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    • 71. 发明申请
    • Ocular fundus portion analyzer and ocular fundus portion analyzing method
    • 眼底部分析仪和眼底部分析法
    • US20070188705A1
    • 2007-08-16
    • US10592228
    • 2005-03-10
    • Fumiaki TajimaNaoki MiyatakeHideaki SatoNobuo Matsuda
    • Fumiaki TajimaNaoki MiyatakeHideaki SatoNobuo Matsuda
    • A61B3/14
    • A61B3/14A61B3/12
    • An ocular fundus portion analyzer and the method are provided for attaining accurate and quick detection and diagnoses of an ocular fundus defect portion, such as an excavation of an optic disk caused by glaucoma and a macula retinae caused by retinal detachment, by dealing with a large number of single-shot ocular fundus images, for example, taken in physical examinations. It is configured to include an image importing portion for importing an image of an ocular fundus portion taken by a visible radiation or a near-infrared radiation; a pixel data generation portion for generating pixel data including pixel positions and luminance of pixels constituting the image; a local plane gradient image generation portion for generating a three-dimensional image from pixel positions and luminance of the pixel data, obtaining a local approximation plane at any pixel and generating a local plane gradient image from a gradient angle with respect to a control plane of the three-dimensional image; and a display portion for displaying the local plane gradient image.
    • 提供眼底部分析仪和该方法,用于通过处理大的眼睛来获得眼底缺损部分的准确和快速的检测和诊断,例如由青光眼引起的视盘的挖掘和由视网膜脱离引起的黄斑视网膜 单眼眼底图像的数量,例如,进行身体检查。 其被配置为包括用于导入由可见光或近红外辐射拍摄的眼底部分的图像的图像导入部分; 像素数据生成部,用于生成包括构成图像的像素的像素位置和亮度的像素数据; 局部平面梯度图像生成部分,用于从像素数据的像素位置和亮度生成三维图像,在任何像素处获得局部近似平面,并从梯度角度相对于控制平面生成局部平面梯度图像 三维图像; 以及用于显示局部平面梯度图像的显示部分。
    • 79. 发明授权
    • Thienylazole compound and thienotriazolodiazepine compound
    • 噻吩唑化合物和噻吩并三唑并噻嗪类化合物
    • US5760032A
    • 1998-06-02
    • US750025
    • 1996-11-22
    • Hiroshi KitajimaSyuji EharaHideaki SatoMinoru MoriwakiKenichi Onishi
    • Hiroshi KitajimaSyuji EharaHideaki SatoMinoru MoriwakiKenichi Onishi
    • C07D409/04C07D409/14C07D495/14A61K31/55C07D491/00C07D513/00C07D515/00
    • C07D409/14C07D409/04C07D495/14
    • Thienylazole compounds (I) and thienotriazolodiazepine compounds (II) of the formulas ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen, halogen, C.sub.1 -C.sub.5 alkyl and the like; --A.dbd.B-- is --N.dbd.N-- and the like; R.sup.3 and R.sup.19 are hydrogen, C.sub.1 -C.sub.5 alkyl and the like; Y is --NHCO--, --NHCONH--, --NHCOO-- and the like; Z.sup.1 and Z.sup.2 are aryl, heteroaryl and the like; Ar is halogen-substituted phenyl and the like; and m is 0 or an integer of 1-5. The compounds of the present invention have CCK antagonistic action and gastrin antagonistic action, particularly potent antagonistic action against CCK-A receptor, and are useful as agents for the prophylaxis and treatment of central and peripheral nervous system diseases (e.g., anxiety, schizophrenia, and the like) and digestive diseases (e.g., pancreatitis, gastric ulcer, enterelcosis, irritable bowel syndrome, constipation, and the like).
    • PCT No.PCT / JP95 / 01071 Sec。 371日期:1996年11月22日 102(e)日期1996年11月22日PCT归档1995年6月1日PCT公布。 公开号WO95 / 32964 日期:1995年12月7日式(I)其中R 1和R 2为氢,卤素,C 1 -C 5烷基等的噻吩唑化合物(I)和噻吩并三唑并二氮杂化合物(Ⅱ) -A = B-是-N = N-等; R3和R19是氢,C1-C5烷基等; Y是-NHCO-,-NHCONH-,-NHCOO-等; Z 1和Z 2是芳基,杂芳基等; Ar是卤素取代的苯基等; m为0或1-5的整数。 本发明的化合物具有CCK拮抗作用和胃泌素拮抗作用,特别是针对CCK-A受体的强效拮抗作用,可用作预防和治疗中枢和周围神经系统疾病(例如焦虑,精神分裂症和 类似物)和消化疾病(例如胰腺炎,胃溃疡,入侵性肠易激综合征,便秘等)。