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71. 发明授权

US07601798B2 Methods of preparing polymers having terminal amine groups using protected amine salts 失效
标题翻译：使用保护的胺盐制备具有末端胺基团的聚合物的方法
公开(公告)号：US07601798B2
公开(公告)日：2009-10-13
申请号：US11242656
申请日：2005-10-04
申请人： Hong Zhao , Belen Rubio
发明人： Hong Zhao , Belen Rubio
IPC分类号： C08F6/06 , C08F6/10 , C08G73/00
CPC分类号： C08G65/33303 , C08G65/3348
摘要： The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal tosylate with a protected amine salt to form a polymer containing a terminal protected amine and thereafter deprotecting the polymer containing the terminal protected amine to form the polymer having a terminal amine. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
摘要翻译：本发明涉及制备高纯度的含有末端胺的聚环氧烷的线性聚合物的方法。一种优选的方法包括使聚环氧烷如含有甲苯磺酸末端的聚乙二醇与受保护的胺盐反应形成含有末端保护的胺的聚合物，然后使包含末端被保护的胺的聚合物脱保护，形成具有末端胺的聚合物。得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

72. 发明申请

US20090156629A1 INDENOISOQUINOLINE-RELEASABLE POLYMER CONJUGATES 审中-公开
标题翻译：硝基喹啉可释放的聚合物共混物
公开(公告)号：US20090156629A1
公开(公告)日：2009-06-18
申请号：US12301346
申请日：2007-06-08
申请人： Hong Zhao , Ying Gao
发明人： Hong Zhao , Ying Gao
IPC分类号： A61K47/48 , C08G65/333
CPC分类号： C07D519/00
摘要： The present invention provides releasably-linked indenoisoquinoline polymer conjugates. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.
摘要翻译：本发明提供可释放连接的茚并异喹啉聚合物共轭物。还公开了制备缀合物的方法和使用其的治疗哺乳动物的方法。

73. 发明授权

US07462687B2 Prodrugs of vancomycin with hydrolysis resistant polymer linkages 失效
标题翻译：万古霉素与抗水解聚合物连接的前药
公开(公告)号：US07462687B2
公开(公告)日：2008-12-09
申请号：US10705740
申请日：2003-11-11
申请人： Richard B. Greenwald , Hong Zhao
发明人： Richard B. Greenwald , Hong Zhao
IPC分类号： A61K38/14
CPC分类号： A61K47/641 , A61K47/60
摘要： Vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are hydrolysis resistant in vitro, are selectively attached to the sugar amino and/or N-methyl amino groups of vancomycin and related compounds. Vancomycin-polymer conjugates made by the methods and methods of treatment using the conjugates are also disclosed.
摘要翻译：公开了万古霉素 - 聚合物共轭物。在优选的方面，体外耐水解的聚合物残基选择性地连接到万古霉素和相关化合物的糖氨基和/或N-甲基氨基上。还公开了通过使用共轭物的方法和方法制备的万古霉素 - 聚合物缀合物。

74. 发明申请

US20070149178A1 Method for transfer of user identity between CDMA wireless communication devices 有权
标题翻译：在CDMA无线通信设备之间传送用户身份的方法
公开(公告)号：US20070149178A1
公开(公告)日：2007-06-28
申请号：US11321123
申请日：2005-12-28
申请人： Dean Thorson , William Alberth , Hong Zhao
发明人： Dean Thorson , William Alberth , Hong Zhao
IPC分类号： H04Q7/22
CPC分类号： H04W8/265
摘要： A method is provided for transferring user identities between one CDMA wireless communication device (120) and another in a wireless CDMA communication system (100) having a network system controller (140). The network controller (140) receives an activation command from a wireless communication device (120), the activation command including identification information identifying the activating wireless communication device (404). Next, the network controller determines whether the activating wireless communication device is a transferred identity wireless communication device in response to the identification information (424). The network controller then activates the activating wireless communication device with a transferred identity (436) if the activating wireless communication device is determined to be a transferred identity wireless communication device (424).
摘要翻译：提供一种用于在具有网络系统控制器（140）的无线CDMA通信系统（100）中的一个CDMA无线通信设备（120）与另一个CDMA无线通信设备（120）之间传送用户身份的方法。网络控制器（140）从无线通信设备（120）接收激活命令，该激活命令包括识别激活的无线通信设备（404）的识别信息。接下来，网络控制器响应于识别信息来确定激活的无线通信设备是否是转移的身份无线通信设备（424）。如果激活的无线通信设备被确定为传送的身份无线通信设备，则网络控制器然后激活具有传送身份（436）的激活无线通信设备（424）。

75. 发明申请

US20070049725A1 Methods of preparing polymers having terminal amine groups 失效
标题翻译：制备具有末端胺基团的聚合物的方法
公开(公告)号：US20070049725A1
公开(公告)日：2007-03-01
申请号：US11212901
申请日：2005-08-26
申请人： Hong Zhao , Belen Rubio , Jing Xia
发明人： Hong Zhao , Belen Rubio , Jing Xia
IPC分类号： C08G79/02
CPC分类号： C08G65/33303 , A61K47/60
摘要： The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
摘要翻译：本发明涉及制备高纯度的含有末端胺的聚环氧烷的线性聚合物的方法。一种优选的方法包括在溶剂中使含有末端叠氮化物的聚乙二醇与膦类还原剂如三苯基膦或碱金属硼氢化物还原剂如硼氢化钠的聚环氧烷反应进行反应。得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

76. 发明授权

US07147778B1 Method and system for nitrifying and denitrifying wastewater 有权
标题翻译：硝化和反硝化废水的方法和系统
公开(公告)号：US07147778B1
公开(公告)日：2006-12-12
申请号：US11326538
申请日：2006-01-05
申请人： Richard W. DiMassimo , Sun-Nan Hong , Hong Zhao , Luther Wood
发明人： Richard W. DiMassimo , Sun-Nan Hong , Hong Zhao , Luther Wood
IPC分类号： C02F3/30
CPC分类号： C02F3/302 , C02F3/121 , C02F3/1263 , C02F3/1268 , C02F3/301 , Y02W10/15 , Y10S210/903 , Y10S210/906
摘要： A wastewater treatment system is provided that includes first and second reactors, each operative to nitrify or denitrify wastewater contained therein. Downstream from the first and second reactors is a membrane reactor that operates under aerobic conditions and includes one or more submersed membranes for separating solids. Extending between the membrane reactor and each of the first and second reactors is a return activated sludge line with appropriate controls for permitting return activated sludge to be directed to one of the reactors at a time. To nitrify and denitrify wastewater, a wastewater influent stream is alternatively directed to the anoxic reactors which are alternatively operated under aerobic and anoxic conditions so as to nitrify or denitrify the wastewater contained therein. To reduce or minimize the dissolved oxygen return from the membrane reactor to the first and second reactors, the flow of return activated sludge is controlled such that generally return activated sludge is returned to the reactor operating under aerobic conditions.
摘要翻译：提供了一种废水处理系统，其包括第一和第二反应器，每个反应器用于硝化或反硝化其中所含的废水。来自第一和第二反应器的下游是在需氧条件下运行并包括用于分离固体的一个或多个浸没膜的膜反应器。在膜反应器和第一和第二反应器中的每一个之间的延伸是具有适当控制的返回活性污泥管线，用于允许一次将返回的活性污泥导向反应器中的一个。对于硝化和反硝化废水，废水流入物流交替地被引导到缺氧反应器，其在有氧和缺氧条件下交替地运行，以便对其中所含的废水进行硝化或反硝化。为了减少或最小化从膜反应器到第一和第二反应器的溶解氧回流，控制回流活性污泥的流动，使得通常返回的活性污泥返回到在需氧条件下运行的反应器。

77. 发明授权

US07122189B2 Releasable polymeric conjugates based on aliphatic biodegradable linkers 有权
标题翻译：基于脂肪族可生物降解接头的可释放聚合物共轭物
公开(公告)号：US07122189B2
公开(公告)日：2006-10-17
申请号：US10218167
申请日：2002-08-13
申请人： Hong Zhao , Richard B. Greenwald , Annapurna Pendri
发明人： Hong Zhao , Richard B. Greenwald , Annapurna Pendri
IPC分类号： A61K39/395 , A01N33/08 , A01N31/06 , A61K39/44
CPC分类号： C07D333/34 , A61K38/00 , A61K47/60 , C07C271/16 , C07C271/20 , C07C271/22 , C07C317/28 , C07D207/452 , C07D277/16 , C07K14/43595
摘要： Activated polymeric bicine derivatives such as as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
摘要翻译：公开了活性聚合物双金属衍生物，以及由其制备的缀合物。还公开了制备和使用双金属衍生物的方法。

78. 发明授权

US06721929B2 High accuracy timing model for integrated circuit verification 失效
标题翻译：用于集成电路验证的高精度时序模型
公开(公告)号：US06721929B2
公开(公告)日：2004-04-13
申请号：US09854146
申请日：2001-05-11
申请人： Jun Li , Hong Zhao , Hsien-Yen Chiu
发明人： Jun Li , Hong Zhao , Hsien-Yen Chiu
IPC分类号： G06F1750
CPC分类号： G06F17/5022
摘要： A variable current source model accurately determines timing delays for designs of circuits implemented in integrated circuits. A design for an integrated circuit specifies a resistive-capacitive (“RC”) network. The RC network couples a driving point and a receiving point, and a circuit specified in the design, drives the RC network at the driving point. The variable current source model determines driving currents for the circuit at the driving point based on the RC network and a characterization model of the circuit. A timing delay between the driving point and the receiving point is determined by simulating the drive of the RC network with the driving current at the driving point.
摘要翻译：可变电流源模型精确地确定了在集成电路中实现的电路设计的定时延迟。集成电路的设计规定了电阻电容（“RC”）网络。 RC网络耦合驱动点和接收点以及设计中指定的电路，在驱动点驱动RC网络。可变电流源模型基于RC网络和电路的表征模型确定驱动点处电路的驱动电流。驱动点和接收点之间的定时延迟通过模拟驱动点处的驱动电流的RC网络的驱动来确定。

79. 发明授权

US06624222B2 Environmentally safe paint stripper emulsion 失效
标题翻译：环保型脱漆剂乳液
公开(公告)号：US06624222B2
公开(公告)日：2003-09-23
申请号：US09768408
申请日：2001-01-24
申请人： Paul E. Kestyn , Augustin T. Chen , Hong Zhao
发明人： Paul E. Kestyn , Augustin T. Chen , Hong Zhao
IPC分类号： C08K510
CPC分类号： C08J3/07 , C08J2329/14 , C09D9/00
摘要： Environmentally safe, e.g. biodegradable, paint stripper compositions comprising 10-99 parts dimethyl esters of C4-C6 aliphatic dibasic acids, 0.1-40 parts polyvinyl butyral and 1-90 parts water. The compositions can be mixed, e.g. in high shear to provide stable emulsions which strip paint, e.g. varnish from wood. Certain embodiments of the invention also comprise water soluble organic solvents, water-miscible organic solvents, surfactants, emulsifiers, thickeners and/or pigments.
摘要翻译：环保，例如包含10-99份C 4 -C 6脂族二元酸二甲酯，0.1-40份聚乙烯醇缩丁醛和1-90份水的脱漆剂组合物。组合物可以混合，例如在高剪切力下提供稳定的乳液，其剥离涂料，例如清漆从木材。本发明的某些实施方案还包括水溶性有机溶剂，水混溶性有机溶剂，表面活性剂，乳化剂，增稠剂和/或颜料。

80. 发明授权

US06204381B1 Process for the preparation of triazine carbamates 失效
标题翻译：制备三嗪氨基甲酸酯的方法
公开(公告)号：US06204381B1
公开(公告)日：2001-03-20
申请号：US09313777
申请日：1999-05-17
申请人： Hong Zhao
发明人： Hong Zhao
IPC分类号： C07D25150
CPC分类号： C07D251/70
摘要： Disclosed is the preparation of 1,3,5-triazine carbamates which are suitable for use as crosslinking agents in curable compositions, particularly in coating compositions which are capable of curing at relatively low temperatures without releasing formaldehyde during cure. The process includes the step of contacting a 1,3,5-triazine derivative having cyanate-displaceable leaving groups (i.e. cyanuric chloride), a cyanate-containing reagent (i.e. potassium cyanate), and an isocyanate-reactive compound such as an alcohol, in the presence of a polar solvent or in the presence of a non-polar solvent in combination with a phase transfer catalyst.
摘要翻译：公开了适合用作可固化组合物中的交联剂的1,3,5-三嗪氨基甲酸酯的制备，特别是在固化期间能够在相对低的温度下固化而不释放甲醛的涂料组合物中。该方法包括使具有氰酸酯置换的离去基团（即氰尿酰氯），含氰酸酯的试剂（即氰酸钾）和异氰酸酯反应性化合物如醇的1,3,5-三嗪衍生物接触的步骤，在极性溶剂的存在下或在非极性溶剂与相转移催化剂的组合的存在下进行。

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