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71. 发明授权

US07012146B2 Ion channel modulating agents 失效
公开(公告)号：US07012146B2
公开(公告)日：2006-03-14
申请号：US09854694
申请日：2001-05-15
申请人： Bo Skaaning Jensen , Dorte Strobaek , Palle Christophersen , Lene Teuber , Jurgen Beyer
发明人： Bo Skaaning Jensen , Dorte Strobaek , Palle Christophersen , Lene Teuber , Jurgen Beyer
IPC分类号： C07D213/02
CPC分类号： C07C69/732 , C07C69/65 , C07C69/734 , C07C69/753 , C07C205/56 , C07C233/22 , C07C233/58 , C07C255/35 , C07C255/37
摘要： The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SK Ca, IK Ca and BK Ca channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, for methods of therapy, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.

72. 发明授权

US06710044B2 Technical field 失效
标题翻译：技术领域
公开(公告)号：US06710044B2
公开(公告)日：2004-03-23
申请号：US10299854
申请日：2002-11-20
申请人： Lene Teuber , Frank Wätjen
发明人： Lene Teuber , Frank Wätjen
IPC分类号： A61K315377
CPC分类号： C07D235/06 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/04
摘要： Chemical compounds of the formula as well as pharmaceutical compositions containing them and methods for their use in the treatment of disorders and diseases responsive to modulation of the GABAA receptor complex of the central nervous system, such disorders and diseases including anxiety, sleep disorders, anesthesia, memory disorders, and epilepsy and other convulsive disorders.
摘要翻译：式的化合物以及含有它们的药物组合物及其用于治疗对中枢神经系统的GABA A受体复合物调节有响应的病症和疾病的方法，包括焦虑，睡眠障碍，麻醉，记忆等疾病和疾病疾病，癫痫和其他惊厥性疾病。

73. 发明授权

US06569880B2 Bis(benzimidazole) derivatives serving as potassium blocking agents 失效
标题翻译：作为钾封闭剂的双（苯并咪唑）衍生物
公开(公告)号：US06569880B2
公开(公告)日：2003-05-27
申请号：US10084179
申请日：2002-02-28
申请人： Bo Skaaning Jensen , Søren Peter Olesen , Lene Teuber , Dan Peters , Dorte Strøbæk
发明人： Bo Skaaning Jensen , Søren Peter Olesen , Lene Teuber , Dan Peters , Dorte Strøbæk
IPC分类号： A61K314184
CPC分类号： C07D235/24 , C07C279/18 , C07D219/08 , C07D235/20 , C07D235/30 , C07D239/42 , C07D255/04 , C07D403/10 , C07D417/04 , C07D417/12
摘要： This invention relates to novel potassium channel blocking agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, in particular asthma, cystic fibrosis, chronic obstructive pulmonary disease and rhinorrhea, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic hearth disease, angina pectoris, coronary hearth disease, traumatic brain injury, psychosis, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labor, baldness, cancer, and immune suppression.
摘要翻译：本发明涉及新型钾通道阻断剂及其在制备药物组合物中的用途。本发明还涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物，特别是哮喘，囊性纤维化，慢性阻塞性肺疾病和鼻漏，惊厥，血管痉挛，冠状动脉痉挛，肾脏疾病，多囊肾病，膀胱痉挛，尿失禁，膀胱流出阻塞，肠易激综合征，肠胃功能障碍，分泌性腹泻，局部缺血，脑缺血缺血性心脏病，心绞痛，冠心病，创伤性脑损伤，精神病，焦虑，抑郁，痴呆，记忆和注意力缺陷，阿尔茨海默病，痛经，发作性睡眠，雷诺病，间歇性跛行，Sjorgren综合征，偏头痛，心律失常，高血压阿本森 ce癫痫发作，肌强直性肌营养不良，口干燥症，II型糖尿病，高胰岛素血症，早产，秃发，癌症和免疫抑制。

74. 发明授权

US06503925B1 1-phenyl-benzimidazole compounds and their use as GABA-A receptor modulators 失效
标题翻译： 1-苯基 - 苯并咪唑化合物及其作为GABA-A受体调节剂的用途
公开(公告)号：US06503925B1
公开(公告)日：2003-01-07
申请号：US09768506
申请日：2001-01-25
申请人： Lene Teuber , Frank Wätjen
发明人： Lene Teuber , Frank Wätjen
IPC分类号： C07D23502
CPC分类号： C07D235/06 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/04
摘要： Chemical compounds of the formula as well as pharmaceutical compositions containing them and methods for their use in the treatment of disorders and diseases responsive to modulation of the GABAA receptor complex of the central nervous system, such disorders and diseases including anxiety, sleep disorders, anesthesia, memory disorders, and epilepsy and other convulsive disorders.
摘要翻译：式的化合物以及含有它们的药物组合物及其用于治疗对中枢神经系统的GABA A受体复合物调节有响应的病症和疾病的方法，包括焦虑，睡眠障碍，麻醉，记忆等疾病和疾病疾病，癫痫和其他惊厥性疾病。

75. 发明授权

US06458846B1 Ion channel modulating agents 失效
公开(公告)号：US06458846B1
公开(公告)日：2002-10-01
申请号：US09854554
申请日：2001-05-15
申请人： Bo Skaaning Jensen , Palle Christophersen , Dorte Strobaek , Lene Teuber
发明人： Bo Skaaning Jensen , Palle Christophersen , Dorte Strobaek , Lene Teuber
IPC分类号： A61K3115
CPC分类号： C07C251/48
摘要： The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of oxime derivatives represented by general formula (I) that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.

76. 发明授权

US5922724A Benzimidazole compounds and their use as modulators of the GABA a receptor complex 失效
标题翻译：苯并咪唑化合物及其用作GABA受体复合物的调节剂
公开(公告)号：US5922724A
公开(公告)日：1999-07-13
申请号：US945023
申请日：1998-02-05
申请人： Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
发明人： Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/28 , A61P43/00 , C07D235/06 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D521/00 , A61K31/425
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, phenyl, halogen, CF.sub.3, amino, nitro, cyano, acyl, acylamino, phenyl and monocyclic heteroaryl; andone of R.sup.6 and R.sup.7 is hydrogen and the other is furanyl or isoxazolyl each of which may be substituted one or more times with substituents selected from halogen, alkyl, alkoxy and phenyl. The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
摘要翻译： PCT No.PCT / EP96 / 01606 Sec。 371日期：1998年2月5日 102（e）1998年2月5日PCT PCT 1996年4月17日PCT公布。出版物WO96 / 33194 日本特开1996年10月24日本专利申请公开了具有下式的化合物或其药学上可接受的盐或其氧化物，其中R 3为其中A，B和D各自为CH，或A，B和D中的一个为N，其他都是CH; R11是苯基，苯并咪唑基或单环杂芳基，其全部可以被选自烷基，烷氧基，苯基，卤素，CF 3，氨基，硝基，氰基，酰基，酰氨基，苯基和单环杂芳基的取代基取代一次或多次; 并且R6和R7中的一个是氢，另一个是呋喃基或异恶唑基，其各自可以被选自卤素，烷基，烷氧基和苯基的取代基取代一次或多次。该化合物可用于治疗各种中枢神经系统疾病如癫痫和其他惊厥性疾病，焦虑症，睡眠障碍和记忆障碍。

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