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71. 发明授权

US07101388B2 Cooling system for indwelling heat exchange catheter 有权
公开(公告)号：US07101388B2
公开(公告)日：2006-09-05
申请号：US10902479
申请日：2004-07-29
申请人： Wayne A. Noda , William J. Worthen
发明人： Wayne A. Noda , William J. Worthen
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61F7/0085 , A61F2007/0054 , A61F2007/126
摘要： A system for exchanging heat with the body of a patient for cooling or warming the patient provides for automatic temperature control in accordance with the monitored temperature of the patient. The system comprises a temperature control module and temperature probes for making body core temperature measurements. The body core temperature measurements are used to control the temperature of fluid circulating within the fluid circuit.

72. 发明授权

US06755851B2 Indwelling heat exchange catheter and method of using same 有权
标题翻译：留置热交换导管及其使用方法
公开(公告)号：US06755851B2
公开(公告)日：2004-06-29
申请号：US10138290
申请日：2002-05-02
申请人： Wayne A. Noda , Scott M. Evans , Mike L. Jones
发明人： Wayne A. Noda , Scott M. Evans , Mike L. Jones
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61M25/1011
摘要： A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes an inlet lumen and an outlet lumen to circulate working fluid wherein at least one of the inlet or outlet lumens is shaped to induce mixing in the body fluid flowing pass it. In one embodiment, at least one lumen is shaped to induce turbulence flow in the body fluid.
摘要翻译：导管适于与诸如血管的体导管中流动的体液（例如血液）进行热交换。导管包括入口腔和出口腔，以循环工作流体，其中入口或出口腔中的至少一个成形为在流体通过的体液中引起混合。在一个实施例中，至少一个腔被成形为在体液中引起湍流。

73. 发明授权

US06719724B1 Central venous line catheter having multiple heat exchange elements and multiple infusion lumens 有权
标题翻译：中央静脉导管具有多个热交换元件和多个输注腔
公开(公告)号：US06719724B1
公开(公告)日：2004-04-13
申请号：US09816645
申请日：2001-03-23
申请人： Blair D. Walker , Scott M. Evans , Wayne A. Noda
发明人： Blair D. Walker , Scott M. Evans , Wayne A. Noda
IPC分类号： A61F712
CPC分类号： A61F7/123 , A61B2018/00011 , A61M1/369 , A61M5/44
摘要： An intravenous catheter system (apparatus and method) for controlling patient temperature includes a generally tubular elongated body having lumens for circulating a heat exchange fluid in a plurality of heat exchange elements provided at spaced intervals along the length of the elongated body. The heat exchange elements preferably comprise inflatable balloons. Heat exchange occurs between the fluid in the balloons and blood in the blood vessel. Each balloon preferably is sized such that, when inflated, each balloon blocks no more than approximately 30% to 75% of the blood vessel in which it is intubated. The catheter preferably has two to four balloons, each of which may have a different shape. The catheter also preferably has three to five infusion lumens for providing access to the patient's blood at different locations in the patient's bloodstream.
摘要翻译：用于控制患者体温的静脉内导管系统（装置和方法）包括一个大致管状的细长体，其具有流体，用于循环沿着细长体的长度以间隔间隔设置的多个热交换元件。热交换元件优选地包括可充气球囊。气球中的流体与血管中的血液之间发生热交换。每个气囊优选的尺寸使得当充气时，每个气囊阻止其插管的血管的不超过约30％至75％。导管优选地具有两个至四个气囊，每个气囊可以具有不同的形状。导管还优选具有三到五个输注腔，用于在患者血流中的不同位置处提供对患者血液的接近。

74. 发明授权

US06530945B1 System and method for controlling patient temperature 有权
标题翻译：用于控制患者体温的系统和方法
公开(公告)号：US06530945B1
公开(公告)日：2003-03-11
申请号：US09723973
申请日：2000-11-28
申请人： Wayne A. Noda , Peter J. Philips
发明人： Wayne A. Noda , Peter J. Philips
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61F2007/0054 , A61F2007/0056
摘要： A controller for a heat exchanger that heats and cools saline flowing through a closed loop heat exchange catheter cools the saline to achieve a target temperature, and then immediately upon reaching target temperature heats the saline. Upon detection of, e.g., a slight patient temperature rise, the controller cools the saline again, with the control loop continuing to tightly control patient temperature in a narrow band around the target temperature.
摘要翻译：用于加热和冷却通过闭环热交换导管的盐水的热交换器的控制器冷却盐水以达到目标温度，然后在达到目标温度后立即加热盐水。当检测到例如轻微的患者温度升高时，控制器再次冷却盐水，控制回路继续在围绕目标温度的窄带中紧密地控制患者体温。

75. 发明授权

US06454792B1 Cooling system for indwelling heat exchange catheter 有权
公开(公告)号：US06454792B1
公开(公告)日：2002-09-24
申请号：US09697667
申请日：2000-10-25
申请人： Wayne A. Noda , William J. Worthen
发明人： Wayne A. Noda , William J. Worthen
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61F7/0085 , A61F2007/0054 , A61F2007/126
摘要： A system for exchanging heat with the body of a patient for cooling or warming the patient provides for automatic temperature control in accordance with the monitored temperature of the patient. The system comprises a temperature control module and temperature probes for making body core temperature measurements. The body core temperature measurements are used to control the temperature of fluid circulating within the fluid circuit.

76. 发明授权

US5653689A Infusion catheter 失效
标题翻译：输液导管
公开(公告)号：US5653689A
公开(公告)日：1997-08-05
申请号：US531242
申请日：1995-09-30
申请人： Terrence J. Buelna , Paul Lubock , Wayne A. Noda
发明人： Terrence J. Buelna , Paul Lubock , Wayne A. Noda
IPC分类号： A61F2/06 , A61F2/84 , A61M25/00 , A61M25/10 , A61M29/02
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0023 , A61M2025/0057 , A61M2025/1013 , A61M2025/105 , A61M25/104
摘要： An infusion catheter, for use in conjunction with a balloon dilatation catheter, comprises an elongate, flexible tube defining an infusion lumen, and an expansible infusion sleeve located near its distal end, the sleeve comprising an expansible network of spacer elements disposed between proximal and distal elastomeric sealing bands. When deployed at a treatment site in a blood vessel or other bodily passage, the elongate tube of the present invention concentrically surrounds the dilatation catheter, the infusion lumen being defined therebetween, with the infusion sleeve concentrically surrounding the balloon. The spacer elements of the expansible network create an axially-elongated, circumferential flow path or interstice between the balloon and the vessel wall when the balloon is inflated, the interstice being in fluid communication with the infusion lumen, through which a therapeutic fluid is delivered to the treatment site. In a first preferred embodiment, the infusion sleeve comprises a network of filaments that define the spacer elements, wherein the network has a substantial degree of shape memory, allowing the sleeve to return to its original shape when the balloon is deflated. The grid is permanently fixed to the proximal and distal sealing bands. In a second preferred embodiment, the sleeve comprises a perforated tube of deformable, biocompatible metal formed as a mesh or latticework that defines a network of spacer elements. The perforated tube is detachably joined to the sealing bands, so that it may be left in place as a stent after the catheter is withdrawn.
摘要翻译：用于与球囊扩张导管结合使用的输注导管包括限定输液腔的细长柔性管和位于其远端附近的可膨胀的输注套筒，所述套管包括设置在近端和远端之间的间隔元件的可扩张网络弹性密封带。当部署在血管或其他身体通道中的治疗部位时，本发明的细长管同心地围绕扩张导管，其间限定了输注腔，输注套筒同心地围绕气囊。当气囊膨胀时，可膨胀网络的间隔元件在气囊和血管壁之间产生轴向细长的周向流动路径或间隙，空隙与输液腔流体连通，通过该间隙元件将治疗性流体输送到治疗现场。在第一优选实施例中，输注套筒包括限定间隔元件的细丝网络，其中网络具有相当程度的形状记忆，允许当气囊放气时套筒返回到其原始形状。网格永久固定在近端和远端密封带上。在第二优选实施例中，套筒包括形成为网格或网格的可变形的生物相容性金属的多孔管，其限定了间隔元件的网络。穿孔管可拆卸地连接到密封带，使得在导管撤回之后其可以作为支架留在适当的位置。

77. 发明授权

US5211650A Dual function suturing device and method 失效
标题翻译：双功能缝合装置及方法
公开(公告)号：US5211650A
公开(公告)日：1993-05-18
申请号：US912353
申请日：1992-07-13
申请人： Wayne A. Noda
发明人： Wayne A. Noda
IPC分类号： A61B17/04 , A61B17/06 , A61B17/12
CPC分类号： A61B17/12013 , A61B17/0469 , A61B17/0485 , A61B17/06166 , A61B17/12009 , A61B2017/00353 , A61B2017/0474 , A61B2017/0477 , A61B2017/0496
摘要： A suturing device includes a shaft with a pair of axial passages extending through the shaft. A length of suture passes through the first axial passage, the suture having a surgical needle attached to its distal end, and a preformed knotted loop disposed at a distal end of the first axial passage. The second axial passage includes a gaseous seal and is configured to receive a surgical instrument for manipulating tissue to facilitate application of the suture. In the method of the invention, the suturing device is inserted through a cannula and a surgical instrument is introduced through the second axial passage. Tissue is manipulated using the surgical instrument to facilitate application of the suture. A needle holder introduced through a separate cannula is used to pass the needle through the wound and through the knotted loop. Tension is then applied to the suture to close the knot and bind the wound.
摘要翻译：缝合装置包括具有延伸穿过轴的一对轴向通道的轴。一段缝合线通过第一轴向通道，缝合线具有附接到其远端的外科手术针，以及设置在第一轴向通道的远端处的预成形的打结环。第二轴向通道包括气体密封件，并且构造成容纳用于操纵组织以便于施加缝合线的外科器械。在本发明的方法中，缝合装置通过套管插入并且手术器械通过第二轴向通道引入。使用手术器械操纵组织以便于缝合线的应用。使用通过单独插管引入的针保持器将针穿过伤口并穿过打结的环。然后将张力施加到缝合线以封闭结并结合伤口。

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