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71. 发明授权

US6124283A Substituted 1,2,3,4-tetrahydronaphthalene derivatives 失效
标题翻译：取代的1,2,3,4-四氢萘衍生物
公开(公告)号：US6124283A
公开(公告)日：2000-09-26
申请号：US836004
申请日：1997-04-25
申请人： Stefan Berg , Lennart Florvall , Svante Ross , Seth-Olov Thorberg
发明人： Stefan Berg , Lennart Florvall , Svante Ross , Seth-Olov Thorberg
IPC分类号： C07D295/12 , A61K31/00 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/22 , A61P25/24 , A61P43/00 , C07D211/24 , C07D211/26 , C07D211/34 , C07D241/00 , C07D295/096 , C07D295/135 , C07D295/215 , C07D295/22 , C07D295/155
CPC分类号： C07D295/096 , A61K31/496 , C07D211/26 , C07D211/34 , C07D241/00 , C07D295/135 , C07D295/215 , C07C2101/16 , C07C2102/10
摘要： New piperidinyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having the formula ##STR1## wherein X is N or CH;Y is NR.sub.2 CH.sub.2, CH.sub.2 --NR.sub.2, NR.sub.2 --CO, CO--NR.sub.2 or NR.sub.2 SO.sub.2 ;R.sub.1 is H, C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl;R.sub.3 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl or (CH.sub.2).sub.n -aryl,where aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted;n is 0-4;as (R)-enantiomer, (S)-enantiomer or a racemate in the form of the free base or a pharmaceutically acceptable salt or hydrate thereof; a pharmaceutical formulation containing the compounds, use of the compounds in the treatment of 5-hydroxytryptamine mediated disorders, processes for the preparation of the compounds and intermediates for the preparation of the compounds.
摘要翻译： PCT No.PCT / SE97 / 00469 Sec。 371日期1997年04月25日 102（e）日期1997年4月25日PCT 1997年3月20日PCT PCT。公开号WO97 / 34883 日期1997年9月25日新式具有下式的哌啶基或哌嗪基 - 取代-1,2,3,4-四氢萘衍生物其中X为N或CH; Y是NR2CH2，CH2-NR2，NR2-CO，CO-NR2或NR2SO2; R1是H，C1-C6烷基或C3-C6环烷基; R 3是C 1 -C 6烷基，C 3 -C 6环烷基或（CH 2）n - 芳基，其中芳基是苯基或含有一个或两个选自N，O和S的杂原子并可以被单取代或二取代的杂芳环; n为0-4; 作为（R） - 对映异构体，（S） - 对映体或游离碱形式的外消旋物或其药学上可接受的盐或水合物; 含有这些化合物的药物制剂，该化合物在治疗5-羟色胺介导的病症中的用途，制备化合物的方法和用于制备化合物的中间体。

72. 发明申请

US20100054968A1 AXIAL-FLOW FAN FOR A VEHICLE RADIATOR 有权
标题翻译：用于车辆散热器的轴流风扇
公开(公告)号：US20100054968A1
公开(公告)日：2010-03-04
申请号：US12515960
申请日：2007-11-15
申请人： Karl-Heinz Fleischmann , Stefan Berg , Alexander Gass
发明人： Karl-Heinz Fleischmann , Stefan Berg , Alexander Gass
IPC分类号： F04D29/58
CPC分类号： F04D25/082
摘要： The invention relates to an axial-flow fan for a vehicle radiator, the fan wheel of which delivering the main air flow is driven by a hub motor centrally rotationally coupled to said fan wheel, the vehicle radiator being arranged on the intake side of the fan wheel, the hub motor during operation being cooled by a secondary air flow, and the cooling air flow of the hub motor flowing out from an air outlet opening situated on the intake side in the hub area of the fan wheel. In order that an air flow sufficient for cooling the hub motor can be provided whilst avoiding a significant reduction in the fan efficiency, an air baffle device allowing the greater part of its cooling air flow to pass is assigned to the hub motor and the cooling air flow passing through the air baffle device is led out of the air outlet opening, avoiding disturbances of the main air flow delivered by the fan wheel.
摘要翻译：本发明涉及一种用于车辆散热器的轴流风扇，其传送主空气流的风扇轮由中心旋转地联接到所述风扇轮的轮毂电动机驱动，车辆散热器布置在风扇的进气侧车轮，轮毂电机在操作期间被二次风流冷却，并且轮毂电机的冷却空气流从位于风扇轮的轮毂区域中的进气侧的出气口流出。为了能够提供足以冷却轮毂电动机的气流，同时避免风扇效率的显着降低，允许其大部分冷却空气流通过的空气挡板装置被分配给轮毂电动机和冷却空气通过空气挡板装置的流动从出气口导出，避免了由风扇轮传递的主空气流的干扰。

73. 发明授权

US07439356B2 Substituted indan derivatives 失效
标题翻译：取代的茚满衍生物
公开(公告)号：US07439356B2
公开(公告)日：2008-10-21
申请号：US11543250
申请日：2006-10-03
申请人： Stefan Berg , Lennart Florvall , Svante Ross , Seth-Olov Thorberg
发明人： Stefan Berg , Lennart Florvall , Svante Ross , Seth-Olov Thorberg
IPC分类号： C07D265/30 , C07D295/135 , C07D211/26 , C07D295/155 , A61K31/495 , A61K31/445
CPC分类号： C07D295/135 , C07D295/155
摘要： The present invention relates to intermediates of the formula useful in the preparation of piperazinyl-substituted indan derivatives, wherein Y is CONR2 wherein R2 is H or C1-C6 alkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted with R4 and/or R5, wherein R4 and R5 are as defined in the specification; and R9 is H, C1-C6 alkyl, C3-C6 cycloalkyl, OCF3, OCHF2, OCH2F, halogen, CN, CF3, OH, C1-C6 alkoxy, C1-C6 alkoxy-C1-C6 alkyl, NR6R7, SO3CH3, SO3CF3, SO2NR6R7, an unsubstituted or substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituent(s) is(are) C1-C6 alkyl; or COR8; wherein R6, R7 and R8 are as defined in the specification. The invention further relates to a process for the preparation of the intermediates.
摘要翻译：本发明涉及可用于制备哌嗪基取代的茚满衍生物的式的中间体，其中Y是CONR 2，其中R 2是H或C 1 C 6 -C 6烷基; R 3是C 1 -C 6烷基，C 3 -C 6烷基，C 3 -C 6烷基，C 3 -C 6烷基，C 3 -C 6烷基，环烷基或（CH 2 CH 2）n - 芳基，其中芳基是苯基或含有一个或两个选自N，O和S的杂原子的杂芳环，并且其可以是单 - 或被R 4和/或R 5二取代，其中R 4和R 5定义如上所定义在规范中; R 9是H，C 1 -C 6烷基，C 3 -C 6烷基，C 1 -C 6烷基，C 3 -C 6烷基， OCF 3，OCHF 2，OCH 2 F，卤素，CN，CF 3 N， OH，C 1 -C 6烷氧基，C 1 -C 6烷氧基-C 1 -C 6烷氧基，C 1 -C 6烷氧基，C 1 -C 6烷氧基， C 6 -C 6烷基，NR 6 R 7，SO 3 CH 3， SO 3，SO 3，CF 3，SO 2，NR 6，R 7，含有一个或两个选自N和O的杂原子的未取代或取代的杂环或杂芳环，其中所述取代基是C 1 -C 6 -C 6烷基; 或COR 8; 其中R 6，R 7和R 8是如说明书中所定义的。本发明还涉及制备中间体的方法。

74. 发明申请

US20080214560A1 Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease 审中-公开
标题翻译：嘧啶衍生物在制造预防和/或治疗阿尔茨海默病药物中的应用
公开(公告)号：US20080214560A1
公开(公告)日：2008-09-04
申请号：US12088899
申请日：2006-10-02
申请人： Lars Andersson , Stefan Berg , Jeremy Burrows , Sven Hellberg , Fernando Huerta , Tobias Rein
发明人： Lars Andersson , Stefan Berg , Jeremy Burrows , Sven Hellberg , Fernando Huerta , Tobias Rein
IPC分类号： A61K31/497 , A61K31/506 , C07D239/28
CPC分类号： C07D403/04 , A61K31/506 , C07D401/14
摘要： Pyrimidine derivatives of formula I, wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification, as a base or a pharmaceutically acceptable salt thereof in the manufacture of pharmaceutical compositions and in the treatment or prophylaxis of Alzheimer's Disease.
摘要翻译：式I的嘧啶衍生物，其中R 1，R 2，R 3，R 4，R 4， > 5，R 6，R 7，R 8和R 9如上所定义。本说明书作为其药物组合物的制备中的碱或其药学上可接受的盐，并且用于治疗或预防阿尔茨海默氏病。

75. 发明申请

US20070149545A1 Substituted indan derivatives 失效
标题翻译：取代的茚满衍生物
公开(公告)号：US20070149545A1
公开(公告)日：2007-06-28
申请号：US11543250
申请日：2006-10-03
申请人： Stefan Berg , Lennart Florvall , Svante Ross , Seth-Olov Thorberg
发明人： Stefan Berg , Lennart Florvall , Svante Ross , Seth-Olov Thorberg
IPC分类号： A61K31/495 , C07D211/06 , A61K31/445 , C07D241/04
CPC分类号： C07D295/135 , C07D295/155
摘要： The present invention relates to intermediates of the formula useful in the preparation of piperazinyl-substituted indan derivatives, wherein Y is CONR2 wherein R2 is H or C1-C6 alkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted with R4 and/or R5, wherein R4 and R5 are as defined in the specification; and R9 is H, C1-C6 alkyl, C3-C6 cycloalkyl, OCF3, OCHF2, OCH2F, halogen, CN, CF3, OH, C1-C6 alkoxy, C1-C6 alkoxy-C1-C6 alkyl, NR6R7, SO3CH3, SO3CF3, SO2NR6R7, an unsubstituted or substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituent(s) is(are) C1-C6 alkyl; or COR8; wherein R6, R7 and R8 are as defined in the specification. The invention further relates to a process for the preparation of the intermediates.
摘要翻译：本发明涉及可用于制备哌嗪基取代的茚满衍生物的式的中间体，其中Y是CONR 2，其中R 2是H或C 1 C 6 -C 6烷基; R 3是C 1 -C 6烷基，C 3 -C 6烷基，C 3 -C 6烷基，C 3 -C 6烷基，C 3 -C 6烷基，环烷基或（CH 2 CH 2）n - 芳基，其中芳基是苯基或含有一个或两个选自N，O和S的杂原子的杂芳环，并且其可以是单 - 或被R 4和/或R 5二取代，其中R 4和R 5定义如上所定义在规范中; R 9是H，C 1 -C 6烷基，C 3 -C 6烷基，C 1 -C 6烷基，C 3 -C 6烷基， OCF 3，OCHF 2，OCH 2 F，卤素，CN，CF 3 N， OH，C 1 -C 6烷氧基，C 1 -C 6烷氧基-C 1 -C 6烷氧基，C 1 -C 6烷氧基，C 1 -C 6烷氧基， C 6 -C 6烷基，NR 6 R 7，SO 3 CH 3， SO 3，SO 3，CF 3，SO 2，NR 6，R 7，含有一个或两个选自N和O的杂原子的未取代或取代的杂环或杂芳环，其中所述取代基是C 1 -C 6 -C 6烷基; 或COR 8; 其中R 6，R 7和R 8是如说明书中所定义的。本发明还涉及制备中间体的方法。

76. 发明申请

US20050222181A1 COMPOUNDS IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER'S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 失效
标题翻译：治疗感染相关疾病的化合物，与GLYCOGEN SYNTHASE KINASE-3相关的阿尔茨海默病和疾病
公开(公告)号：US20050222181A1
公开(公告)日：2005-10-06
申请号：US10499388
申请日：2002-12-18
申请人： Stefan Berg , Ratan Bhat , Philip Edwards , Sven Hellberg
发明人： Stefan Berg , Ratan Bhat , Philip Edwards , Sven Hellberg
IPC分类号： A61K31/517 , A61K31/55 , A61P9/10 , A61P15/00 , A61P15/16 , A61P17/14 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00 , C07D403/04 , C07D403/14 , C07D413/14 , C07D43/04
CPC分类号： C07D403/04 , C07D403/14 , C07D413/14
摘要： The present invention relates to new compounds of formula I wherein R1, R2, R3, n, m are defined as in claim 1, a process for their preparation and new intermediates used in the preparation thereof, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy, especially in the prevention and/or treatment of dementia related diseases, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3.
摘要翻译：本发明涉及新的式I化合物，其中R 1，R 2，R 3，n，m如权利要求1中所定义，其制备方法和用于制备其的新中间体，含有所述治疗活性化合物的药物制剂和所述活性化合物在治疗中的用途，特别是在预防和/或治疗痴呆症相关疾病，阿尔茨海默病和病症与糖原合酶激酶-3有关。

77. 发明申请

US20050096326A1 Substituted indian derivatives 审中-公开
标题翻译：取代印度衍生品
公开(公告)号：US20050096326A1
公开(公告)日：2005-05-05
申请号：US10807918
申请日：2004-03-24
申请人： Stefan Berg , Lennart Florvall , Svante Ross , Seth-Olov Thorberg
发明人： Stefan Berg , Lennart Florvall , Svante Ross , Seth-Olov Thorberg
IPC分类号： C07D295/14 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/5375 , A61K31/5377 , A61P1/04 , A61P3/04 , A61P9/10 , A61P9/12 , A61P15/00 , A61P15/10 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/32 , A61P25/34 , A61P29/00 , A61P35/00 , C07D211/26 , C07D211/34 , C07D295/135 , C07D295/155 , A61K31/496 , A61K31/454
CPC分类号： C07D295/135 , C07D295/155
摘要： The present invention relates to new piperidyl- or piperazinyl-substituted indan derivatives of the formula I as (R)-enantiomers, (S)-enantiomers, or racemates in the form of a free base or pharmaceutically acceptable salts or solvates thereof. The present invention further relates to a process for the preparation of the compounds, to pharmaceutical compositions containing the compounds and to methods of treatment of 5-hydroxytryptamine-mediated disorders comprising administering the compounds.
摘要翻译：本发明涉及式I的新的哌啶基或哌嗪基取代的茚满衍生物作为（R） - 对映体，（S） - 对映异构体或游离碱形式的外消旋体或其药学上可接受的盐或溶剂合物。本发明还涉及制备所述化合物的方法，含有所述化合物的药物组合物和治疗5-羟色胺介导的病症的方法，包括给予所述化合物。

78. 发明申请

US20050070559A1 Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3 审中-公开
标题翻译：羟吲哚衍生物在治疗痴呆相关疾病，阿尔茨海默氏病和与糖原合酶激酶-3相关的病症中的应用
公开(公告)号：US20050070559A1
公开(公告)日：2005-03-31
申请号：US10499950
申请日：2002-12-18
申请人： Stefan Berg , Ratan Bhat , Philip Edwards , Sven Hellberg
发明人： Stefan Berg , Ratan Bhat , Philip Edwards , Sven Hellberg
IPC分类号： A61K31/496 , A61K31/517 , A61K31/5377 , A61P9/10 , A61P15/16 , A61P15/18 , A61P17/14 , A61P21/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00 , C07D209/34 , C07D239/86 , C07D239/90 , C07D239/93 , C07D295/185 , C07D403/04 , C07D403/14 , C07D405/14 , C07D43/04
CPC分类号： C07D295/185 , A61K31/517 , C07D209/34 , C07D239/86 , C07D239/90 , C07D239/93 , C07D403/04 , C07D403/14 , C07D405/14
摘要： The present invention relates to a new use of oxindole derivatives of formula I, as a free base or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, m and n arm as defined as in claim 1, as well as to new compounds, a process for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy, especially in the prevention and/or treatment of dementia related diseases, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3.
摘要翻译：本发明涉及式I的羟吲哚衍生物作为游离碱或其药学上可接受的盐的新用途，其中R 1，R 2，R 3，m和n臂的定义如权利要求1，以及新化合物，其制备方法和其制备中使用的新中间体，含有所述治疗活性化合物的药物组合物和所述活性化合物在治疗中的用途，特别是在预防和/或治疗中痴呆症相关疾病，阿尔茨海默病和与糖原合酶激酶-3有关的病症。

79. 发明申请

US20050054698A1 4-(4Methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)urea and its use in the treatment of conditions associated with glycogen-synthase kinase-3(gsk3) 失效
标题翻译： 4-（4-甲氧基苄基）-n' - （5-硝基-1,3-噻唑-2-基）脲及其在治疗与糖原合成酶激酶-3（gsk3）相关的病症中的用途，
公开(公告)号：US20050054698A1
公开(公告)日：2005-03-10
申请号：US10481711
申请日：2002-07-03
申请人： Stefan Berg , Sven Hellberg
发明人： Stefan Berg , Sven Hellberg
IPC分类号： C07D277/20 , A61K31/426 , A61P3/10 , A61P15/00 , A61P17/14 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/24 , A61P25/28 , A61P43/00 , C07D277/44 , C07D277/58
CPC分类号： C07D277/58
摘要： The present invention relates to a new compound of formula I as a free base or a pharmaceutically acceptable salt thereof, a process for the preparation, pharmaceutical formulations containing said therapeutically active compound and to the use of said compound in therapy.
摘要翻译：本发明涉及作为游离碱或其药学上可接受的盐的新型式I化合物，制备方法，含有所述治疗活性化合物的药物制剂以及所述化合物在治疗中的用途。

80. 发明授权

US06228857B1 Morpholinobenzamide salts 有权
公开(公告)号：US06228857B1
公开(公告)日：2001-05-08
申请号：US09621387
申请日：2000-07-21
申请人： Stefan Berg , Daniel Sohn
发明人： Stefan Berg , Daniel Sohn
IPC分类号： A61K315377
摘要： The present invention relates to pharmaceutically acceptable salts of the compound of formula I or solvates of said salt in which the compound of formula I is as the (R)-enantiomer, the (S)-enantiomer or the racemate, a process for their preparation, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.

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