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71. 发明授权

US08663960B2 Endoglucanases 有权
标题翻译：内切葡聚糖酶
公开(公告)号：US08663960B2
公开(公告)日：2014-03-04
申请号：US13493795
申请日：2012-06-11
申请人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
发明人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
IPC分类号： C12N9/00
CPC分类号： C12N9/2437 , C07K2319/02 , C12N9/2445 , C12N15/75 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.
摘要翻译：本发明涉及与野生型内切葡聚糖酶相比具有改进性质的变体内切葡聚糖酶，特别是内切葡聚糖酶。

72. 发明授权

US08637294B2 Variant Hypocrea jercorina CBH1 cellulases 失效
标题翻译：变异Hococia jercorina CBH1纤维素酶
公开(公告)号：US08637294B2
公开(公告)日：2014-01-28
申请号：US11728219
申请日：2007-03-22
申请人： Anthony Day , Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Paulien Neefe , Mats Sandgren , Andrew Shaw , Jerry Stahlberg
发明人： Anthony Day , Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Paulien Neefe , Mats Sandgren , Andrew Shaw , Jerry Stahlberg
IPC分类号： C12N9/42 , C12P19/02 , C12P19/00 , G01N33/53
CPC分类号： C12N9/2437 , C11D3/38645 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , D21C5/005 , Y02E50/16
摘要： Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
摘要翻译：本文描述的是H.jecorina CBH I，Cel7酶的变体。本发明提供了具有改善的热稳定性和可逆性的新型纤维二糖水解酶。

73. 发明申请

US20130344541A1 COMPOSITIONS AND METHODS FOR PRODUCTION OF FERMENTABLE SUGARS 审中-公开
标题翻译：用于生产可食用糖的组合物和方法
公开(公告)号：US20130344541A1
公开(公告)日：2013-12-26
申请号：US13882658
申请日：2011-11-01
申请人： Ish Kumar Dhawan , Dipnath Baidyaroy , Andrew Shaw , Oleh Tanchak , Christopher Hill , Chengsong Liu , Amala Chokshi , Brian R. Scott
发明人： Ish Kumar Dhawan , Dipnath Baidyaroy , Andrew Shaw , Oleh Tanchak , Christopher Hill , Chengsong Liu , Amala Chokshi , Brian R. Scott
IPC分类号： C12P19/14
CPC分类号： C12P19/14 , C12N9/0006 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/12 , C12P2203/00 , C12Y101/99018 , C13K1/02 , Y02E50/16
摘要： The present application provides genetically modified fungal organisms that produce enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to glucose, enzyme mixtures produced by the genetically modified fungal organisms, and processes for producing glucose from cellulose using such enzyme mixtures.
摘要翻译：本申请提供了经遗传修饰的真菌生物体，其产生显示纤维素材料对葡萄糖的增强水解，由遗传修饰的真菌生物体产生的酶混合物的酶混合物，以及使用这种酶混合物从纤维素生产葡萄糖的方法。

74. 发明授权

US08507244B2 Variants of bacillus sp. TS-23 alpha-amylase with altered properties 有权
标题翻译：杆菌属的变种具有改变性质的TS-23α-淀粉酶
公开(公告)号：US08507244B2
公开(公告)日：2013-08-13
申请号：US13410486
申请日：2012-03-02
申请人： Andrew Shaw , Sandra Ramer , Scott D. Power , Claudine Chang , Melodie Estabrook , Brian E. Jones , Clement Choy , Marc Kolkmam , Chris Leeflang , Casper Vroeman , Walter Weyler , Karsten Kraugh , Mansi Goyal , Thomas Graycar , Victoria Huang
发明人： Andrew Shaw , Sandra Ramer , Scott D. Power , Claudine Chang , Melodie Estabrook , Brian E. Jones , Clement Choy , Marc Kolkmam , Chris Leeflang , Casper Vroeman , Walter Weyler , Karsten Kraugh , Mansi Goyal , Thomas Graycar , Victoria Huang
IPC分类号： C12N9/28 , C12N9/26 , C12N9/24 , C12N1/20 , C12N1/00 , C12N15/00 , C12P21/06 , C12P19/34 , C07H21/04 , C07K1/00
CPC分类号： C12N9/2417 , A21D8/042 , A23K20/189 , A23K50/75 , A23L29/06
摘要： Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased thermostability, reduced calcium dependence, increased washing/cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.
摘要翻译：芽孢杆菌的变种 TS-23菌株α-淀粉酶表现出改善的酶性能，包括增加的热稳定性，降低的钙依赖性，提高的洗涤/清洁性能和烘烤能力。包含这些变体的组合物可用于淀粉加工，淀粉液化，粉化，淀粉糖化，清洗，洗衣，纺织品退浆，烘烤和生物膜除去的方法。

75. 发明申请

US20120107881A1 COMPOSITIONS AND METHODS FOR PRODUCTION OF FERMENTABLE SUGARS 有权
标题翻译：用于生产可食用糖的组合物和方法
公开(公告)号：US20120107881A1
公开(公告)日：2012-05-03
申请号：US13286972
申请日：2011-11-01
申请人： Ish Kumar Dhawan , Dipnath Baidyaroy , Andrew Shaw , Oleh Tanchak , Christopher Hill , Chengsong Liu , Amala Chokshi , Brian R. Scott
发明人： Ish Kumar Dhawan , Dipnath Baidyaroy , Andrew Shaw , Oleh Tanchak , Christopher Hill , Chengsong Liu , Amala Chokshi , Brian R. Scott
IPC分类号： C12P7/14 , C12P19/12 , C12P7/16 , C12N1/15 , C12P19/02
CPC分类号： C12P19/14 , C12N9/0006 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/12 , C12P2203/00 , C12Y101/99018 , C13K1/02 , Y02E50/16
摘要： The present application provides genetically modified fungal organisms that produce enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to glucose, enzyme mixtures produced by the genetically modified fungal organisms, and processes for producing glucose from cellulose using such enzyme mixtures.
摘要翻译：本申请提供了经遗传修饰的真菌生物体，其产生显示纤维素材料对葡萄糖的增强水解，由遗传修饰的真菌生物体产生的酶混合物的酶混合物，以及使用这种酶混合物从纤维素生产葡萄糖的方法。

76. 发明授权

US08143048B2 Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof 有权
标题翻译：特异性淀粉酶多肽，编码那些多肽的核酸及其用途
公开(公告)号：US08143048B2
公开(公告)日：2012-03-27
申请号：US10886903
申请日：2004-07-07
申请人： Karsten Matthias Kragh , Kirsten Bojsen , Casper Tune Berg , Patrick M. F. Derkx , Anja H. Kellett-Smith , Charlotte Refdahl Thoudahl , Carol Fioresi , Wei Liu , Andrew Shaw , Gijsbert Gerritse
发明人： Karsten Matthias Kragh , Kirsten Bojsen , Casper Tune Berg , Patrick M. F. Derkx , Anja H. Kellett-Smith , Charlotte Refdahl Thoudahl , Carol Fioresi , Wei Liu , Andrew Shaw , Gijsbert Gerritse
IPC分类号： C12N9/28 , C12N15/00 , C12N9/88
CPC分类号： C12N9/2417
摘要： This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exospecifity.
摘要翻译：本发明涉及淀粉酶多肽和编码多肽的核酸及其用途。本发明的淀粉酶已被设计成具有更多的有益品质。具体地说，本发明的淀粉酶表现出改变的促进作用。

77. 发明授权

US08129511B2 Modified amylases, nucleic acids encoding those amylases and uses thereof 有权
标题翻译：改性淀粉酶，编码这些淀粉酶的核酸及其用途
公开(公告)号：US08129511B2
公开(公告)日：2012-03-06
申请号：US13023061
申请日：2011-02-08
申请人： Karsten Matthias Kragh , Bo Spange Sørensen , Casper Tune Berg , Kirsten Bojsen , Patrick M. F. Derkx , Carol Fioresi , Anja H. Kellett-Smith , Charlotte Refdahl Thoudahl , Oene R. Veltman , Gijsbert Gerritse , Wei Liu , Andrew Shaw
发明人： Karsten Matthias Kragh , Bo Spange Sørensen , Casper Tune Berg , Kirsten Bojsen , Patrick M. F. Derkx , Carol Fioresi , Anja H. Kellett-Smith , Charlotte Refdahl Thoudahl , Oene R. Veltman , Gijsbert Gerritse , Wei Liu , Andrew Shaw
IPC分类号： C07H21/00 , C12N1/21 , C12N1/15 , C12N1/19
CPC分类号： C12N9/2417 , A21D8/042 , A23L29/06 , A23L29/35 , A23L33/17 , A23V2002/00 , A23V2300/21
摘要： This invention relates to nucleic acids encoding amylase polypeptides, the encoded polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exo-specificity and/or thermostability. Some embodiments of the invention relate to said polypeptides and nucleic acids and their uses as non-maltogenic exoamylases in producing food products.
摘要翻译：本发明涉及编码淀粉酶多肽的核酸，编码的多肽及其用途。本发明的淀粉酶已被设计成具有更多的有益品质。具体地，本发明的淀粉酶显示出改变的外部特异性和/或热稳定性。本发明的一些实施方案涉及所述多肽和核酸及其在制备食品中的非麦芽糖胞外淀粉酶的用途。

78. 发明授权

US08088608B2 Endoglucanases 有权
标题翻译：内切葡聚糖酶
公开(公告)号：US08088608B2
公开(公告)日：2012-01-03
申请号：US12751985
申请日：2010-03-31
申请人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
发明人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
IPC分类号： C12N9/00
CPC分类号： C12N9/2437 , C07K2319/02 , C12N9/2445 , C12N15/75 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.
摘要翻译：本发明涉及与野生型内切葡聚糖酶相比具有改进性质的变体内切葡聚糖酶，特别是内切葡聚糖酶。

79. 发明申请

US20110065783A1 HYDROXYLATED NEBIVOLOL METABOLITES 审中-公开
标题翻译：羟化的NEBIVOLOL代谢物
公开(公告)号：US20110065783A1
公开(公告)日：2011-03-17
申请号：US12908336
申请日：2010-10-20
申请人： John P. O'Donnell , Walter Owens , Joseph Duncan , Andrew Shaw , Jinn Wu
发明人： John P. O'Donnell , Walter Owens , Joseph Duncan , Andrew Shaw , Jinn Wu
IPC分类号： A61K31/353 , A61P9/12
CPC分类号： C07D311/58 , A61K31/353
摘要： Hydroxylated nebivolol metabolites increase NO release from human endothelial cell preparations in a concentration dependent fashion following acute administration. In addition, hydroxylated nebivolol metabolites, including but not limited to 4-hydroxy-6,6′difluoro-, 4-hydroxy-5-phenol-6,6′difluoro-, and 4-hydroxy-8-pheno-6,6′difluoro-, have the ability to increase the capacity for NO release in human endothelial cells following chronic administration. This invention provides hydroxylated nebivolol metabolites and compositions comprising nebivolol and/or at least one hydroxylated metabolite of nebivolol and/or at least one additional compound used to treat cardiovascular diseases or a pharmaceutically acceptable salt thereof. In addition, this invention provides methods of treating and/or preventing vascular diseases by administering at least one hydroxylated metabolite of nebivolol that is capable of releasing a therapeutically effective amount of nitric oxide to a targeted site affected by the vascular disease. Also, this invention is directed to the treatment and/or prevention of migraine headaches administering at least one hydroxylated metabolite of nebivolol. This invention may also be used in conjunction with or as a single treatment of metabolic syndrome disorders.
摘要翻译：急性给药后羟化的奈比洛尔代谢物以浓度依赖的方式增加人内皮细胞制剂的NO释放。此外，羟基化的奈比洛尔代谢物，包括但不限于4-羟基-6,6'-二氟 - ，4-羟基-5-苯酚-6,6'-二氟和4-羟基-8-苯基-6,6 “二氟”具有增加慢性给药后人体内皮细胞NO释放能力的能力。本发明提供羟基化的奈比洛尔代谢物和包含奈比洛尔和/或至少一种羟基化的奈必洛尔代谢物和/或用于治疗心血管疾病的至少一种另外的化合物或其药学上可接受的盐的组合物。此外，本发明提供了治疗和/或预防血管疾病的方法，其通过施用能够将治疗有效量的一氧化氮释放到受血管疾病影响的靶位点的奈比洛尔的羟基化代谢物。此外，本发明涉及治疗和/或预防给予至少一种羟基化的奈必洛尔代谢物的偏头痛。本发明还可以与代谢综合征病症联合使用或作为单一治疗代用综合征病症使用。

80. 发明申请

US20090314286A1 Geobacillus Stearothermophilus Alpha-Amylase (AmyS) Variants with Improved Properties 有权
标题翻译：具有改善性质的嗜热脂肪芽孢杆菌α-淀粉酶（AmyS）变体
公开(公告)号：US20090314286A1
公开(公告)日：2009-12-24
申请号：US12477028
申请日：2009-06-02
申请人： William A. Cuevas , Sang-Kyu Lee , Sandra W. Ramer , Andrew Shaw , Amr R. Toppozada , David E. Estell , Sura H. Hadi , Walter Weyler
发明人： William A. Cuevas , Sang-Kyu Lee , Sandra W. Ramer , Andrew Shaw , Amr R. Toppozada , David E. Estell , Sura H. Hadi , Walter Weyler
IPC分类号： C08B31/00 , C12N9/28
CPC分类号： D06M16/003 , C11D3/38609 , C11D3/38618 , C11D3/3869 , C12N9/2417 , C12Y302/01001 , D06L4/40
摘要： Described are variants of a parent α-amylase that exhibits an alteration in at least one of the following properties relative to said parent α-amylase: specific activity, substrate specificity, substrate binding, substrate cleavage, thermal stability, pH-dependent activity, pH-dependent stability, oxidative stability, Ca2+ dependency, pI, and wash performance. The variants are suitable for starch conversion, ethanol production, laundry washing, dish washing, hard surface cleaning, textile desizing, and/or sweetener production.
摘要翻译：描述了相对于所述亲本α-淀粉酶在下列性质中的至少一个表现出改变的母体α-淀粉酶的变体：比活性，底物特异性，底物结合，底物切割，热稳定性，pH依赖性活性，pH 依赖稳定性，氧化稳定性，Ca2 +依赖性，pI和洗涤性能。这些变体适用于淀粉转化，乙醇生产，洗衣，洗碗，硬表面清洗，纺织品退浆和/或甜味剂生产。

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