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71. 发明授权

US08128229B2 RNFL measurement analysis 有权
标题翻译： RNFL测量分析
公开(公告)号：US08128229B2
公开(公告)日：2012-03-06
申请号：US12859727
申请日：2010-08-19
申请人： Scott A. Meyer , Mary K. Durbin , Paul F. Stetson , Bagrat Amirbekian
发明人： Scott A. Meyer , Mary K. Durbin , Paul F. Stetson , Bagrat Amirbekian
IPC分类号： A61B3/10
CPC分类号： A61B3/12 , A61B3/1241
摘要： One embodiment of the present invention accounts for individual anatomical variation when evaluating optical nerve fiber measurements. In one aspect, contextual information is used to compensate or correct measurement data. In another aspect, reference coordinates are remapped for improved comparison or visualization. In one embodiment of this latter aspect, the method uses measurements of nerve fiber capacity and maps of nerve fiber retinal service to improve sensitivity and specificity in eye function metrics. In one instance, we use the birefringence of nerve fibers to determine the orientation of the fibers within the RNFL. Orientation of the fibers about the ONH is indicative of the service provided by the fibers and is used to improve the interpretation of thickness measurements of the nerve fiber layer. Normalized nerve fiber measurements about the optic nerve head improve specificity and sensitivity as compared to the standard model. These improvements are a result of partitioning the normative database or modifying the measurement data prior to comparison. Statistics on normalized measurements of nerve fiber bundles also show improvements in specificity and sensitivity.
摘要翻译：评估光学神经纤维测量时，本发明的一个实施例解释了个体解剖学变化。在一个方面，使用上下文信息来补偿或校正测量数据。在另一方面，重新映射参考坐标以改善比较或可视化。在后一方面的一个实施例中，该方法使用神经纤维能力的测量和神经纤维视网膜服务的图来提高眼睛功能度量中的灵敏度和特异性。在一种情况下，我们使用神经纤维的双折射来确定RNFL内纤维的取向。关于ONH的纤维的取向指示由纤维提供的服务，并且用于改善对神经纤维层的厚度测量的解释。与标准模型相比，关于视神经头的规范化神经纤维测量提高了特异性和灵敏度。这些改进是在比较之前划分规范性数据库或修改测量数据的结果。关于神经纤维束的归一化测量的统计数据也显示出特异性和灵敏度的改善。

72. 发明授权

US08050504B2 Method and apparatus for measuring motion of a subject using a series of partial images from an imaging system 有权
标题翻译：用于使用来自成像系统的一系列部分图像来测量对象的运动的方法和装置
公开(公告)号：US08050504B2
公开(公告)日：2011-11-01
申请号：US12861672
申请日：2010-08-23
申请人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
发明人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
IPC分类号： G06K9/68 , G06K9/00
CPC分类号： A61B3/102 , A61B3/113
摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.
摘要翻译：行扫描成像器用于确定被摄体的运动。将来自行扫描成像器的每行图像数据与参考图像进行比较。参考图像中匹配线的位置显示了被摄体的位移。可以基于每行图像数据来确定当前被摄体位移。所得到的位移信息可用于将其他光束正确地放置在被摄体上。该方法可以应用于跟踪人眼以便于用光束辐射进行测量，成像或处理。

73. 发明申请

US20100305649A1 SYSTEM AND METHOD FOR DECOMPENSATION DETECTION AND TREATMENT BASED ON PATIENT HEMODYNAMICS 有权
标题翻译：基于患者血液动力学的去除检测和治疗的系统和方法
公开(公告)号：US20100305649A1
公开(公告)日：2010-12-02
申请号：US12787630
申请日：2010-05-26
申请人： Barun Maskara , Lili Liu , Guy Alvarez , Scott A. Meyer
发明人： Barun Maskara , Lili Liu , Guy Alvarez , Scott A. Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/36564
摘要： A system and method for detecting and treating symptoms of early decompensation utilizing a cardiac rhythm management. The system applies an electrical stimulus to the patient's heart at a first set of pacing parameters including a lower rate limit (LRL) setting, and acquires a coronary venous pressure (CVP) signal from a pressure sensor implanted in a coronary vein of the patient. An average coronary venous end diastolic pressure (CV-EDP) value is calculated from the CVP signal. The system monitors the average CV-EDP value over a predetermined interval, and dynamically adjusts the LRL setting responsive to the detection of a first or a second predetermined event based on the average CV-EDP value.
摘要翻译：一种利用心律管理检测和治疗早期失代偿症状的系统和方法。该系统以包括较低速率限制（LRL）设置在内的第一组起搏参数对患者的心脏施加电刺激，并从植入患者冠状静脉的压力传感器获取冠状静脉压（CVP）信号。根据CVP信号计算平均冠状静脉舒张末期压（CV-EDP）值。该系统在预定间隔内监视平均CV-EDP值，并且响应于基于平均CV-EDP值的第一或第二预定事件的检测动态地调整LRL设置。

74. 发明授权

US07805009B2 Method and apparatus for measuring motion of a subject using a series of partial images from an imaging system 有权
标题翻译：用于使用来自成像系统的一系列部分图像来测量对象的运动的方法和装置
公开(公告)号：US07805009B2
公开(公告)日：2010-09-28
申请号：US11389351
申请日：2006-03-24
申请人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
发明人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
IPC分类号： G06K9/68 , G06K9/00
CPC分类号： A61B3/102 , A61B3/113
摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.
摘要翻译：行扫描成像器用于确定被摄体的运动。将来自行扫描成像器的每行图像数据与参考图像进行比较。参考图像中匹配线的位置显示了被摄体的位移。可以基于每行图像数据来确定当前被摄体位移。所得到的位移信息可用于将其他光束正确地放置在被摄体上。该方法可以应用于跟踪人眼以便于用光束照射进行测量，成像或处理。

75. 发明申请

US20100226542A1 METHOD OF BIOIMAGE DATA PROCESSING FOR REVEALING MORE MEANINGFUL ANATOMIC FEATURES OF DISEASED TISSUES 有权
标题翻译：生物数据处理方法发布疾病组织的更多意义的解剖特征
公开(公告)号：US20100226542A1
公开(公告)日：2010-09-09
申请号：US12709234
申请日：2010-02-19
申请人： Matthew J. Everett , Scott A. Meyer , Paul F. Stetson , Yan Zhou
发明人： Matthew J. Everett , Scott A. Meyer , Paul F. Stetson , Yan Zhou
IPC分类号： G06K9/00
CPC分类号： A61B5/0066 , G06T7/0014 , G06T19/00 , G06T2200/24 , G06T2207/10101 , G06T2207/30041 , G06T2210/41
摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.
摘要翻译：本发明公开了一种用于产生相对于拟合的参考表面的组织层/边界的仰角图或图像的方法，包括以下步骤：找到并分割所需的组织层/边界; 将平滑的参考表面拟合到分段的组织层/边界; 计算相对于拟合参考表面的相同或其它组织层/边界的高度; 并产生相对于拟合表面的高程图。高程可以以各种方式显示，包括三维表面效果图，地形轮廓图，轮廓图，面孔颜色图和面对灰度图。也可以将高程组合并同时显示另一个组织层/边界依赖的图像数据集，以提供用于诊断的附加信息。

76. 发明申请

US20100131027A1 Methods and Systems for Selecting Capture Verification Modes 有权
标题翻译：用于选择捕获验证模式的方法和系统
公开(公告)号：US20100131027A1
公开(公告)日：2010-05-27
申请号：US12697853
申请日：2010-02-01
申请人： Alok Sathaye , Scott A. Meyer , Derek D. Bohn
发明人： Alok Sathaye , Scott A. Meyer , Derek D. Bohn
IPC分类号： A61N1/08
CPC分类号： A61N1/3712 , A61N1/3627
摘要： Methods and systems are directed to selecting from a variety of capture verification modes. A plurality of capture verification modes, including a beat by beat capture detection mode and a capture threshold testing mode without intervening beat by beat capture detection is provided. An efficacy of at least one of the capture verification modes is evaluated and, based on the evaluation, a capture verification mode is selected.
摘要翻译：方法和系统旨在从各种捕获验证模式中进行选择。提供了多个拍摄验证模式，包括拍拍拍摄检测模式和拍摄阈值测试模式，而不会通过拍摄捕获检测进行中间拍摄。评估捕获验证模式中的至少一个的功效，并且基于评估，选择捕获验证模式。

77. 发明授权

US07574258B2 Cardiac therapy triggered by capture verification 有权
标题翻译：通过捕获验证触发心脏治疗
公开(公告)号：US07574258B2
公开(公告)日：2009-08-11
申请号：US11300674
申请日：2005-12-14
申请人： Haris J. Sih , Scott A. Meyer , Paul A. Haefner
发明人： Haris J. Sih , Scott A. Meyer , Paul A. Haefner
IPC分类号： A61N1/08 , A61N1/39
CPC分类号： A61N1/3962
摘要： The present invention provides methods and systems for tachyarrhythmia therapy involving pacing the heart to prior to the application of a cardioversion/defibrillation shock. One or more pace pulses are delivered to the arrhythmic chamber or chambers. The pace pulses may be delivered to the heart at an adaptable rate selected to organize the electrical activity of the heart. If the pace pulses produce capture, cardioversion/defibrillation stimulation is delivered.
摘要翻译：本发明提供了用于在应用心脏复律/除颤休克之前心脏起搏的快速性心律失常治疗的方法和系统。将一个或多个步速脉冲输送到心律失常室或腔室。速度脉冲可以以选择用于组织心脏的电活动的适应速率递送到心脏。如果速度脉冲产生捕获，则输送心脏复律/除颤刺激。

78. 发明申请

US20080065166A1 Capture detection based on propagated depolarization from a remote pacing site 有权
标题翻译：基于来自远程起搏站点的传播去极化的捕获检测
公开(公告)号：US20080065166A1
公开(公告)日：2008-03-13
申请号：US11517699
申请日：2006-09-08
申请人： Alok S. Sathaye , M. Jason Brooke , Scott A. Meyer
发明人： Alok S. Sathaye , M. Jason Brooke , Scott A. Meyer
IPC分类号： A61N1/00
CPC分类号： A61N1/371
摘要： A methods and devices for capture detection are based on sensing a propagated depolarization from a contralateral cardiac chamber. An intersite sensing interval is determined based on an intersite pacing delay and an intersite conduction delay associated with first and second pacing sites. Pacing pulses are delivered to the first pacing site and the second pacing site, the pacing pulses separated in time by the intersite pacing delay. An intersite sensing interval is timed. The process includes sensing, during the intersite sensing interval, at the first pacing site for a depolarization propagated to the first pacing site from the second pacing site. It a depolarization propagated from the second pacing site is not sensed, then capture of the first and second pacing sites is detected.
摘要翻译：用于捕获检测的方法和装置基于感测来自对侧心室的传播的去极化。基于场间起搏延迟和与第一和第二起搏部位相关联的间歇间传导延迟确定位置间感测间隔。起搏脉冲被传送到第一起搏部位和第二起搏部位，起搏脉冲及时地通过位置间起搏延迟分开。站间感知间隔是定时的。该过程包括在第一起搏部位期间在站间感测间隔期间感测到从第二起搏部位传播到第一起搏部位的去极化。从第二起搏部位传播的去极化不被感测，然后检测到第一和第二起搏部位的捕获。

79. 发明授权

US06575572B2 Method and apparatus for measuring optical aberrations of an eye 有权
公开(公告)号：US06575572B2
公开(公告)日：2003-06-10
申请号：US09960113
申请日：2001-09-21
申请人： Ming Lai , Jay Wei , Scott A. Meyer , James P. Foley , Jochen M. Horn
发明人： Ming Lai , Jay Wei , Scott A. Meyer , James P. Foley , Jochen M. Horn
IPC分类号： A61B310
CPC分类号： A61B3/1015 , A61B3/156
摘要： Embodiments of the present invention provide a method and apparatus for measurement of aberration of an eye. One or more embodiments provide an aberration measurement instrument that enables measurement wherein Hartmann-Shack spots have reduced speckle; one or more embodiments provide an aberration measurement instrument that enables measurement of an eye having a large diopter power variation over different zones of the eye; one or more embodiments provide an aberration measurement instrument that enables measurement with accommodation control; one or more embodiment provide an aberration measurement instrument wherein radiation reflected by a cornea and radiation scattered by intra-ocular elements are blocked; and one or more embodiment provide an aberration measurement instrument wherein a hazy background produced by radiation multiply scattered within an eye is reduced.

80. 发明授权

US09144375B2 Method for determining the power of an intraocular lens 有权
标题翻译：确定眼内透镜功率的方法
公开(公告)号：US09144375B2
公开(公告)日：2015-09-29
申请号：US12630656
申请日：2009-12-03
申请人： Rudolf Murai Von Bünau , Burkhart Wagner , Scott A. Meyer , Xunchang Chen
发明人： Rudolf Murai Von Bünau , Burkhart Wagner , Scott A. Meyer , Xunchang Chen
IPC分类号： A61B3/00 , A61F2/16
CPC分类号： A61B3/0025 , A61B3/1005 , A61B3/117 , A61B3/1173 , A61F2/16 , A61F2/1605 , A61F2240/002
摘要： For the pre-operative calculation of the power of an intraocular lens, three input parameters are needed: the axial length of the eye (AL), the refractive power of the cornea, and the distance between the front of the cornea and the back focal plane of the intraocular lens, the so-called effective lens position (ELP). The invention shows a novel approach to the determination of the ELP.
摘要翻译：对于术前计算眼内透镜的功率，需要三个输入参数：眼睛的轴向长度（AL），角膜的屈光度以及角膜前部和背部焦点之间的距离眼内透镜的平面，所谓的有效透镜位置（ELP）。本发明显示了一种确定ELP的新方法。

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