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71. 发明申请

US20110064728A1 IL-17 Homologous Polypeptides and Therapeutic Uses Thereof 审中-公开
标题翻译： IL-17同源多肽及其治疗用途
公开(公告)号：US20110064728A1
公开(公告)日：2011-03-17
申请号：US12825263
申请日：2010-06-28
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gumey , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gumey , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC分类号： A61K39/395 , A61K38/16 , A61P1/00 , A61P11/06 , A61P17/00 , A61P19/00
CPC分类号： A61K38/20 , C07K14/54 , C07K14/7155 , C07K2319/30 , C12N15/1136 , C12N2310/11 , C12N2310/12 , C12N2310/15
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译：本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

72. 发明授权

US07876468B2 Line utilization in integrated document delivery method and apparatus 有权
标题翻译：集成文件传送方式和装置中的线路利用
公开(公告)号：US07876468B2
公开(公告)日：2011-01-25
申请号：US12567656
申请日：2009-09-25
申请人： Kevin Phillips , Eric C. Chen , Curtis R. Powell , Jian Chen , Kamal Punn
发明人： Kevin Phillips , Eric C. Chen , Curtis R. Powell , Jian Chen , Kamal Punn
IPC分类号： G06F3/12
CPC分类号： H04N1/00209 , H04L12/66 , H04L51/066 , H04N1/00244 , H04N1/00395 , H04N1/32523 , H04N1/32529 , H04N1/32545 , H04N1/32561 , H04N1/32587 , H04N2201/0093
摘要： A document delivery network server having a set of integrated functions including sending, receiving, routing and filing of FAXes and e-mails to other users which achieves numerous advantages over the prior art. The document delivery system is based on a client/server model having both analog and digital Fax line capabilities. The server side provides very highly integrated systems functionality based on industry standard, commercially available hardware and a mix of industry standard and proprietary software components including integrated FAX/modem modules, an embedded OS, embedded plug-and-play driver sets, embedded e-mail gateways, an embedded FAX archive, embedded back-up/restore, proprietary high efficiency line utilization and highly efficient load balancing.
摘要翻译：一种文档传送网络服务器，其具有一组集成功能，包括向其他用户发送，接收，路由和归档传真和电子邮件，这相对于现有技术实现了许多优点。文档传送系统基于具有模拟和数字传真线路功能的客户端/服务器模型。服务器端提供非常高度集成的系统功能，基于行业标准，市售硬件以及业界标准和专有软件组件的混合，包括集成的传真/调制解调器模块，嵌入式操作系统，嵌入式即插即用驱动程序集，邮件网关，嵌入式FAX归档，嵌入式备份/恢复，专有的高效率线路利用率和高效负载平衡。

73. 发明授权

US07846706B2 PCSK9 polypeptides 有权
标题翻译： PCSK9多肽
公开(公告)号：US07846706B2
公开(公告)日：2010-12-07
申请号：US12456798
申请日：2009-06-23
申请人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
发明人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
IPC分类号： C12N9/00 , C12N9/50 , C12N1/20 , C12N15/00 , C07H21/02 , C07H21/04
CPC分类号： C07K16/40 , A61K38/00 , C07K2317/41 , C07K2317/76 , C12N9/6424 , C12Y302/01008 , C12Y304/21061 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

74. 发明申请

US20100192308A1 METHOD FOR SCOURING AND BLEACHING COTTON FABRIC WITH COMPOSITE ENZYME PREPARATION IN ONE BATH 审中-公开
标题翻译：一次浴中复合酶制剂的洗涤和漂白棉织物的方法
公开(公告)号：US20100192308A1
公开(公告)日：2010-08-05
申请号：US12667577
申请日：2008-06-16
申请人： Jian Chen , Guocheng Du , Hejing Yan , Jianghua Li
发明人： Jian Chen , Guocheng Du , Hejing Yan , Jianghua Li
IPC分类号： D06L3/14
CPC分类号： D06M16/003 , D06L4/40 , D06L4/75 , D06M2101/06
摘要： A method for scouring and bleaching cotton fabric with composite enzyme preparation in one bath is provided. The method relates to the application of composite alkaline enzyme preparation in scouring and bleaching processes of cotton fabric. The enzyme preparation for scouring and bleaching cotton fabric is compounded from cutinase, alkaline pectase, alkaline xylanase, alkaline cellulose, and carbohydrate oxidase. The method includes: scouring the cotton fabric by adding the composite enzyme preparation, glucose, oxidation bleaching stabilizer RB-3, penetrant JFC, and Triton X-100 in a treating bath at 55-70° C. and pH 8-10, and then bleaching the cotton fabric for 30 min by directly adding tetraacetyl ethylenediamine (TAED) in the scouring bath to activate hydrogen peroxide. After being treated by the method of the present invention, the cotton fabric has high impurity removal ratio, favorable wettability, and high whiteness. The present invention has the advantages of low power consumption, short process flow, and being environment friendly, and may be used to replace conventional chemical treatment process under the condition of concentrated alkali and high temperature.
摘要翻译：提供了在一个浴中用复合酶制剂冲洗和漂白棉织物的方法。该方法涉及复合碱性酶制剂在棉织物的漂洗和漂白过程中的应用。用于冲洗和漂白棉织物的酶制剂由角质酶，碱性果胶酶，碱性木聚糖酶，碱性纤维素和碳水化合物氧化酶组合。该方法包括：通过在55-70℃和pH8-10的处理浴中加入复合酶制剂，葡萄糖，氧化漂白稳定剂RB-3，渗透剂JFC和Triton X-100来洗涤棉织物，以及然后通过在洗涤浴中直接加入四乙酰乙二胺（TAED）来活化过氧化氢，使棉织物漂白30分钟。在通过本发明的方法处理之后，棉织物具有高杂质去除率，良好的润湿性和高白度。本发明具有功耗低，工艺流程短，环保的优点，可用于在浓碱和高温条件下代替常规化学处理工艺。

75. 发明授权

US07718770B2 PRO1305-polypeptides 有权
标题翻译： PRO1305-多肽
公开(公告)号：US07718770B2
公开(公告)日：2010-05-18
申请号：US10183012
申请日：2002-06-26
申请人： Kevin P. Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Victoria Smith , Colin K. Watanabe , William I. Wood , Zemin Zhang
发明人： Kevin P. Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Victoria Smith , Colin K. Watanabe , William I. Wood , Zemin Zhang
IPC分类号： C07K14/435 , C07H21/00
CPC分类号： C07K14/47 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/00 , C07K16/18 , C07K16/28 , C07K2319/30 , C12N9/90 , C12N2799/026 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5082 , G01N33/5308 , G01N33/574 , G01N33/57411 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2500/10 , C12Q2563/131 , C12Q2527/137
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

76. 发明申请

US20100104584A1 GENES INVOLVED IN MITOCHONDRIAL BIOGENESIS 审中-公开
标题翻译：基因涉及生物生物学
公开(公告)号：US20100104584A1
公开(公告)日：2010-04-29
申请号：US12526674
申请日：2008-02-14
申请人： Jian Chen , Dan Garza , Hao Li , Susan C. Stevenson , Zhidan Wu
发明人： Jian Chen , Dan Garza , Hao Li , Susan C. Stevenson , Zhidan Wu
IPC分类号： A61K39/395 , A61P3/10 , A61K31/7052 , C12Q1/68 , G01N33/68 , A61P35/00
CPC分类号： G01N33/5079 , C12N15/111 , C12N2310/14 , C12N2320/12 , C12N2330/31 , G01N2800/52
摘要： The invention discloses suitable gene and polypeptide targets for the development of new therapeutics to treat, prevent or ameliorate conditions associated with mitochondrial dysfunction. The invention also relates to methods to treat, prevent or ameliorate said conditions and pharmaceutical compositions therefor, as well as to a method to identify compounds with therapeutic usefulness to treat conditions associated with mitochondrial dysfunction.
摘要翻译：本发明公开了用于开发治疗，预防或改善与线粒体功能障碍相关的病症的新治疗剂的合适的基因和多肽靶标。本发明还涉及治疗，预防或改善所述病症及其药物组合物的方法，以及鉴定具有治疗用途以治疗与线粒体功能障碍相关的病症的化合物的方法。

77. 发明申请

US20100067262A1 Switching power source device, switching power source control circuit, and switching power source device control method 有权
标题翻译：开关电源装置，开关电源控制电路和开关电源装置控制方式
公开(公告)号：US20100067262A1
公开(公告)日：2010-03-18
申请号：US12461593
申请日：2009-08-18
申请人： Jian Chen , Koji SONOBE
发明人： Jian Chen , Koji SONOBE
IPC分类号： H02M3/335
CPC分类号： H02M3/33592 , Y02B70/1433 , Y02B70/1475
摘要： A switching power source device for supplying power to a load includes a series resonant circuit, a plurality of main switch elements or main switch element groups for switching a current. path of the series resonant circuit, a transformer for inducing a secondary current from the series resonant circuit, a plurality of synchronous rectification switch elements for rectifying the secondary current, a maximum on width control circuit for ordering a start and a completion of a maximum on width to the synchronous rectification switch element in synchronization with a timing of turning on the main switch elements Or the main switch element groups, and a synchronous control circuit. The circuit controls an on period of the synchronous rectification switch element so as to turn on the synchronous rectification switch element in synchronization with a particular timing, and turn off in synchronization with another timing.
摘要翻译：用于向负载供电的开关电源装置包括串联谐振电路，用于切换电流的多个主开关元件或主开关元件组。串联谐振电路的路径，用于从串联谐振电路感应次级电流的变压器，用于整流二次电流的多个同步整流开关元件，用于排序开始和完成最大值的最大宽度控制电路同步整流开关元件的宽度与打开主开关元件或主开关元件组的定时同步，以及同步控制电路。电路控制同步整流开关元件的导通周期，以与特定定时同步地接通同步整流开关元件，并与另一定时同步地关断。

78. 发明授权

US07616499B2 Retention margin program verification 有权
标题翻译：保留保证金计划验证
公开(公告)号：US07616499B2
公开(公告)日：2009-11-10
申请号：US11617541
申请日：2006-12-28
申请人： Jun Wan , Jeffrey W. Lutze , Jian Chen , Yan Li , Alex Mak
发明人： Jun Wan , Jeffrey W. Lutze , Jian Chen , Yan Li , Alex Mak
IPC分类号： G11C11/34 , G11C16/04 , G11C16/06
CPC分类号： G11C16/0483 , G11C11/5628 , G11C16/3454 , G11C16/3459 , G11C2211/5621
摘要： Data verification in a memory device using a portion of a data retention margin is provided. A bit count is read from the region to determine whether errors will result in the memory. A read in one or more retention margin portions is performed after the normal program verify sequence and if the number of bits in these regions is more than a pre-set the memory will fail verify status. A method of verifying data in a memory device includes the steps of: defining an retention margin between adjacent data thresholds; programming the memory device with data; determining whether bits are present in the data retention margin; and if the number of bits in the retention margin exceeds a threshold, generating an error.
摘要翻译：提供了使用部分数据保留余量的存储器件中的数据验证。从区域读取位计数，以确定错误是否会导致内存。在正常程序验证序列之后执行在一个或多个保留边缘部分中的读取，并且如果这些区域中的位数大于预设，则存储器将失败验证状态。验证存储器件中的数据的方法包括以下步骤：定义相邻数据阈值之间的保留余量; 使用数据对存储设备进行编程; 确定位是否存在于数据保留余量中; 并且如果保留余量中的比特数超过阈值，则产生错误。

79. 发明授权

US07598348B2 Adiponectin receptor variant, AdipoR2v2 有权
标题翻译：脂联素受体变体，AdipoR2v2
公开(公告)号：US07598348B2
公开(公告)日：2009-10-06
申请号：US12148669
申请日：2008-04-21
申请人： Jian Chen , Ning Lee , Dong Cheng
发明人： Jian Chen , Ning Lee , Dong Cheng
IPC分类号： C07K14/72
CPC分类号： C07K14/72
摘要： The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽，其片段及其同源物的新型多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新的人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽应用于诊断，治疗和/或治疗的诊断和治疗方法。预防与这些多肽相关的各种疾病和/或病症。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

80. 发明授权

US07569465B2 Use of voids between elements in semiconductor structures for isolation 有权
标题翻译：在半导体结构中的元件之间使用空隙进行隔离
公开(公告)号：US07569465B2
公开(公告)日：2009-08-04
申请号：US11210218
申请日：2005-08-22
申请人： Jian Chen , Masaaki Higashitani
发明人： Jian Chen , Masaaki Higashitani
IPC分类号： H01L21/336 , H01L21/469
CPC分类号： H01L27/11521 , H01L21/7682 , H01L23/5222 , H01L27/115 , H01L2924/0002 , H01L2924/00
摘要： A flash EEPROM or other type of memory cell array having adjacent charge storage elements is formed with a gas filled void between them in order to reduce the level of capacitive coupling between storage elements, thus reducing cross-coupling between charge storage elements and resulting errors occurring in the data read from the array.
摘要翻译：具有相邻电荷存储元件的快闪EEPROM或其它类型的存储单元阵列在它们之间形成有气体填充的空隙，以便降低存储元件之间的电容耦合的电平，从而减少电荷存储元件之间的交叉耦合和产生的错误在从数组读取的数据中。

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