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71. 发明授权

US09572865B2 Activin-actriia antagonists and uses for treating multiple myeloma 有权
标题翻译：活化素活性拮抗剂和用于治疗多发性骨髓瘤的用途
公开(公告)号：US09572865B2
公开(公告)日：2017-02-21
申请号：US13460342
申请日：2012-04-30
申请人： John Knopf , Jasbir Seehra , Ravindra Kumar
发明人： John Knopf , Jasbir Seehra , Ravindra Kumar
IPC分类号： A61K38/17 , C07K14/71
CPC分类号： C07K16/3061 , A61K38/179 , A61K38/1796 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K14/71 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2319/02 , C07K2319/30
摘要： In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.
摘要翻译：在某些方面，本发明提供用于促进骨生长和增加骨密度以及用于治疗多发性骨髓瘤的组合物和方法。

72. 发明授权

US08703927B2 Isolated nucleotide sequences encoding GDF traps 有权
标题翻译：分离的编码GDF陷阱的核苷酸序列
公开(公告)号：US08703927B2
公开(公告)日：2014-04-22
申请号：US13542269
申请日：2012-07-05
申请人： Jasbir Seehra , Robert Scott Pearsall , Ravindra Kumar
发明人： Jasbir Seehra , Robert Scott Pearsall , Ravindra Kumar
IPC分类号： C07H21/04
CPC分类号： C07K14/495 , A61K31/00 , A61K31/454 , A61K31/7068 , A61K38/1709 , A61K38/179 , A61K38/1796 , A61K38/1816 , A61K38/193 , A61K39/39533 , A61K45/06 , C07K14/475 , C07K14/505 , A61K2300/00
摘要： In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
摘要翻译：在某些方面，本发明提供用于增加脊椎动物（包括啮齿动物和灵长类动物，特别是人）中红细胞和/或血红蛋白水平的组合物和方法。

73. 发明授权

US08703694B2 Methods for increasing thermogenic adipocytes 有权
标题翻译：增加产热脂肪细胞的方法
公开(公告)号：US08703694B2
公开(公告)日：2014-04-22
申请号：US13403657
申请日：2012-02-23
申请人： John Knopf , Jasbir Seehra , Ravindra Kumar
发明人： John Knopf , Jasbir Seehra , Ravindra Kumar
IPC分类号： A61K38/00 , C07K16/46
CPC分类号： C07K16/40 , A61K31/7088 , A61K38/00 , A61K38/1796 , A61P3/00 , A61P3/04 , A61P3/10 , A61P21/00 , C07K14/71 , C07K2319/30 , C12N5/0602
摘要： In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF 11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.
摘要翻译：在某些方面，本发明提供通过施用ActRIIB信号传导途径的拮抗剂来增加产热脂肪细胞（例如，棕色脂肪细胞或其他表达UCP-1的脂肪细胞）的组合物和方法。这些拮抗剂的实例包括ActRIIB多肽，抗ActRIIB抗体，抗肌生成抑制素抗体，抗GDF3抗体，抗-Nodal，抗激活素和抗GDF11抗体。可以通过引起生热脂肪细胞的增加来治疗各种代谢和其它疾病。

74. 发明申请

US20130071393A1 METHODS FOR INCREASING RED BLOOD CELL LEVELS AND TREATING ANEMIA USING A COMBINATION OF GDF TRAPS AND ERYTHROPOIETIN RECEPTOR ACTIVATORS 有权
标题翻译：使用GDF TRAPS和ERYTHROPOIETIN受体激活剂组合增加红血球细胞水平和治疗神经痛的方法
公开(公告)号：US20130071393A1
公开(公告)日：2013-03-21
申请号：US13542269
申请日：2012-07-05
申请人： Jasbir Seehra , Robert Scott Pearsall , Ravindra Kumar
发明人： Jasbir Seehra , Robert Scott Pearsall , Ravindra Kumar
IPC分类号： A61K38/17 , A61K39/395 , A61K38/18
CPC分类号： C07K14/495 , A61K31/00 , A61K31/454 , A61K31/7068 , A61K38/1709 , A61K38/179 , A61K38/1796 , A61K38/1816 , A61K38/193 , A61K39/39533 , A61K45/06 , C07K14/475 , C07K14/505 , A61K2300/00
摘要： In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
摘要翻译：在某些方面，本发明提供用于增加脊椎动物（包括啮齿动物和灵长类动物，特别是人）中红细胞和/或血红蛋白水平的组合物和方法。

75. 发明授权

US08343933B2 Variants derived from ActRIIB and uses therefor 有权
标题翻译：衍生自ActRIIB的变体并用于此
公开(公告)号：US08343933B2
公开(公告)日：2013-01-01
申请号：US12893976
申请日：2010-09-29
申请人： John Knopf , Jasbir Seehra , Ravindra Kumar
发明人： John Knopf , Jasbir Seehra , Ravindra Kumar
IPC分类号： A61K38/16 , C07K14/00 , C07K14/705 , C07K14/71
CPC分类号： C07K14/71 , A61K38/00 , C07K14/705 , C07K14/72 , C07K16/18 , C07K2319/30 , C07K2319/70
摘要： In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
摘要翻译：在某些方面，本发明提供用于调节（促进或抑制）组织如骨，软骨，肌肉，脂肪和/或神经元组织的生长的组合物和方法。本发明还提供筛选调节ActRIIB蛋白和/或ActRIIB配体的活性的化合物的方法。本文提供的组合物和方法可用于治疗与ActRIIB蛋白和/或ActRIIB配体的异常活性相关的疾病。

76. 发明授权

US08271556B1 Method and system for managing clustered and non-clustered storage systems 有权
标题翻译：用于管理群集和非群集存储系统的方法和系统
公开(公告)号：US08271556B1
公开(公告)日：2012-09-18
申请号：US13241000
申请日：2011-09-22
申请人： Raja Shekar , Ravindra Kumar , Kartik Kumar
发明人： Raja Shekar , Ravindra Kumar , Kartik Kumar
IPC分类号： G06F17/30 , G06F12/00
CPC分类号： G06F17/30067 , H04L12/1435 , H04L41/12 , H04L41/22 , H04L43/0817 , H04L67/1097
摘要： Method and system for managing a storage environment having a cluster based storage system and a non-cluster based storage system is provided. A management application collects information regarding components of both the cluster based storage system and the non-cluster based storage system. A layout having a plurality of data structures is generated and maintained by the management application. The data structures include information regarding the components and their relationships with each other, if any. The layout is used for responding to user requests and presenting an integrated view of the storage environment on a display device with selectable options for selecting the cluster based storage system components and the non-cluster based storage system components.
摘要翻译：提供了一种用于管理具有基于群集的存储系统和基于非群集的存储系统的存储环境的方法和系统。管理应用程序收集有关基于群集的存储系统和基于非群集的存储系统的组件的信息。具有多个数据结构的布局由管理应用程序生成和维护。数据结构包括关于组件及其彼此之间的关系的信息（如果有的话）。该布局用于响应用户请求，并在显示设备上呈现存储环境的集成视图，其具有用于选择基于群集的存储系统组件和基于非群集的存储系统组件的可选择选项。

77. 发明授权

US08232252B2 P-selectin ligand protein 失效
标题翻译： P-选择蛋白配体蛋白
公开(公告)号：US08232252B2
公开(公告)日：2012-07-31
申请号：US12167705
申请日：2008-07-03
申请人： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
发明人： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
IPC分类号： A61K38/10 , A61K38/16 , C07K7/08 , C07K14/435 , C12N15/09
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/4703 , C07K14/51 , C07K14/52 , C07K14/5431 , C07K14/705 , C07K16/2851 , C07K16/2854 , C07K19/00 , C07K2319/00 , C07K2319/24 , C12N9/10 , C12N9/1051 , C12N9/6454 , C12N2770/36222
摘要： A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
摘要翻译：公开了一种新型P-选择蛋白配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。

78. 发明申请

US20120156204A1 METHODS FOR INCREASING ADIPONECTIN 有权
标题翻译：增加ADIPONECTIN的方法
公开(公告)号：US20120156204A1
公开(公告)日：2012-06-21
申请号：US13404593
申请日：2012-02-24
申请人： Jasbir Seehra , Ravindra Kumar , Jennifer Lachey , Alan Koncarevic
发明人： Jasbir Seehra , Ravindra Kumar , Jennifer Lachey , Alan Koncarevic
IPC分类号： A61K39/395 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/10 , A61P3/08
CPC分类号： C07K16/40 , A61K31/00 , A61K31/7088 , A61K38/179 , A61K2039/505 , C07K14/705 , C07K16/22 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2319/30
摘要： In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-activin A and/or B antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, and anti-BMP7 antibodies. Also provided are methods for ameliorating one or more undesired effects of anti-androgen therapy, including muscle loss, bone loss, increased adiposity, and/or increased insulin resistance. A variety of disorders may be treated by causing an increase in circulating adiponectin concentrations.
摘要翻译：在某些方面，本发明提供了通过施用ActRIIB信号通路的拮抗剂来增加有需要的患者中的脂连蛋白的组合物和方法。此类拮抗剂的实例包括ActRIIB多肽，抗ActRIIB抗体，抗激活素A和/或B抗体，抗肌生成抑制素抗体，抗GDF3抗体和抗BMP7抗体。还提供了用于改善一种或多种不期望的抗雄激素治疗效果的方法，包括肌肉损失，骨丢失，增加的肥胖和/或增加的胰岛素抵抗。可以通过引起循环中脂联素浓度的增加来治疗多种疾病。

79. 发明授权

US08173601B2 Activin-ActRIIa antagonists and uses for treating multiple myeloma 有权
标题翻译： Activin-ActRIIa拮抗剂和治疗多发性骨髓瘤的用途
公开(公告)号：US08173601B2
公开(公告)日：2012-05-08
申请号：US12012525
申请日：2008-02-01
申请人： John Knopf , Jasbir Seehra , Ravindra Kumar
发明人： John Knopf , Jasbir Seehra , Ravindra Kumar
IPC分类号： A61K38/00 , C07K19/00
CPC分类号： C07K16/3061 , A61K38/179 , A61K38/1796 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K14/71 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2319/02 , C07K2319/30
摘要： In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.
摘要翻译：在某些方面，本发明提供用于促进骨生长和增加骨密度以及用于治疗多发性骨髓瘤的组合物和方法。

80. 发明授权

US08138142B2 Methods for increasing adiponectin in a patient in need thereof 有权
标题翻译：在有需要的患者中增加脂连蛋白的方法
公开(公告)号：US08138142B2
公开(公告)日：2012-03-20
申请号：US12657146
申请日：2010-01-13
申请人： Jasbir Seehra , Ravindra Kumar , Jennifer Lachey , Alan Koncarevic
发明人： Jasbir Seehra , Ravindra Kumar , Jennifer Lachey , Alan Koncarevic
IPC分类号： A61K38/00 , C07K16/46
CPC分类号： C07K16/40 , A61K31/00 , A61K31/7088 , A61K38/179 , A61K2039/505 , C07K14/705 , C07K16/22 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2319/30
摘要： In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-activin A and/or B antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, and anti-BMP7 antibodies. Also provided are methods for ameliorating one or more undesired effects of anti-androgen therapy, including muscle loss, bone loss, increased adiposity, and/or increased insulin resistance. A variety of disorders may be treated by causing an increase in circulating adiponectin concentrations.
摘要翻译：在某些方面，本发明提供了通过施用ActRIIB信号通路的拮抗剂来增加有需要的患者中的脂连蛋白的组合物和方法。此类拮抗剂的实例包括ActRIIB多肽，抗ActRIIB抗体，抗激活素A和/或B抗体，抗肌生成抑制素抗体，抗GDF3抗体和抗BMP7抗体。还提供了用于改善一种或多种不期望的抗雄激素治疗效果的方法，包括肌肉损失，骨丢失，增加的肥胖和/或增加的胰岛素抵抗。可以通过引起循环中脂联素浓度的增加来治疗多种疾病。

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