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71. 发明授权

US07559938B2 Instrument for effecting anastomosis of respective tissues defining two body lumens 有权
标题翻译：用于实现定义两个体腔的各组织吻合的仪器
公开(公告)号：US07559938B2
公开(公告)日：2009-07-14
申请号：US11093646
申请日：2005-03-30
申请人： Christopher J. Hess , Robert P. Gill , William B. Weisenburgh, II , James W. Voegele
发明人： Christopher J. Hess , Robert P. Gill , William B. Weisenburgh, II , James W. Voegele
IPC分类号： A61B17/08
CPC分类号： A61B17/0401 , A61B17/0482 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/11 , A61B17/115 , A61B17/1155 , A61B2017/00004 , A61B2017/0412 , A61B2017/0417 , A61B2017/0419 , A61B2017/0427 , A61B2017/06176 , A61B2017/0647 , A61B2017/1103 , A61B2017/1135 , A61B2017/1139 , A61B2017/22069 , A61B2017/2905 , A61B2017/2923
摘要： The instrument disclosed may comprise a tube assembly supporting an end effector that may be adapted for insertion into and through the urethra, and adapted for use in effecting the anastomosis of a patient's bladder and urethra following a prostatectomy. In one embodiment the end effector may comprise a positioner having an extendable and retractable petal operably connected to a tube, and an anchor driver. In another embodiment the end effector may comprise a positioner and an anchor driver having a driver pin operably connected to a tube.
摘要翻译：所公开的仪器可以包括支撑末端执行器的管组件，其可以适于插入和穿过尿道，并适于用于在前列腺切除术之后实现患者膀胱和尿道的吻合。在一个实施例中，端部执行器可以包括定位器，该定位器具有可操作地连接到管的可伸展和可缩回的花瓣，以及锚固器。在另一个实施例中，末端执行器可以包括定位器和锚定器驱动器，其具有可操作地连接到管的驱动器销。

72. 发明授权

US07553317B2 Instrument for effecting anastomosis of respective tissues defining two body lumens 有权
标题翻译：用于实现定义两个体腔的各组织吻合的仪器
公开(公告)号：US07553317B2
公开(公告)日：2009-06-30
申请号：US11093802
申请日：2005-03-30
申请人： William B. Weisenburgh, II , Robert P. Gill , Christopher J. Hess , James W. Voegele
发明人： William B. Weisenburgh, II , Robert P. Gill , Christopher J. Hess , James W. Voegele
IPC分类号： A61B17/08
CPC分类号： A61B17/0401 , A61B17/0482 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/11 , A61B17/115 , A61B17/1155 , A61B2017/00004 , A61B2017/0412 , A61B2017/0417 , A61B2017/0419 , A61B2017/0427 , A61B2017/06176 , A61B2017/0647 , A61B2017/1103 , A61B2017/1135 , A61B2017/1139 , A61B2017/22069 , A61B2017/2905 , A61B2017/2923
摘要： The instrument disclosed may comprise a tube assembly supporting an end effector that may be adapted for insertion into and through the urethra, and adapted for use in effecting the anastomosis of a patient's bladder and urethra following a prostatectomy. In one embodiment the end effector may comprise a positioner having a positioner arm that is extendable and retractable by rotation of a tube, and an anchor driver. In another embodiment the end effector may comprise a positioner and an anchor driver having a driver arm that is extendable and retractable by rotation of a tube.
摘要翻译：所公开的仪器可以包括支撑末端执行器的管组件，其可以适于插入和穿过尿道，并适于用于在前列腺切除术之后实现患者膀胱和尿道的吻合。在一个实施例中，末端执行器可以包括具有定位器臂的定位器，该定位器臂可以通过管的旋转而延伸和缩回，以及锚定器。在另一个实施例中，末端执行器可以包括定位器和锚定器驱动器，其具有通过管的旋转而可伸缩的驱动臂。

73. 发明申请

US20090118587A1 Manifold for laparoscopic seal assembly 有权
标题翻译：歧管用于腹腔镜密封组装
公开(公告)号：US20090118587A1
公开(公告)日：2009-05-07
申请号：US11979638
申请日：2007-11-06
申请人： James W. Voegele , Christopher J. Hess , William B. Weisenburgh, II , Robert P. Gill , Daniel W. Drew , Frank L. Lyman , Michael D. Cronin
发明人： James W. Voegele , Christopher J. Hess , William B. Weisenburgh, II , Robert P. Gill , Daniel W. Drew , Frank L. Lyman , Michael D. Cronin
IPC分类号： A61B1/32
CPC分类号： A61B17/3423 , A61B17/3498 , A61B2017/00265 , A61B2017/00438 , A61B2090/308 , A61B2217/005
摘要： A laparoscopic seal assembly includes a seal cap having a seal with an access opening. The seal cap also includes a manifold connection for attachment of a functional apparatus. The seal assembly further includes a retractor.
摘要翻译：腹腔镜密封组件包括具有与入口的密封件的密封帽。密封盖还包括用于附接功能装置的歧管连接件。密封组件还包括牵开器。

74. 发明授权

US07500972B2 Device for alternately holding, or effecting relative longitudinal movement, of members of a medical instrument 有权
标题翻译：用于交替地保持或实现医疗器械的构件的相对纵向移动的装置
公开(公告)号：US07500972B2
公开(公告)日：2009-03-10
申请号：US11094119
申请日：2005-03-30
申请人： James W. Voegele , Robert P. Gill , Christopher J. Hess , William B. Weisenburgh, II
发明人： James W. Voegele , Robert P. Gill , Christopher J. Hess , William B. Weisenburgh, II
IPC分类号： A61M27/00
CPC分类号： A61B17/0401 , A61B17/0482 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/11 , A61B17/115 , A61B17/1155 , A61B2017/00004 , A61B2017/0412 , A61B2017/0417 , A61B2017/0419 , A61B2017/0427 , A61B2017/06176 , A61B2017/0647 , A61B2017/1103 , A61B2017/1135 , A61B2017/1139 , A61B2017/22069 , A61B2017/2905 , A61B2017/2923
摘要： The disclosed device can hold, or effect relative longitudinal movement between, two members of a medical instrument, such as an instrument used for fastening two hollow organs together. The device may comprise a handle member having a longitudinal guide defining a line of travel and a longitudinal groove having a detent catch therein; a longitudinally spring-biased moving member slidable within the longitudinal guide and having pawl receiving slots along a line parallel with the line of travel; and a transversely and rotationally spring-biased driving trigger member comprising a pawl proximate to the moving member and adapted to engage the pawl receiving slots when aligned therewith, and a fulcrum member movable within the groove and adapted to be releasably captured by the detent, the driving trigger member being rotatable about the fulcrum member to cause the pawl to engage or disengage the pawl receiving slots.
摘要翻译：所公开的装置可以保持或影响医疗器具的两个构件之间的相对纵向运动，例如用于将两个中空器件紧固在一起的仪器。该装置可以包括具有限定行程线的纵向引导件和在其中具有止动钩的纵向凹槽的手柄构件; 纵向弹簧偏移的移动构件，其可在纵向引导件内滑动并且具有沿着与行程线平行的直线的棘爪接收槽; 以及横向和旋转的弹簧偏压的驱动触发器构件，其包括靠近所述移动构件的棘爪，并且适于在与所述棘爪接合槽对齐时接合所述棘爪接收槽;以及支撑构件，其可在所述凹槽内移动并且适于被所述棘爪可释放地捕获，驱动触发器构件可围绕支点构件旋转，以使棘爪接合或脱离棘爪接收槽。

75. 发明申请

US20080319307A1 Method for medical imaging using fluorescent nanoparticles 审中-公开
标题翻译：使用荧光纳米粒子的医学成像方法
公开(公告)号：US20080319307A1
公开(公告)日：2008-12-25
申请号：US11820354
申请日：2007-06-19
申请人： James W. Voegele , Robert P. Gill
发明人： James W. Voegele , Robert P. Gill
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B6/032 , A61B6/037 , A61B6/481 , A61B6/485
摘要： A first method for medically imaging a patient includes obtaining a carrier medium containing fluorescent nanoparticles. The carrier medium containing the fluorescent nanoparticles is disposed inside the patient at a site where the carrier medium will migrate to specific tissue of known shape. The nanoparticles are activated to fluoresce. Image data of the patient is obtained including the specific tissue after the specific tissue has picked-up the fluorescing fluorescent nanoparticles. The known shape of the specific tissue is identified in the image data. An image representation of the image data is created using the identified known shape as a fiducial. An image of the image representation of the image data is displayed. In a second method, the carrier medium is injected inside tissue of the patient at a site where the carrier medium will be localized in the injected tissue, and the injecting deposits the medium in a predetermined shape in the tissue.
摘要翻译：用于医学成像患者的第一种方法包括获得含有荧光纳米颗粒的载体介质。含有荧光纳米颗粒的载体介质在载体介质将迁移到具有已知形状的特定组织的位置处置于患者体内。纳米颗粒被激活以发荧光。在特定组织拾取荧光荧光纳米颗粒后，获得包括特定组织的患者的图像数据。在图像数据中识别特定组织的已知形状。使用所识别的已知形状作为基准来创建图像数据的图像表示。显示图像数据的图像表示的图像。在第二种方法中，将载体介质注射到患者的组织内，在载体介质将被定位在注入的组织中的位置处，并且注射将培养基以预定形状沉积在组织中。

76. 发明申请

US20080255403A1 MAGNETIC NANOPARTICLE THERAPIES 审中-公开
标题翻译：磁性纳米治疗
公开(公告)号：US20080255403A1
公开(公告)日：2008-10-16
申请号：US11771399
申请日：2007-06-29
申请人： James W. Voegele , Robert P. Gill
发明人： James W. Voegele , Robert P. Gill
IPC分类号： A61N2/00
CPC分类号： A61K41/0052 , A61B1/043 , A61B1/3132 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/415 , A61B5/418 , A61K49/0017 , A61K49/0093
摘要： Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and/or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect.
摘要翻译：提供使用可用作标记物，指示剂和光源的荧光纳米颗粒的各种组合物，方法和装置。荧光纳米颗粒可以由包围生物相容的外壳如二氧化硅壳的荧光团芯形成。在一个实施方案中，荧光纳米颗粒可以被递送到组织以标记组织，使得能够识别和定位组织，和/或照亮组织周围的区域。在另一个实施方案中，荧光纳米颗粒可用于装置或植入物以将装置或植入物定位在体内，指示装置或植入物的取向，和/或照亮装置或植入物周围的区域。荧光纳米颗粒也可用于提供治疗效果。

77. 发明申请

US20080161850A1 SUTURE ANCHORING SYSTEM 审中-公开
标题翻译： SUTURE锚固系统
公开(公告)号：US20080161850A1
公开(公告)日：2008-07-03
申请号：US11617375
申请日：2006-12-28
申请人： William Bruce Weisenburgh , Michael S. Cropper , Robert P. Gill , David T. Martin , Christopher J. Hess , James W. Voegele
发明人： William Bruce Weisenburgh , Michael S. Cropper , Robert P. Gill , David T. Martin , Christopher J. Hess , James W. Voegele
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/06004 , A61B2017/00004 , A61B2017/00526 , A61B2017/0403 , A61B2017/0409 , A61B2017/0414 , A61B2017/0417 , A61B2017/0458 , A61B2017/06052 , A61B2017/06057
摘要： A first extruded member in joined to a molded member to form an integrated component. In one exemplary form, a surgical anchor is overmolded onto the end of an extruded suture to form a suture/anchor system.
摘要翻译：第一挤压构件，其连接到模制构件以形成集成部件。在一个示例性形式中，手术锚固件被包覆模制到挤压缝合线的端部上以形成缝线/锚定系统。

78. 发明授权

US10092291B2 Surgical instrument with selectively rigidizable features 有权
公开(公告)号：US10092291B2
公开(公告)日：2018-10-09
申请号：US13013147
申请日：2011-01-25
申请人： James W. Voegele , Aaron C. Voegele
发明人： James W. Voegele , Aaron C. Voegele
IPC分类号： A61B17/00 , A61M25/00 , A61B17/072 , A61B17/115 , A61B17/34
摘要： Mechanisms for altering the shape of a cell or chamber of a shaft or an actuation drive of an instrument are provided. The mechanisms may selectively rigidize the shaft of surgical or diagnostic instruments. The shaft assembly includes a shaft operatively connectable to a control member, at least one cell or a set of cells defined within the shaft, a shape altering material contained within the cell or cells, and, an activation link operatively connectable to a source of activation energy for delivering activation energy to each cell for activating the shape altering material to selectively rigidize or unrigidize the shaft. An actuator for producing work is also provided that includes an element within a housing that defines a cell or a set of cells. The shape altering material is contained within the cells, and a source of activation energy operatively connected to each cell for activating the shape altering material to expand or contract the cell. The element is operatively connectable to a driving member of an instrument such that the change in the cell is translated to the driving member to facilitate the production of work.

79. 发明申请

US20140088487A1 METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE WITH LIGHT 审中-公开
标题翻译：用于用光激活褐色扁桃体组织的方法和装置
公开(公告)号：US20140088487A1
公开(公告)日：2014-03-27
申请号：US13977536
申请日：2011-12-21
申请人： Jason L. Harris , Lee M. Kaplan , David N. Plescia , Taylor W. Aronhalt , James W. Voegele , Nicholas Stylopoulos
发明人： Jason L. Harris , Lee M. Kaplan , David N. Plescia , Taylor W. Aronhalt , James W. Voegele , Nicholas Stylopoulos
IPC分类号： A61N5/06
CPC分类号： A61N5/0613 , A61M5/14276 , A61M2230/06 , A61M2230/201 , A61N5/062
摘要： Methods and devices are provided for activating brown adipose tissue (BAT) with light. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by using light to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The light can be configured to directly or indirectly stimulate the nerves and/or the brown adipocytes. The light can be configured to indirectly stimulate the nerves and/or the brown adipocytes by activating a light activatable medium administered to a patient and configured to respond to the light to cause activation of the brown adipose tissue.
摘要翻译：提供了用于用光激活棕色脂肪组织（BAT）的方法和装置。通常，方法和装置可以激活BAT以增加产热，例如增加患者的热产生，其随着时间推移可导致体重减轻和/或改善的代谢功能。在一个实施方案中，提供了一种医疗装置，其通过使用光来刺激BAT来激发BAT，和/或直接刺激棕色脂肪细胞，从而增加BAT中的产热，并通过能量消耗引起体重减轻和/或改善的代谢功能来激活BAT 。光可以配置成直接或间接刺激神经和/或棕色脂肪细胞。光可以被配置为通过激活施用于患者的光可激活介质并配置为响应于光以引起棕色脂肪组织的激活来间接刺激神经和/或棕色脂肪细胞。

80. 发明授权

US08608652B2 Vaginal entry surgical devices, kit, system, and method 有权
标题翻译：阴道入口手术器械，套件，系统和方法
公开(公告)号：US08608652B2
公开(公告)日：2013-12-17
申请号：US12612911
申请日：2009-11-05
申请人： James W. Voegele , David B. Griffith , Mark S. Zeiner
发明人： James W. Voegele , David B. Griffith , Mark S. Zeiner
IPC分类号： A61B1/32
CPC分类号： A61B1/303 , A61B17/3423 , A61B2017/345 , A61B2017/3466 , A61B2017/348
摘要： A surgical method, system, kit, and various devices are provided for use in, among other things, vaginal entry during a natural orifice translumenal endoscopic surgical procedure. A system and/or method provide for the rapid creation of a conduit and/or multiple ports in a natural orifice, such as a patient's vagina, while accommodating anatomical variation to reduce the need to excise additional tissue from the patient.
摘要翻译：提供外科手术方法，系统，试剂盒和各种装置，用于除了别的以外，还可用于天然口腔内窥镜手术中的阴道进入。一种系统和/或方法提供了在诸如患者的阴道之类的自然孔中快速产生导管和/或多个端口，同时容纳解剖变异以减少从患者切除额外组织的需要。

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