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71. 发明申请

US20080279894A1 Bacterial Glycolipid Activation of Cd1d-Restricted Nkt Cells 有权
标题翻译：细菌糖脂激活Cd1d限制性Nkt细胞
公开(公告)号：US20080279894A1
公开(公告)日：2008-11-13
申请号：US11814103
申请日：2006-01-26
申请人： Paul B. Savage , Albert Bendelac , Luc Teyton
发明人： Paul B. Savage , Albert Bendelac , Luc Teyton
IPC分类号： A61K39/02 , C12N5/06 , A61K39/00
CPC分类号： A61K39/39 , A61K31/7032 , A61K35/74 , A61K38/1774 , A61K2039/55594 , Y02A50/403
摘要： Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.
摘要翻译：公开了用于激活NKT细胞的方法，刺激受试者的免疫应答的方法，改善疫苗功效的方法以及治疗感染的方法。还公开了促进肿瘤排斥，治疗癌症，调节自身免疫并抑制受试者中变应原诱导的超敏反应的方法。所述方法包括使NKT细胞与与CD1分子复合的细菌糖脂接触以激活NKT细胞。细菌糖脂可以衍生自阿尔法糖酵母属的成员。

72. 发明授权

US06486148B2 Steroid derived antibiotics 有权
标题翻译：类固醇衍生的抗生素
公开(公告)号：US06486148B2
公开(公告)日：2002-11-26
申请号：US09927926
申请日：2001-08-10
申请人： Paul B. Savage , Chunhong Li
发明人： Paul B. Savage , Chunhong Li
IPC分类号： A61K3156
CPC分类号： C07J41/0055 , C07J9/00 , C07J9/005 , C07J31/003 , C07J41/0094
摘要： A series of novel steroid derivatives are described. The steroid derivatives are antibacterial agents. The steroid derivatives also act to sensitize bacteria to other antibiotics including erythromycin and novobiocin.
摘要翻译：描述了一系列新型类固醇衍生物。类固醇衍生物是抗菌剂。类固醇衍生物还用于使细菌对其他抗生素（包括红霉素和新生霉素）敏感。

73. 发明授权

US06350738B1 Steroid derived antibiotics 有权
公开(公告)号：US06350738B1
公开(公告)日：2002-02-26
申请号：US09234008
申请日：1999-01-19
申请人： Paul B. Savage , Chunhong Li
发明人： Paul B. Savage , Chunhong Li
IPC分类号： A61K3156
CPC分类号： C07J41/0055 , C07J9/00 , C07J9/005 , C07J31/003 , C07J41/0094
摘要： A series of novel steroid derivatives are described. The steroid derivatives are antibacterial agents. The steroid derivatives also act to sensitize bacteria to other antibiotics including erythromycin and novobiocin.

74. 发明申请

US20200368253A1 USE OF CSA COMPOUNDS TO STIMULATE STEM CELLS AND HAIR GROWTH 审中-公开
公开(公告)号：US20200368253A1
公开(公告)日：2020-11-26
申请号：US16880590
申请日：2020-05-21
申请人： Paul B. Savage , Michael C. Moore , Chad S. Beus
发明人： Paul B. Savage , Michael C. Moore , Chad S. Beus
IPC分类号： A61K31/575 , A61K9/00
摘要： The present disclosure describes compositions and methods for regenerating tissue and/or preventing tissue loss by stimulating stem cells. A method includes providing a treatment composition including one or more CSA compounds and a carrier, applying the treatment composition to a targeted tissue region of a subject, and the treatment composition stimulating tissue regeneration and/or preventing tissue degradation at the targeted region of the subject.

75. 发明授权

US10155788B2 Cationic steroidal antimicrobial prodrug compositions and uses thereof 有权
公开(公告)号：US10155788B2
公开(公告)日：2018-12-18
申请号：US14875953
申请日：2015-10-06
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： A61K31/575 , C07J41/00 , A61K45/06
摘要： Prodrugs or pharmaceutically acceptable salts, stereoisomers, solvates, or polymorphs thereof include a pharmaceutically and/or diagnostically active cationic steroidal antimicrobial (hereinafter “CSA”) compound or pharmaceutically acceptable salt, stereoisomer, solvate, or polymorph thereof, and one or more cleavable groups (C.G.). Some embodiments include a CSA compound prepared in an inactive or less active form and that is capable of conversion to a fully active form upon administration to a subject, upon preparation of a pharmaceutical formulation containing the CSA composition, and/or upon exposure to physiological conditions. Pharmaceutical compositions include the prodrug or pharmaceutically acceptable salt, stereoisomer, solvate, or polymorph thereof and one or more pharmaceutically acceptable excipients. Methods of treatment of bacterial infections in a patient in need utilize prodrugs or pharmaceutically acceptable salts, stereoisomers, solvates, polymorphs thereof and/or the pharmaceutical compositions described herein.

76. 发明授权

US09943614B2 Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods 有权
公开(公告)号：US09943614B2
公开(公告)日：2018-04-17
申请号：US13000010
申请日：2009-06-16
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： A61K51/04
CPC分类号： A61K51/0493
摘要： The invention relates to diagnostic, detection, screening and imaging methods. In various embodiments, methods of diagnosis, detection, screening and imaging include administering a cationic steroid antimicrobial or CSA to a subject having or at risk of having an infection or a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in an amount effective to diagnose or detect the infection or the hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in the subject. In a particular aspect, a detectable CSA, namely CSA-13 labeled with 99mTc is used to detect the presence of an infection.

77. 发明申请

US20170210776A1 CATIONIC STEROIDAL ANTIMICROBIALS 审中-公开
公开(公告)号：US20170210776A1
公开(公告)日：2017-07-27
申请号：US15481884
申请日：2017-04-07
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： C07J41/00
CPC分类号： C07J41/0088
摘要： Disclosed herein are cationic steroidal antimicrobials (“CSA compounds” or “ceragenins”) and methods of making the same. Particularly advantageous methods are identified for the synthesis of CSA compounds. CSA compounds may be formulated for treating subjects with ailments responsive to CSA compounds, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering CSA compounds.

78. 发明授权

US09686966B2 Methods and apparatus for cleaning or disinfecting a water delivery system 有权
公开(公告)号：US09686966B2
公开(公告)日：2017-06-27
申请号：US14694028
申请日：2015-04-23
申请人： Chad S. Beus , Paul B. Savage
发明人： Chad S. Beus , Paul B. Savage
IPC分类号： A61L2/00 , A61B1/00 , B08B3/00 , A01K7/00 , B08B9/08 , A61K31/575 , A01N33/08 , A01N37/44 , B08B9/027 , B08B3/08 , C02F1/50 , A01N45/00 , C02F1/68
CPC分类号： A01K7/00 , A01N33/08 , A01N37/44 , A01N45/00 , A61K31/575 , B08B3/08 , B08B9/027 , B08B9/08 , B08B9/0856 , C02F1/50 , C02F1/688 , C02F2303/04 , C02F2307/14
摘要： Methods for cleaning or disinfecting water delivery systems, self-cleaning or self-disinfecting water delivery systems, and inserts for use in cleaning or disinfecting water delivery systems utilize cationic steroidal antimicrobial (CSA) molecules to kill microbes and/or break up biofilms within water delivery systems. The methods and systems involve adding CSA molecules to water to form an aqueous CSA composition and passing the aqueous CSA composition through the water delivery system, such as a water storage vessel and/or water delivery line to clean or disinfect the water delivery system. CSA molecules can be added to a water storage vessel, water delivery line, or well, such as by a solid or liquid CSA composition. A CSA-eluting composition may provide CSA molecules to water to form an aqueous CSA composition that passes through or is stored within the water delivery system. CSA molecules provided to agricultural animals in drinking water may improve animal health.

79. 发明授权

US09533063B1 Aerosols incorporating ceragenin compounds and methods of use thereof 有权
标题翻译：包含cerornin化合物的气溶胶及其使用方法
公开(公告)号：US09533063B1
公开(公告)日：2017-01-03
申请号：US13783007
申请日：2013-03-01
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： A61L2/18 , A61L2/22
CPC分类号： A01N45/00 , A01N25/06 , A01N25/12
摘要： Aerosols that include ceragenin compounds (i.e., ceragenin-containing aerosols), methods for delivering such aerosols, and devices for delivering such aerosols. Ceragenins can be used to kill a broad range of microbes (e.g., bacteria, viruses, fungi, bacterial spores, fungal spores, and the like), yet they are thought to be completely non-toxic to humans and other higher eukaryotes. Aerosols can penetrate into the nooks and crannies of a space and kill microbes that may lurk in a space. In addition, ceragenins have a extended mode of action, which allows them to continue killing microbes in a space for an extended period of time.
摘要翻译：包括cerornin化合物（即含有ceragenin的气溶胶），递送这种气溶胶的方法和用于递送这种气溶胶的装置的气溶胶。 Ceragenins可用于杀死广泛的微生物（例如细菌，病毒，真菌，细菌孢子，真菌孢子等），但是它们被认为对人类和其它高等真核生物完全无毒。气溶胶可以渗透到空间的角落和角落，并杀死可能潜伏在空间中的微生物。此外，ceragenins具有延长的作用方式，允许它们在长时间内继续杀死空间中的微生物。

80. 发明授权

US09434759B1 Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds 有权
标题翻译：阳离子甾族抗微生物化合物及其制备方法
公开(公告)号：US09434759B1
公开(公告)日：2016-09-06
申请号：US14866213
申请日：2015-09-25
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： C07J41/00 , A61K31/575 , C07C225/00 , C07C211/00
CPC分类号： C07J41/0088 , A61K31/575 , C07C211/00 , C07C225/00 , C07J41/0055 , C07J41/0061
摘要： Cationic steroidal antimicrobial (CSA) compounds having amide functionality and methods of manufacturing such CSA compounds. The CSA compound can be a compound of Formula (I), Formula (II), Formula (III), or a salt thereof: where R18 has the following structure: —R20—(C═O)—N—R21R22 R20 is omitted or substituted or unsubstituted alkyl, alkenyl, alkynyl, or aryl, and R21 and R22 are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or substituted or unsubstituted aryl, provided that at least one of R21 and R22 is not hydrogen.

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