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71. 发明申请

US20080027496A1 System and Method for Altering Pacing Modality 有权
标题翻译：改变起搏方式的系统和方法
公开(公告)号：US20080027496A1
公开(公告)日：2008-01-31
申请号：US11461111
申请日：2006-07-31
申请人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
发明人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3688
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

72. 发明申请

US20080027491A1 Pacing Mode Event Classification with Increased Ventricular Sensing 有权
标题翻译：起搏模式事件分类与增加心室感觉
公开(公告)号：US20080027491A1
公开(公告)日：2008-01-31
申请号：US11461146
申请日：2006-07-31
申请人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
发明人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
IPC分类号： A61N1/00
CPC分类号： A61N1/37 , A61N1/368
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

73. 发明申请

US20080027489A1 System and Method for Providing Improved Atrial Pacing Based on Physiological Need 有权
标题翻译：基于生理需要提供改善心房起搏的系统和方法
公开(公告)号：US20080027489A1
公开(公告)日：2008-01-31
申请号：US11461138
申请日：2006-07-31
申请人： Todd J. Sheldon , Robert A. Betzold , Michael O. Sweeney
发明人： Todd J. Sheldon , Robert A. Betzold , Michael O. Sweeney
IPC分类号： A61N1/00
CPC分类号： A61N1/368
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

74. 发明申请

US20070293897A1 System and Method for Promoting Instrinsic Conduction Through Atrial Timing Modification and Calculation of Timing Parameters 有权
标题翻译：通过心房定时修正和时间参数计算促进内在传导的系统和方法
公开(公告)号：US20070293897A1
公开(公告)日：2007-12-20
申请号：US11424383
申请日：2006-06-15
申请人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
发明人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle in truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.
摘要翻译：基于心房的起搏方案促进内在传导。监测整个心动周期的心室活动，并允许心室活动失效。在这种跳过的搏动之后，心室起搏可以在心脏周期中使用。在监测内部心室事件时，预期在给定的窗口内会发生事件。如果没有检测到这样的事件，心脏周期被截断，导致没有心室活动的更短的周期。随后的周期具有心室感测事件的高可能性，并且在起搏之前提供大于正常的AV间隔。

75. 发明授权

US07280868B2 Capture management improvements 有权
标题翻译：捕获管理改进
公开(公告)号：US07280868B2
公开(公告)日：2007-10-09
申请号：US10434689
申请日：2003-05-09
申请人： John C. Rueter , Christopher M. Manrodt , James W. Busacker , Todd J. Sheldon
发明人： John C. Rueter , Christopher M. Manrodt , James W. Busacker , Todd J. Sheldon
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/371 , A61N1/3712 , A61N1/3714 , A61N2001/083
摘要： A capture detection algorithm detects and distinguishes atrial capture. Atrial chamber reset (ACR) and AV conduction (AVC) algorithms are implemented to measure an atrial pacing threshold The data that is used to choose between ACR and AVC methods is used to determine the progression of the patient's disease state. Some of the significant aspects of the invention include enablement of accurate threshold measurements, including calculation of stability criteria, precise interval measurements and the use of reference interval to determine capture and loss of capture.
摘要翻译：捕获检测算法检测并区分心房捕获。实施房室复位（ACR）和AV传导（AVC）算法来测量心房起搏阈值用于在ACR和AVC方法之间选择的数据用于确定患者疾病状态的进展。本发明的一些重要方面包括启用准确的阈值测量，包括稳定性标准的计算，精确的间隔测量以及参考间隔的使用以确定捕获和捕获的丢失。

76. 发明授权

US07130690B2 Atrial capture management during atrial and ventricular pacing 有权
标题翻译：心房和心室起搏过程中心房采集管理
公开(公告)号：US07130690B2
公开(公告)日：2006-10-31
申请号：US10625344
申请日：2003-07-23
申请人： John C. Rueter , Todd J. Sheldon
发明人： John C. Rueter , Todd J. Sheldon
IPC分类号： A61N1/362
CPC分类号： A61N1/3712 , A61N1/362 , A61N1/3714
摘要： In an atrial pacing system, the A-PACE pulse energy, defined by the pulse width and pulse amplitude, sufficient to reliably capture the atrium without being wasteful of battery energy is periodically determined in accordance with atrial capture management (ACM) algorithms. The ACM algorithms allow a slow intrinsic atrial heart rate that is suppressed by delivered A-PACE pulses resulting in A-CAPTURE and that occurs when delivered test A-PACE pulses result in ALOC to be detected. ALOC is declared if an A-EVENT of the slow intrinsic atrial heart rate is detected either during an ACM test window timed from the last delivered test A-PACE pulse or during delivery of a sequence of test A-PACE pulses delivered within or defining the ACM test window correlated to the slow intrinsic atrial heart rate.
摘要翻译：在心房起搏系统中，根据心房捕获管理（ACM）算法周期性地确定由脉冲宽度和脉冲幅度定义的足够可靠地捕获心房而不浪费电池能量的A-PACE脉冲能量。 ACM算法允许由传递的A-PACE脉冲抑制的内在心房心率慢，导致A-CAPTURE，并且当递送的测试A-PACE脉冲导致检测到ALOC时发生。如果在从最后传送的测试A-PACE脉冲定时的ACM测试窗口期间或在递送在其中传送或定义的测试A-PACE脉冲序列期间检测到慢内在心房心率的A-EVENT，则ALOC被声明 ACM测试窗口与内在心房心率缓慢相关。

77. 发明授权

US6044297A Posture and device orientation and calibration for implantable medical devices 有权
标题翻译：植入式医疗设备的姿势和设备定向和校准
公开(公告)号：US6044297A
公开(公告)日：2000-03-28
申请号：US160647
申请日：1998-09-25
申请人： Todd J. Sheldon , William J. Combs , Mark K. Erickson , Can Cinbis
发明人： Todd J. Sheldon , William J. Combs , Mark K. Erickson , Can Cinbis
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/36542 , A61N1/36535
摘要： A method of and apparatus for determining the physical posture of a patient's body, having a superior-inferior body axis, an anterior-posterior body axis and a lateral-medial body axis, in relation to earth's gravitational field. A medical device having first, second and, optionally, third accelerometers having sensitive axes mounted orthogonally within an implantable housing is adapted to be implanted with the sensitive axes nominally aligned with ideal X, Y and Z device axes correlated to patient body axes. Each accelerometer generates DC accelerometer signals having characteristic magnitudes and polarities on alignment of the sensitive axis with, against or normal to earth's gravitational field and DC accelerometer signals of varying magnitudes and polarities when not so aligned. The actual pitch and roll angles of the sensitive axes of the accelerometers in the implanted IMD with respect to the true gravitational axes are determined and the yaw angles are determined or estimated. Corrected DC accelerometer output signals are derived from the pitch, roll and yaw angles and are compared to a set of stored thresholds for each body posture to determine the actual body posture. Storage of these comparisons or the raw signals themselves can be used for histogram data to provide theraputic or research benefits also described.
摘要翻译：一种用于确定患者身体的物理姿势的方法和装置，其具有相对于地球重力场的上下身体轴线，前后身体轴线和侧向内侧身体轴线。具有第一，第二和第三加速度计的医疗设备具有正交安装在可植入的外壳内的敏感轴，适于植入与名义上与理想的与患者体轴相关的X，Y和Z装置轴对准的敏感轴。每个加速度计产生具有特征幅度和极性的特征幅度和极性的直流加速度计信号，当不对准时，敏感轴对准或反对或垂直于地球重力场和具有不同幅度和极性的直流加速度计信号。确定和估计在植入的IMD中相对于真重力轴的加速度计的敏感轴的实际俯仰角和倾斜角，并且确定或估计偏航角。校正的直流加速度计输出信号是从俯仰角，偏转角和偏航角度得出的，并且与每个身体姿势的一组存储的阈值进行比较，以确定实际的身体姿势。这些比较或原始信号本身的存储可用于直方图数据，以提供还描述的治疗或研究益处。

78. 发明授权

US5725562A Rate responsive cardiac pacemaker and method for discriminating stair climbing from other activities 失效
标题翻译：速率响应心脏起搏器和方法来区分爬梯与其他活动
公开(公告)号：US5725562A
公开(公告)日：1998-03-10
申请号：US668524
申请日：1996-06-28
申请人： Todd J. Sheldon
发明人： Todd J. Sheldon
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61N1/36585 , A61N1/36535
摘要： A method of and apparatus for pacing a patient's heart at a pacing rate dependent on patient activity and posture particularly during stair climbing. A dual chamber, rate responsive pacemaker for pacing a patient's heart includes at least one DC accelerometer mounted in the pacemaker pulse generator for implantation such that the sensitive axis of the DC accelerometer is sensitive to the effects of gravity during forward lean of the patient characteristic of stair climbing posture. The DC and AC signal outputs of the accelerometer are processed to develop a tilt signal and an activity signal. A target rate control signal is derived from the activity signal dependent on the level of activity. A stair climbing rate is selected for controlling the physiologic pacing rate between a lower and an upper pacing rate in the presence of an activity signal indicative of a patient walking rate and a tilt signal value falling within a tilt window. The target rate control signal is used to control the pacing rate if the activity signal is indicative of faster patient movement, e.g. running, or if the tilt signal is outside the tilt window indicating that the patient is either upright or prone.
摘要翻译：一种用于根据患者活动和姿势起搏患者心脏的起搏速度的方法和装置，特别是在楼梯攀爬期间。用于起搏患者心脏的双室速率响应起搏器包括安装在起搏器脉冲发生器中用于植入的至少一个DC加速度计，使得DC加速度计的敏感轴对患者特征向前倾斜时的重力影响敏感楼梯攀登姿势。处理加速度计的直流和交流信号输出以产生倾斜信号和活动信号。根据活动水平从活动信号导出目标速率控制信号。在存在指示患者行走速度的活动信号和落在倾斜窗内的倾斜信号值的情况下，选择楼梯攀爬速率来控制较低和较高起搏速率之间的生理起搏速率。如果活动信号表示更快的患者运动，则目标速率控制信号用于控制起搏速率，例如，运行，或者如果倾斜信号在倾斜窗口之外，指示患者直立或倾向。

79. 发明授权

US09919158B2 Configuring operating parameters of a medical device based on exposure to a disruptive energy field 有权
公开(公告)号：US09919158B2
公开(公告)日：2018-03-20
申请号：US12648690
申请日：2009-12-29
申请人： Michael L. Ellingson , Hyun J. Yoon , Todd J. Sheldon
发明人： Michael L. Ellingson , Hyun J. Yoon , Todd J. Sheldon
IPC分类号： A61N1/00 , A61N1/37 , A61N1/368
CPC分类号： A61N1/3718 , A61N1/3688 , A61N1/37
摘要： An implantable medical device (IMD) determines an effect of the disruptive energy field and adjusts one or more operating parameters of the IMD based on at least the determined effect. In some instances, the IMD may determine an actual effect of the disruptive energy field, such as a temperature change, impedance change, pacing or sensing threshold change, MRI-induced interference one pacing or sensing, or other actual effect. In other instances, the IMD may determine a predicted effect of the disruptive energy field based on one or more characteristics of the exposure. In any case, the IMD adjusts one or more parameters based on at least the determined effect.

80. 发明授权

US08417337B2 Method of continuous capture verification in cardiac resynchronization devices 有权
标题翻译：心脏再同步装置中连续捕获验证的方法
公开(公告)号：US08417337B2
公开(公告)日：2013-04-09
申请号：US12501691
申请日：2009-07-13
申请人： James W. Busacker , Todd J. Sheldon
发明人： James W. Busacker , Todd J. Sheldon
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： In bi-ventricular pacing devices (including CRT devices) analysis of myocardial electrogram signals in one ventricle (e.g., a left ventricle, or “LV”) can be used to infer capture or loss-of-capture (LOC) of an earlier stimulus pulse in the same ventricle, on a continuous (every pacing cycle), triggered, aperiodic and/or periodic basis. Rather than using an evoked-response principle as has been the basis of capture detection in prior art and other systems, a principle employed via the present invention uses evidence of inter-ventricular conduction (i.e., from the opposite chamber) and/or atrio-ventricular conduction as evidence of LOC, since a non-capturing pacing stimulus provided to a first chamber will allow the myocardial tissue of the first chamber to remain non-refractory and thus inter-ventricular and atrio-ventricular wavefront propagation and conduction can commence and be detected thereby revealing whether LOC has occurred.
摘要翻译：在双心室起搏装置（包括CRT装置）中，可以使用一个心室（例如左心室或左心室）心肌电图信号的分析来推断早期刺激脉冲的捕获或丢失（LOC）相同的心室，连续（每个起搏周期），触发，非周期性和/或周期性基础。而不是使用诱发反应原理作为现有技术和其他系统中的捕获检测的基础，通过本发明采用的原理使用心室间传导（即，从相对的室）和/或心室传导的证据，心室传导作为LOC的证据，因为提供给第一腔室的非捕获起搏刺激将允许第一腔室的心肌组织保持不耐受，因此可以开始心室间壁和心房内波前传播和传导检测出来是否显示LOC是否发生。

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