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71. 发明申请

US20110158957A1 Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases 有权
标题翻译：使用工程化锌指蛋白核酸酶靶向破坏T细胞受体基因
公开(公告)号：US20110158957A1
公开(公告)日：2011-06-30
申请号：US12927292
申请日：2010-11-10
申请人： Maria Chiara Bonini , Pietro Genovese , Philip D. Gregory , Michael C. Holmes , Luigi Naldini , David Paschon , Elena Provasi , Lei Zhang
发明人： Maria Chiara Bonini , Pietro Genovese , Philip D. Gregory , Michael C. Holmes , Luigi Naldini , David Paschon , Elena Provasi , Lei Zhang
IPC分类号： A61K35/12 , C12N9/16 , C07H21/04 , C12N15/63 , C12N5/07 , C12N5/00 , A61P35/00 , A61P37/06 , A61P31/00
CPC分类号： A61K35/28 , A61K35/00 , A61K35/17 , A61K38/00 , C07K14/7051 , C07K2319/81 , C07K2319/95 , C12N9/22 , C12N15/01
摘要： Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.
摘要翻译：本文公开了在能够保持细胞活力的条件下使用锌指核酸酶（ZFN）灭活TCR基因的方法和组合物，所述锌指核酸酶包含锌指蛋白和切割结构域或切割半结构域。还提供了编码ZFN的多核苷酸，包含编码ZFN的多核苷酸的载体和包含编码ZFN和/或包含ZFN的细胞的多核苷酸的细胞。本文公开的也是在T淋巴细胞（包括具有中枢记忆表型的淋巴细胞）中不存在内源性TCR表达时表达功能性外源性TCR的方法和组合物。还提供了编码外源性TCR的多核苷酸，包含编码外源性TCR的多核苷酸的载体和包含编码外源性TCR的多核苷酸的细胞和/或包含外源TCR的细胞。

72. 发明申请

US20110136916A1 6-SHOGAOL FOR USING IN A METHOD FOR THE TREATMENT OF LEUKEMIA 审中-公开
标题翻译： 6-SHOGAOL用于治疗低密度脂蛋白的方法
公开(公告)号：US20110136916A1
公开(公告)日：2011-06-09
申请号：US12938949
申请日：2010-11-03
申请人： Ping Li , Yongbo Peng , Lianwen Qi , Xiaodong Wen , Jiang Ma , Ping Zhou , Lei Zhang , Qun Liu , Ehu Liu , Jun Chen
发明人： Ping Li , Yongbo Peng , Lianwen Qi , Xiaodong Wen , Jiang Ma , Ping Zhou , Lei Zhang , Qun Liu , Ehu Liu , Jun Chen
IPC分类号： A61K31/122 , C07C49/255 , A61P35/02
CPC分类号： A61K31/122
摘要： The present invention relates to the field of natural drugs, particularly to 6-shogaol for using in a method for the treatment of leukemia. The present invention provides a method for treating leukemia by applying a therapeutically effective dose of 6-shogaolt and this therapeutic method can be used for treating leukemia in mammals including human being.
摘要翻译：本发明涉及天然药物领域，特别涉及用于治疗白血病的方法中的6-shoolol。本发明提供了通过施用治疗有效剂量的6-shogaolt治疗白血病的方法，并且该治疗方法可用于治疗包括人在内的哺乳动物的白血病。

73. 发明申请

US20110128889A1 Method for Selecting and Configuring Network Supernodes 失效
标题翻译：选择和配置网络超频的方法
公开(公告)号：US20110128889A1
公开(公告)日：2011-06-02
申请号：US12730866
申请日：2010-03-24
申请人： Jianxin Liao , Jing Wang , Chun Wang , Wei Li , Li Wan , Xiaomin Zhu , Lei Zhang , Tong Xu , Lejian Zhang , Qiwei Shen , Limin Fan , Li Cheng
发明人： Jianxin Liao , Jing Wang , Chun Wang , Wei Li , Li Wan , Xiaomin Zhu , Lei Zhang , Tong Xu , Lejian Zhang , Qiwei Shen , Limin Fan , Li Cheng
IPC分类号： H04L12/28
CPC分类号： H04L41/0893 , H04L45/04 , H04L67/1051 , H04L67/1093
摘要： A method for selecting and configuring network supernodes including the following operational steps: in a first set period T1, each node other than the control node in a network sends information on interactions between the node and other nodes to the control node regularly; and in a second set period T2, the control node divides the nodes into a plurality of node clusters according to the received information on interactions among the nodes, and selects supernodes from each node cluster, each node belonging uniquely to a node cluster. The supernode selection according to the invention takes into account both performance and resource conditions of itself and interactions with other nodes. Therefore, when implementing control over other nodes in the node cluster to which it belongs, the selected supernode can find the corresponding node in a short time and shorten the searching time and path, thereby improving the working efficiency. Meanwhile, parameters such as the acquiring period of node interaction information, and the division and adjustment periods of node clusters can be adjusted dynamically with the actual interaction conditions of the network.
摘要翻译：一种用于选择和配置网络超节点的方法，包括以下操作步骤：在第一设定周期T1中，除了网络中的控制节点之外的每个节点向节点定期向控制节点发送关于节点与其他节点之间的交互的信息; 并且在第二设定周期T2中，控制节点根据接收到的关于节点之间的交互的信息将节点划分为多个节点簇，并且从每个节点簇选择每个节点的节点簇唯一的节点。根据本发明的超级节点选择考虑了自身的性能和资源状况以及与其他节点的交互。因此，当对其所属的节点集群中的其他节点实施控制时，所选择的超节点可以在短时间内找到相应的节点，缩短搜索时间和路径，从而提高工作效率。同时，可以根据网络的实际交互条件动态调整节点交互信息采集周期等参数，节点集群划分和调整周期。

74. 发明申请

US20110082078A1 Methods and compositions for treating neuropathies 有权
标题翻译：治疗神经病的方法和组合物
公开(公告)号：US20110082078A1
公开(公告)日：2011-04-07
申请号：US12658258
申请日：2010-02-04
申请人： Carolyn Dent , Josee Laganiere , Xiangdong Meng , David Paschon , Siyuan Tan , Lei Zhang , Steve H. Zhang
发明人： Carolyn Dent , Josee Laganiere , Xiangdong Meng , David Paschon , Siyuan Tan , Lei Zhang , Steve H. Zhang
IPC分类号： A61K38/17 , C07K14/00 , C07H21/04 , A61P3/10 , A61P25/16 , A61P27/02 , C12N5/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： Disclosed herein are methods and compositions for treating neuropathies by modulating endogenous NT-3 of GDNF gene expression.
摘要翻译：本文公开了通过调节GDNF基因表达的内源性NT-3来治疗神经病的方法和组合物。

75. 发明授权

US07914665B2 Method for making a lubricating oil with improved low temperature properties 有权
标题翻译：制造具有改善的低温性能的润滑油的方法
公开(公告)号：US07914665B2
公开(公告)日：2011-03-29
申请号：US11667236
申请日：2005-11-14
申请人： Lei Zhang , Elizabeth Stavens , Lisa I-Ching Yeh , Ian A. Cody , William J. Murphy , Thomas R. Palmer
发明人： Lei Zhang , Elizabeth Stavens , Lisa I-Ching Yeh , Ian A. Cody , William J. Murphy , Thomas R. Palmer
IPC分类号： C10G29/20 , C10G47/02
CPC分类号： G01N33/30 , C10G67/04 , C10G2300/1022 , C10G2300/1037 , C10G2300/1062 , C10G2300/1074 , C10G2300/202 , C10G2300/301 , C10G2300/302 , C10G2300/304 , C10G2300/4018 , C10G2300/4025 , C10G2300/44 , C10G2400/10 , G01N30/463 , G01N2030/025
摘要： The invention relates to a process for preparing lube oil basestocks from lube oil boiling range feeds. More particularly, the present invention is directed toward a process wherein a wax containing feed is solvent dewaxed to produce at least a partially dewaxed lube oil boiling range stream, which is hydrodewaxed to produce a first lube basestock. The first lube basestock is added to an independently selected second lube basestock and additives to make a lubricating oil.
摘要翻译：本发明涉及从润滑油沸程饲料制备润滑油基础油料的方法。更具体地，本发明涉及一种方法，其中将含蜡进料溶剂脱蜡以产生至少部分脱蜡的润滑油沸程流，其被加氢脱蜡以产生第一润滑油基础油料。将第一润滑油基础油加入到独立选择的第二润滑油基础油和添加剂中以制备润滑油。

76. 发明申请

US20100320746A1 PIPING CONNECTOR AND METHOD ON CONNECTING PIPE 审中-公开
标题翻译：管道连接器和连接管道的方法
公开(公告)号：US20100320746A1
公开(公告)日：2010-12-23
申请号：US12516531
申请日：2007-11-28
申请人： Michael Lin , Lei Zhang
发明人： Michael Lin , Lei Zhang
IPC分类号： F16L21/00 , F16L25/00
CPC分类号： F16L13/141 , F16L2201/10
摘要： A method to connect piping and a piping connection, having the features of a ring connector configured to snugly fit around an external diameter of a pipe; and a piping shield connected to the ring connector, the piping shield having at least one observation window cut into the shield, wherein the piping shield covers an abutment end of the pipe to be connected, wherein a joint between the ring connector and the piping shield forms a connection.
摘要翻译：一种连接管道和管道连接的方法，其具有环形连接器的特征，其被配置为紧密地配合在管的外径周围; 以及连接到所述环形连接器的管道屏蔽件，所述管道屏蔽件具有切割到所述屏蔽件中的至少一个观察窗口，其中所述管道屏蔽罩覆盖要连接的所述管道的邻接端，其中所述环形连接器和所述管道屏蔽形成一个连接。

77. 发明授权

US07806109B2 Fuel supply apparatus 有权
标题翻译：燃油供应装置
公开(公告)号：US07806109B2
公开(公告)日：2010-10-05
申请号：US12149672
申请日：2008-05-06
申请人： Mamoru Tateishi , Yasuo Hosokawa , Tetsuji Inoue , Lei Zhang , Hiroya Abe
发明人： Mamoru Tateishi , Yasuo Hosokawa , Tetsuji Inoue , Lei Zhang , Hiroya Abe
IPC分类号： F02M37/08 , F02M37/04
CPC分类号： F02M37/103 , B01D35/027 , B01D35/26
摘要： A fuel pump unit includes a fuel pump which is driven by a motor, a secondary filter case placed to surround the fuel pump and contains a filter, a reserve cup which houses the fuel pump and the secondary filter case, and a pump controller which drivingly controls the fuel pump. A shielding material is provided in the reserve cup to shield electrical noise generated by the fuel pump. The shielding material is grounded. The pump controller includes a pump drive circuit which is provided with an electric filter.
摘要翻译：燃料泵单元包括由电动机驱动的燃料泵，放置在燃料泵周围并包含过滤器的二次过滤器壳体，容纳燃料泵和辅助过滤器壳体的储备杯以及驱动的泵控制器控制燃油泵。在储备杯中设置屏蔽材料以屏蔽由燃料泵产生的电噪声。屏蔽材料接地。泵控制器包括具有电过滤器的泵驱动电路。

78. 发明申请

US20100211927A1 WEBSITE DESIGN PATTERN MODELING 有权
标题翻译：网站设计图案建模
公开(公告)号：US20100211927A1
公开(公告)日：2010-08-19
申请号：US12389368
申请日：2009-02-19
申请人： Rui Cai , Jiang-Ming Yang , Lei Zhang , Wei-Ying Ma
发明人： Rui Cai , Jiang-Ming Yang , Lei Zhang , Wei-Ying Ma
IPC分类号： G06F9/44
CPC分类号： G06F17/218 , G06F8/75 , G06F17/27
摘要： Website design pattern modeling technique embodiments are presented that model a website's design patterns. This can be based on the website's layout elements, its URL tokens, or both. When based on both, the design patterns can be modeled separately using first the layout elements and then the URL tokens, or vice versa. Alternately, the modeling can be based on coupled layout and URL token patterns. In operation, the modeling involves first identifying layout elements and/or URL tokens found on at least some of the pages of the website. The website design patterns are then modeled based on the occurrences of the identified layout elements and/or URL tokens in pages of the website. In cases where a coupled modeling scheme is employed, a modeling technique that exploits the correlations between the layout elements and URL tokens is used.
摘要翻译：呈现网站设计模式建模技术实施例，模拟网站的设计模式。这可以基于网站的布局元素，其网址令牌或两者兼而有之。当基于这两者时，可以使用第一个布局元素和URL令牌来分别设计设计模式，反之亦然。或者，建模可以基于耦合的布局和URL令牌模式。在操作中，建模涉及首先识别在网站的至少一些页面上发现的布局元素和/或URL令牌。然后基于网站页面中识别的布局元素和/或URL令牌的出现来对网站设计模式进行建模。在使用耦合建模方案的情况下，使用利用布局元素和URL令牌之间的相关性的建模技术。

79. 发明申请

US20100211533A1 EXTRACTING STRUCTURED DATA FROM WEB FORUMS 审中-公开
标题翻译：从网站提取结构化数据
公开(公告)号：US20100211533A1
公开(公告)日：2010-08-19
申请号：US12388517
申请日：2009-02-18
申请人： Jiangming Yang , Rui Cai , Lei Zhang , Wei-Ying Ma
发明人： Jiangming Yang , Rui Cai , Lei Zhang , Wei-Ying Ma
IPC分类号： G06F15/18 , G06N5/02
CPC分类号： G06N20/00 , G06F16/958
摘要： The web forum data extraction technique is designed for the structured data extraction of data on web forums using both page-level information and site-level knowledge. To do this, the technique finds the kinds of page objects a forum site has, which object a page belongs to, and how different page objects are connected with each other. This information can be obtained by re-constructing the sitemap of the target forum which is based on a Data Object Model of the target forum. The web forum data extraction technique collects three kinds of evidence for data extraction: 1) inner-page features which cover both semantic and layout information on an individual page; 2) inter-vertex features which describe linkage-related observations; and 3) inner-vertex features which characterize interrelationships among pages in one vertex. The technique employs Markov Logic Networks to combine the types of evidence statistically for inference and thereby can extract the desired structures.
摘要翻译：网络论坛数据提取技术是为了使用页面级信息和站点级知识，在Web论坛上的数据结构化数据提取。为此，该技术可以找到论坛网站所拥有的页面对象的种类，页面所属的对象以及不同的页面对象如何相互连接。该信息可以通过重新构建基于目标论坛的数据对象模型的目标论坛的站点地图来获得。网络论坛数据提取技术收集了三种数据提取证据：1）内页特征，涵盖单个页面上的语义和布局信息; 2）描述连锁相关观察的顶点间特征; 和3）表示一个顶点中的页面之间的相互关系的内顶点特征。该技术采用马可夫逻辑网络来统计证据的类型，从而推断出所需的结构。

80. 发明申请

US20100191686A1 Answer Ranking In Community Question-Answering Sites 有权
标题翻译：社区回答排名问题回答网站
公开(公告)号：US20100191686A1
公开(公告)日：2010-07-29
申请号：US12358517
申请日：2009-01-23
申请人： Xin-Jing Wang , Lei Zhang , Wei-Ying Ma
发明人： Xin-Jing Wang , Lei Zhang , Wei-Ying Ma
IPC分类号： G06N5/02 , G06F17/30 , G06F7/06
CPC分类号： G06F17/30675 , G06F17/30634 , G09B7/02
摘要： In some implementations, a plurality of first questions and corresponding first answers are identified at a community question-answer (CQA) site as a plurality of first question-answer (q-a) pairs. A query thread comprised of a second question and a plurality of candidate second answers is selected for making a determination of answer quality. A set of the first questions that are similar to the second question are identified from the plurality of first questions. First linking features between the identified set of first questions and their corresponding first answers are used for determining an analogy with second linking features between the second question and candidate answers for ranking the candidate answers.
摘要翻译：在一些实现中，多个第一问题和对应的第一答案在社区问答（CQA）站点被识别为多个第一问答（q-a）对。选择由第二个问题和多个候选的第二个答案构成的查询线索，以便确定回答质量。从多个第一个问题中识别出与第二个问题相似的一组第一个问题。所识别的第一个问题集合与其相应的第一个答案之间的第一个链接特征被用于确定与第二个问题和候选答案之间的第二个链接特征的类比，以便对候选答案进行排名。

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