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71. 外观设计

USD676344S1 Banknote counting machine 有权
标题翻译：钞票计数机
公开(公告)号：USD676344S1
公开(公告)日：2013-02-19
申请号：US29433506
申请日：2012-10-01
申请人： Chih-Kun Shih , Wan-Cheng Luo , Xiao-Mao Xie , Wei Xu , Si-He Hu , Tao Hou
设计人： Chih-Kun Shih , Wan-Cheng Luo , Xiao-Mao Xie , Wei Xu , Si-He Hu , Tao Hou

72. 外观设计

USD676343S1 Banknote counting machine 有权
公开(公告)号：USD676343S1
公开(公告)日：2013-02-19
申请号：US29433504
申请日：2012-10-01
申请人： Chih-Kun Shih , Wan-Cheng Luo , Xiao-Mao Xie , Wei Xu , Si-He Hu , Yong-Gui Pan
设计人： Chih-Kun Shih , Wan-Cheng Luo , Xiao-Mao Xie , Wei Xu , Si-He Hu , Yong-Gui Pan

73. 发明授权

US08362017B2 C-kit modulators and methods of use 失效
标题翻译： C-kit调节剂和使用方法
公开(公告)号：US08362017B2
公开(公告)日：2013-01-29
申请号：US10569873
申请日：2004-08-27
申请人： Wei Cheng , Erick Wang Co , Moon Hwan Kim , Rhett Ronald Klein , Donna T. Le , Amy Lew , John M. Nuss , Wei Xu , William Bajjalieh
发明人： Wei Cheng , Erick Wang Co , Moon Hwan Kim , Rhett Ronald Klein , Donna T. Le , Amy Lew , John M. Nuss , Wei Xu , William Bajjalieh
IPC分类号： A61K31/498 , A61K31/41 , A61K31/4192 , A61K31/505 , A61K31/4406 , A61K31/167 , A61K31/4196 , C07D257/04 , C07D249/06 , C07D213/30 , C07D239/26 , C07D249/08 , C07D241/42 , C07C233/15
CPC分类号： A61K31/41 , A61K31/495 , C07D207/333 , C07D207/404 , C07D209/12 , C07D213/30 , C07D215/14 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D261/08 , C07D307/42 , C07D307/91 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention provides compounds for modulating c-Kit kinase activity and methods of treating diseases mediated by c-Kit activity utilizing the compounds and pharmaceutical compositions thereof.
摘要翻译：本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。甚至更具体地，本发明提供了用于调节c-Kit激酶活性的化合物和使用其化合物及其药物组合物治疗由c-Kit活性介导的疾病的方法。

74. 发明授权

US08335403B2 Soft edge smoothness prior and application on alpha channel super resolution 有权
标题翻译：软边缘光滑度先于Alpha通道超分辨率应用
公开(公告)号：US08335403B2
公开(公告)日：2012-12-18
申请号：US11869906
申请日：2007-10-10
申请人： Shengyang Dai , Mei Han , Wei Xu , Ying Wu , Yihong Gong
发明人： Shengyang Dai , Mei Han , Wei Xu , Ying Wu , Yihong Gong
IPC分类号： G06K9/32
CPC分类号： G06T3/403
摘要： Systems and methods are disclosed for processing a low resolution image by performing a high resolution edge segment extraction on the low resolution image; performing an image super resolution on each edge segment; performing reconstruction constraint reinforcement; and generating a high quality image from the low quality image.
摘要翻译：公开了通过在低分辨率图像上执行高分辨率边缘段提取来处理低分辨率图像的系统和方法; 在每个边缘片段上执行图像超分辨率; 执行重建约束加固; 并从低质量图像生成高质量图像。

75. 发明授权

US08242129B2 6-phenylpyrimidinones as PIM modulators 失效
标题翻译： 6-苯基嘧啶酮作为PIM调节剂
公开(公告)号：US08242129B2
公开(公告)日：2012-08-14
申请号：US12597275
申请日：2008-04-25
申请人： Amy L. Tsuhako , Naing Aay , S. David Brown , Wai Ki Vicky Chan , Hongwang Du , Ping Huang , Brian Kane , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Michael Pack , Wei Xu , Peiwen Zhou
发明人： Amy L. Tsuhako , Naing Aay , S. David Brown , Wai Ki Vicky Chan , Hongwang Du , Ping Huang , Brian Kane , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Michael Pack , Wei Xu , Peiwen Zhou
IPC分类号： A61K31/505
CPC分类号： C07D213/64 , C07D239/36 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： A compound having Formula I or II (Formula I) or (Formula II), or a pharmaceutically acceptable salt thereof, wherein X, Z, R1, R2, R11 and R12 are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
摘要翻译：具有式I或II（式I）或（式II）的化合物或其药学上可接受的盐，其中X，Z，R 1，R 2，R 11和R 12如说明书中所定义; 其药物组合物; 及其使用方法。

76. 发明授权

US08203707B2 Method and apparatus for distributed sensing utilizing optical scattering in optical waveguides 有权
标题翻译：在光波导中利用光散射的分布式感测的方法和装置
公开(公告)号：US08203707B2
公开(公告)日：2012-06-19
申请号：US11938781
申请日：2007-11-13
申请人： Wei Xu
发明人： Wei Xu
IPC分类号： G01J3/44
CPC分类号： G01F23/292 , G01D5/35358 , G01F23/22
摘要： The present invention relates to a method and apparatus for distributed sensing utilizing optical scattering in optical waveguides and reveals two types of the invention. One type of the invention is to characterize optical scattering while actively controlling the temperature of the optical waveguide. The other type of the invention is to characterize optical scattering while strain/stress is induced into the optical waveguide through interaction of the jackets or coatings of the optical waveguide with objects under test. In one embodiment of the invention, the optical scattering based method and apparatus can sense liquid level, liquid distribution, and temperature gradient on ground and in low gravity. Other embodiments of the invention can detect location and concentration of liquid spill and gas leak along pipelines, or measure liquid or gas flow rates. Moreover, the method and apparatus described in the invention have capabilities of sensing multiple physical and chemical parameters using one sensing optical waveguide.
摘要翻译：本发明涉及利用光波导中光散射的分布式感测方法和装置，揭示了本发明的两种类型。本发明的一种类型是在主动地控制光波导的温度的同时表征光散射。本发明的另一种类型是表征光学散射，同时通过光波导的外套或涂层与被测对象的相互作用将应变/应力引入到光波导中。在本发明的一个实施例中，基于光散射的方法和装置可以感测地面和低重力的液面，液体分布和温度梯度。本发明的其他实施例可以检测液体泄漏的位置和浓度以及沿管道的气体泄漏，或者测量液体或气体流速。此外，本发明中描述的方法和装置具有使用一个感测光波导感测多个物理和化学参数的能力。

77. 发明授权

US08172123B2 Surgical stapling head assembly with a rotary cutter 有权
标题翻译：带旋转切割器的手术吻合头组件
公开(公告)号：US08172123B2
公开(公告)日：2012-05-08
申请号：US12666964
申请日：2008-06-26
申请人： Wangdong Chen , Wei Xu , Shouye Xie
发明人： Wangdong Chen , Wei Xu , Shouye Xie
IPC分类号： A61B17/068
CPC分类号： A61B17/072 , A61B17/115 , A61B17/32053 , A61B2017/07285
摘要： A rotary cutter head for a surgical stapling instrument includes a staple cartridge, an annular cutter, a staple-pushing seat and a staple chamber. The staple-pushing seat and the annular cutter are connected by a bearing structure and provided with guide projections. The inner wall of the staple cartridge or the outboard of the expand-stopping tube is integral injection molded with a metal cylinder insert, on which is provided with a forward helix track and a backward track mutually independent and communicated with each other. The guide projections are mated with the two guide tracks and guiding the annular cutter to move along a helical path.
摘要翻译：用于外科缝合器械的旋转刀头包括钉仓，环形切割器，钉推动座和钉仓。主推座和环形切割器通过轴承结构连接并设置有引导突起。钉仓的内壁或膨胀停止管的外侧是与金属圆柱形插入件一体注射成型的，其上设置有相互独立且相互连通的前螺旋轨道和后向轨道。引导突起与两个引导轨道配合，并引导环形刀具沿螺旋路径移动。

78. 发明申请

US20120083627A1 Method of Synthesis of Arylsulfur Trifluorides and Use as in situ Deoxofluorination Reagent 审中-公开
标题翻译：芳基三氟化硫的合成方法，用作原位脱氟氟化试剂
公开(公告)号：US20120083627A1
公开(公告)日：2012-04-05
申请号：US13249385
申请日：2011-09-30
申请人： William R. Dolbier, JR. , Wei Xu
发明人： William R. Dolbier, JR. , Wei Xu
IPC分类号： C07C381/00
CPC分类号： C07C17/18 , C07C381/00 , C07C19/08 , C07C22/08 , C07C25/13
摘要： The invention is a method of synthesizing Arylsulfur Trifluorides, such as Fluolead, by reacting BR2 and KF (or suitable alkali metal fluoride) in acetonitrile (or other suitable solvent). The invention also comprises using the Fluolead (or its substitutes), thus prepared, in situ as deoxofluorination reagents with a suitable aldehyde, ketone, or alcohol such as one selected from the group consisting of benzaldehyde Benzaldehyde, p-Bromobenzaldehyde, p-Tolualdehyde, Acetophenone, 2-Butanone, or Isobutyraldehyde, wherein the mixture is heated to reflux until completion. The respective products are then isolated after extraction by hexane and destruction of the sulfinyl fluoride co-product.
摘要翻译：本发明是通过使BR2和KF（或合适的碱金属氟化物）在乙腈（或其它合适的溶剂）中反应来合成氟化三氟甲磺酸酯的方法。本发明还包括使用如下制备的氟烷（或其替代物），其由合适的醛，酮或醇如原位制备为脱氧氟化试剂，例如选自苯甲醛苯甲醛，对溴苯甲醛，对甲苯醛，苯乙酮，2-丁酮或异丁醛，其中将混合物加热至回流直到完成。然后在通过己烷萃取后分离各产物并破坏亚磺酰氟共同产物。

79. 发明申请

US20110201599A1 CDK Modulators 审中-公开
标题翻译： CDK调制器
公开(公告)号：US20110201599A1
公开(公告)日：2011-08-18
申请号：US13002195
申请日：2009-07-02
申请人： Suleyman Bahceci , Bryan Chan , Diva Sze-Ming Chan , Jeff Chen , Timothy Patrick Forsyth , Maurizio Franzini , Vasu Jammalamadaka , Joon Won Jeong , Lisa Renee Jones , Ryan Michael Kelley , Moon Hwan Kim , James W. Leahy , Morrison B. Mac , Robin Tammie Noguchi , Pallavi Rao , Brian Hugh Ridgway , Wei Xu , Yong Wang
发明人： Suleyman Bahceci , Bryan Chan , Diva Sze-Ming Chan , Jeff Chen , Timothy Patrick Forsyth , Maurizio Franzini , Vasu Jammalamadaka , Joon Won Jeong , Lisa Renee Jones , Ryan Michael Kelley , Moon Hwan Kim , James W. Leahy , Morrison B. Mac , Robin Tammie Noguchi , Pallavi Rao , Brian Hugh Ridgway , Wei Xu , Yong Wang
IPC分类号： A61K31/55 , C07D471/04 , C07D401/14 , C07D403/14 , C07D413/00 , C07D413/14 , C12N5/071 , A61K31/437 , A61K31/505 , A61K31/497 , A61K31/5377 , A61P35/00 , A61P35/02 , A61P37/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： A compound according to Formula I: or a pharmaceutically-acceptable salt thereof, wherein R1, R3, A, B and D are as defined in the specification; pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译：根据式I的化合物或其药学上可接受的盐，其中R 1，R 3，A，B和D如说明书中所定义; 其药物组合物及其使用方法。

80. 发明授权

US07951972B2 Human adam-10 inhibitors 失效
标题翻译：人类adam-10抑制剂
公开(公告)号：US07951972B2
公开(公告)日：2011-05-31
申请号：US12322422
申请日：2009-02-02
申请人： S. David Brown , Lynne Canne-Bannen , Erick Wang Co , Vasu Jammalamadaka , Rickard George Khoury , Moon Hwan Kim , Donna T. Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , John M. Nuss , Michael P. Prisbylla , Wei Xu
发明人： S. David Brown , Lynne Canne-Bannen , Erick Wang Co , Vasu Jammalamadaka , Rickard George Khoury , Moon Hwan Kim , Donna T. Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , John M. Nuss , Michael P. Prisbylla , Wei Xu
IPC分类号： C07C311/19 , C07C311/29 , C07C259/06 , C07C259/08 , C07D213/32 , C07D213/68 , A61K31/16 , A61K31/44 , A61P19/02 , A61P35/00 , A61P9/10
CPC分类号： C07D409/04 , C07C311/29 , C07C2601/14 , C07D207/09 , C07D211/34 , C07D213/56 , C07D213/65 , C07D213/70 , C07D233/48 , C07D233/64 , C07D295/13 , C07D295/15 , C07D295/185 , C07D295/215 , C07D311/70
摘要： The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.
摘要翻译：本发明提供了可用于抑制ADAM-10蛋白质的化合物。这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。本发明还提供从其制备双芳基醚磺酰氯和ADAM-10调节剂的方法。

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