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71. 发明授权

US08391972B2 Safety control system for implantable neural stimulator 有权
公开(公告)号：US08391972B2
公开(公告)日：2013-03-05
申请号：US13282325
申请日：2011-10-26
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/37
摘要： A neural stimulation system includes a safety control system that prevents delivery of neural stimulation pulses from causing potentially harmful effects. The neural stimulation pulses are delivered to one or more nerves to control the physiological functions regulated by the one or more nerves. Examples of such harmful effects include unintended effects in physiological functions associated with autonomic neural stimulation and nerve injuries caused by excessive delivery of the neural stimulation pulses.

72. 发明授权

US08374688B2 System and methods for wireless body fluid monitoring 有权
标题翻译：无线体液监测系统及方法
公开(公告)号：US08374688B2
公开(公告)日：2013-02-12
申请号：US12210078
申请日：2008-09-12
申请人： Imad Libbus , Mark Bly
发明人： Imad Libbus , Mark Bly
IPC分类号： A61B5/05
CPC分类号： A61B5/02028 , A61B5/0002 , A61B5/0004 , A61B5/0006 , A61B5/0008 , A61B5/01 , A61B5/02055 , A61B5/02405 , A61B5/0245 , A61B5/04012 , A61B5/04085 , A61B5/04087 , A61B5/044 , A61B5/0452 , A61B5/0531 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0816 , A61B5/1114 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4875 , A61B5/6833 , A61B5/6843 , A61B5/6885 , A61B5/7264 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B2560/0412 , A61B2560/0468 , A61B2562/0209 , A61B2562/0214 , A61B2562/043 , A61B2562/164 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： An adherent device to monitor a tissue hydration of a patient comprises an adhesive patch to adhere to a skin of the patient. At least four electrodes are connected to the patch and capable of electrically coupling to the patient. Impedance circuitry is coupled to the at least four electrodes to measure a tissue resistance of the patient, where the circuitry is configured to determine the tissue hydration in response to tissue resistance. The circuitry may comprise a processor system and the tissue resistance may correspond to a change in patient body fluid. The impedance circuitry is configured to measure the hydration signal using at least one low measurement frequency, which may be in the range of 0 to 10 kHz. Multiple measurement frequencies may be used and the hydration signal may include a tissue reactance measurement.
摘要翻译：用于监测患者的组织水合的粘附装置包括粘附到患者皮肤上的粘合贴片。至少四个电极连接到贴片并且能够电耦合到患者。阻抗电路耦合到至少四个电极以测量患者的组织电阻，其中电路被配置为响应于组织电阻确定组织水合。电路可以包括处理器系统，并且组织电阻可以对应于患者体液的变化。阻抗电路被配置为使用至少一个低测量频率来测量水合信号，该低测量频率可以在0至10kHz的范围内。可以使用多个测量频率，并且水合信号可以包括组织电抗测量。

73. 发明授权

US08332047B2 System and method for closed-loop neural stimulation 有权
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US08332047B2
公开(公告)日：2012-12-11
申请号：US11280940
申请日：2005-11-16
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36053 , A61N1/36117
摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.
摘要翻译：各种装置实施例包括脉冲发生器，信号处理模块和控制器。脉冲发生器适于提供在自主神经系统（ANS）内的神经模拟部位应用的神经刺激信号。信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经流量。控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。本文提供了其它方面和实施例。

74. 发明授权

US08321023B2 Baroreflex modulation to gradually decrease blood pressure 有权
标题翻译： Baroreflex调制逐渐降低血压
公开(公告)号：US08321023B2
公开(公告)日：2012-11-27
申请号：US12321949
申请日：2009-01-27
申请人： Imad Libbus , Julio C. Spinelli
发明人： Imad Libbus , Julio C. Spinelli
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/36146 , A61N1/36564
摘要： An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex stimulation therapy by a predetermined rate of change to lower systemic blood pressure to a target pressure. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及一种压力反射刺激器。刺激器的实施例包括脉冲发生器，以通过电极提供压力反射刺激信号和调制器。该调节剂调节压力反射刺激信号以增加压力反射刺激疗法预定的变化率，从而将全身血压降低到目标压力。本文提供了其他方面。

75. 发明申请

US20120172764A1 PHYSIOLOGICAL RESPONSE TO POSTURE CHANGE 有权
标题翻译：生理反应的改变
公开(公告)号：US20120172764A1
公开(公告)日：2012-07-05
申请号：US13415281
申请日：2012-03-08
申请人： John D. Hatlestad , Imad Libbus , Aaron Lewicke
发明人： John D. Hatlestad , Imad Libbus , Aaron Lewicke
IPC分类号： A61M37/00 , A61N1/36 , A61M5/168 , A61B5/11
CPC分类号： A61B5/1116 , A61B5/0031 , A61B5/021 , A61B5/02405 , A61B5/076 , A61B5/686 , A61B2562/0219 , A61N1/05
摘要： In an embodiment, an implantable medical device includes a controller circuit, a posture sensing circuit, and a physiological sensing circuit. The controller circuit senses a change in a physiological signal as a result of a change in posture, and generates a response as a function of that change. In another embodiment, the controller circuit identifies a heart failure condition as a function of the change in the physiological signal.
摘要翻译：在一个实施例中，可植入医疗装置包括控制器电路，姿势感测电路和生理感测电路。控制器电路作为姿势变化的结果感测生理信号的变化，并产生作为该变化的函数的响应。在另一个实施例中，控制器电路根据生理信号的变化来识别心力衰竭状况。

76. 发明授权

US08200331B2 System and method for filtering neural stimulation 有权
公开(公告)号：US08200331B2
公开(公告)日：2012-06-12
申请号：US10982001
申请日：2004-11-04
申请人： Imad Libbus , Scot Boon
发明人： Imad Libbus , Scot Boon
IPC分类号： A61N1/37
CPC分类号： A61N1/36114 , A61N1/37211
摘要： Various aspects of the present subject matter provide a filter module. In various embodiments, the filter module comprises an input, an output, a signal path from the input to the output, a filter and a switch. The filter has a transfer response to attenuate a frequency of a neural stimulation signal. The switch is adapted to place the filter in the signal path when the neural stimulation signal is applied and to remove the filter from the signal path when the neural stimulation signal is not applied. Other aspects are provided herein.

77. 发明授权

US08195290B2 Controlled titration of neurostimulation therapy 有权
标题翻译：神经刺激治疗的控制滴定
公开(公告)号：US08195290B2
公开(公告)日：2012-06-05
申请号：US12886328
申请日：2010-09-20
申请人： Marina V. Brockway , Imad Libbus , Krzysztof Z. Siejko , Robert J. Sweeney
发明人： Marina V. Brockway , Imad Libbus , Krzysztof Z. Siejko , Robert J. Sweeney
IPC分类号： A61N1/362
CPC分类号： A61N1/3727 , A61B5/02405 , A61B5/4035 , A61B5/4839 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/362 , A61N1/37264
摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.
摘要翻译：本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。因为用于治疗心力衰竭的其它治疗也可能影响患者的自主平衡，用于递送神经刺激的装置被配置为以开环或闭环方式适当地滴定这种治疗。

78. 发明申请

US20120123495A1 BAROREFLEX STIMULATION TO TREAT ACUTE MYOCARDIAL INFARCTION 有权
标题翻译： BAROREFLEX刺激治疗急性心肌梗塞
公开(公告)号：US20120123495A1
公开(公告)日：2012-05-17
申请号：US13357932
申请日：2012-01-25
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36117 , A61N1/36564
摘要： An aspect of the present subject relates to an implantable medical system. An embodiment of the system includes a baroreflex stimulator, a myocardial infarction detector, and a controller. The baroreflex stimulator applies a baroreflex stimulation signal through an electrode. The myocardial infarction detector detects an event indicative of myocardial infarction, The controller is connected to the baroreflex stimulator and to the myocardial infarction detector, and is adapted to apply a baroreflex therapy in response to a detected event indicative of myocardial infarction. Other aspects are provided herein.
摘要翻译：本发明的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器，心肌梗死检测器和控制器。压力反射刺激器通过电极施加压力反射刺激信号。心肌梗死检测器检测到指示心肌梗死的事件。控制器连接到压力反射刺激器和心肌梗塞检测器，并且适于对检测到的指示心肌梗塞的事件应用压力反射治疗。本文提供了其他方面。

79. 发明授权

US08170668B2 Baroreflex sensitivity monitoring and trending for tachyarrhythmia detection and therapy 有权
标题翻译： Baroreflex敏感性监测和慢性心律失常检测和治疗趋势
公开(公告)号：US08170668B2
公开(公告)日：2012-05-01
申请号：US11457644
申请日：2006-07-14
申请人： Benjamin Ettori , Dan Li , Imad Libbus
发明人： Benjamin Ettori , Dan Li , Imad Libbus
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61B5/0464 , A61B5/7285
摘要： A system comprising an implantable medical device (IMD) that includes a tachyarrhythmia detector, a baroreflex detector to obtain baroreflex information, and a processor in communication with the tachyarrhythmia detector and the baroreflex detector. The processor adjusts at least one of a tachyarrhythmia detection parameter of the IMD or a tachyarrhythmia therapy parameter of the IMD using the baroreflex information.
摘要翻译：一种包括可植入医疗装置（IMD）的系统，其包括快速性心律失常检测器，用于获得压力反射信息的压力反射检测器，以及与快速性心律失常检测器和压力反射检测器通信的处理器。处理器使用压力反射信息来调节IMD的心律失常检测参数或IMD的快速心律失常治疗参数中的至少一个。

80. 发明授权

US08145304B2 Neural stimulation system for cardiac fat pads 有权
标题翻译：心脏脂肪垫的神经刺激系统
公开(公告)号：US08145304B2
公开(公告)日：2012-03-27
申请号：US12836802
申请日：2010-07-15
申请人： Julia Moffitt , Imad Libbus
发明人： Julia Moffitt , Imad Libbus
IPC分类号： A61N1/08
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/056 , A61N1/0587 , A61N1/36135 , A61N1/36514 , A61N1/3962 , A61N1/3987
摘要： Various aspects relate to a device which, in various embodiments, comprises a header, a neural stimulator, a detector and a controller. The header includes at least one port to connect to at least one lead, and includes first and second channels for use to provide neural stimulation to first and second neural stimulation sites for a heart. The controller is connected to the detector and the neural stimulator to selectively deliver a therapy based on the feedback signal. A first therapy signal is delivered to the first neural stimulation site to selectively control contractility and a second therapy signal is delivered to the second neural stimulation site to selectively control one of a sinus rate and an AV conduction. Other aspects and embodiments are provided herein.
摘要翻译：各种方面涉及在各种实施例中包括头部，神经刺激器，检测器和控制器的装置。头部包括至少一个连接至少一个引线的端口，并且包括用于向心脏的第一和第二神经刺激部位提供神经刺激的第一和第二通道。控制器连接到检测器和神经刺激器，以基于反馈信号选择性地递送治疗。第一治疗信号被递送到第一神经刺激部位以选择性地控制收缩性，并且第二治疗信号被递送到第二神经刺激部位以选择性地控制窦速率和AV传导之一。本文提供了其它方面和实施例。

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