or no intraventricular conduction defect can be detected using received intrinsic cardiac information from a subject, and a first atrioventricular (AV) delay can be calculated using a first relationship if the left intraventricular conduction defect or no intraventricular conduction defect is detected, or a second AV delay can be calculated using a second relationship if the right intraventricular conduction defect is detected.
摘要翻译：可以使用来自受试者的接收的固有心脏信息来检测左室内传导缺陷，右心室内传导缺陷或无心室内传导缺陷中的至少一个，并且可以使用第一关系来计算第一房室（AV）延迟，如果如果检测到右心室传导缺陷，则检测到左心室内传导缺陷或无心室传导缺陷，或者可以使用第二关系计算第二AV延迟。

77. 发明申请

US20090054945A1 Method, apparatus, and system to optimize cardiac preload based on measured pulmonary artery pressure 有权
标题翻译：基于测量的肺动脉压力来优化心脏预压的方法，装置和系统
公开(公告)号：US20090054945A1
公开(公告)日：2009-02-26
申请号：US11894082
申请日：2007-08-20
申请人： Abhilash Patangay , Jiang Ding , Jonathan T. Kwok , Barun Maskara , Yinghong Yu
发明人： Abhilash Patangay , Jiang Ding , Jonathan T. Kwok , Barun Maskara , Yinghong Yu
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/36564 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Optimizing cardiac preload based on measured pulmonary artery pressure involves varying, for each repetition of an acute burst protocol, a parameter of pacing applied to a patient's heart during the acute burst protocol. Pulmonary artery pressure is measured during the repetitions of the acute burst protocol. An optimum ventricular preload is determined based on the measured pulmonary artery pressure. Pacing therapy is provided using a value of the parameter that is selected based on the determination of optimum ventricular preload.
摘要翻译：基于测量的肺动脉压优化心脏预压，对于急性突发协议的每个重复，涉及在急性突发协议期间应用于患者心脏的起搏参数的变化。在急性突发方案的重复期间测量肺动脉压。基于测量的肺动脉压力确定最佳心室预负荷。使用基于最佳心室预压的确定选择的参数值来提供起搏治疗。

78. 发明申请

US20070150013A1 METHOD AND SYSTEM FOR SETTING CARDIAC RESYNCHRONIZATION THERAPY PARAMETERS 有权
标题翻译：用于设置心脏再生治疗参数的方法和系统
公开(公告)号：US20070150013A1
公开(公告)日：2007-06-28
申请号：US11681244
申请日：2007-03-02
申请人： Jiang Ding , Yinghong Yu , Bruce KenKnight
发明人： Jiang Ding , Yinghong Yu , Bruce KenKnight
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.
摘要翻译：提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

79. 发明授权

US07206634B2 Method and apparatus for optimizing cardiac pumping performance 有权
标题翻译：用于优化心脏泵送性能的方法和装置
公开(公告)号：US07206634B2
公开(公告)日：2007-04-17
申请号：US10206131
申请日：2002-07-26
申请人： Jiang Ding , Yinghong Yu , Qingsheng Zhu
发明人： Jiang Ding , Yinghong Yu , Qingsheng Zhu
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61N1/36514 , A61N1/3682 , A61N1/3684
摘要： A cardiac rhythm and function management device configured to automatically adjust stimulation parameters used in delivering cardiac resynchronization therapy. Mechanical contraction intervals are measured using appropriately placed accelerometers and compared with optimum values. The stimulation parameters can then be adjusted accordingly in a manner that moves the mechanical contraction intervals toward their optimum values.
摘要翻译：心律和功能管理装置被配置为自动调整用于递送心脏再同步治疗的刺激参数。使用适当放置的加速度计测量机械收缩间隔，并与最佳值进行比较。然后可以以使机械收缩间隔向其最佳值移动的方式相应地调节刺激参数。

80. 发明申请

US20060253162A1 Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US20060253162A1
公开(公告)日：2006-11-09
申请号：US11125068
申请日：2005-05-09
申请人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey Stahmann , Carlos Ricci , Scott Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey Stahmann , Carlos Ricci , Scott Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

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